| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C P Chen, J T Alder, D M Bowen, M M Esiri, B McDonald, T Hope, K A Jobst, P T Franci. Presynaptic serotonergic markers in community-acquired cases of Alzheimer's disease: correlations with depression and neuroleptic medication. Journal of neurochemistry. vol 66. issue 4. 1996-06-25. PMID:8627315. |
presynaptic serotonergic markers, serotonin uptake sites, and concentrations of serotonin and 5-hydroxyindoleacetic acid were studied in the frontal and temporal cortex of 20 community-acquired cases of alzheimer's disease and 16 controls matched for age, sex, postmortem delay, and storage. |
1996-06-25 |
2023-08-12 |
human |
| C P Chen, J T Alder, D M Bowen, M M Esiri, B McDonald, T Hope, K A Jobst, P T Franci. Presynaptic serotonergic markers in community-acquired cases of Alzheimer's disease: correlations with depression and neuroleptic medication. Journal of neurochemistry. vol 66. issue 4. 1996-06-25. PMID:8627315. |
these data suggest previous studies that reported uniform serotonergic dysfunction may have been subject to unintentional selection of behaviourally disturbed alzheimer cases or those receiving chronic neuroleptic medication. |
1996-06-25 |
2023-08-12 |
human |
| L A Mamounas, M E Blue, J A Siuciak, C A Alta. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 12. 1996-06-06. PMID:8613731. |
a pathology of brain serotonergic (5-ht) systems has been found in psychiatric disturbances, normal aging and in neurodegenerative disorders including alzheimer's and parkinson's disease. |
1996-06-06 |
2023-08-12 |
rat |
| M Tárczy, I Szirma. Failure of dopamine metabolism: borderlines of parkinsonism and dementia. Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma. vol 66. issue 3-4. 1996-03-14. PMID:8578941. |
several factors may take part in the development of cognitive impairment: i/ defective function of subcortico-cortical pathways including the mesocorticolimbic dopamine deficiency with cell loss in medial substantia nigra, the degeneration of noradrenergic, serotonergic and cholinergic systems ii/ cortical and limbic alzheimer pathology iii/ cortical lewy bodies iv/ vascular alterations. |
1996-03-14 |
2023-08-12 |
Not clear |
| P Riekkinen, M Riekkine. Effects of tetrahydroaminoacridine and nicotine in nucleus basalis and serotonin-lesioned rats. European journal of pharmacology. vol 279. issue 1. 1995-11-21. PMID:7556384. |
the present results suggest that, in alzheimer's disease, combined degeneration of nucleus basalis cholinergic and brainstem serotonergic cells decreases the therapeutic effect of nicotine, but not that of tetrahydroaminoacridine. |
1995-11-21 |
2023-08-12 |
rat |
| J L Yau, P A Kelly, J R Seck. Increased glucocorticoid receptor gene expression in the rat hippocampus following combined serotonergic and medial septal cholinergic lesions. Brain research. Molecular brain research. vol 27. issue 1. 1995-04-06. PMID:7877448. |
degeneration of both cholinergic and serotonergic (5-ht) hippocampal afferents is prominent in aged rats and alzheimer's disease. |
1995-04-06 |
2023-08-12 |
rat |
| M A Raskind, E R Peskin. Neurobiologic bases of noncognitive behavioral problems in Alzheimer disease. Alzheimer disease and associated disorders. vol 8 Suppl 3. 1995-01-26. PMID:7999346. |
currently available drugs that alter brain noradrenergic or serotonergic activity should be evaluated for efficacy in the management of noncognitive behavioral disorders complicating alzheimer disease. |
1995-01-26 |
2023-08-12 |
Not clear |
| F T Crews, P Kurian, G Freun. Cholinergic and serotonergic stimulation of phosphoinositide hydrolysis is decreased in Alzheimer's disease. Life sciences. vol 55. issue 25-26. 1995-01-18. PMID:7997058. |
cholinergic and serotonergic stimulation of phosphoinositide hydrolysis is decreased in alzheimer's disease. |
1995-01-18 |
2023-08-12 |
human |
| F T Crews, P Kurian, G Freun. Cholinergic and serotonergic stimulation of phosphoinositide hydrolysis is decreased in Alzheimer's disease. Life sciences. vol 55. issue 25-26. 1995-01-18. PMID:7997058. |
ca2+ of ppi hydrolysis was not different between controls and alzheimer's patients suggesting that muscarinic cholinergic and serotonergic receptors are uncoupled from plc in alzheimer's disease. |
1995-01-18 |
2023-08-12 |
human |
| F T Crews, P Kurian, G Freun. Cholinergic and serotonergic stimulation of phosphoinositide hydrolysis is decreased in Alzheimer's disease. Life sciences. vol 55. issue 25-26. 1995-01-18. PMID:7997058. |
