| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antonio Orlacchio, Toshitaka Kawarai, Eleonora Paciotti, Alessandro Stefani, Aldo Orlacchio, Sandro Sorbi, Peter H St George-Hyslop, Giorgio Bernard. Association study of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease. Neuroscience letters. vol 325. issue 1. 2002-07-10. PMID:12023056. |
serotonergic (5-hydroxytryptamine; 5-ht) transmission has been implicated in the pathogenesis of alzheimer's disease (ad). |
2002-07-10 |
2023-08-12 |
Not clear |
| Marlene Jimenez Del Rio, Carlos Velez-Pard. Monoamine neurotoxins-induced apoptosis in lymphocytes by a common oxidative stress mechanism: involvement of hydrogen peroxide (H(2)O(2)), caspase-3, and nuclear factor kappa-B (NF-kappaB), p53, c-Jun transcription factors. Biochemical pharmacology. vol 63. issue 4. 2002-05-17. PMID:11992635. |
the destruction of dopaminergic and serotonergic nerve cells by selective 6-hydroxydopamine (6-ohda), 5,6-dihydroxytryptamine (5,6-dht) and 5,7-dihydroxytryptamine (5,7-dht), respectively, is a commonly used tool to investigate the mapping of neuronal pathways, elucidation of function and to mimic human neurodegenerative disease such as parkinson's and alzheimer's diseases. |
2002-05-17 |
2023-08-12 |
human |
| J Thome, W Retz, M Baader, B Pesold, M Hu, M Cowen, N Durany, G Adler, F A Henn, M Rösle. Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 10. 2002-04-16. PMID:11725820. |
in order to identify gene variants related to the serotonergic neurotransmitter system that possibly represent a hereditary risk factor for sporadic alzheimer's disease (ad), patients suffering from ad and non-demented psychiatric inpatients without symptoms of dementia were genotyped for polymorphisms of htr6 (267c/t) and htr2a (-1438g/a). |
2002-04-16 |
2023-08-12 |
Not clear |
| J E Mintze. Underlying mechanisms of psychosis and aggression in patients with Alzheimer's disease. The Journal of clinical psychiatry. vol 62 Suppl 21. 2001-10-11. PMID:11584984. |
patients with alzheimer's disease exhibit aggressive behavior, and alterations in their serotonergic function have been identified. |
2001-10-11 |
2023-08-12 |
Not clear |
| J S Rubinsztein, R D Rogers, W J Riedel, M A Mehta, T W Robbins, B J Sahakia. Acute dietary tryptophan depletion impairs maintenance of "affective set" and delayed visual recognition in healthy volunteers. Psychopharmacology. vol 154. issue 3. 2001-09-20. PMID:11351939. |
altered serotonergic transmission in affective disorders and alzheimer's disease has prompted research aimed at defining the precise cognitive effects of depleting central serotonin in humans, using acute dietary tryptophan depletion. |
2001-09-20 |
2023-08-12 |
human |
| Y C Wang, S J Tsai, T Y Liu, H C Liu, C J Hon. No association between tryptophan hydroxylase gene polymorphism and Alzheimer's disease. Neuropsychobiology. vol 43. issue 1. 2001-07-05. PMID:11150890. |
serotonergic dysfunction is implicated in alzheimer's disease (ad) on the basis of studies of serotonin and its metabolite in postmortem specimens and csf. |
2001-07-05 |
2023-08-12 |
human |
| N F Woods, E S Mitchell, C Adam. Memory functioning among midlife women: observations from the Seattle Midlife Women's Health Study. Menopause (New York, N.Y.). vol 7. issue 4. 2000-11-16. PMID:10914619. |
because of the evidence linking estrogen with cholinergic and serotonergic activity in the brain and with central nervous system development of dendritic arborization, and mixed evidence of estrogen use with incidence of alzheimer's disease, the effects of the perimenopause on memory functioning are of interest. |
2000-11-16 |
2023-08-12 |
Not clear |
| H J Cassaday, E L Simpson, E A Gaffa. Rapid visual learning in the rat: effects at the 5-HT1a receptor subtype. The Quarterly journal of experimental psychology. B, Comparative and physiological psychology. vol 53. issue 3. 2000-10-18. PMID:11006720. |
its reversal with way-100635 offers support to the hypothesis that 5-ht1a receptor antagonists could improve cognitive function, under conditions of pre-existing impairment due to overactive serotonergic inhibition, as is thought to occur in alzheimer's disease. |
2000-10-18 |
2023-08-12 |
rat |
| L Trabace, T Cassano, L Steardo, C Pietra, G Villetti, K M Kendrick, V Cuom. Biochemical and neurobehavioral profile of CHF2819, a novel, orally active acetylcholinesterase inhibitor for Alzheimer's disease. The Journal of pharmacology and experimental therapeutics. vol 294. issue 1. 2000-07-24. PMID:10871311. |
these findings suggest that the anti-amnestic properties of chf2819, together with its stimulatory effect on cholinergic and serotonergic functions, might have a therapeutic potential mainly for the symptomatic treatment of alzheimer's disease patients in which the cognitive impairment is accompanied by a depressive syndrome. |
2000-07-24 |
2023-08-12 |
rat |
| R Seidl, S T Kaehler, H Prast, N Singewald, N Cairns, M Gratzer, G Lube. Serotonin (5-HT) in brains of adult patients with Down syndrome. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666678. |
as the serotonergic system plays a well known role in integrating emotion, cognition and motor function, serotonin (5-ht) and its main metabolite, 5-hydroxyindol-3-acetic acid (5-hiaa) were investigated in post-mortem tissue samples from temporal cortex, thalamus, caudate nucleus, occipital cortex and cerebellum of adult patients with ds, alzheimer's disease (ad) and controls by use of high performance liquid chromatography (hplc). |
