| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masaaki Hirouch. [Current status and perspectives on the development of therapeutic agents for Alzheimer's disease]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 123. issue 6. 2004-07-20. PMID:15170082. |
acetylcholinesterase inhibitors have beneficial effects to improve the cognitive impairment in patients with mild to moderate alzheimer's disease (ad). |
2004-07-20 |
2023-08-12 |
Not clear |
| Yasuyuki Abe, Atsushi Aoyagi, Takao Hara, Kazumi Abe, Reina Yamazaki, Yoshihiro Kumagae, Shunji Naruto, Kazuo Koyama, Shinji Marumoto, Keiko Tago, Narihiro Toda, Kazuko Takami, Naho Yamada, Mayuko Ori, Hiroshi Kogen, Tsugio Kanek. Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease. Journal of pharmacological sciences. vol 93. issue 1. 2004-07-09. PMID:14501158. |
pharmacological characterization of rs-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of alzheimer's disease. |
2004-07-09 |
2023-08-12 |
mouse |
| David H Smal. Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease? Trends in neurosciences. vol 27. issue 5. 2004-07-06. PMID:15111005. |
do acetylcholinesterase inhibitors boost synaptic scaling in alzheimer's disease? |
2004-07-06 |
2023-08-12 |
Not clear |
| Burt M Sharp, M Yatsula, Yitong F. Effects of galantamine, a nicotinic allosteric potentiating ligand, on nicotine-induced catecholamine release in hippocampus and nucleus accumbens of rats. The Journal of pharmacology and experimental therapeutics. vol 309. issue 3. 2004-07-01. PMID:14769831. |
galantamine, a drug for treatment of alzheimer's disease, is a novel cholinergic agent with a dual mode of action that inhibits acetylcholinesterase and allosterically modulates nicotinic cholinergic receptors (nachrs). |
2004-07-01 |
2023-08-12 |
rat |
| Kornkanok Ingkaninan, Prapapan Temkitthawon, Kanchanaporn Chuenchom, Thitaree Yuyaem, Warawit Thongno. Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies. Journal of ethnopharmacology. vol 89. issue 2-3. 2004-06-29. PMID:14611889. |
acetylcholinesterase (ache) inhibitor has been used as a drug for the symptomatic treatment of alzheimer's disease. |
2004-06-29 |
2023-08-12 |
Not clear |
| Xiao Zhan. Cholinergic activity and amyloid precursor protein processing in aging and Alzheimer's disease. Current drug targets. CNS and neurological disorders. vol 3. issue 2. 2004-06-10. PMID:15078189. |
the current clinical treatments for alzheimer's disease solely rely on cholinomimetic drugs i.e., acetylcholinesterase inhibitors. |
2004-06-10 |
2023-08-12 |
mouse |
| Z Rakoncza. Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and Alzheimer's disease brain. Acta biologica Hungarica. vol 54. issue 2. 2004-06-02. PMID:14535624. |
potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and alzheimer's disease brain. |
2004-06-02 |
2023-08-12 |
human |
| Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kaneko, Hiroshi Koge. A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease. Bioorganic & medicinal chemistry. vol 11. issue 20. 2004-06-01. PMID:13129577. |
a conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for alzheimer's disease. |
2004-06-01 |
2023-08-12 |
Not clear |
| Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kaneko, Hiroshi Koge. A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease. Bioorganic & medicinal chemistry. vol 11. issue 20. 2004-06-01. PMID:13129577. |
alzheimer's disease (ad) has been treated with acetylcholinesterase (ache) inhibitors such as donepezil. |
2004-06-01 |
2023-08-12 |
Not clear |
