| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M P Mattson, P B Guthrie, S B Kate. Intrinsic factors in the selective vulnerability of hippocampal pyramidal neurons. Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2690106. |
selective degeneration of pyramidal neurons in regions ca1 and ca3 of the hippocampus is a common structural correlate of several neurodegenerative conditions including alzheimer's disease, epilepsy and stroke. |
1990-01-31 |
2023-08-11 |
rat |
| R N Kalaria, A C Andorn, M Tabaton, P J Whitehouse, S I Harik, J R Unnerstal. Adrenergic receptors in aging and Alzheimer's disease: increased beta 2-receptors in prefrontal cortex and hippocampus. Journal of neurochemistry. vol 53. issue 6. 1989-12-21. PMID:2553864. |
adrenergic receptors in aging and alzheimer's disease: increased beta 2-receptors in prefrontal cortex and hippocampus. |
1989-12-21 |
2023-08-11 |
human |
| R M Sapolsky, E A Morrow, G C Tombaug. Venn diagrams and neuronal vulnerability. Neurobiology of aging. vol 10. issue 5. 1989-12-18. PMID:2812238. |
greenamyre and young note that there is poor correlation between which hippocampal regions are damaged in alzheimer's disease and which have the highest concentrations of nmda receptors. |
1989-12-18 |
2023-08-11 |
Not clear |
| E D London, M J Ball, S B Walle. Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's dementia. Neurochemical research. vol 14. issue 8. 1989-12-18. PMID:2812250. |
nicotinic binding sites in cerebral cortex and hippocampus in alzheimer's dementia. |
1989-12-18 |
2023-08-11 |
human |
| E D London, M J Ball, S B Walle. Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's dementia. Neurochemical research. vol 14. issue 8. 1989-12-18. PMID:2812250. |
postmortem cerebral neocortical and hippocampal samples were taken from patients who died with dementia of the alzheimer type (dat) and individuals without diagnoses of neurological or psychiatric disease (control). |
1989-12-18 |
2023-08-11 |
human |
| S Kuzuhara, Y Ihara, Y Toyokura, H Shimad. [A semiquantitative study on Alzheimer neurofibrillary tangles demonstrated immunohistochemically with anti-tau antibodies, in the brains of non-demented and demented old people]. No to shinkei = Brain and nerve. vol 41. issue 5. 1989-11-28. PMID:2508732. |
alzheimer neurofibrillary tangles (nfts) which were specifically and selectively stained by anti-tau were semiquantitatively counted in the areas of the hippocampus, parahippocampal gyrus and lateral occipitotemporal gyrus. |
1989-11-28 |
2023-08-11 |
human |
| N W Bond, J Walton, J Prus. Restoration of memory following septo-hippocampal grafts: a possible treatment for Alzheimer's disease. Biological psychology. vol 28. issue 1. 1989-11-09. PMID:2675993. |
it examines the role of cholinergic dysfunction in the memory deficits associated with alzheimer's disease, the effects of hippocampal lesions on memory in infra-human animals, and the anatomy of the hippocampus. |
1989-11-09 |
2023-08-11 |
rat |
| S J Kish, Y Robitaille, M el-Awar, J H Deck, J Simmons, L Schut, L J Chang, L DiStefano, M Freedma. Non-Alzheimer-type pattern of brain cholineacetyltransferase reduction in dominantly inherited olivopontocerebellar atrophy. Annals of neurology. vol 26. issue 3. 1989-11-08. PMID:2802535. |
in contradistinction to findings in alzheimer's disease (ad), mean chat levels in opca amygdala and hippocampal subdivisions were either normal or only mildly reduced. |
1989-11-08 |
2023-08-11 |
Not clear |
| L A Wong, J P Gallaghe. A direct nicotinic receptor-mediated inhibition recorded intracellularly in vitro. Nature. vol 341. issue 6241. 1989-11-07. PMID:2797167. |
central nicotinic receptors have been implicated in alzheimer's disease, seizure activity, the generation of slow-wave theta rhythm in the hippocampus and the potential abuse liability of nicotine. |
1989-11-07 |
2023-08-11 |
rat |
| B C Rogers, M I Barnes, C L Mitchell, H A Tilso. Functional deficits after sustained stimulation of the perforant path. Brain research. vol 493. issue 1. 1989-10-25. PMID:2776009. |
several reports have implicated the overactivity of hippocampal glutaminergic systems in neurodegenerative conditions including senile dementia of the alzheimer's type (sdat). |
1989-10-25 |
2023-08-11 |
Not clear |
| J R Duguid, C W Bohmont, N G Liu, W W Tourtellott. Changes in brain gene expression shared by scrapie and Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 18. 1989-10-24. PMID:2780570. |
the abundance of sulfated glycoprotein 2 rna is increased in hippocampus from patients with alzheimer disease and pick disease, whereas transferrin rna is not strongly modulated in these conditions. |
1989-10-24 |
2023-08-11 |
Not clear |
