| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ninoslav Mimica, Dorotea Mück-Seler, Nela Pivac, Maja Mustapić, Martina Dezeljin, Tamara Stipcević, Paola Presecki, Elizabeta Radonić, Vera Folnegović-Smal. Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features. Collegium antropologicum. vol 32 Suppl 1. 2008-05-01. PMID:18405069. |
post mortem brain studies indicate that alterations in serotonergic and catecholaminergic systems might be associated with alzheimer's disease (ad). |
2008-05-01 |
2023-08-12 |
human |
| Tischa J M van der Cammen, Henning Tiemeier, Marianne J Engelhart, Durk Fekke. Abnormal neurotransmitter metabolite levels in Alzheimer patients with a delirium. International journal of geriatric psychiatry. vol 21. issue 9. 2007-07-26. PMID:16955437. |
several studies have suggested the presence of disturbed cholinergic, dopaminergic and serotonergic pathways in delirium as well as in alzheimer's disease. |
2007-07-26 |
2023-08-12 |
Not clear |
| David Craig, Caroline Donnelly, Dominic Hart, Robyn Carson, Peter Passmor. Analysis of the 5HT-2A T102C receptor polymorphism and psychotic symptoms in Alzheimer's disease. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 1. 2007-02-27. PMID:16967466. |
although the aetiology of psychotic symptoms in alzheimer's disease (ad) is multi-factorial, alterations in serotonergic neurotransmission are often implicated. |
2007-02-27 |
2023-08-12 |
human |
| Monica Garcia-Alloza, Natalia Zaldua, Monica Diez-Ariza, Beatriz Marcos, Berta Lasheras, Francisco Javier Gil-Bea, Maria Javier Ramire. Effect of selective cholinergic denervation on the serotonergic system: implications for learning and memory. Journal of neuropathology and experimental neurology. vol 65. issue 11. 2006-12-27. PMID:17086104. |
these data imply that the serotonergic system in the frontal cortex can compensate for diminished cholinergic function and support the investigation of the serotonergic system as a therapeutic target to treat alzheimer disease. |
2006-12-27 |
2023-08-12 |
rat |
| Dietrich E Lorke, Gang Lu, Eric Cho, David T Ye. Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients. BMC neuroscience. vol 7. 2006-08-23. PMID:16640790. |
it has been hypothesized that alterations of the serotonergic system contribute to neuropsychiatric symptoms in alzheimer disease (ad). |
2006-08-23 |
2023-08-12 |
Not clear |
| Birgitte R Kornum, Pia Weikop, Arne Moller, Lars C B Ronn, Gitte M Knudsen, Susana Azna. Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus. Brain research. vol 1073-1074. 2006-07-19. PMID:16426583. |
interactions between the serotonergic and cholinergic systems are known to occur and are believed to play a role in the mechanism underlying both major depression and alzheimer's disease. |
2006-07-19 |
2023-08-12 |
rat |
| Agnes L Nishimura, Camila Guindalini, João R M Oliveira, Ricardo Nitrini, Valéria S Bahia, Paulo R de Brito-Marques, Paulo A Otto, Mayana Zat. Monoamine oxidase a polymorphism in Brazilian patients: risk factor for late-onset Alzheimer's disease? Journal of molecular neuroscience : MN. vol 27. issue 2. 2005-12-06. PMID:16186632. |
different studies have attempted to find polymorphisms involved in the serotonergic pathway that could be involved in mood disorders and late-onset alzheimer's disease (load) symptoms. |
2005-12-06 |
2023-08-12 |
Not clear |
| Rui Kan, Binbin Wang, Chuanfang Zhang, Ze Yang, Shun Ji, Zeping Lu, Chenguang Zheng, Feng Jin, Li Wan. Association of the HTR6 polymorphism C267T with late-onset Alzheimer's disease in Chinese. Neuroscience letters. vol 372. issue 1-2. 2005-01-14. PMID:15531082. |
serotonergic neurotransmitter system has been implicated in the pathogenesis of alzheimer's disease (ad). |
2005-01-14 |
2023-08-12 |
Not clear |
| Xiang-Rong Jiang, Monika Z Wrona, Susan S Alguindigue, Glenn Dryhurs. Reactions of the putative neurotoxin tryptamine-4,5-dione with L-cysteine and other thiols. Chemical research in toxicology. vol 17. issue 3. 2004-10-08. PMID:15025506. |
thus, 1 has been suggested to play a role in the degeneration of serotonergic neurons in brain disorders such as alzheimer's disease or evoked by amphetamine drugs. |
2004-10-08 |
2023-08-12 |
Not clear |
| Yasuyuki Abe, Atsushi Aoyagi, Takao Hara, Kazumi Abe, Reina Yamazaki, Yoshihiro Kumagae, Shunji Naruto, Kazuo Koyama, Shinji Marumoto, Keiko Tago, Narihiro Toda, Kazuko Takami, Naho Yamada, Mayuko Ori, Hiroshi Kogen, Tsugio Kanek. Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease. Journal of pharmacological sciences. vol 93. issue 1. 2004-07-09. PMID:14501158. |
these results suggest that both cholinergic and serotonergic systems are involved in maintaining brain arousal and that a dual inhibitor of ache and sert may be useful for the treatment of cognitive disorders associated with reduced brain activity such as in alzheimer's disease. |
2004-07-09 |
2023-08-12 |
mouse |
