| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Dow, B D Dulery, J M Hornsperger, G F Di Francesco, P Keshary, K D Haegel. Pharmacokinetics and pharmacodynamics of the acetylcholinesterase inhibitor 2,2,2-trifluoro-1-(3-trimethylsilylphenyl) ethanone in dog. Potential for transdermal patch delivery. Arzneimittel-Forschung. vol 45. issue 12. 1996-04-11. PMID:8595078. |
mdl 73,745 (2,2,2-trifluoro-1-(3-trimethylsilylphenyl) ethanone, cas 132236(18-1) is a novel tight-binding inhibitor of acetylcholinesterase (ache), which is in development as a potential therapeutic compound in the symptomatic treatment of alzheimer's disease. |
1996-04-11 |
2023-08-12 |
dog |
| W Tong, E R Collantes, Y Chen, W J Wels. A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors. Journal of medicinal chemistry. vol 39. issue 2. 1996-02-28. PMID:8558505. |
these compounds have been found to inhibit the metabolic breakdown of the neurotransmitter acetylcholine (ach) by the enzyme acetylcholinesterase (ache) and hence alleviate memory deficits in patients with alzheimer's disease by potentiating cholinergic transmission. |
1996-02-28 |
2023-08-12 |
human |
| C Geula, M M Mesula. Cholinesterases and the pathology of Alzheimer disease. Alzheimer disease and associated disorders. vol 9 Suppl 2. 1996-02-07. PMID:8534419. |
alzheimer disease (ad) is accompanied by a marked loss of acetylcholinesterase (ache) activity associated with cortical cholinergic axons and cholinoceptive neurons. |
1996-02-07 |
2023-08-12 |
Not clear |
| P G Laye. Nonclassical roles of cholinesterases in the embryonic brain and possible links to Alzheimer disease. Alzheimer disease and associated disorders. vol 9 Suppl 2. 1996-02-07. PMID:8534420. |
evidence about nonclassic functions of acetyl- (ache) and butyryl-cholinesterase (bche) during embryonic development of vertebrate brains is compared with evidence of their expression in alzheimer disease (ad). |
1996-02-07 |
2023-08-12 |
Not clear |
| J Bajgar, G M Bisso, H Michale. Differential inhibition of rat brain acetylcholinesterase molecular forms by 7-methoxytacrine in vitro. Toxicology letters. vol 80. issue 1-3. 1995-12-14. PMID:7482577. |
the differential inhibition of ache molecular forms by 7-meota is discussed in relation to its possible clinical application for treatment of disorders such as alzheimer's disease, in which a reduction of brain cholinergic neurotransmission is believed to play a role. |
1995-12-14 |
2023-08-12 |
rat |
| Y P Pang, A P Kozikowsk. Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program. Journal of computer-aided molecular design. vol 8. issue 6. 1995-06-07. PMID:7738604. |
the topography of the calculated e2020 binding sites provides insights into understanding the high potency of e2020 in the inhibition of ache and provides hints as to possible structural modifications for identifying improved ache inhibitors as potential therapeutics for the palliative treatment of alzheimer's disease. |
1995-06-07 |
2023-08-12 |
Not clear |
| H Namba, T Irie, K Fukushi, M Iy. In vivo measurement of acetylcholinesterase activity in the brain with a radioactive acetylcholine analog. Brain research. vol 667. issue 2. 1995-05-03. PMID:7697367. |
the method would be applicable for in vivo studies of human brain ache activity in disorders of central cholinergic systems such as alzheimer's disease. |
1995-05-03 |
2023-08-12 |
human |
| M R Emmerling, V E Gregor, R D Schwarz, J D Scholten, M J Callahan, C Lee, C J Moore, C Raby, W J Lipinski, R E Davi. PD 142676 (CI 1002), a novel anticholinesterase and muscarinic antagonist. Molecular neurobiology. vol 9. issue 1-3. 1995-04-18. PMID:7888109. |
inhibition of brain acetylcholinesterase (ache) can provide relief from the cognitive loss associated with alzheimer's disease (ad). |
1995-04-18 |
2023-08-12 |
rat |
| L Minthon, L Edvinsson, L Gustafso. Tacrine treatment modifies cerebrospinal fluid neuropeptide levels in Alzheimer's disease. Dementia (Basel, Switzerland). vol 5. issue 6. 1995-03-29. PMID:7866482. |
biochemical and histochemical studies have demonstrated a widespread deficit in the activity of acetylcholinesterase (ache) in the brains of patients with alzheimer's disease (dat). |
1995-03-29 |
2023-08-12 |
Not clear |
| S Iijima, N H Greig, P Garofalo, E L Spangler, B Heller, A Brossi, D K Ingra. Phenserine: a physostigmine derivative that is a long-acting inhibitor of cholinesterase and demonstrates a wide dose range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze. Psychopharmacology. vol 112. issue 4. 1995-03-29. PMID:7871051. |
we have assessed the potential clinical value of phenserine for cholinomimetic therapy of cognitive impairments associated with aging and alzheimer's disease by evaluating its duration of in vivo activity against rat plasma acetylcholinesterase (ache) and its effect on attenuating a scopolamine-induced impairment in learning performance of young rats in a shock-motivated 14-unit t-maze. |
1995-03-29 |
2023-08-12 |
rat |
| Z X She. Acetylcholinesterase provides deeper insights into Alzheimer's disease. Medical hypotheses. vol 43. issue 1. 1994-12-07. PMID:7968717. |
