| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E K Perry, I McKeith, P Thompson, E Marshall, J Kerwin, S Jabeen, J A Edwardson, P Ince, G Blessed, D Irvin. Topography, extent, and clinical relevance of neurochemical deficits in dementia of Lewy body type, Parkinson's disease, and Alzheimer's disease. Annals of the New York Academy of Sciences. vol 640. 1992-02-28. PMID:1723256. |
cholinergic and monoaminergic (dopaminergic and serotonergic) activities have been examined in postmortem brain tissue in senile dementia of lewy body type, parkinson's disease, and alzheimer's disease. |
1992-02-28 |
2023-08-11 |
Not clear |
| A Gedy. Serotonergic treatment for aggression in a Down's syndrome adult showing signs of Alzheimer's disease. Journal of mental deficiency research. vol 35 ( Pt 3). 1991-11-21. PMID:1833553. |
serotonergic treatment for aggression in a down's syndrome adult showing signs of alzheimer's disease. |
1991-11-21 |
2023-08-11 |
Not clear |
| J P Blass, L Ko, H M Wisniewsk. Pathology of Alzheimer's disease. The Psychiatric clinics of North America. vol 14. issue 2. 1991-08-02. PMID:2062726. |
at the neurotransmitter level, alzheimer's disease involves not only loss of cholinergic cells but of serotonergic and other neurotransmitter systems as well. |
1991-08-02 |
2023-08-11 |
Not clear |
| W J McEntee, T H Croo. Serotonin, memory, and the aging brain. Psychopharmacology. vol 103. issue 2. 1991-06-12. PMID:2027916. |
abnormalities of the serotonergic nervous system are well documented in pathologic studies of alzheimer's disease and there is evidence suggesting that changes in this system occur in association with non-disease aging. |
1991-06-12 |
2023-08-11 |
Not clear |
| K J Reinikainen, H Soininen, P J Riekkine. Neurotransmitter changes in Alzheimer's disease: implications to diagnostics and therapy. Journal of neuroscience research. vol 27. issue 4. 1991-04-26. PMID:1981917. |
changes in the cholinergic, serotonergic, noradrenergic, dopaminergic, gabaergic and somatostatinergic neurons were investigated to determine their roles in alzheimer's disease (ad). |
1991-04-26 |
2023-08-11 |
cat |
| C H Vanderwolf, C T Dickson, G B Bake. Effects of p-chlorophenylalanine and scopolamine on retention of habits in rats. Pharmacology, biochemistry, and behavior. vol 35. issue 4. 1990-07-02. PMID:2140608. |
combined blockade of central cholinergic and serotonergic neurotransmission in rats may provide a useful animal model of alzheimer's disease. |
1990-07-02 |
2023-08-11 |
rat |
| G Richter-Levin, M Sega. Spatial performance is severely impaired in rats with combined reduction of serotonergic and cholinergic transmission. Brain research. vol 477. issue 1-2. 1989-05-19. PMID:2539238. |
furthermore they propose that deficits in cognitive abilities, observed in aging or alzheimer's disease, may result from the combined reduction in cholinergic and serotonergic transmission. |
1989-05-19 |
2023-08-11 |
rat |
| B A Lawlor, T Sunderland, A M Mellow, J L Hill, P A Newhouse, D L Murph. A preliminary study of the effects of intravenous m-chlorophenylpiperazine, a serotonin agonist, in elderly subjects. Biological psychiatry. vol 25. issue 6. 1989-05-05. PMID:2923931. |
the safety of m-cpp in elderly populations and its potential usefulness in exploring possible serotonergic dysfunction in alzheimer's disease and normal aging were assessed by examining the behavioral, neuroendocrine, and physiological effects of this agent in 15 elderly subjects (mean age 69 +/- 2 years): 9 alzheimer patients and 6 healthy normal volunteers. |
1989-05-05 |
2023-08-11 |
human |
| G L Wen. Amnesia and Alzheimer's disease: which neurotransmitter system is responsible? Neurobiology of aging. vol 9. issue 5-6. 1989-02-16. PMID:2905431. |
the cholinergic, noradrenergic, and serotonergic neurotransmitter systems show a consistent pattern of degeneration associated with alzheimer's disease (ad) and, to a lesser extent, normal aging. |
1989-02-16 |
2023-08-11 |
Not clear |
| O G Nilsson, R E Strecker, A Daszuta, A Björklun. Combined cholinergic and serotonergic denervation of the forebrain produces severe deficits in a spatial learning task in the rat. Brain research. vol 453. issue 1-2. 1988-09-15. PMID:3401761. |
this indicates that the recently proposed serotonergic deficit in patients with alzheimer's disease may contribute importantly to the cognitive disabilities in these patients. |
1988-09-15 |
2023-08-11 |
rat |
| B A Lawlor, A M Mellow, T Sunderland, J L Hill, D L Murph. A pilot study of serotonergic system responsivity in Alzheimer's disease. Psychopharmacology bulletin. vol 24. issue 1. 1988-08-09. PMID:3290935. |
a pilot study of serotonergic system responsivity in alzheimer's disease. |
1988-08-09 |
2023-08-11 |
Not clear |