| Michelle Hendricksen, Alan J Thomas, I Nicol Ferrier, Paul Ince, John T O'Brie. Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression. The American journal of psychiatry. vol 161. issue 6. 2004-06-24. PMID:15169699. |
the authors hypothesized that greater neurofibrillary pathology and fewer serotonergic neurons would be found in the dorsal raphe nuclei in depressed elderly subjects, compared with nondepressed elderly subjects, and in alzheimer's disease patients with depression, compared to alzheimer's disease patients without depression. |
2004-06-24 |
2023-08-12 |
human |
| Satoshi Minoshima, Kirk A Frey, Donna J Cross, David E Kuh. Neurochemical imaging of dementias. Seminars in nuclear medicine. vol 34. issue 1. 2004-05-11. PMID:14735460. |
cholinergic, dopaminergic, and serotonergic systems, as well as benzodiazepine receptors, opioid receptors, and glutamatergic receptors have been imaged in alzheimer disease and other dementing disorders. |
2004-05-11 |
2023-08-12 |
human |
| M Garcia-Alloza, W D Hirst, C P L-H Chen, B Lasheras, P T Francis, M J Ramíre. Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 2. 2004-04-27. PMID:14571255. |
growing evidence suggests that a compromised serotonergic system plays an important role in the pathophysiology of alzheimer's disease (ad). |
2004-04-27 |
2023-08-12 |
Not clear |
| Monika Z Wrona, Xiang-Rong Jiang, Yashige Kotake, Glenn Dryhurs. Stability of the putative neurotoxin tryptamine-4,5-dione. Chemical research in toxicology. vol 16. issue 4. 2004-03-23. PMID:12703966. |
tryptamine-4,5-dione (1) is formed by oxidation of the neurotransmitter 5-hydroxytryptamine by reactive oxygen and reactive nitrogen species, and on the basis of in vitro and in vivo studies, it has been proposed to be a neurotoxin that may contribute to the selective neurodegeneration in alzheimer's disease and the serotonergic neurotoxicity of methamphetamine. |
2004-03-23 |
2023-08-12 |
Not clear |
| Gabor G Kovacs, Stefan Klöppel, Ingeborg Fischer, Suzanne Dorner, Elisabeth Lindeck-Pozza, Peter Birner, Ingolf C Bötefür, Peter Pilz, Benedikt Volk, Herbert Budk. Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders. Neuroreport. vol 14. issue 1. 2003-04-25. PMID:12544834. |
to evaluate the involvement of serotonergic raphe nuclei, we compared the percentage of neurons synthesizing serotonin in the nucleus centralis superior (ncs), raphe obscurus and pallidus (nrop) in alzheimer's disease (ad), progressive supranuclear palsy (psp), parkinson's disease (pd), multiple system atrophy (msa), and control brains. |
2003-04-25 |
2023-08-12 |
human |
| Scott A Lyness, Chris Zarow, Helena C Chu. Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis. Neurobiology of aging. vol 24. issue 1. 2003-03-26. PMID:12493547. |
cell counts in the cholinergic nucleus basalis (nb), noradrenergic locus coeruleus (lc), dopaminergic substantia nigra (sn), and the serotonergic dorsal raphe nucleus (drn) were assessed from primary-level reports in patients with alzheimer disease (ad) and in controls. |
2003-03-26 |
2023-08-12 |
Not clear |
| Krista L Lanctôt, Nathan Herrmann, Goran Eryavec, Robert van Reekum, Kenton Reed, Claudio A Naranj. Central serotonergic activity is related to the aggressive behaviors of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 4. 2002-11-19. PMID:12377401. |
central serotonergic activity is related to the aggressive behaviors of alzheimer's disease. |
2002-11-19 |
2023-08-12 |
human |
| Richard J Porter, Elizabeth F Marshall, John T O'Brie. Effects of rapid tryptophan depletion on salivary and plasma cortisol in Alzheimer's disease and the healthy elderly. Journal of psychopharmacology (Oxford, England). vol 16. issue 1. 2002-10-08. PMID:11949775. |
serotonergic function is reduced in dementia of alzheimer type (dat) and abnormalities in the hypothalamic-pituitary-adrenal (hpa) axis are also common. |
2002-10-08 |
2023-08-12 |
human |
| Krista L Lanctôt, Nathan Herrmann, Robert van Reekum, Goran Eryavec, Claudio A Naranj. Gender, aggression and serotonergic function are associated with response to sertraline for behavioral disturbances in Alzheimer's disease. International journal of geriatric psychiatry. vol 17. issue 6. 2002-07-30. PMID:12112177. |
gender, aggression and serotonergic function are associated with response to sertraline for behavioral disturbances in alzheimer's disease. |
2002-07-30 |
2023-08-12 |
Not clear |
| Krista L Lanctôt, Nathan Herrmann, Robert van Reekum, Goran Eryavec, Claudio A Naranj. Gender, aggression and serotonergic function are associated with response to sertraline for behavioral disturbances in Alzheimer's disease. International journal of geriatric psychiatry. vol 17. issue 6. 2002-07-30. PMID:12112177. |
indications for serotonergic medications in the treatment of behavioral disorders associated with alzheimer's disease (ad) remain to be established. |
2002-07-30 |
2023-08-12 |
Not clear |