| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L M Callahan, W A Vaules, P D Colema. Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles. Journal of neuropathology and experimental neurology. vol 58. issue 3. 1999-04-23. PMID:10197819. |
combining immunocytochemistry with in situ hybridization of alzheimer disease (ad) hippocampus demonstrated a 50% reduction in grain density for synaptophysin message over ca1 pyramidal neurons containing neurofibrillary tangles (nft) relative to near neighbor nft-free neurons. |
1999-04-23 |
2023-08-12 |
Not clear |
| P F Chapman, G L White, M W Jones, D Cooper-Blacketer, V J Marshall, M Irizarry, L Younkin, M A Good, T V Bliss, B T Hyman, S G Younkin, K K Hsia. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nature neuroscience. vol 2. issue 3. 1999-04-21. PMID:10195221. |
we investigated synaptic communication and plasticity in hippocampal slices from mice overexpressing mutated 695-amino-acid human amyloid precursor protein (app695swe), which show behavioral and histopathological abnormalities simulating alzheimer's disease. |
1999-04-21 |
2023-08-12 |
mouse |
| P F Chapman, G L White, M W Jones, D Cooper-Blacketer, V J Marshall, M Irizarry, L Younkin, M A Good, T V Bliss, B T Hyman, S G Younkin, K K Hsia. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nature neuroscience. vol 2. issue 3. 1999-04-21. PMID:10195221. |
these deficits are accompanied by minimal or no loss of presynaptic or postsynaptic elementary structural elements in the hippocampus, suggesting that impairments in functional synaptic plasticity may underlie some of the cognitive deficits in these mice and, possibly, in alzheimer's patients. |
1999-04-21 |
2023-08-12 |
mouse |
| C Beh. Effects of glucocorticoids on oxidative stress-induced hippocampal cell death: implications for the pathogenesis of Alzheimer's disease. Experimental gerontology. vol 33. issue 7-8. 1999-04-15. PMID:9951616. |
effects of glucocorticoids on oxidative stress-induced hippocampal cell death: implications for the pathogenesis of alzheimer's disease. |
1999-04-15 |
2023-08-12 |
mouse |
| C Beh. Effects of glucocorticoids on oxidative stress-induced hippocampal cell death: implications for the pathogenesis of Alzheimer's disease. Experimental gerontology. vol 33. issue 7-8. 1999-04-15. PMID:9951616. |
hippocampal neurons are among the first neuronal cells to degenerate in the brain of patients affected by alzheimer's disease (ad). |
1999-04-15 |
2023-08-12 |
mouse |
| J B Leverenz, C W Wilkinson, M Wamble, S Corbin, J E Grabber, M A Raskind, E R Peskin. Effect of chronic high-dose exogenous cortisol on hippocampal neuronal number in aged nonhuman primates. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 6. 1999-04-13. PMID:10066285. |
it has been proposed that increased brain exposure to glucocorticoids may lower the threshold for hippocampal neuronal degeneration in human aging and alzheimer's disease. |
1999-04-13 |
2023-08-12 |
human |
| I J Kim, K W Lee, B Y Park, J K Lee, J Park, I Y Choi, S J Eom, T S Chang, M J Kim, Y I Yeom, S K Chang, Y D Lee, E J Choi, P L Ha. Molecular cloning of multiple splicing variants of JIP-1 preferentially expressed in brain. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098834. |
in situ hybridization data showed that the hybridized jip messages were heavily concentrated in adult brain, and were particularly enriched in the cerebral cortex and hippocampus, the brain regions vulnerable to pathological states such as hypoxia-ischemia, epilepsy, and alzheimer's disease. |
1999-04-13 |
2023-08-12 |
Not clear |
| C J Pik. Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer's disease. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098861. |
we report neuronal colocalization of estrogen receptor and bcl-xl immunoreactivities that is most prominent in hippocampal subfield ca3, a region that shows relatively little immunoreactivity to paired helical filament-1, a marker of alzheimer's disease neurodegeneration. |
1999-04-13 |
2023-08-12 |
human |
| L L Bambrick, B K Kruege. Neuronal apoptosis in mouse trisomy 16: mediation by caspases. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098888. |
hippocampal neurons from the trisomy 16 (ts16) mouse, a potential animal model of down's syndrome (trisomy 21) and neurodegenerative disorders such as alzheimer's disease (ad), die at an accelerated rate in vitro. |
1999-04-13 |
2023-08-12 |
mouse |
| P S Aisen, A Luddy, M Durner, J F Reinhard, G M Pasinett. HLA-DR4 influences glial activity in Alzheimer's disease hippocampus. Journal of the neurological sciences. vol 161. issue 1. 1999-03-29. PMID:9879683. |
hla-dr4 influences glial activity in alzheimer's disease hippocampus. |
1999-03-29 |
2023-08-12 |
human |