these studies indicate that there are changes in cholinergic and serotonergic signal transduction in alzheimer's disease. |
1995-01-18 |
2023-08-12 |
human |
| D M McLoughlin, J V Lucey, T G Dina. Central serotonergic hyperresponsivity in late-onset Alzheimer's disease. The American journal of psychiatry. vol 151. issue 11. 1994-11-15. PMID:7943465. |
central serotonergic hyperresponsivity in late-onset alzheimer's disease. |
1994-11-15 |
2023-08-12 |
Not clear |
| E Mohr, T Mendis, I N Rusk, J D Grime. Neurotransmitter replacement therapy in Alzheimer's disease. Journal of psychiatry & neuroscience : JPN. vol 19. issue 1. 1994-05-06. PMID:7908537. |
deficiencies in central noradrenergic, serotonergic, gabaergic and perhaps dopaminergic neural transmission may also play a critical role in some of the clinical manifestations of alzheimer's disease. |
1994-05-06 |
2023-08-12 |
Not clear |
| E K Perry, E Marshall, P Thompson, I G McKeith, D Collerton, A F Fairbairn, I N Ferrier, D Irving, R H Perr. Monoaminergic activities in Lewy body dementia: relation to hallucinosis and extrapyramidal features. Journal of neural transmission. Parkinson's disease and dementia section. vol 6. issue 3. 1994-04-12. PMID:8123190. |
serotonergic (5-ht) and dopaminergic activities have been examined in lewy body dementia (lbd) and compared with parkinson's disease (pd) and alzheimer's disease (ad). |
1994-04-12 |
2023-08-12 |
Not clear |
| J Blin, J C Baron, B Dubois, C Crouzel, M Fiorelli, D Attar-Lévy, B Pillon, D Fournier, M Vidailhet, Y Agi. Loss of brain 5-HT2 receptors in Alzheimer's disease. In vivo assessment with positron emission tomography and [18F]setoperone. Brain : a journal of neurology. vol 116 ( Pt 3). 1993-07-21. PMID:8513389. |
using [18f]setoperone and positron emission tomography (pet), alterations in serotonergic 5-ht2 receptor binding were studied in cerebral cortex of nine unmedicated patients with probable alzheimer's disease and 37 healthy controls. |
1993-07-21 |
2023-08-12 |
Not clear |
| A M Palmer, S T DeKosk. Monoamine neurons in aging and Alzheimer's disease. Journal of neural transmission. General section. vol 91. issue 2-3. 1993-07-16. PMID:8099796. |
the integrity of dopaminergic, noradrenergic and serotonergic neurons in normal aging and alzheimer's disease is reviewed. |
1993-07-16 |
2023-08-12 |
Not clear |
| A M Palmer, S T DeKosk. Monoamine neurons in aging and Alzheimer's disease. Journal of neural transmission. General section. vol 91. issue 2-3. 1993-07-16. PMID:8099796. |
alzheimer's disease is associated with more pronounced noradrenergic and serotonergic denervation but, unlike normal aging, dopaminergic innervation of neostriatum is intact; although dopamine neurons are probably dysfunctional in this region. |
1993-07-16 |
2023-08-12 |
Not clear |
| P T Francis, M N Pangalos, P H Stephens, J R Bartlett, P K Bridges, A L Malizia, D Neary, A W Procter, D J Thomas, D M Bowe. Antemortem measurements of neurotransmission: possible implications for pharmacotherapy of Alzheimer's disease and depression. Journal of neurology, neurosurgery, and psychiatry. vol 56. issue 1. 1993-03-10. PMID:7679142. |
the results are discussed in relation to treating depression with serotonergic agents and targeting corticocortical glutamatergic neurons as well as acetylcholine in alzheimer's disease. |
1993-03-10 |
2023-08-12 |
human |
| S S Jossan, A Adem, B Winblad, L Orelan. Characterisation of dopamine and serotonin uptake inhibitory effects of tetrahydroaminoacridine in rat brain. Pharmacology & toxicology. vol 71. issue 3 Pt 1. 1992-12-04. PMID:1438045. |
the re-uptake blocking effect of tha on dopaminergic and serotonergic neurones, following tha treatment, might lead to increased levels of these monoamines in brains of alzheimer patients and contribute in the therapeutic effects of the drug. |
1992-12-04 |
2023-08-11 |
rat |
| A W Procter, P T Francis, G C Stratmann, D M Bowe. Serotonergic pathology is not widespread in Alzheimer patients without prominent aggressive symptoms. Neurochemical research. vol 17. issue 9. 1992-11-02. PMID:1357564. |
serotonergic pathology is not widespread in alzheimer patients without prominent aggressive symptoms. |
1992-11-02 |
2023-08-11 |
Not clear |
| M A Aletrino, O J Vogels, P H Van Domburg, H J Ten Donkelaa. Cell loss in the nucleus raphes dorsalis in Alzheimer's disease. Neurobiology of aging. vol 13. issue 4. 1992-09-21. PMID:1508296. |
marked neuron loss in the predominantly serotonergic nucleus raphes dorsalis (nrd) in alzheimer's disease (ad) has repeatedly been reported in the literature. |
1992-09-21 |
2023-08-11 |
Not clear |