| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Cataldo, C Y Thayer, E D Bird, T R Wheelock, R A Nixo. Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin. Brain research. vol 513. issue 2. 1990-07-16. PMID:2350688. |
to investigate the role of proteolysis in amyloid formation, we studied the localization of the proteolytic enzymes, cathepsin d and cathepsin b, in the prefrontal cerebral cortex and hippocampus of human postmortem brains from patients with alzheimer's disease and from individuals free of neurological disease. |
1990-07-16 |
2023-08-11 |
human |
| A M Iacopino, S Christako. Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 11. 1990-07-12. PMID:2140897. |
comparison of diseased human brain tissue with age- and sex-matched controls yielded significant decreases (60-88%) in calbindin protein and mrna in the substantia nigra (parkinson disease), in the corpus striatum (huntington disease), in the nucleus basalis (alzheimer disease), and in the hippocampus and nucleus raphe dorsalis (parkinson, huntington, and alzheimer diseases) but not in the cerebellum, neocortex, amygdala, or locus ceruleus. |
1990-07-12 |
2023-08-11 |
human |
| J B Penney, W F Maragos, J T Greenamyre, D L Debowey, Z Hollingsworth, A B Youn. Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias. Journal of neurology, neurosurgery, and psychiatry. vol 53. issue 4. 1990-06-25. PMID:2160518. |
excitatory amino acid binding sites in the hippocampal region of alzheimer's disease and other dementias. |
1990-06-25 |
2023-08-11 |
human |
| J B Penney, W F Maragos, J T Greenamyre, D L Debowey, Z Hollingsworth, A B Youn. Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias. Journal of neurology, neurosurgery, and psychiatry. vol 53. issue 4. 1990-06-25. PMID:2160518. |
quantitative receptor autoradiography was used to measure muscarinic cholinergic, benzodiazepine, kainate, phencyclidine (pcp), n-methyl-d-aspartate (nmda) (measured in tris acetate), quisqualate-sensitive, non-quisqualate-sensitive and total glutamate (measured in tris chloride buffer) binding sites in adjacent sections of the hippocampal region of 10 alzheimer's disease, nine control, and six demented, non-alzheimer's disease postmortem human brains. |
1990-06-25 |
2023-08-11 |
human |
| D Dewar, K Horsburgh, D I Graham, D N Brooks, J McCulloc. Selective alterations of high affinity [3H]forskolin binding sites in Alzheimer's disease: a quantitative autoradiographic study. Brain research. vol 511. issue 2. 1990-06-14. PMID:2110494. |
in the hippocampal region [3h]forskolin binding was no different in the alzheimer brains compared to controls, although chat activity was significantly reduced. |
1990-06-14 |
2023-08-11 |
Not clear |
| T Sato, Y Ito, T Mizuno, H Tauchi, T Inagaki, T Yamamot. [Morphological studies of the hippocampus of 100 elderly females in relation to age and grade of dementia]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. vol 26. issue 6. 1990-05-31. PMID:2634126. |
the number of the nerve cells, appearance of alzheimer's neurofibrillary tangles and of senile plaques in the hippocampus of 100 female autopsy cases aged 56-101 were compared in relation to age and grade of dementia. |
1990-05-31 |
2023-08-11 |
Not clear |
| P Cervera, C Duyckaerts, M Ruberg, E Hirsch, G Ransmayr, J J Hauw, Y Agi. Tyrosine hydroxylase-like immunoreactivity in senile plaques is not related to the density of tyrosine hydroxylase-positive fibers in patients with Alzheimer's disease. Neuroscience letters. vol 110. issue 1-2. 1990-05-24. PMID:1970142. |
the numbers of silver-stained senile plaques and plaques containing tyrosine hydroxylase (th)-like immunoreactivity were counted in the neocortex, amygdala and hippocampus of control subjects and patients with alzheimer's disease, and compared with the density of th-positive nerve fibers. |
1990-05-24 |
2023-08-11 |
human |
| K Ohtsubo, N Izumiyama, H Shimada, T Tachikawa, H Nakamur. Three-dimensional structure of Alzheimer's neurofibrillary tangles of the aged human brain revealed by the quick-freeze, deep-etch and replica method. Acta neuropathologica. vol 79. issue 5. 1990-05-24. PMID:2327247. |
the three-dimensional structure of alzheimer's neurofibrillary tangles in the pyramidal cells of the hippocampus and in the nerve cells of the parahippocampal gyrus was examined by the quick-freeze, deep-etch and replica method. |
1990-05-24 |
2023-08-11 |
human |
| T I Mandybur, C C Chuirazz. Astrocytes and the plaques of Alzheimer's disease. Neurology. vol 40. issue 4. 1990-05-07. PMID:1690867. |
we demonstrated senile plaques with glial fibrillary acidic protein (gfap) stain in prefrontal and parietal cortex and in hippocampus of 3 cases of alzheimer's disease. |
1990-05-07 |
2023-08-11 |
Not clear |
| H Arai, V M Lee, L Otvos, B D Greenberg, D E Lowery, S K Sharma, M L Schmidt, J Q Trojanowsk. Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 6. 1990-04-25. PMID:1690426. |