this article reviews the considerable evidence which rejects the cholinergic hypothesis of alzheimer's disease (ad) and proposes that it is the ache system of which the lightly stained neurons are located in the entorhinal cortex, the ca1/subiculum of the hippocampus and the amygdala which are the most vulnerable and are the earliest affected in the pathological processes of ad. |
1994-12-07 |
2023-08-12 |
Not clear |
| P Novales-L. Characterization of immunoglobulin M antibodies raised by in vitro immunization specific to soluble human caudate nucleus and cerebrospinal fluid acetylcholinesterase. Biochemical and biophysical research communications. vol 203. issue 2. 1994-10-18. PMID:8093024. |
with csf samples from alzheimer's patients, immunoblotting of isoelectric focussing (ief) gels with the four mabs failed to demonstrate any positive binding to the anomalous ache band. |
1994-10-18 |
2023-08-12 |
human |
| J Chelliah, J D Smith, M W Faris. Inhibition of cholinesterase activity by tetrahydroaminoacridine and the hemisuccinate esters of tocopherol and cholesterol. Biochimica et biophysica acta. vol 1206. issue 1. 1994-06-21. PMID:8186246. |
such potent and synergistic inhibition of ache suggest that ts or cs, alone and in combination with tha, may prove beneficial in the treatment of organophosphate poisoning and alzheimer's disease. |
1994-06-21 |
2023-08-12 |
Not clear |
| Y Ashani, J Grunwald, C Kronman, B Velan, A Shafferma. Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase. Molecular pharmacology. vol 45. issue 3. 1994-05-05. PMID:8145739. |
huperzine a (hup), a natural, potent, 'slow,' reversible inhibitor of antiacetylcholinesterase (ache), has been suggested to be superior to antiacetylcholinesterase drugs now being used for management of alzheimer's disease. |
1994-05-05 |
2023-08-12 |
human |
| A H Mohamme. Effects of cholinesterase inhibitors on learning and memory in rats: a brief review with special reference to THA. Acta neurologica Scandinavica. Supplementum. vol 149. 1994-04-14. PMID:8128832. |
research on memory enhancing effects of acetylcholinesterase (ache) inhibitors was stimulated by the finding of diminished cholinergic markers in patients with alzheimer's disease, and the correlation of cognitive impairment to cholinergic deficits in these patients. |
1994-04-14 |
2023-08-12 |
rat |
| W C Benzing, E J Mufson, D M Armstron. Immunocytochemical distribution of peptidergic and cholinergic fibers in the human amygdala: their depletion in Alzheimer's disease and morphologic alteration in non-demented elderly with numerous senile plaques. Brain research. vol 625. issue 1. 1993-12-29. PMID:8242391. |
as part of an ongoing investigation devoted to understanding the pathogenesis of senile plaques, we employed histochemical and immunocytochemical techniques to examine the distribution and cytologic features of acetylcholinesterase (ache), choline acetyltransferase (chat), somatostatin (som), neurotensin (nt) and substance p (sp) containing fibers and neurons within the amygdala of: (1) patients with alzheimer's disease (ad); (2) age-matched non-demented controls (nc); and (3) a group of non-demented cases, who upon postmortem neuropathologic examination exhibited sufficient numbers of senile plaques to be classified as ad. |
1993-12-29 |
2023-08-12 |
human |
| C I Wright, C Geula, M M Mesula. Protease inhibitors and indolamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer's disease. Annals of the New York Academy of Sciences. vol 695. 1993-12-10. PMID:8239315. |
neurofibrillary tangles and amyloid plaques express acetylcholinesterase (ache) and butyrylcholinesterase (bche) activity in alzheimer's disease. |
1993-12-10 |
2023-08-12 |
Not clear |
| C I Wright, C Geula, M M Mesula. Neurological cholinesterases in the normal brain and in Alzheimer's disease: relationship to plaques, tangles, and patterns of selective vulnerability. Annals of neurology. vol 34. issue 3. 1993-09-30. PMID:8363355. |
butyrylcholinesterase (bche) and an altered form of acetylcholinesterase (ache) accumulate in the plaques and tangles of alzheimer's disease (ad). |
1993-09-30 |
2023-08-12 |
Not clear |
| S Michaelson, D H Smal. A protease is recovered with a dimeric form of acetylcholinesterase in fetal bovine serum. Brain research. vol 611. issue 1. 1993-07-29. PMID:8518952. |
a protease activity which co-purified with affinity-purified fetal bovine serum acetylcholinesterase (ache) has been shown to release the amyloid protein precursor (app) of alzheimer's disease from cell membranes. |
1993-07-29 |
2023-08-12 |
cattle |
| L Slomianka, F A Genese. Distribution of acetylcholinesterase in the hippocampal region of the mouse. III. The area dentata. The Journal of comparative neurology. vol 331. issue 2. 1993-07-15. PMID:7685362. |
the functional significance of the ache pattern is discussed in relation to species differences and connectivity and also with respect to possible activities of the enzyme other than hydrolysis of ach, which may be involved in growth-related functions and in the plastic and degenerative processes observed in alzheimer's disease. |
1993-07-15 |
2023-08-12 |
mouse |