| M J de Leon, A E George, L A Stylopoulos, G Smith, D C Mille. Early marker for Alzheimer's disease: the atrophic hippocampus. Lancet (London, England). vol 2. issue 8664. 1989-10-18. PMID:2570916. |
early marker for alzheimer's disease: the atrophic hippocampus. |
1989-10-18 |
2023-08-11 |
Not clear |
| R N Kalaria, S I Hari. Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease. Journal of neurochemistry. vol 53. issue 4. 1989-10-12. PMID:2769254. |
we studied the hexose transporter protein of the frontal and temporal neocortex, hippocampus, putamen, cerebellum, and cerebral microvessels (which constitute the blood-brain barrier) in alzheimer disease and control subjects by reversible and covalent binding with [3h]cytochalasin b and by immunological reactivity. |
1989-10-12 |
2023-08-11 |
human |
| R N Kalaria, S I Hari. Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease. Journal of neurochemistry. vol 53. issue 4. 1989-10-12. PMID:2769254. |
in alzheimer disease subjects, we found a marked decrease in the hexose transporter in brain microvessels and in the cerebral neocortex and hippocampus, regions that are most affected in alzheimer disease, but there were no abnormalities in the putamen or cerebellum. |
1989-10-12 |
2023-08-11 |
human |
| J Q Trojanowski, M L Schmidt, L Otvos, R C Gur, R E Gur, H Hurtig, V M Le. Selective expression of epitopes in multiphosphorylation repeats of the high and middle molecular weight neurofilament proteins in Alzheimer neurofibrillary tangles. Annals of medicine. vol 21. issue 2. 1989-10-05. PMID:2475147. |
analyses of the low (nf-l), middle (nf-m), and high (nf-m), and high (nf-h) molecular weight neurofilament (nf) proteins with greater than 500 mabs enumerated epitopes shared by nf proteins and the intraneuronal neurofibrillary tangles (nfts) that occur in the hippocampus and brainstem of alzheimer's disease (ad) subjects. |
1989-10-05 |
2023-08-11 |
human |
| S I Harik, M J Mitchell, R N Kalari. Ouabain binding in the human brain. Effects of Alzheimer's disease and aging. Archives of neurology. vol 46. issue 9. 1989-09-26. PMID:2549926. |
we studied na+,k+-adenosine triphosphatase by assaying specific tritiated ouabain binding in the frontal cortex, temporal cortex, hippocampus, putamen, cerebellum, and cerebral microvessels in subjects with alzheimer's disease and control subjects. |
1989-09-26 |
2023-08-11 |
human |
| G B Baker, G P Reynold. Biogenic amines and their metabolites in Alzheimer's disease: noradrenaline, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid depleted in hippocampus but not in substantia innominata. Neuroscience letters. vol 100. issue 1-3. 1989-09-15. PMID:2474777. |
biogenic amines and their metabolites in alzheimer's disease: noradrenaline, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid depleted in hippocampus but not in substantia innominata. |
1989-09-15 |
2023-08-11 |
human |
| G B Baker, G P Reynold. Biogenic amines and their metabolites in Alzheimer's disease: noradrenaline, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid depleted in hippocampus but not in substantia innominata. Neuroscience letters. vol 100. issue 1-3. 1989-09-15. PMID:2474777. |
the following monoamine transmitters and related neurochemicals were analyzed in hippocampus and substantia innominata from postmortem brain tissue of subjects with senile dementia of the alzheimer's type (sdat): tryptophan (tp), 5-hydroxytryptamine (5-ht), 5-hydroxyindole-3-acetic acid (5-hiaa), noradrenaline (na), dopamine (da) and homovanillic acid (hva). |
1989-09-15 |
2023-08-11 |
human |
| W R Gibb, C Q Mountjoy, D M Mann, A J Lee. A pathological study of the association between Lewy body disease and Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 52. issue 6. 1989-08-25. PMID:2545826. |
counts of tangles and plaques in hippocampus, frontal and temporal cortex were lower in cases of alzheimer's disease with lewy bodies compared with those without, but cortical choline acetyltransferase (chat) activities were similar. |
1989-08-25 |
2023-08-11 |
Not clear |
| O J Vogels, K Renkawek, C A Broere, H J ter Laak, F van Worku. Galanin-like immunoreactivity within Ch2 neurons in the vertical limb of the diagonal band of Broca in aging and Alzheimer's disease. Acta neuropathologica. vol 78. issue 1. 1989-07-21. PMID:2472041. |
the severe deficiency of the cholinergic hippocampal projection system arising mainly from the vertical limb nucleus of the diagonal band of broca, also referred to as ch2 region, is a constant finding in alzheimer's disease, a disorder which is neuropathologically characterized by the appearance of senile plaques, neurofibrillary tangles and congophilic angiopathy in neo- and archicortical structures. |
1989-07-21 |
2023-08-11 |
human |