| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Urakami, K Takahashi, H Saito, A Okada, S Nakamura, S Tanaka, N Kitaguchi, Y Tokushima, S Yamamot. Amyloid beta protein precursors with kunitz-type inhibitor domains and acetylcholinesterase in cerebrospinal fluid from patients with dementia of the Alzheimer type. Acta neurologica Scandinavica. vol 85. issue 5. 1992-08-06. PMID:1377855. |
we used the elisa to measure the concentration of amyloid protein precursor with kunitz type trypsin inhibitor domains (appi) in csf of dementia of the alzheimer type (dat) and examined the correlation of appi with acetylcholinesterase (ache) and somatostatin (srif). |
1992-08-06 |
2023-08-11 |
Not clear |
| J W Sowell, Y Tang, M J Valli, J M Chapman, L A Usher, C M Vaughan, J W Kos. Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine. Journal of medicinal chemistry. vol 35. issue 6. 1992-04-28. PMID:1552502. |
in an effort to develop novel, nonquaternary ache inhibitors capable of penetrating into the cns and alleviating the cholinergic deficit characteristic of alzheimer's disease, a series of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine has been synthesized. |
1992-04-28 |
2023-08-11 |
mouse |
| P Gomez-Ramos, E J Mufson, M A Mora. Ultrastructural localization of acetylcholinesterase in neurofibrillary tangles, neuropil threads and senile plaques in aged and Alzheimer's brain. Brain research. vol 569. issue 2. 1992-04-03. PMID:1540829. |
acetylcholinesterase (ache) histochemistry was used to evaluate the accumulation of this enzyme in senile plaques, neurofibrillary tangles and neuropil threads using light and electron microscopy in alzheimer's disease as well as non-demented aged brains. |
1992-04-03 |
2023-08-11 |
Not clear |
| H A Berman, K Leonar. Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase. Molecular pharmacology. vol 41. issue 2. 1992-03-27. PMID:1538717. |
this paper examines inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (buche) by tetrahydroaminoacridine (tha), an acridine analog under consideration for palliative treatment of alzheimer's dementia. |
1992-03-27 |
2023-08-11 |
Not clear |
| O Yasuhara, S Nakamura, I Akiguchi, J Kimura, M Kameyam. [The distribution of senile plaques and acetylcholinesterase staining in the thalamus in dementia of Alzheimer type]. Rinsho shinkeigaku = Clinical neurology. vol 31. issue 4. 1991-11-05. PMID:1717194. |
to determine whether the regional distribution of senile plaques is related to the pattern of cholinergic innervation, we studied the distribution of plaques and changes in acetylcholinesterase (ache) reactivity in the thalamus of patients with dementia of alzheimer type (dat). |
1991-11-05 |
2023-08-11 |
Not clear |
| P L Moriearty, C L Womack, B W Dick, J A Colliver, R S Robbs, R E Becke. Stability of peripheral hematological parameters after chronic acetylcholinesterase inhibition in man. American journal of hematology. vol 37. issue 4. 1991-08-23. PMID:1858789. |
ache is also a major enzyme in the central nervous system; alteration of its activity has been proposed as a therapeutic strategy in alzheimer disease. |
1991-08-23 |
2023-08-11 |
human |
| P L Moriearty, C L Womack, B W Dick, J A Colliver, R S Robbs, R E Becke. Stability of peripheral hematological parameters after chronic acetylcholinesterase inhibition in man. American journal of hematology. vol 37. issue 4. 1991-08-23. PMID:1858789. |
we recently treated 18 alzheimer disease patients with metrifonate, a long-acting ache inhibitor, over periods up to 7 months, with resulting erythrocyte ache inhibition as high as 82 per cent of baseline values. |
1991-08-23 |
2023-08-11 |
human |
| K A Carson, C Geula, M M Mesula. Electron microscopic localization of cholinesterase activity in Alzheimer brain tissue. Brain research. vol 540. issue 1-2. 1991-07-31. PMID:2054612. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) activity was localized by electron microscopic enzyme cytochemistry in cortex from alzheimer brains and brains from non-demented cases. |
1991-07-31 |
2023-08-11 |
Not clear |
| K A Carson, C Geula, M M Mesula. Electron microscopic localization of cholinesterase activity in Alzheimer brain tissue. Brain research. vol 540. issue 1-2. 1991-07-31. PMID:2054612. |
in the tangle-rich medial temporal cortex of the alzheimer brain, most of the neuronal ache was associated with neurofibrillary tangles. |
1991-07-31 |
2023-08-11 |
Not clear |
| M Xu, Y Nakamura, T Yamamoto, K Natori, T Irie, H Utsumi, T Kat. Determination of basal acetylcholine release in vivo by rat brain dialysis with a U-shaped cannula: effect of SM-10888, a putative therapeutic drug for Alzheimer's disease. Neuroscience letters. vol 123. issue 2. 1991-06-12. PMID:2027531. |
when sm-10888, a novel ache inhibitor and putative therapeutic drug for alzheimer's disease, was injected intraperitoneally, ach in the dialysate of the cortex increased in a dose-dependent manner. |
1991-06-12 |
2023-08-11 |
rat |
