| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ali Mahzarnia, Michael W Lutz, Alexandra Bade. A Continuous Extension of Gene Set Enrichment Analysis using the Likelihood Ratio Test Statistics Identifies VEGF as a Candidate Pathway for Alzheimer's disease. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662249. |
alzheimer's disease involves brain pathologies such as amyloid plaque depositions and hyperphosphorylated tau tangles and is accompanied by cognitive decline. |
2023-09-04 |
2023-09-07 |
Not clear |
| Zhentao Yu, Zhuoyu Shi, Tingting Dan, Mustafa Dere, Minjeong Kim, Quefeng Li, Guorong W. Uncovering Diverse Mechanistic Spreading Pathways in Disease Progression of Alzheimer's Disease. Journal of Alzheimer's disease reports. vol 7. issue 1. 2023-09-04. PMID:37662609. |
the at[n] research framework focuses on three major biomarkers in alzheimer's disease (ad): amyloid-\xce\xb2 deposition (a), pathologic tau (t), and neurodegeneration [n]. |
2023-09-04 |
2023-09-07 |
Not clear |
| Pablo Mart\\xc3\\xadnez-Ca\\xc3\\xb1ada, Eduardo Perez-Valero, Jesus Minguillon, Francisco Pelayo, Miguel A L\\xc3\\xb3pez-Gordo, Christian Morilla. Combining aperiodic 1/f slopes and brain simulation: An EEG/MEG proxy marker of excitation/inhibition imbalance in Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 15. issue 3. 2023-09-04. PMID:37662693. |
accumulation and interaction of amyloid-beta (a\xce\xb2) and tau proteins during progression of alzheimer's disease (ad) are shown to tilt neuronal circuits away from balanced excitation/inhibition (e/i). |
2023-09-04 |
2023-09-07 |
human |
| Anny Ho, Bidii Ngala, Chiaki Yamada, Christopher Garcia, Carolina Duarte, Juliet Akkaoui, Dumitru Ciolac, Amilia Nusbaum, William Kochen, Daniela Efremova, Stanislav Groppa, Lubov Nathanson, Stephanie Bissel, Adrian Oblak, Melissa A Kacena, Alexandru Movil. IL-34 exacerbates pathogenic features of Alzheimer's disease and calvaria osteolysis in triple transgenic (3x-Tg) female mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-09-04. PMID:37666180. |
hallmark features of alzheimer's disease (ad) include elevated accumulation of aggregated a\xce\xb240 and a\xce\xb242 peptides, hyperphosphorylated tau (p-tau), and neuroinflammation. |
2023-09-04 |
2023-09-07 |
mouse |
| Jie Ding, Chushu Shen, Zhenguo Wang, Yongfeng Yang, Georges El Fakhri, Jie Lu, Dong Liang, Hairong Zheng, Yun Zhou, Tao Su. Tau-PET abnormality as a biomarker for Alzheimer's disease staging and early detection: a topological perspective. Cerebral cortex (New York, N.Y. : 1991). 2023-09-01. PMID:37653600. |
alzheimer's disease can be detected early through biomarkers such as tau positron emission tomography (pet) imaging, which shows abnormal protein accumulations in the brain. |
2023-09-01 |
2023-09-07 |
human |
| Xiaoyu Tang, Zhipeng Kan, Na Li, Jinbao Huang, Jinsong Zhang, Henry J Thompson, Feng Gao, Yong Shen, Liang Zhang, Zhongwen Xie, Xiaochun Wan, Yijun Wan. Mechanisms underlying large-leaf yellow tea mediated inhibition of cognitive impairment in the 5xFAD model of Alzheimer's disease. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 120. 2023-08-31. PMID:37651754. |
alzheimer's disease (ad) is the most common cause of dementia and is characterized by amyloid-\xce\xb2 (a\xce\xb2) peptides and hyperphosphorylated tau proteins. |
2023-08-31 |
2023-09-07 |
Not clear |
