| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B A Yankner, A Caceres, L K Duff. Nerve growth factor potentiates the neurotoxicity of beta amyloid. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 22. 1991-01-10. PMID:2174172. |
the early and profound degeneration of hippocampal and basal forebrain cholinergic neurons that occurs in alzheimer disease may result from a neurotoxic interaction of beta amyloid with ngf. |
1991-01-10 |
2023-08-11 |
Not clear |
| V D Deshmukh, S V Deshmuk. Stress-adaptation failure hypothesis of Alzheimer's disease. Medical hypotheses. vol 32. issue 4. 1990-12-20. PMID:2233421. |
such chronic stress-adaptation failure leads to a vicious circular reaction, namely: intense, stressful stimuli----neocortico-limbic excitation----hypothalamo-pituitary-adrenocortical (hpa) axis activation----excessive secretion of neurohormones including cortisol----stimulation of inhibitory glucocorticoid sensitive hippocampal neurons----failure to terminate the hpa axis response----chronic excessive secretion of neurohormones including cortisol----overstimulation degeneration of glucocorticoid sensitive hippocampal inhibitory neurons----progressive cognitive-affective behavioral disorganizational failure which is typical of dementia of the alzheimer's type. |
1990-12-20 |
2023-08-11 |
Not clear |
| D Dewar, D I Graham, J McCulloc. 5 HT2 receptors in dementia of Alzheimer type: a quantitative autoradiographic study of frontal cortex and hippocampus. Journal of neural transmission. Parkinson's disease and dementia section. vol 2. issue 2. 1990-12-13. PMID:2222780. |
5 ht2 receptors in dementia of alzheimer type: a quantitative autoradiographic study of frontal cortex and hippocampus. |
1990-12-13 |
2023-08-11 |
human |
| D Dewar, D I Graham, J McCulloc. 5 HT2 receptors in dementia of Alzheimer type: a quantitative autoradiographic study of frontal cortex and hippocampus. Journal of neural transmission. Parkinson's disease and dementia section. vol 2. issue 2. 1990-12-13. PMID:2222780. |
using both quantitative autoradiography in sections and a homogenate preparation assay, the distribution and density of 3h-ketanserin binding to 5 ht2 receptors was examined in frontal cortex and the hippocampal region from six control subjects and seven subjects who had dementia of the alzheimer type (dat). |
1990-12-13 |
2023-08-11 |
human |
| C F Lippa, T W Smith, U Degirolami, D A Drachma. The indusium griseum: is it involved in Alzheimer's disease? Neurobiology of aging. vol 11. issue 5. 1990-12-12. PMID:2234286. |
the histopathology of the indusium griseum (ig), a displaced hippocampal anlage, was studied in five patients with alzheimer's disease (ad) and five controls. |
1990-12-12 |
2023-08-11 |
Not clear |
| E R Popovitch, H M Wisniewski, M Barcikowska, W Silverman, C Bancher, E Sersen, G Y We. Alzheimer neuropathology in non-Down's syndrome mentally retarded adults. Acta neuropathologica. vol 80. issue 4. 1990-12-04. PMID:2239148. |
comprehensive morphometric analyses of neocortical, hippocampal and parahippocampal areas indicated that recommended age-specific quantitative criteria for the diagnosis of alzheimer disease [khachaturian zs (1985) arch neurol 42:1097-1105] were met in 9.5% of cases less than 50 years of age, 54.2% between 50 and 65, 70% between 66 and 75, and 87% of the cases greater than 75 years of age. |
1990-12-04 |
2023-08-11 |
Not clear |
| M O Kristense. [Neurotransmitters in Alzheimer's disease]. Ugeskrift for laeger. vol 152. issue 30. 1990-10-16. PMID:1975961. |
alzheimer's disease is characterized by markedly reduced concentration of acetylcholine in hippocampus and neocortex, caused by degeneration of cholinergic neurons. |
1990-10-16 |
2023-08-11 |
Not clear |
| J C Martel, R Alagar, Y Robitaille, R Quirio. Neuropeptide Y receptor binding sites in human brain. Possible alteration in Alzheimer's disease. Brain research. vol 519. issue 1-2. 1990-10-16. PMID:2168782. |
additionally, the affinities and densities of [3h]npy binding sites were compared in the temporal cortex, hippocampus and putamen of patients dying from alzheimer's disease (ad) and aged matched controls. |
1990-10-16 |
2023-08-11 |
human |
| A J Barton, P J Harrison, A Najlerahim, J Heffernan, B McDonald, J R Robinson, D C Davies, W J Harrison, P Mitra, J A Hard. Increased tau messenger RNA in Alzheimer's disease hippocampus. The American journal of pathology. vol 137. issue 3. 1990-10-12. PMID:2119143. |
increased tau messenger rna in alzheimer's disease hippocampus. |
