| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dwight C German, Omar Nelson, Fen Liang, Chang-Lin Liang, Dora Game. The PDAPP mouse model of Alzheimer's disease: locus coeruleus neuronal shrinkage. The Journal of comparative neurology. vol 492. issue 4. 2006-01-19. PMID:16228992. |
alzheimer's disease is characterized by neuronal degeneration in the cerebral cortex and hippocampus and subcortical neuronal degeneration in such nuclei as the locus coeruleus (lc). |
2006-01-19 |
2023-08-12 |
mouse |
| Serge Rombouts, Philip Schelten. Functional connectivity in elderly controls and AD patients using resting state fMRI: a pilot study. Current Alzheimer research. vol 2. issue 2. 2006-01-18. PMID:15974906. |
conventionally, alzheimer's disease (ad) and other dementias are diagnosed using clinical assessment, neuropsychology and also structural neuroimaging, showing neuronal degeneration starting in the hippocampal regions. |
2006-01-18 |
2023-08-12 |
Not clear |
| Agata Adamczyk, Henryk Jeśko, Robert Piotr Strosznajde. Alzheimer's disease related peptides affected cholinergic receptor mediated poly(ADP-ribose) polymerase activity in the hippocampus. Folia neuropathologica. vol 43. issue 3. 2006-01-18. PMID:16245207. |
alzheimer's disease related peptides affected cholinergic receptor mediated poly(adp-ribose) polymerase activity in the hippocampus. |
2006-01-18 |
2023-08-12 |
Not clear |
| T R Stoub, M Bulgakova, S Leurgans, D A Bennett, D Fleischman, D A Turner, L deToledo-Morrel. MRI predictors of risk of incident Alzheimer disease: a longitudinal study. Neurology. vol 64. issue 9. 2006-01-06. PMID:15883311. |
to determine if baseline entorhinal and hippocampal volumes and their rate of atrophy could predict the risk of incident alzheimer disease (ad). |
2006-01-06 |
2023-08-12 |
Not clear |
| L Mosconi, W-H Tsui, S De Santi, J Li, H Rusinek, A Convit, Y Li, Madhu Boppana, M J de Leo. Reduced hippocampal metabolism in MCI and AD: automated FDG-PET image analysis. Neurology. vol 64. issue 11. 2005-12-27. PMID:15955934. |
to facilitate image analysis, most recent 2-[18f]fluoro-2-deoxy-d-glucose pet (fdg-pet) studies of glucose metabolism (mrglc) have used automated voxel-based analysis (vba) procedures but paradoxically none reports hippocampus mrglc reductions in mild cognitive impairment (mci) or alzheimer disease (ad). |
2005-12-27 |
2023-08-12 |
Not clear |
| T Kitamura, K Sugimori, S Sudo, K Kobayash. Relationship between microtubule-binding repeats and morphology of neurofibrillary tangle in Alzheimer's disease. Acta neurologica Scandinavica. vol 112. issue 5. 2005-12-23. PMID:16218916. |
the present study was performed to compare the distributions of three-repeat (3r) and four-repeat (4r) neurofibrillary tangles (nft) with those of pretangles (p-nft), intracellular nft (i-nft), and extracellular nft (e-nft) in the hippocampus of alzheimer's disease brains. |
2005-12-23 |
2023-08-12 |
Not clear |
| Qin Wang, Randall L Woltjer, P J Cimino, Catherine Pan, Kathleen S Montine, Jing Zhang, Thomas J Montin. Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 7. 2005-12-22. PMID:15746184. |
we performed proteomic analysis of neurofibrillary tangles (nfts) obtained by laser capture microdissection from pyramidal neurons in hippocampal sector ca1 in patients with alzheimer disease (ad) using liquid chromatography (lc)-mass spectrometry (ms)/ms. |
2005-12-22 |
2023-08-12 |
Not clear |
| Wangtao Zhong, Hidehisa D Yamagata, Keiko Taguchi, Hiroyasu Akatsu, Kouzin Kamino, Takayuki Yamamoto, Kenji Kosaka, Masatoshi Takeda, Ikuko Kondo, Tetsuro Mik. Lymphocyte-specific protein tyrosine kinase is a novel risk gene for Alzheimer disease. Journal of the neurological sciences. vol 238. issue 1-2. 2005-12-20. PMID:16109429. |
it has been shown to be significantly down-regulated in alzheimer disease (ad) hippocampus compared with non-demented controls. |
2005-12-20 |
2023-08-12 |
Not clear |
| M J Rowan, I Klyubin, Q Wang, R Anwy. Synaptic plasticity disruption by amyloid beta protein: modulation by potential Alzheimer's disease modifying therapies. Biochemical Society transactions. vol 33. issue Pt 4. 2005-12-14. PMID:16042545. |
ad (alzheimer's disease) is characterized by a progressive and devastating mental decline that is usually presaged by impairment of a form of memory dependent on medial temporal lobe structures, including the hippocampus. |
2005-12-14 |
2023-08-12 |
Not clear |
| Walter J Lukiw, Jian-Guo Cui, Victor L Marcheselli, Merete Bodker, Anja Botkjaer, Katherine Gotlinger, Charles N Serhan, Nicolas G Baza. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. The Journal of clinical investigation. vol 115. issue 10. 2005-12-12. PMID:16151530. |
dha and npd1 were reduced in alzheimer disease (ad) hippocampal cornu ammonis region 1, but not in the thalamus or occipital lobes from the same brains. |
2005-12-12 |
2023-08-12 |
human |