| Hasaeam Cho, Jimin Lee, Hanjoon Nho, Keunmin Lee, Bopil Gim, Juncheol Lee, Jaehee Lee, Kai K Ewert, Youli Li, Stuart C Feinstein, Cyrus R Safinya, Kyeong Sik Jin, Myung Chul Cho. Synchrotron X-ray study of intrinsically disordered and polyampholytic Tau 4RS and 4RL under controlled ionic strength. The European physical journal. E, Soft matter. vol 46. issue 9. 2023-08-31. PMID:37653246. |
aggregated and hyperphosphorylated tau is one of the pathological hallmarks of alzheimer's disease. |
2023-08-31 |
2023-09-07 |
Not clear |
| Meichen Yu, Shannon L Risacher, Kwangsik T Nho, Qiuting Wen, Adrian L Oblak, Frederick W Unverzagt, Liana G Apostolova, Martin R Farlow, Jared R Brosch, David G Clark, Sophia Wang, Rachael Deardorff, Yu-Chien Wu, Sujuan Gao, Olaf Sporns, Andrew J Sayki. Spatial transcriptomic patterns underlying regional vulnerability to amyloid-\\xce\\xb2 and tau pathologies and their relationships to cognitive dysfunction in Alzheimer's disease. medRxiv : the preprint server for health sciences. 2023-08-30. PMID:37645867. |
spatial transcriptomic patterns underlying regional vulnerability to amyloid-\xce\xb2 and tau pathologies and their relationships to cognitive dysfunction in alzheimer's disease. |
2023-08-30 |
2023-09-07 |
human |
| Meichen Yu, Shannon L Risacher, Kwangsik T Nho, Qiuting Wen, Adrian L Oblak, Frederick W Unverzagt, Liana G Apostolova, Martin R Farlow, Jared R Brosch, David G Clark, Sophia Wang, Rachael Deardorff, Yu-Chien Wu, Sujuan Gao, Olaf Sporns, Andrew J Sayki. Spatial transcriptomic patterns underlying regional vulnerability to amyloid-\\xce\\xb2 and tau pathologies and their relationships to cognitive dysfunction in Alzheimer's disease. medRxiv : the preprint server for health sciences. 2023-08-30. PMID:37645867. |
amyloid-\xce\xb2 (a\xce\xb2) and tau proteins accumulate within distinct neuronal systems in alzheimer's disease (ad). |
2023-08-30 |
2023-09-07 |
human |
| Cory M Nadel, Kristin Wucherer, Abby Oehler, Aye C Thwin, Koli Basu, Matthew D Callahan, Daniel R Southworth, Daniel A Mordes, Charles S Craik, Jason E Gestwick. Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645969. |
microtubule-associated protein tau (mapt/tau) accumulates in a family of neurodegenerative diseases, including alzheimer's disease (ad). |
2023-08-30 |
2023-09-07 |
Not clear |
| Michiel Bertsch, Bruno Franchi, Maria Carla Tesi, Veronica Tor. The role of A[Formula: see text] and Tau proteins in Alzheimer's disease: a mathematical model on graphs. Journal of mathematical biology. vol 87. issue 3. 2023-08-30. PMID:37646953. |
the role of a[formula: see text] and tau proteins in alzheimer's disease: a mathematical model on graphs. |
2023-08-30 |
2023-09-07 |
human |
| Michiel Bertsch, Bruno Franchi, Maria Carla Tesi, Veronica Tor. The role of A[Formula: see text] and Tau proteins in Alzheimer's disease: a mathematical model on graphs. Journal of mathematical biology. vol 87. issue 3. 2023-08-30. PMID:37646953. |
toxic proteins such as [formula: see text] amyloid and tau play in fact a crucial role in the development of alzheimer's disease and, separately, have been targets of medical treatments. |
2023-08-30 |
2023-09-07 |
human |
| Xin Wang, Erin E Sundermann, Rachel F Buckley, Sarah J Bank. Sex differences in the association between tau PET and cognitive performance in a non-Hispanic White cohort with preclinical AD. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-08-29. PMID:37641484. |
we investigated how the associations between tau and cognitive measures differ by sex in the preclinical alzheimer's disease (ad) stage. |