1990-10-12 |
2023-08-11 |
Not clear |
| A J Barton, P J Harrison, A Najlerahim, J Heffernan, B McDonald, J R Robinson, D C Davies, W J Harrison, P Mitra, J A Hard. Increased tau messenger RNA in Alzheimer's disease hippocampus. The American journal of pathology. vol 137. issue 3. 1990-10-12. PMID:2119143. |
we detected tau mrna using in situ hybridization histochemistry in the hippocampus, visual cortex, and cerebellum, and compared its level in alzheimer's disease with controls. |
1990-10-12 |
2023-08-11 |
Not clear |
| D G Flood, P D Colema. Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer's disease. Progress in brain research. vol 83. 1990-09-28. PMID:2203107. |
hippocampal plasticity in normal aging and decreased plasticity in alzheimer's disease. |
1990-09-28 |
2023-08-11 |
human |
| D G Flood, P D Colema. Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer's disease. Progress in brain research. vol 83. 1990-09-28. PMID:2203107. |
different patterns of age-related dendritic change have been reported in different zones of the human hippocampal region in the normal and alzheimer's disease (ad) brain. |
1990-09-28 |
2023-08-11 |
human |
| P Cras, M Kawai, S Siedlak, P Mulvihill, P Gambetti, D Lowery, P Gonzalez-DeWhitt, B Greenberg, G Perr. Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease. The American journal of pathology. vol 137. issue 2. 1990-09-17. PMID:2117395. |
in addition, dystrophic neurites in different types of senile plaques and degenerating neurons in the temporal cortex and hippocampus of alzheimer's disease patients were immunostained. |
1990-09-17 |
2023-08-11 |
human |
| R N Kalaria, I Grahova. Serum amyloid P immunoreactivity in hippocampal tangles, plaques and vessels: implications for leakage across the blood-brain barrier in Alzheimer's disease. Brain research. vol 516. issue 2. 1990-08-13. PMID:2364299. |
serum amyloid p immunoreactivity in hippocampal tangles, plaques and vessels: implications for leakage across the blood-brain barrier in alzheimer's disease. |
1990-08-13 |
2023-08-11 |
human |
| R N Kalaria, I Grahova. Serum amyloid P immunoreactivity in hippocampal tangles, plaques and vessels: implications for leakage across the blood-brain barrier in Alzheimer's disease. Brain research. vol 516. issue 2. 1990-08-13. PMID:2364299. |
we used immunohistochemical methods to demonstrate sap reactivity in both tangles and plaques, as well as vessels, in lightly fixed frozen tissue sections of hippocampus and parahippocampal gyrus from subjects with alzheimer's disease (ad) and normal controls. |
1990-08-13 |
2023-08-11 |
human |
| C Peterson, C W Cotma. Decreased survival of hippocampal neurons in medium conditioned by fibroblasts from aged and Alzheimer donors. Brain research. vol 515. issue 1-2. 1990-08-01. PMID:2357575. |
decreased survival of hippocampal neurons in medium conditioned by fibroblasts from aged and alzheimer donors. |
1990-08-01 |
2023-08-11 |
Not clear |
| C Peterson, C W Cotma. Decreased survival of hippocampal neurons in medium conditioned by fibroblasts from aged and Alzheimer donors. Brain research. vol 515. issue 1-2. 1990-08-01. PMID:2357575. |
hippocampal neurons from 18- to 19-day-old embryos were maintained in medium conditioned by skin fibroblasts from young, aged or alzheimer donors. |
1990-08-01 |
2023-08-11 |
Not clear |
| C Peterson, C W Cotma. Decreased survival of hippocampal neurons in medium conditioned by fibroblasts from aged and Alzheimer donors. Brain research. vol 515. issue 1-2. 1990-08-01. PMID:2357575. |
these findings suggest that both aged and alzheimer donors secrete less of the substances that are necessary for survival and neurite outgrowth of hippocampal neurons. |
1990-08-01 |
2023-08-11 |
Not clear |
| I Ferrer, F Gullott. Down's syndrome and Alzheimer's disease: dendritic spine counts in the hippocampus. Acta neuropathologica. vol 79. issue 6. 1990-07-31. PMID:2141748. |
down's syndrome and alzheimer's disease: dendritic spine counts in the hippocampus. |
1990-07-31 |
2023-08-11 |
Not clear |
| I Ferrer, F Gullott. Down's syndrome and Alzheimer's disease: dendritic spine counts in the hippocampus. Acta neuropathologica. vol 79. issue 6. 1990-07-31. PMID:2141748. |
samples of the hippocampus of four patients with down's syndrome [two men aged 35 and 36 years with no evidence of alzheimer's disease (ad) and two patients aged 47 and 55 years with associated ad] were obtained at post mortem and processed according to the rapid golgi method. |
1990-07-31 |
2023-08-11 |
Not clear |