| Linda Lundström, Anna Elmquist, Tamas Bartfai, Ulo Lange. Galanin and its receptors in neurological disorders. Neuromolecular medicine. vol 7. issue 1-2. 2005-12-08. PMID:16052044. |
significant increase in galanin expression is observed after peripheral nerve injury, in the basal forebrain in alzheimer's disease (ad), during neuronal development, and after stimulation with estrogen, while seizure activity deplete galanin in the hippocampus. |
2005-12-08 |
2023-08-12 |
Not clear |
| B Puig, I Ferrer, R F Ludueña, J Avil. BetaII-tubulin and phospho-tau aggregates in Alzheimer's disease and Pick's disease. Journal of Alzheimer's disease : JAD. vol 7. issue 3. 2005-12-02. PMID:16006664. |
the expression of betai-, betaii- and betaiii-tubulin isotypes was examined by immunohistochemistry in the entorhinal and transentorhinal cortices, hippocampus and dentate gyrus in normal human brains and in cases with alzheimer's disease (ad), pick's disease (pid) and in argyrophilic grain disease (agd). |
2005-12-02 |
2023-08-12 |
human |
| Naoki Maruyama, Akihito Ishigami, Yoshitaka Kond. [Molecular abnormality in aging: its contribution to clinical pathology]. Rinsho byori. The Japanese journal of clinical pathology. vol 53. issue 8. 2005-11-22. PMID:16190359. |
we detected abnormal accumulation of citrullinated proteins in the alzheimer disease (ad) hippocampus, but not in the normal brain. |
2005-11-22 |
2023-08-12 |
Not clear |
| Manuel Buttini, Eliezer Masliah, Robin Barbour, Henry Grajeda, Ruth Motter, Kelly Johnson-Wood, Karen Khan, Peter Seubert, Stephen Freedman, Dale Schenk, Dora Game. Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 40. 2005-11-21. PMID:16207868. |
the loss of synapses, and particularly the associated presynaptic vesicle protein synaptophysin in the hippocampus and association cortices, has been widely reported to be one of the most robust correlates of alzheimer's disease-associated cognitive decline. |
2005-11-21 |
2023-08-12 |
mouse |
| Manuel Buttini, Eliezer Masliah, Robin Barbour, Henry Grajeda, Ruth Motter, Kelly Johnson-Wood, Karen Khan, Peter Seubert, Stephen Freedman, Dale Schenk, Dora Game. Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 40. 2005-11-21. PMID:16207868. |
in this study, we show that abeta reduction by active or passive abeta immunization protects against the progressive loss of synaptophysin in the hippocampal molecular layer and frontal neocortex of a transgenic mouse model of alzheimer's disease. |
2005-11-21 |
2023-08-12 |
mouse |
| S Rosi, C B Pert, M R Ruff, K McGann-Gramling, G L Wen. Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience. vol 134. issue 2. 2005-11-15. PMID:15979806. |
chemokine receptor 5 antagonist d-ala-peptide t-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of alzheimer's disease. |
2005-11-15 |
2023-08-12 |
rat |
| Jens Noraberg, Frantz Rom Poulsen, Morten Blaabjerg, Bjarne Winther Kristensen, Christian Bonde, Maria Montero, Morten Meyer, Jan Bert Gramsbergen, Jens Zimme. Organotypic hippocampal slice cultures for studies of brain damage, neuroprotection and neurorepair. Current drug targets. CNS and neurological disorders. vol 4. issue 4. 2005-11-15. PMID:16101559. |
here we summarize and review studies using hippocampal slice cultures to investigate mechanisms and treatment strategies for the neurodegenerative disorders like stroke (cerebral ischemia), alzheimer's disease (ad) and epilepsia. |
2005-11-15 |
2023-08-12 |
mouse |
| Sonia J Lupien, Georges Schwartz, Ying Kin Ng, Alexandra Fiocco, Nathalie Wan, Jens C Pruessner, Michael J Meaney, N P Vasavan Nai. The Douglas Hospital Longitudinal Study of Normal and Pathological Aging: summary of findings. Journal of psychiatry & neuroscience : JPN. vol 30. issue 5. 2005-11-10. PMID:16151537. |
we describe one participant who was included in the group of older adults presenting with increased cortisol levels over time, memory impairments and reduced hippocampal volume and in whom major depression, followed by alzheimer's disease, developed during the course of the study. |
2005-11-10 |
2023-08-12 |
human |
| Owen T Carmichael, Howard A Aizenstein, Simon W Davis, James T Becker, Paul M Thompson, Carolyn Cidis Meltzer, Yanxi Li. Atlas-based hippocampus segmentation in Alzheimer's disease and mild cognitive impairment. NeuroImage. vol 27. issue 4. 2005-11-09. PMID:15990339. |
atlas-based hippocampus segmentation in alzheimer's disease and mild cognitive impairment. |
2005-11-09 |
2023-08-12 |
human |
| Owen T Carmichael, Howard A Aizenstein, Simon W Davis, James T Becker, Paul M Thompson, Carolyn Cidis Meltzer, Yanxi Li. Atlas-based hippocampus segmentation in Alzheimer's disease and mild cognitive impairment. NeuroImage. vol 27. issue 4. 2005-11-09. PMID:15990339. |
this study assesses the performance of public-domain automated methodologies for mri-based segmentation of the hippocampus in elderly subjects with alzheimer's disease (ad) and mild cognitive impairment (mci). |
2005-11-09 |
2023-08-12 |
human |