| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M P Mattson, J Partin, J G Begle. Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites. Brain research. vol 807. issue 1-2. 1998-12-10. PMID:9757026. |
synapse loss in cerebral cortex and hippocampus is a prominent feature of alzheimer's disease (ad) that is correlated with cognitive impairment. |
1998-12-10 |
2023-08-12 |
Not clear |
| A Islam, R N Kalaria, B Winblad, A Ade. Enhanced localization of amyloid beta precursor protein in the rat hippocampus following long-term adrenalectomy. Brain research. vol 806. issue 1. 1998-11-20. PMID:9739118. |
using various antibodies to the amyloid ss precursor protein (app) associated with alzheimer's disease, we investigated changes in the distribution of app in the hippocampus and neocortex of adrenalectomized (adx) rats. |
1998-11-20 |
2023-08-12 |
rat |
| R D Terr. The cytoskeleton in Alzheimer disease. Journal of neural transmission. Supplementum. vol 53. 1998-11-12. PMID:9700652. |
the strongest physical correlate with the severity of dementia in alzheimer's disease and its most rational cause are the loss of neocortical and hippocampal synapses. |
1998-11-12 |
2023-08-12 |
Not clear |
| A Delacourt. [Diagnosis of Alzheimer's disease]. Annales de biologie clinique. vol 56. issue 2. 1998-11-04. PMID:9754238. |
but the diagnosis of "definite alzheimer's disease" requires a post-mortem brain examination and the demonstration of numerous senile plaques and neurofibrillary tangles in hippocampal and association cortical areas. |
1998-11-04 |
2023-08-12 |
Not clear |
| H Blain, C Jeande. [Alzheimer disease, markers in the cerebrospinal fluid. Support of physiopathologic hypotheses]. Presse medicale (Paris, France : 1983). vol 27. issue 15. 1998-11-03. PMID:9767915. |
certain diagnosis: because the certainty diagnosis of alzheimer's disease is defined after autopsy or brain biopsy by the presence of neurofibrillar degeneration (nfd), extracellular senile plaques and vascular deposits of amyloid in the hippocampus amygdalus and the cerebral cortex, some authors have searched for biological ante-mortem markers of ad, particularly in the cerebrospinal fluid (csf) which is essentially derived from brain tissue. |
1998-11-03 |
2023-08-12 |
Not clear |
| K Chandrasekaran, K Hatanpää, D R Brady, J Stoll, S I Rapopor. Downregulation of oxidative phosphorylation in Alzheimer disease: loss of cytochrome oxidase subunit mRNA in the hippocampus and entorhinal cortex. Brain research. vol 796. issue 1-2. 1998-10-29. PMID:9689449. |
downregulation of oxidative phosphorylation in alzheimer disease: loss of cytochrome oxidase subunit mrna in the hippocampus and entorhinal cortex. |
1998-10-29 |
2023-08-12 |
human |
| D J Libon, B Bogdanoff, B S Cloud, S Skalina, T Giovannetti, H L Gitlin, J Bonavit. Declarative and procedural learning, quantitative measures of the hippocampus, and subcortical white alterations in Alzheimer's disease and ischaemic vascular dementia. Journal of clinical and experimental neuropsychology. vol 20. issue 1. 1998-10-28. PMID:9672817. |
declarative and procedural learning, quantitative measures of the hippocampus, and subcortical white alterations in alzheimer's disease and ischaemic vascular dementia. |
1998-10-28 |
2023-08-12 |
human |
| M J Marino, S T Rouse, A I Levey, L T Potter, P J Con. Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 19. 1998-10-26. PMID:9736760. |
evidence suggests that cholinergic input to the hippocampus plays an important role in learning and memory and that degeneration of cholinergic terminals in the hippocampus may contribute to the memory loss associated with alzheimer's disease. |
1998-10-26 |
2023-08-12 |
Not clear |
| W A Kaufmann, U Barnas, C Humpel, K Nowakowski, C DeCol, P Gurka, G Ransmayr, H Hinterhuber, H Winkler, J Marksteine. Synaptic loss reflected by secretoneurin-like immunoreactivity in the human hippocampus in Alzheimer's disease. The European journal of neuroscience. vol 10. issue 3. 1998-10-22. PMID:9753176. |
synaptic loss reflected by secretoneurin-like immunoreactivity in the human hippocampus in alzheimer's disease. |
1998-10-22 |
2023-08-12 |
human |
| W A Kaufmann, U Barnas, C Humpel, K Nowakowski, C DeCol, P Gurka, G Ransmayr, H Hinterhuber, H Winkler, J Marksteine. Synaptic loss reflected by secretoneurin-like immunoreactivity in the human hippocampus in Alzheimer's disease. The European journal of neuroscience. vol 10. issue 3. 1998-10-22. PMID:9753176. |
secretoneurin is a recently described peptide derived by endoproteolytic processing from secretogranin ii, previously named chromogranin c. in this study, we have investigated the distribution of secretoneurin-like immunoreactivity in the human hippocampus in controls and in alzheimer's disease patients, and compared the staining pattern to that of calretinin. |
