| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Arendt, M K Brückner, M Lange, V Big. Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development--a study of molecular forms. Neurochemistry international. vol 21. issue 3. 1993-06-24. PMID:1303164. |
the pattern of molecular forms of acetylcholinesterase (ache, ec 3.1.1.7) and butyrylcholinesterase (bche, ec 3.1.1.8) separated by density gradient centrifugation was investigated in the brain and cerebrospinal fluid in alzheimer's disease (ad), in human embryonic brain and in rat brain after experimental cholinergic deafferentation of the cerebral cortex. |
1993-06-24 |
2023-08-11 |
human |
| A A al-Jafar. The inhibitory effect of tetramethylethylene diamine on water soluble and membrane bound acetylcholinesterase activity. The International journal of biochemistry. vol 25. issue 3. 1993-05-04. PMID:8462722. |
moreover there is a possibility that it can be used as a therapeutic agent for the treatment of alzheimer's disease, myasthenia gravia and glaucoma like some other inhibitors of ache. |
1993-05-04 |
2023-08-12 |
Not clear |
| C Saldanha, T Quintão, C Garci. [Evaluation of blood esterases in Alzheimer's disease]. Acta medica portuguesa. vol 5. issue 11. 1993-04-08. PMID:1293953. |
blood samples of 34 alzheimer's patients (18f and 16m) were obtained and haemoglobin concentration, haematocrit, plasma (butyrylcholinesterase, buche) and erythrocyte (ache) esterase activities and fluorescence polarization after introduction of dph in erythrocyte membrane have been determined. |
1993-04-08 |
2023-08-11 |
human |
| P L Moriearty, R E Becke. Inhibition of human brain and RBC acetylcholinesterase (AChE) by heptylphysostigmine (HPTL). Methods and findings in experimental and clinical pharmacology. vol 14. issue 8. 1993-03-08. PMID:1494302. |
heptylphysostigmine (hptl), a derivative of the ache inhibitor physostigmine (phy), is under investigation as a therapeutic agent in alzheimer's disease. |
1993-03-08 |
2023-08-11 |
human |
| K M Schegg, L S Harrington, S Neilsen, R M Zweig, J H Peacoc. Soluble and membrane-bound forms of brain acetylcholinesterase in Alzheimer's disease. Neurobiology of aging. vol 13. issue 6. 1993-02-26. PMID:1491735. |
in order to determine the effect of alzheimer's disease on the relative distribution of soluble and membrane-bound molecular forms of acetylcholinesterase (ache) in the brain, postmortem samples (delay interval less than 12 h) were obtained from parietal cortex (brodmann area 40) and hippocampus as well as the areas containing their respective projection nuclei, i.e., substantia innominata and septal nucleus, in 9 patients with alzheimer's disease (ad) and 4 normal controls. |
1993-02-26 |
2023-08-11 |
Not clear |
| M E Appleyar. Secreted acetylcholinesterase: non-classical aspects of a classical enzyme. Trends in neurosciences. vol 15. issue 12. 1993-02-11. PMID:1282748. |
loss of ache and its non-classical actions would have a profound effect on brain function in neurodegenerative diseases such as alzheimer's disease where there is widespread loss of ache-containing neurons. |
1993-02-11 |
2023-08-11 |
Not clear |
| A E Coleman, C Geula, B H Price, M M Mesula. Differential laminar distribution of acetylcholinesterase and butyrylcholinesterase containing tangles in the cerebral cortex of Alzheimer's disease. Brain research. vol 596. issue 1-2. 1993-01-28. PMID:1467998. |
a sensitive histochemical method for the visualization of acetylcholinesterase (ache) and butyrylcholinesterase (bche) activity was used to determine the laminar distribution of cholinesterase-positive cortical tangles in alzheimer's disease (ad). |
1993-01-28 |
2023-08-11 |
Not clear |
| M E Appleyard, B McDonal. Acetylcholinesterase and butyrylcholinesterase activities in cerebrospinal fluid from different levels of the neuraxis of patients with dementia of the Alzheimer type. Journal of neurology, neurosurgery, and psychiatry. vol 55. issue 11. 1993-01-26. PMID:1469405. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) activities of cerebrospinal fluid (csf) collected post mortem from the lateral ventricles, cisterna magna, and lumbar regions of the spinal cord of patients with a histologically confirmed diagnosis of alzheimer's disease were compared with those of normal, age matched control patients, patients with dementia of non-alzheimer aetiology, and patients with non-dementing neurological disorders. |
1993-01-26 |
2023-08-11 |
Not clear |
| M E Appleyard, B McDonal. Acetylcholinesterase and butyrylcholinesterase activities in cerebrospinal fluid from different levels of the neuraxis of patients with dementia of the Alzheimer type. Journal of neurology, neurosurgery, and psychiatry. vol 55. issue 11. 1993-01-26. PMID:1469405. |
the ache activity of the ventricular csf of patients with alzheimer's disease was 48% lower (p < 0.005) than that of age matched controls or patients with other types of dementia, and the ache activity of csf sampled from the basal cistern was 40% lower (p < 0.005) in patients with alzheimer's disease. |
1993-01-26 |
2023-08-11 |
Not clear |
| M E Appleyard, B McDonal. Acetylcholinesterase and butyrylcholinesterase activities in cerebrospinal fluid from different levels of the neuraxis of patients with dementia of the Alzheimer type. Journal of neurology, neurosurgery, and psychiatry. vol 55. issue 11. 1993-01-26. PMID:1469405. |