we localized distinct beta-app domains, including the beta-amyloid protein or a4 region, within the sps of 13 end-stage alzheimer disease (ad) and 13 age-matched control samples of hippocampus and entorhinal cortex. |
1990-04-25 |
2023-08-11 |
Not clear |
| S A Johnson, J Rogers, C E Finc. APP-695 transcript prevalence is selectively reduced during Alzheimer's disease in cortex and hippocampus but not in cerebellum. Neurobiology of aging. vol 10. issue 6. 1990-04-24. PMID:2483450. |
app-695 transcript prevalence is selectively reduced during alzheimer's disease in cortex and hippocampus but not in cerebellum. |
1990-04-24 |
2023-08-11 |
Not clear |
| W Bondareff, C Q Mountjoy, M Roth, D L Hause. Neurofibrillary degeneration and neuronal loss in Alzheimer's disease. Neurobiology of aging. vol 10. issue 6. 1990-04-24. PMID:2628782. |
neuronal loss in alzheimer's disease, especially in cerebral cortex and hippocampus, appears closely associated with the process of neurofibrillary degeneration. |
1990-04-24 |
2023-08-11 |
Not clear |
| A E George, M J de Leon, L A Stylopoulos, J Miller, A Kluger, G Smith, D C Mille. CT diagnostic features of Alzheimer disease: importance of the choroidal/hippocampal fissure complex. AJNR. American journal of neuroradiology. vol 11. issue 1. 1990-03-15. PMID:2105589. |
the presence of characteristic hippocampal lucency, apparently due to enlargement of the choroid and hippocampal fissures, showed the highest sensitivity and classification accuracy of all the variables tested (82 and 80% respectively; p less than .001), correctly identifying 82% of alzheimer patients and 80% of alzheimer patients and control subjects. |
1990-03-15 |
2023-08-11 |
human |
| A E George, M J de Leon, L A Stylopoulos, J Miller, A Kluger, G Smith, D C Mille. CT diagnostic features of Alzheimer disease: importance of the choroidal/hippocampal fissure complex. AJNR. American journal of neuroradiology. vol 11. issue 1. 1990-03-15. PMID:2105589. |
these results indicate that ct detection of structural changes in the temporal lobe and hippocampus strongly support the diagnosis of alzheimer disease. |
1990-03-15 |
2023-08-11 |
human |
| R Quirion, I Aubert, P A Lapchak, R P Schaum, S Teolis, S Gauthier, D M Arauj. Muscarinic receptor subtypes in human neurodegenerative disorders: focus on Alzheimer's disease. Trends in pharmacological sciences. vol Suppl. 1990-03-06. PMID:2694529. |
much evidence has clearly revealed the existence of marked cholinergic deficits in cortical and hippocampal areas in alzheimer's disease. |
1990-03-06 |
2023-08-11 |
human |
| R Quirion, I Aubert, P A Lapchak, R P Schaum, S Teolis, S Gauthier, D M Arauj. Muscarinic receptor subtypes in human neurodegenerative disorders: focus on Alzheimer's disease. Trends in pharmacological sciences. vol Suppl. 1990-03-06. PMID:2694529. |
we report here that in addition to deficits in choline acetyltransferase (chat) activity, the maximal densities of high affinity [3h]acetylcholine and [3h]af-dx 116 (possibly m2), but not m1 muscarinic receptor binding sites are decreased in cortex and hippocampus in alzheimer's disease. |
1990-03-06 |
2023-08-11 |
human |
| D M Mann, A Brown, D P Wilks, C A Davie. Immunocytochemical and lectin histochemical studies of plaques and tangles in Down's syndrome patients at different ages. Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2532371. |
the presence of numerous senile plaques (sp) and neurofibrillary tangles (nft) within association areas of the neocortex and within the hippocampus and amygdala, is generally regarded as providing the histopathological hallmarks of alzheimer's disease (ad) (mann, 1985). |
1990-01-31 |
2023-08-11 |
Not clear |
| R N Kalaria, S I Hari. Abnormalities of the glucose transporter at the blood-brain barrier and in brain in Alzheimer's disease. Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2602426. |
in this study, we assessed the gt protein in the frontal cortex, hippocampus, cerebellum, and cerebral microvessels in subjects with alzheimer's disease (ad) and controls. |
1990-01-31 |
2023-08-11 |
human |
| K M Schegg, S Nielsen, R M Zweig, J H Peacoc. Decrease in membrane-bound G4 form of acetylcholinesterase in postmortem Alzheimer brain. Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2602428. |
samples of left hippocampus, septal nucleus, parietal lobe (area 40), and nucleus basalis of meynert (nbm) were removed from eight patients with pathologically confirmed alzheimer's disease (ad), four controls, and three patients with non-alzheimer's dementia. |
1990-01-31 |
2023-08-11 |
mouse |
| D M Michaelson, J Chapman, O Bachar, A D Korczyn, E Wertma. Serum antibodies to cholinergic neurons in Alzheimer's disease. Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2602432. |
alzheimer's disease (ad) is associated with degenerative changes in nuclei of the basal forebrain which provide most of the cholinergic innervation of the cortex and hippocampus. |
1990-01-31 |
2023-08-11 |
human |