2000-04-12 |
2023-08-12 |
Not clear |
| S J Tsai, H C Liu, T Y Liu, Y C Wang, C J Hon. Association analysis of the 5-HT6 receptor polymorphism C267T in Alzheimer's disease. Neuroscience letters. vol 276. issue 2. 2000-02-15. PMID:10624811. |
serotonergic dysfunction has been implicated in the pathogenesis of alzheimer's disease (ad). |
2000-02-15 |
2023-08-12 |
Not clear |
| A W Procter, M Qurne, P T Franci. Neurochemical features of frontotemporal dementia. Dementia and geriatric cognitive disorders. vol 10 Suppl 1. 1999-10-01. PMID:10436347. |
this study examines neurochemical measures of cholinergic, serotonergic and glutamatergic innervation in frontal temporal and parietal cerebral cortex from 16 subjects with frontotemporal dementia (ftd) including 10 subjects with pick pathology and 6 with dementia of frontal lobe type (dft) together with 9 subjects with alzheimer's disease, and 28 matched controls. |
1999-10-01 |
2023-08-12 |
human |
| J J Claus, I de Koning, F van Harskamp, M M Breteler, B Voet, H Gutzmann, F Dahlke, T van der Cammen, A Hofma. Lisuride treatment of Alzheimer's disease. A preliminary placebo-controlled clinical trial of safety and therapeutic efficacy. Clinical neuropharmacology. vol 21. issue 3. 1998-08-14. PMID:9617511. |
however, this study's sample size was relatively small, and larger studies are needed to ascertain the treatment effects of serotonergic antagonists on alzheimer's disease. |
1998-08-14 |
2023-08-12 |
Not clear |
| C C Meltzer, G Smith, S T DeKosky, B G Pollock, C A Mathis, R Y Moore, D J Kupfer, C F Reynold. Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 18. issue 6. 1998-06-23. PMID:9571651. |
there is also increasing evidence that a combination of disturbances in cholinergic and serotonergic function may play a role in cognitive impairment in alzheimer's disease (ad), with serotonergic dysfunction potentially responsible for a significant portion of the behavioral aspects of the disease. |
1998-06-23 |
2023-08-12 |
human |
| K A Jellinge. Morphological substrates of dementia in parkinsonism. A critical update. Journal of neural transmission. Supplementum. vol 51. 1998-03-20. PMID:9470129. |
degeneration of subcortical ascending systems with neuronal losses in dopaminergic, noradrenergic, serotonergic, cholinergic or multiple systems including the amygdyloid nucleus; 2. limbic and/or cortical alzheimer and/or lewy body pathologies, with loss of synapses and neurons, and 3. a combination of these lesions or additional cns pathologies. |
1998-03-20 |
2023-08-12 |
Not clear |
| S Chapman, D M Michaelso. Specific neurochemical derangements of brain projecting neurons in apolipoprotein E-deficient mice. Journal of neurochemistry. vol 70. issue 2. 1998-02-24. PMID:9453565. |
the rank order of these presynaptic derangements at comparable distances from the respective cell bodies was found to be septohippocampal cholinergic > nucleus basalis cholinergic > locus coeruleus adrenergic > raphe serotonergic > nigrostriatal dopaminergic, which interestingly is similar to that observed in alzheimer's disease. |
1998-02-24 |
2023-08-12 |
mouse |
| M Heider, R Schliebs, S Rossner, V Big. Basal forebrain cholinergic immunolesion by 192IgG-saporin: evidence for a presynaptic location of subpopulations of alpha 2- and beta-adrenergic as well as 5-HT2A receptors on cortical cholinergic terminals. Neurochemical research. vol 22. issue 8. 1997-10-22. PMID:9239751. |
to study whether the changes in cortical noradrenergic and serotonergic mechanisms observed in patients with alzheimer's disease are the consequence of reduced cortical cholinergic activity, a novel colinergic immunotoxin (conjugate of the monoclonal antibody 192igg against the lower affinity nerve growth factor receptor with the cytotoxic protein saporin, 192igg-saporin) was used to produce a specific and selective loss of cholinergic cells in rat basal forebrain nuclei. |
1997-10-22 |
2023-08-12 |
rat |
| D Weinstein, D Magnuson, J Le. Altered G-protein coupling of a frontal cortical low affinity [3H]8-hydroxy-N,N-dipropyl-2-aminotetralin serotonergic binding site in Alzheimer's disease. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788528. |
altered g-protein coupling of a frontal cortical low affinity [3h]8-hydroxy-n,n-dipropyl-2-aminotetralin serotonergic binding site in alzheimer's disease. |
1996-12-04 |
2023-08-12 |
Not clear |
| D Weinstein, D Magnuson, J Le. Altered G-protein coupling of a frontal cortical low affinity [3H]8-hydroxy-N,N-dipropyl-2-aminotetralin serotonergic binding site in Alzheimer's disease. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788528. |
in alzheimer's disease (ad), there are marked deficits in the function of both the cholinergic and serotonergic systems. |
1996-12-04 |
2023-08-12 |
Not clear |
| C P Chen, J T Alder, D M Bowen, M M Esiri, B McDonald, T Hope, K A Jobst, P T Franci. Presynaptic serotonergic markers in community-acquired cases of Alzheimer's disease: correlations with depression and neuroleptic medication. Journal of neurochemistry. vol 66. issue 4. 1996-06-25. PMID:8627315. |
presynaptic serotonergic markers in community-acquired cases of alzheimer's disease: correlations with depression and neuroleptic medication. |
1996-06-25 |
2023-08-12 |
human |