| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James T Becker, Simon W Davis, Kiralee M Hayashi, Carolyn Cidis Meltzer, Arthur W Toga, Oscar L Lopez, Paul M Thompso. Three-dimensional patterns of hippocampal atrophy in mild cognitive impairment. Archives of neurology. vol 63. issue 1. 2006-03-02. PMID:16401741. |
to measure hippocampal volumes in patients diagnosed as having subtypes of mild cognitive impairment (mci) relative to those of elderly control subjects and those of patients with alzheimer disease (ad) using 3-dimensional mesh reconstructions. |
2006-03-02 |
2023-08-12 |
human |
| Meghan Gallant, Margaret Rak, Adriana Szeghalmi, Marc R Del Bigio, David Westaway, Jin Yang, Robert Julian, Kathleen M Goug. Focally elevated creatine detected in amyloid precursor protein (APP) transgenic mice and Alzheimer disease brain tissue. The Journal of biological chemistry. vol 281. issue 1. 2006-02-28. PMID:16267054. |
relatively large creatine deposits were also found in hippocampal sections from post-mortem alzheimer diseased human brain, compared with hippocampus from non-demented brain. |
2006-02-28 |
2023-08-12 |
mouse |
| Zhao Zhong Chong, Faqi Li, Kenneth Maies. Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity. Current neurovascular research. vol 2. issue 5. 2006-02-24. PMID:16375720. |
yet, it remains unclear whether the protective capacity of epo may be effective for chronic neurodegenerative disorders such as alzheimer's disease (ad) that involve beta-amyloid (abeta) apoptotic injury to hippocampal neurons. |
2006-02-24 |
2023-08-12 |
Not clear |
| Maria C Vanzani, Ruben F Iacono, Roberto L Caccuri, Maria I Berri. Immunochemical and morphometric features of astrocyte reactivity vs. plaque location in Alzheimer's disease. Medicina. vol 65. issue 3. 2006-02-23. PMID:16042131. |
the quantitative relationship between glial fibrillary acidic protein (gfap) hyper-reactivity and beta-amyloid protein (betaap) deposition was investigated by double immunoperoxidase labeling of hippocampal and entorhinal cortex sections from five alzheimer's disease (ad) cases and five age-matched controls. |
2006-02-23 |
2023-08-12 |
Not clear |
| Thomas A Comery, Robert L Martone, Suzan Aschmies, Kevin P Atchison, George Diamantidis, Xiaohai Gong, Hua Zhou, Anthony F Kreft, Menelas N Pangalos, June Sonnenberg-Reines, J Steven Jacobsen, Karen L Marqui. Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 39. 2006-02-21. PMID:16192379. |
transgenic mice (tg2576) overexpressing the swedish mutation of the human amyloid precursor protein display biochemical, pathological, and behavioral markers consistent with many aspects of alzheimer's disease, including impaired hippocampal function. |
2006-02-21 |
2023-08-12 |
mouse |
| Michael A Rapp, Michal Schnaider-Beeri, Hillel T Grossman, Mary Sano, Daniel P Perl, Dushyant P Purohit, Jack M Gorman, Vahram Haroutunia. Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression. Archives of general psychiatry. vol 63. issue 2. 2006-02-16. PMID:16461859. |
increased hippocampal plaques and tangles in patients with alzheimer disease with a lifetime history of major depression. |
2006-02-16 |
2023-08-12 |
Not clear |
| Michael A Rapp, Michal Schnaider-Beeri, Hillel T Grossman, Mary Sano, Daniel P Perl, Dushyant P Purohit, Jack M Gorman, Vahram Haroutunia. Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression. Archives of general psychiatry. vol 63. issue 2. 2006-02-16. PMID:16461859. |
the hallmark pathological changes in alzheimer disease (ad) are abundant plaque and tangle formation, especially in the temporal lobes and hippocampus. |
2006-02-16 |
2023-08-12 |
Not clear |
| Tom den Heijer, Mirjam I Geerlings, Freek E Hoebeek, Albert Hofman, Peter J Koudstaal, Monique M B Bretele. Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people. Archives of general psychiatry. vol 63. issue 1. 2006-02-15. PMID:16389197. |
patients with alzheimer disease and mild cognitive impairment have marked atrophy of the hippocampus and amygdala compared with healthy elderly people. |
2006-02-15 |
2023-08-12 |
Not clear |
| Shaoyu Ge, John A Dan. Nicotinic acetylcholine receptors at glutamate synapses facilitate long-term depression or potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 26. 2006-02-14. PMID:15987938. |
during alzheimer's dementia, nachrs and cholinergic innervation decline in the hippocampus. |
2006-02-14 |
2023-08-12 |
mouse |
| Richard E Hartman, Yukitoshi Izumi, Kelly R Bales, Steven M Paul, David F Wozniak, David M Holtzma. Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 26. 2006-02-14. PMID:15987951. |
treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of alzheimer's disease. |
2006-02-14 |
2023-08-12 |
mouse |