| K J Reinikainen, L Paljärvi, M Huuskonen, H Soininen, M Laakso, P J Riekkine. A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease. Journal of the neurological sciences. vol 84. issue 1. 1988-06-13. PMID:2452858. |
a post-mortem study of noradrenergic, serotonergic and gabaergic neurons in alzheimer's disease. |
1988-06-13 |
2023-08-11 |
Not clear |
| K J Reinikainen, L Paljärvi, M Huuskonen, H Soininen, M Laakso, P J Riekkine. A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease. Journal of the neurological sciences. vol 84. issue 1. 1988-06-13. PMID:2452858. |
involvement of noradrenergic, serotonergic and gabaergic neurons in alzheimer's disease/senile dementia of alzheimer type (ad/sdat) was studied in 20 histologically confirmed ad/sdat cases by comparing these with 14 control patients. |
1988-06-13 |
2023-08-11 |
Not clear |
| E Koyama, A Minegishi, T Ishizak. Simultaneous determination of four monoamine metabolites and serotonin in cerebrospinal fluid by "high-performance" liquid chromatography with electrochemical detection; application for patients with Alzheimer's disease. Clinical chemistry. vol 34. issue 4. 1988-06-07. PMID:2452037. |
preliminary data on monoaminergic metabolites by the current assay showed that concentrations of dopaminergic and serotonergic metabolites were significantly (p less than 0.05) lower in patients with alzheimer's disease than in the age-matched controls. |
1988-06-07 |
2023-08-11 |
human |
| R H Perry, E K Perry, C J Smith, J H Xuereb, D Irving, C A Whitford, J M Candy, A J Cros. Cortical neuropathological and neurochemical substrates of Alzheimer's and Parkinson's diseases. Journal of neural transmission. Supplementum. vol 24. 1988-01-19. PMID:2824687. |
in a subgroup of parkinsonian cases (both demented and non-demented), examined neurochemically, there were both similarities (decreased choline acetyltransferase, nicotinic and serotonergic s 1 receptor activities) and distinctions (increased muscarinic receptor binding--particularly to the "l" subtype, and normal serotonergic s 2, somatostatin, and d-aspartate binding together with normal levels of an endogenous nicotine binding inhibitor) compared with a group of cases with alzheimer's disease. |
1988-01-19 |
2023-08-11 |
Not clear |
| R H Perry, E K Perry, C J Smith, J H Xuereb, D Irving, C A Whitford, J M Candy, A J Cros. Cortical neuropathological and neurochemical substrates of Alzheimer's and Parkinson's diseases. Journal of neural transmission. Supplementum. vol 24. 1988-01-19. PMID:2824687. |
it is suggested that whilst coincidental classical alzheimer's disease is infrequent in parkinson's disease (5% in the present series) alzheimer's disease itself is distinguished from parkinson's disease by the formation of numerous neocortical neurofibrillary tangles and a reduction in glutamate uptake, serotonergic s 2 receptors and possibly in endogenous nicotine binding inhibitor. |
1988-01-19 |
2023-08-11 |
Not clear |
| J C Winter, D T Pett. The effects of 8-hydroxy-2-(di-n-propylamino)tetralin and other serotonergic agonists on performance in a radial maze: a possible role for 5-HT1A receptors in memory. Pharmacology, biochemistry, and behavior. vol 27. issue 4. 1987-10-29. PMID:2958885. |
the present results taken in light of 8-oh-dpat's preferential binding to 5-ht1a receptors, the high density of these receptors in hippocampus, and the observation that the number of 5-ht1a receptors is decreased in alzheimer's disease, suggest a possible role for this serotonergic receptor subtype in memory. |
1987-10-29 |
2023-08-11 |
rat |
| G Wenk, D Hughey, V Boundy, A Kim, L Walker, D Olto. Neurotransmitters and memory: role of cholinergic, serotonergic, and noradrenergic systems. Behavioral neuroscience. vol 101. issue 3. 1987-08-28. PMID:2886134. |
in alzheimer's disease (ad), pathological changes are found in the basal forebrain cholinergic system (bfcs), serotonergic raphe (ra), and noradrenergic locus coeruleus (lc) systems. |
1987-08-28 |
2023-08-11 |
rat |
| A M Palmer, G K Wilcock, M M Esiri, P T Francis, D M Bowe. Monoaminergic innervation of the frontal and temporal lobes in Alzheimer's disease. Brain research. vol 401. issue 2. 1987-03-30. PMID:2434191. |
seven markers of ascending (corticopetal) dopaminergic, noradrenergic and serotonergic neurones and choline acetyltransferase activity have been studied postmortem in frontal and temporal cortex from subjects with alzheimer's disease and compared with a matched group of controls. |
1987-03-30 |
2023-08-11 |
human |
| A M Palmer, P T Francis, J S Benton, N R Sims, D M Mann, D Neary, J S Snowden, D M Bowe. Presynaptic serotonergic dysfunction in patients with Alzheimer's disease. Journal of neurochemistry. vol 48. issue 1. 1987-01-29. PMID:2432177. |
presynaptic serotonergic dysfunction in patients with alzheimer's disease. |
1987-01-29 |
2023-08-11 |
Not clear |