1998-10-22 |
2023-08-12 |
human |
| W A Kaufmann, U Barnas, C Humpel, K Nowakowski, C DeCol, P Gurka, G Ransmayr, H Hinterhuber, H Winkler, J Marksteine. Synaptic loss reflected by secretoneurin-like immunoreactivity in the human hippocampus in Alzheimer's disease. The European journal of neuroscience. vol 10. issue 3. 1998-10-22. PMID:9753176. |
this study shows that secretoneurin is distinctly distributed in the human hippocampus and that significant changes of secretoneurin-like immunoreactivity occur in alzheimer's disease, reflecting synaptic loss. |
1998-10-22 |
2023-08-12 |
human |
| V R Lombardi, M García, R Cacabelo. APOE-induced microglial activation: an in vitro assay to screen sera from Alzheimer's disease patients and novel therapeutic compounds. Methods and findings in experimental and clinical pharmacology. vol 20. issue 5. 1998-10-15. PMID:9701775. |
in this study, in vitro cell cultures were established to investigate the effect of different concentrations of human sera (2.5% and 10%) with specific apoe genotypes from alzheimer and non-alzheimer subjects on ameboid and flat microglial cells obtained from adult rat hippocampus. |
1998-10-15 |
2023-08-12 |
human |
| L Terrisse, J Poirier, P Bertrand, A Merched, S Visvikis, G Siest, R Milne, E Rassar. Increased levels of apolipoprotein D in cerebrospinal fluid and hippocampus of Alzheimer's patients. Journal of neurochemistry. vol 71. issue 4. 1998-10-14. PMID:9751198. |
increased levels of apolipoprotein d in cerebrospinal fluid and hippocampus of alzheimer's patients. |
1998-10-14 |
2023-08-12 |
human |
| L Terrisse, J Poirier, P Bertrand, A Merched, S Visvikis, G Siest, R Milne, E Rassar. Increased levels of apolipoprotein D in cerebrospinal fluid and hippocampus of Alzheimer's patients. Journal of neurochemistry. vol 71. issue 4. 1998-10-14. PMID:9751198. |
as apod may have an important function in the nervous system and, particularly, in nerve regeneration, we measured immunoreactive apod levels in the hippocampus and in csf of patients with either alzheimer's disease (ad) or other neuropathologies. |
1998-10-14 |
2023-08-12 |
human |
| P Davies, B Anderton, J Kirsch, A Konnerth, R Nitsch, M Sheet. First one in, last one out: the role of gabaergic transmission in generation and degeneration. Progress in neurobiology. vol 55. issue 6. 1998-10-07. PMID:9670223. |
the discussions focused on the possible role of gaba in the development and maturation of the hippocampus and in neurodegeneration in alzheimer's disease (ad). |
1998-10-07 |
2023-08-12 |
Not clear |
| E D Menschik, L H Finke. Neuromodulatory control of hippocampal function: towards a model of Alzheimer's disease. Artificial intelligence in medicine. vol 13. issue 1-2. 1998-09-24. PMID:9654381. |
neuromodulatory control of hippocampal function: towards a model of alzheimer's disease. |
1998-09-24 |
2023-08-12 |
Not clear |
| I Maurer, S Zierz, H J Mölle. Carnitine acyltransferases are not changed in Alzheimer disease. Alzheimer disease and associated disorders. vol 12. issue 2. 1998-09-08. PMID:9651134. |
we evaluated the activities of carnitine palmitoyltransferase (cpt), carnitine octanoyltransferase (cot), and carnitine acetyltransferase (cat) in the frontal cortex, temporal cortex, parietal cortex, hippocampus, and cerebellum of alzheimer disease (ad) patients and normal human brains. |
1998-09-08 |
2023-08-12 |
human |
| B M Bradt, W P Kolb, N R Coope. Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide. The Journal of experimental medicine. vol 188. issue 3. 1998-09-08. PMID:9687521. |
large numbers of neuritic plaques (np), largely composed of a fibrillar insoluble form of the beta-amyloid peptide (abeta), are found in the hippocampus and neocortex of alzheimer's disease (ad) patients in association with damaged neuronal processes, increased numbers of activated astrocytes and microglia, and several proteins including the components of the proinflammatory complement system. |
1998-09-08 |
2023-08-12 |
Not clear |
| O Berezovska, M Q Xia, B T Hyma. Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 57. issue 8. 1998-09-08. PMID:9720489. |
moreover, notch1 expression in sporadic alzheimer disease hippocampus is elevated more than 2-fold in comparison to that in control human hippocampus by both immunohistochemistry and western blot analysis (p < 0.007). |
1998-09-08 |
2023-08-12 |
mouse |
| H Hanyu, H Sakurai, T Iwamoto, M Takasaki, H Shindo, K Ab. Diffusion-weighted MR imaging of the hippocampus and temporal white matter in Alzheimer's disease. Journal of the neurological sciences. vol 156. issue 2. 1998-08-27. PMID:9588857. |
diffusion-weighted mr imaging of the hippocampus and temporal white matter in alzheimer's disease. |
1998-08-27 |
2023-08-12 |
Not clear |