| K Kantarci, R C Petersen, B F Boeve, D S Knopman, S D Weigand, P C O'Brien, M M Shiung, G E Smith, R J Ivnik, E G Tangalos, C R Jac. DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment. Neurology. vol 64. issue 5. 2006-02-09. PMID:15753434. |
the authors assessed whether measures of hippocampal water diffusivity at baseline can predict future progression to alzheimer disease (ad) in amnestic mild cognitive impairment (amci). |
2006-02-09 |
2023-08-12 |
Not clear |
| Kenichi Tokita, Tatsuo Inoue, Shunji Yamazaki, Feng Wang, Takayuki Yamaji, Nobuya Matsuoka, Seitaro Muto. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. European journal of pharmacology. vol 527. issue 1-3. 2006-02-08. PMID:16325809. |
these results suggest that fk962 ameliorates cognitive impairment in rats via activation of the somatostatinergic nervous system in the hippocampus, indicating that fk962 could be a potent cognitive enhancer and therefore might be of therapeutic value for cognitive disorders such as alzheimer's disease. |
2006-02-08 |
2023-08-12 |
rat |
| Naoki Amada, Koutoku Aihara, Rivka Ravid, Masato Hori. Reduction of NR1 and phosphorylated Ca2+/calmodulin-dependent protein kinase II levels in Alzheimer's disease. Neuroreport. vol 16. issue 16. 2006-02-07. PMID:16237332. |
by comparative western blot analysis, we show a reduction of nr1 and phosphorylated ca2+/calmodulin-dependent protein kinase ii levels in the frontal cortex and hippocampus of alzheimer's disease brains. |
2006-02-07 |
2023-08-12 |
Not clear |
| E M Blalock, K-C Chen, A J Stromberg, C M Norris, I Kadish, S D Kraner, N M Porter, P W Landfiel. Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation. Ageing research reviews. vol 4. issue 4. 2006-01-26. PMID:16257272. |
age-related changes in hippocampal regions also may be harbingers of more severe decrements to come from neurodegenerative disorders such as alzheimer's disease (ad). |
2006-01-26 |
2023-08-12 |
human |
| Rutger Goekoop, Philip Scheltens, Frederik Barkhof, Serge A R B Rombout. Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study. Brain : a journal of neurology. vol 129. issue Pt 1. 2006-01-25. PMID:16251213. |
cholinergic challenge in alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fmri study. |
2006-01-25 |
2023-08-12 |
Not clear |
| Rutger Goekoop, Philip Scheltens, Frederik Barkhof, Serge A R B Rombout. Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study. Brain : a journal of neurology. vol 129. issue Pt 1. 2006-01-25. PMID:16251213. |
in alzheimer patients, acute exposure increased activation bilaterally in hippocampal areas, whereas prolonged exposure decreased activation in these areas. |
2006-01-25 |
2023-08-12 |
Not clear |
| Rutger Goekoop, Philip Scheltens, Frederik Barkhof, Serge A R B Rombout. Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study. Brain : a journal of neurology. vol 129. issue Pt 1. 2006-01-25. PMID:16251213. |
the reactivity of posterior cingulate and hippocampal structures to cholinergic challenge suggests a key role of the cholinergic system in the functional processes that lead to alzheimer's disease. |
2006-01-25 |
2023-08-12 |
Not clear |
| Kate M Webber, Arun K Raina, Michael W Marlatt, Xiongwei Zhu, María I Prat, Laura Morelli, Gemma Casadesus, George Perry, Mark A Smit. The cell cycle in Alzheimer disease: a unique target for neuropharmacology. Mechanisms of ageing and development. vol 126. issue 10. 2006-01-20. PMID:15936057. |
we propose that the dysregulation of the cell cycle that occurs in neurons susceptible to degeneration in the hippocampus during alzheimer disease is a potential causative factor that, together with oxidative stress, would initiate all known pathological events. |
2006-01-20 |
2023-08-12 |
Not clear |
| Matthias J Müller, Dirk Greverus, Paulo Roberto Dellani, Carsten Weibrich, Paulo R Wille, Armin Scheurich, Peter Stoeter, Andreas Fellgiebe. Functional implications of hippocampal volume and diffusivity in mild cognitive impairment. NeuroImage. vol 28. issue 4. 2006-01-20. PMID:16084115. |
hippocampal atrophy has been related to mild cognitive impairment (mci) and early alzheimer disease (ad), but the diagnostic significance of cross-sectionally determined hippocampal volumes is still ambiguous. |
2006-01-20 |
2023-08-12 |
human |
| Sivan Vadakkadath Meethal, Mark A Smith, Richard L Bowen, Craig S Atwoo. The gonadotropin connection in Alzheimer's disease. Endocrine. vol 26. issue 3. 2006-01-19. PMID:16034187. |
lh is known to cross the blood-brain barrier, receptors for lh are most concentrated in the hippocampus, that region of the brain most vulnerable to alzheimer's disease (ad) and lh is significantly elevated in both the serum and the pyramidal neurons of ad subjects. |
2006-01-19 |
2023-08-12 |
mouse |