| P S Aisen, A Luddy, M Durner, J F Reinhard, G M Pasinett. HLA-DR4 influences glial activity in Alzheimer's disease hippocampus. Journal of the neurological sciences. vol 161. issue 1. 1999-03-29. PMID:9879683. |
we investigated the influence of the hla-dr4 allele on glial activity, assessed by quantification of glial fibrillary acidic protein (gfap), in hippocampal tissue from subjects with alzheimer's disease. |
1999-03-29 |
2023-08-12 |
human |
| P S Aisen, A Luddy, M Durner, J F Reinhard, G M Pasinett. HLA-DR4 influences glial activity in Alzheimer's disease hippocampus. Journal of the neurological sciences. vol 161. issue 1. 1999-03-29. PMID:9879683. |
the mean gfap level was significantly higher in alzheimer's disease hippocampal specimens lacking the hla-dr4 allele compared to specimens with similar neuropathological findings that were hla-dr4 positive. |
1999-03-29 |
2023-08-12 |
human |
| S D Ginsberg, P B Crino, S E Hemby, J A Weingarten, V M Lee, J H Eberwine, J Q Trojanowsk. Predominance of neuronal mRNAs in individual Alzheimer's disease senile plaques. Annals of neurology. vol 45. issue 2. 1999-03-29. PMID:9989619. |
the sequestration of rna in alzheimer's disease (ad) senile plaques (sps) and the production of intraneuronal amyloid-beta peptides (abeta) prompted analysis of the mrna profile in single immunocytochemically identified sps in sections of ad hippocampus. |
1999-03-29 |
2023-08-12 |
human |
| F Muramori, K Kobayashi, I Nakamur. A quantitative study of neurofibrillary tangles, senile plaques and astrocytes in the hippocampal subdivisions and entorhinal cortex in Alzheimer's disease, normal controls and non-Alzheimer neuropsychiatric diseases. Psychiatry and clinical neurosciences. vol 52. issue 6. 1999-03-26. PMID:9895207. |
a quantitative study of neurofibrillary tangles, senile plaques and astrocytes in the hippocampal subdivisions and entorhinal cortex in alzheimer's disease, normal controls and non-alzheimer neuropsychiatric diseases. |
1999-03-26 |
2023-08-12 |
Not clear |
| F Muramori, K Kobayashi, I Nakamur. A quantitative study of neurofibrillary tangles, senile plaques and astrocytes in the hippocampal subdivisions and entorhinal cortex in Alzheimer's disease, normal controls and non-Alzheimer neuropsychiatric diseases. Psychiatry and clinical neurosciences. vol 52. issue 6. 1999-03-26. PMID:9895207. |
regional densities of senile plaques (sp), neurofibrillary tangles (nft) and astrocytes in the cornu ammonis (ca), subiculum and entorhinal cortex were measured and differences in these densities among alzheimer's disease (ad), nand and nc were statistically compared. |
1999-03-26 |
2023-08-12 |
Not clear |
| S Nakamura, K Arima, S Haga, T Aizawa, Y Motoi, M Otsuka, A Ueki, K Iked. Fibroblast growth factor (FGF)-9 immunoreactivity in senile plaques. Brain research. vol 814. issue 1-2. 1999-03-16. PMID:9838127. |
we examined fibroblast growth factor (fgf)-9 immunoreactivity in human hippocampal sections of alzheimer's disease (ad). |
1999-03-16 |
2023-08-12 |
human |
| A J Harding, G M Halliday, J J Kri. Variation in hippocampal neuron number with age and brain volume. Cerebral cortex (New York, N.Y. : 1991). vol 8. issue 8. 1999-03-16. PMID:9863698. |
hippocampal size and neuron number are reduced in a number of conditions, including temporal lobe epilepsy and alzheimer's disease. |
1999-03-16 |
2023-08-12 |
human |
| C D Smith, M Malcein, K Meurer, F A Schmitt, W R Markesbery, L C Pettigre. MRI temporal lobe volume measures and neuropsychologic function in Alzheimer's disease. Journal of neuroimaging : official journal of the American Society of Neuroimaging. vol 9. issue 1. 1999-03-11. PMID:9922716. |
compared to aged controls, alzheimer's subjects showed further volume reductions in amygdala (33%, p = 0.0001) and hippocampus (20%, p = 0.006) but not temporal lobe (7%, p = 0.15). |
1999-03-11 |
2023-08-12 |
human |
| A McShea, D A Zelasko, J L Gerst, M A Smit. Signal transduction abnormalities in Alzheimer's disease: evidence of a pathogenic stimuli. Brain research. vol 815. issue 2. 1999-02-26. PMID:9878757. |
hippocampal and select cortical neuronal populations in alzheimer's disease exhibit phenotypic changes characteristic of cells re-entering the cell division cycle. |
1999-02-26 |
2023-08-12 |
Not clear |
| E G Stopa, L Volicer, V Kuo-Leblanc, D Harper, D Lathi, B Tate, A Satli. Pathologic evaluation of the human suprachiasmatic nucleus in severe dementia. Journal of neuropathology and experimental neurology. vol 58. issue 1. 1999-02-26. PMID:10068311. |
neuropathologic examination indicated that among 30 patients with a clinical history of severe dementia, 22 had braak and braak stage v-vi alzheimer disease, 3 had combined alzheimer and parkinson disease, 3 had pick disease and 2 had severe hippocampal sclerosis. |
1999-02-26 |
2023-08-12 |
human |