| D S Navaratnam, J D Priddle, B McDonald, M M Esiri, J R Robinson, A D Smit. Anomalous molecular form of acetylcholinesterase in cerebrospinal fluid in histologically diagnosed Alzheimer's disease. Lancet (London, England). vol 337. issue 8739. 1991-03-13. PMID:1671469. |
the possibility that the different molecular forms of acetylcholinesterase (ache) in cerebrospinal fluid (csf) which can be revealed by isoelectric focusing may reflect changes in ache in pathologically affected neurons in alzheimer's disease was tested in a retrospective study. |
1991-03-13 |
2023-08-11 |
Not clear |
| D S Navaratnam, J D Priddle, B McDonald, M M Esiri, J R Robinson, A D Smit. Anomalous molecular form of acetylcholinesterase in cerebrospinal fluid in histologically diagnosed Alzheimer's disease. Lancet (London, England). vol 337. issue 8739. 1991-03-13. PMID:1671469. |
an additional band indicating an anomalous molecular form of ache was present in csf from 19 of 23 patients with a histological diagnosis of alzheimer's disease and no other central nervous system disorder but in none of the 19 non-demented patients (without a histological diagnosis of alzheimer's disease). |
1991-03-13 |
2023-08-11 |
Not clear |
| D S Navaratnam, J D Priddle, B McDonald, M M Esiri, J R Robinson, A D Smit. Anomalous molecular form of acetylcholinesterase in cerebrospinal fluid in histologically diagnosed Alzheimer's disease. Lancet (London, England). vol 337. issue 8739. 1991-03-13. PMID:1671469. |
the absence of the anomalous form of ache from the csf of non-demented patients and its presence in the csf of the majority of patients with alzheimer's disease has implications for our understanding of the biological basis of the disease and might form the basis of an antemortem diagnostic test. |
1991-03-13 |
2023-08-11 |
Not clear |
| S Nakamura, S Kawashima, S Nakano, T Tsuji, W Arak. Subcellular distribution of acetylcholinesterase in Alzheimer's disease: abnormal localization and solubilization. Journal of neural transmission. Supplementum. vol 30. 1990-10-04. PMID:2391513. |
ache activity was detected mainly in membrane-bound fractions in the frontal cortex of autopsied control or alzheimer brain as well as rat cerebral cortex. |
1990-10-04 |
2023-08-11 |
rat |
| S Nakamura, S Kawashima, S Nakano, T Tsuji, W Arak. Subcellular distribution of acetylcholinesterase in Alzheimer's disease: abnormal localization and solubilization. Journal of neural transmission. Supplementum. vol 30. 1990-10-04. PMID:2391513. |
however, the distribution of ache among various membrane fractions was different between control and alzheimer brains. |
1990-10-04 |
2023-08-11 |
rat |
| G C Siek, L S Katz, E B Fishman, T S Korosi, J K Marqui. Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain. Biological psychiatry. vol 27. issue 6. 1990-05-24. PMID:2322617. |
we have previously reported that the 10s molecular form (g4) of acetylcholinesterase (ache) is selectively lost from several cortical areas of alzheimer's disease (ad) brain. |
1990-05-24 |
2023-08-11 |
Not clear |
| J A Nielsen, E E Mena, I H Williams, M R Nocerini, D Listo. Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes. European journal of pharmacology. vol 173. issue 1. 1990-02-22. PMID:2606156. |
we conclude that brain ache inhibition by tha is sufficient to explain its purported therapeutic activity in alzheimer's disease and that its favorable brain/plasma distribution in vivo may account for its central cholinergic action without inducing the severe peripheral cholinergic effects typically seen with other ache inhibitors. |
1990-02-22 |
2023-08-11 |
mouse |
| V Kumar, E Giacobini, S Markwel. CSF choline and acetylcholinesterase in early-onset vs. late-onset Alzheimer's disease patients. Acta neurologica Scandinavica. vol 80. issue 5. 1989-12-28. PMID:2589014. |
cerebrospinal fluid acetylcholinesterase (ache) activity levels and choline (ch) levels were studied in 52 dementia of alzheimer type (dat) patients and 20 age-matched controls. |
1989-12-28 |
2023-08-11 |
Not clear |
| F J Huff, C T Reiter, J Protetc. Activities and kinetic properties of lumbar cerebrospinal fluid cholinesterases in relation to clinical diagnosis, severity, and progression of Alzheimer's disease. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 16. issue 4. 1989-12-20. PMID:2804802. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) activities of lumbar cerebrospinal fluid (csf) have been measured in seventeen patients with a clinical diagnosis of probable alzheimer's disease (prob ad), possible alzheimer's disease (poss ad), or dementia of non-alzheimer aetiology (non-ad). |
1989-12-20 |
2023-08-11 |
Not clear |
| K Urakami, Y Adachi, E Awaki, K Takahash. Characterization of the course of senile dementia of the Alzheimer type using cerebrospinal fluid levels of acetylcholinesterase and somatostatin. Acta neurologica Scandinavica. vol 80. issue 3. 1989-11-20. PMID:2572139. |
the acetylcholinesterase (ache) activity and somatostatin (srif) concentration of the cerebrospinal fluid (csf) were measured in patients with alzheimer's disease (ad) and 3 types of sdat. |
1989-11-20 |
2023-08-11 |
human |