there were no significant differences between the ache activity in alzheimer's disease and control patients in csf collected from the lumbar cistern. |
1993-01-26 |
2023-08-11 |
Not clear |
| M E Appleyard, B McDonal. Acetylcholinesterase and butyrylcholinesterase activities in cerebrospinal fluid from different levels of the neuraxis of patients with dementia of the Alzheimer type. Journal of neurology, neurosurgery, and psychiatry. vol 55. issue 11. 1993-01-26. PMID:1469405. |
the secretion of ache from forebrain and hindbrain regions is reduced in alzheimer's disease patients, leading to decreased ventricular and cisternal levels of the enzyme. |
1993-01-26 |
2023-08-11 |
Not clear |
| M E Appleyard, B McDonal. Acetylcholinesterase and butyrylcholinesterase activities in cerebrospinal fluid from different levels of the neuraxis of patients with dementia of the Alzheimer type. Journal of neurology, neurosurgery, and psychiatry. vol 55. issue 11. 1993-01-26. PMID:1469405. |
secretion from more caudal regions of the central nervous system seems to be unaffected by the disease, resulting in ache in the lumbar csf of patients with alzheimer's disease being in the control range. |
1993-01-26 |
2023-08-11 |
Not clear |
| O Strada, E C Hirsch, F Javoy-Agid, S Lehéricy, M Ruberg, J J Hauw, Y Agi. Does loss of nerve growth factor receptors precede loss of cholinergic neurons in Alzheimer's disease? An autoradiographic study in the human striatum and basal forebrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 12. 1993-01-15. PMID:1464766. |
in contrast, ache staining decreased less in the nucleus basalis of meynert in all alzheimer's disease patients, and in the ventral striatum of those most severely affected. |
1993-01-15 |
2023-08-11 |
human |
| S Nakamura, M Takemura, T Suenaga, I Akiguchi, J Kimura, O Yasuhara, T Kimura, N Kitaguch. Occurrence of acetylcholinesterase activity closely associated with amyloid beta/A4 protein is not correlated with acetylcholinesterase-positive fiber density in amygdala of Alzheimer's disease. Acta neuropathologica. vol 84. issue 4. 1992-12-18. PMID:1441923. |
to investigate the possible relationship between acetylcholinesterase (ache)-containing fiber density and senile plaque density and between ache-positive plaques and beta/a4 protein deposition, ache histochemistry, the modified bielschowsky's method and beta/a4 protein immunohistochemistry were performed on the amygdala of alzheimer's disease (ad) and aged control cases. |
1992-12-18 |
2023-08-11 |
Not clear |
| J Sirviö, P J Riekkine. Brain and cerebrospinal fluid cholinesterases in Alzheimer's disease, Parkinson's disease and aging. A critical review of clinical and experimental studies. Journal of neural transmission. Parkinson's disease and dementia section. vol 4. 1992-11-17. PMID:1388703. |
additional work is needed to clarify the role of ache abnormality in the formation of pathology changes in patients with alzheimer's disease. |
1992-11-17 |
2023-08-11 |
Not clear |
| M Z Wrona, R N Goyal, D J Turk, C L Blank, G Dryhurs. 5,5'-Dihydroxy-4,4'-bitryptamine: a potentially aberrant, neurotoxic metabolite of serotonin. Journal of neurochemistry. vol 59. issue 4. 1992-10-26. PMID:1357095. |
furthermore, an unidentified autoxidation product of this neurotransmitter is an inhibitor of acetylcholinesterase (ache), an enzyme compromised in the alzheimer brain. |
1992-10-26 |
2023-08-11 |
mouse |
| S Heckers, C Geula, M M Mesula. Acetylcholinesterase-rich pyramidal neurons in Alzheimer's disease. Neurobiology of aging. vol 13. issue 4. 1992-09-21. PMID:1508295. |
the distribution of acetylcholinesterase (ache)-rich pyramidal neurons was studied in the cortices of 7 alzheimer's disease (ad) patients and 4 normal-aged subjects. |
1992-09-21 |
2023-08-11 |
human |
| M Konagaya, Y Konagaya, M Iid. [CSF acetylcholinesterase activity in central neurological diseases involving cholinergic systems]. Rinsho shinkeigaku = Clinical neurology. vol 32. issue 3. 1992-08-19. PMID:1628449. |
csf ache of alzheimer type dementia (ad/sdat, n = 12: 21.9 +/- 4.7 nmol/ml/min) showed no significant change from those of both control group (22.1 +/- 3.9) and vascular dementia (9: 21.7 +/- 6.7). |
1992-08-19 |
2023-08-11 |
Not clear |
| E K Perry, M Johnson, J M Kerwin, M A Piggott, J A Court, P J Shaw, P G Ince, A Brown, R H Perr. Convergent cholinergic activities in aging and Alzheimer's disease. Neurobiology of aging. vol 13. issue 3. 1992-08-12. PMID:1625768. |
choline acetyltransferase (chat) and acetylcholinesterase (ache) activities have been examined postmortem in a series of 66 individuals with no evidence of cns disease, ranging in age from 24 gestational weeks to 95 years and in 33 cases of alzheimer's disease (ad) aged 57-89 years. |
1992-08-12 |
2023-08-11 |
human |
| R P Gaykema, C Nyakas, E Horvath, L B Hersh, C Majtenyi, P G Luite. Cholinergic fiber aberrations in nucleus basalis lesioned rat and Alzheimer's disease. Neurobiology of aging. vol 13. issue 3. 1992-08-12. PMID:1625774. |
in addition, ache histochemistry was performed on human cortical sections derived from autopsy brains of normal aged and alzheimer's disease (ad) patients. |
1992-08-12 |
2023-08-11 |
human |