2023-08-29 |
2023-09-07 |
Not clear |
| Camilla A Molobekova, Elena M Kondaurova, Tatiana V Ilchibaeva, Alexander Ya Rodnyy, Natalia A Stefanova, Nataliya G Kolosova, Vladimir S Naumenk. Amisulpride decreases tau protein hyperphosphorylation in the brain of OXYS rats. Current Alzheimer research. 2023-08-29. PMID:37641989. |
in this study, oxys rats of three ages (1, 3, and 6 months), a proven model of alzheimer's disease (ad), at various stages of disease progression were used to thoroughly study the effects of amisulpride on behavior and tau protein phosphorylation. |
2023-08-29 |
2023-09-07 |
rat |
| Cecilia Monteiro, Balazs Toth, Flavia Brunstein, Ashwini Bobbala, Seema Datta, Ryan Ceniceros, Sandra Sanabria Bohorquez, Veronica Anania, Kristin Wildsmith, Stephen Schauer, Julie Lee, Michael Dolton, Vidya Ramakrishnan, Daniel Abramzon, Edmond Ten. A Randomized Phase II Study of the Safety and Efficacy of Semorinemab in Participants with Mild-to-Moderate Alzheimer's Disease (Lauriet). Neurology. 2023-08-29. PMID:37643887. |
accumulation of tau pathology in alzheimer's disease (ad) correlates with cognitive decline. |
2023-08-29 |
2023-09-07 |
human |
| William P Flavin, Helia Hosseini, Jeffrey W Ruberti, H Pirouz Kavehpour, Christopher C Giza, Mayumi L Prin. Traumatic brain injury and the pathways to cerebral tau accumulation. Frontiers in neurology. vol 14. 2023-08-28. PMID:37638180. |
there are many pathways involved in phosphorylating tau including diabetes, stroke, alzheimer's disease (ad), brain injury, aging, and drug use. |
2023-08-28 |
2023-09-07 |
Not clear |
| Nathalie Moussa, Ninar Dayou. Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 31. issue 9. 2023-08-28. PMID:37638222. |
in addition to cox-2 enzymes role in inflammation, the formation of amyloid plaques and neurofibrillary tangles in the brain, the review emphasizes that coxs-2 have a crucial role in normal synaptic activity and plasticity, and have a relationship with acetylcholine, tau protein, and beta-amyloid (a\xce\xb2) which are the main causes of alzheimer's disease. |
2023-08-28 |
2023-09-07 |
Not clear |
| Nathalie Moussa, Ninar Dayou. Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 31. issue 9. 2023-08-28. PMID:37638222. |
furthermore, the review points out that cox-2 enzymes have a relationship with kinase enzymes, including cyclin dependent kinase 5 (cdk5) and glycogen synthase kinase 3\xce\xb2 (gsk3\xce\xb2), which are known to play a role in tau phosphorylation and are strongly associated with alzheimer's disease. |
2023-08-28 |
2023-09-07 |
Not clear |
| Ruizhi Wang, Kun Ping Lu, Xiao Zhen Zho. Function and regulation of cis P-tau in the pathogenesis and treatment of conventional and nonconventional tauopathies. Journal of neurochemistry. 2023-08-28. PMID:37638382. |
conventional tauopathies are a group of disease characterized by tau inclusions in the brains, including alzheimer's disease (ad), pick's disease (pid), progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and certain types of frontotemporal dementia (ftd), among which ad is the most prevalent. |
2023-08-28 |
2023-09-07 |
Not clear |
| George S Bloom, Andr\\xc3\\xa9s Norambuen. Dysregulation of mTOR by tau in Alzheimer's disease. Cytoskeleton (Hoboken, N.J.). 2023-08-28. PMID:37638691. |
dysregulation of mtor by tau in alzheimer's disease. |
2023-08-28 |
2023-09-07 |
Not clear |