| Stephen M Stahl, Jeffrey S Markowitz, George Papadopoulos, Kay Sadi. Examination of nighttime sleep-related problems during double-blind, placebo-controlled trials of galantamine in patients with Alzheimer's disease. Current medical research and opinion. vol 20. issue 4. 2004-05-21. PMID:15119989. |
acetylcholinesterase inhibitors (achei) are now widely used as treatment for alzheimer's disease (ad). |
2004-05-21 |
2023-08-12 |
Not clear |
| Stéphane Riou. [Acetylcholinesterase inhibitors]. Revue medicale de la Suisse romande. vol 123. issue 7. 2004-05-20. PMID:15088511. |
the approach to the treatment of alzheimer's dementia has been greatly modified by the acetylcholinesterase inhibitor drugs, first donepezil (aricept) and then rivastigmine (exelon) and galantamine (reminyl), and the ever-increasing number of demented people forces us to be familiar with their use. |
2004-05-20 |
2023-08-12 |
Not clear |
| Shigenobu Nakamur. A guideline for the treatment of dementia in Japan. Internal medicine (Tokyo, Japan). vol 43. issue 1. 2004-05-11. PMID:14964575. |
in contrast, only one acetylcholinesterase inhibitor, donepezil has been proven effective and used for patients with mild or moderate alzheimer's disease in japan. |
2004-05-11 |
2023-08-12 |
Not clear |
| Thomas C Rosenthal, Natan Khotiano. Managing Alzheimer dementia tomorrow. The Journal of the American Board of Family Practice. vol 16. issue 5. 2004-05-06. PMID:14645333. |
acetylcholinesterase inhibitors are the first drugs to alter the devastating effects of alzheimer disease. |
2004-05-06 |
2023-08-12 |
Not clear |
| P J Whitehous. Donepezil. Drugs of today (Barcelona, Spain : 1998). vol 34. issue 4. 2004-05-05. PMID:15010720. |
donepezil is a highly selective, long-acting acetylcholinesterase inhibitor which has been approved in numerous countries for the treatment of alzheimer's disease. |
2004-05-05 |
2023-08-12 |
Not clear |
| Th Gallarda, H Lô. [Mémantine (Ebixa): a new therapeutic strategy for the treatment of moderate to severe forms of Alzheimer's disease]. L'Encephale. vol 30. issue 1. 2004-05-04. PMID:15029079. |
the four existing acetylcholinesterase inhibitors having confirmed symptomatic action in patients with mild to moderate alzheimer's disease have now been joined by memantine (ebixa), a non-competitive agonist of n-methyl-d-aspartate (nmda) receptors. |
2004-05-04 |
2023-08-12 |
Not clear |
| Ho Jin Heo, Mi-Jeong Kim, Jung-Min Lee, Soo Jung Choi, Hong-Yon Cho, Bumshik Hong, Hye-Kyung Kim, Eunki Kim, Dong-Hoon Shi. Naringenin from Citrus junos has an inhibitory effect on acetylcholinesterase and a mitigating effect on amnesia. Dementia and geriatric cognitive disorders. vol 17. issue 3. 2004-05-03. PMID:14739537. |
this study was performed to identify safe and more effective acetylcholinesterase (ache) inhibitors in the treatment of alzheimer's disease. |
2004-05-03 |
2023-08-12 |
mouse |
| Shigeru Akasofu, Takashi Kosasa, Manami Kimura, Atsuhiko Kubot. Protective effect of donepezil in a primary culture of rat cortical neurons exposed to oxygen-glucose deprivation. European journal of pharmacology. vol 472. issue 1-2. 2004-04-23. PMID:12860473. |
donepezil hydrochloride (donepezil: (+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-indan-1-one monohydrochloride) is a potent acetylcholinesterase inhibitor used for treatment of alzheimer's disease. |
2004-04-23 |
2023-08-12 |
rat |
| Shigeru Akasofu, Takashi Kosasa, Manami Kimura, Atsuhiko Kubot. Protective effect of donepezil in a primary culture of rat cortical neurons exposed to oxygen-glucose deprivation. European journal of pharmacology. vol 472. issue 1-2. 2004-04-23. PMID:12860473. |
although acetylcholinesterase inhibitors are used as a symptomatic treatment for alzheimer's disease, it is not clear whether or not they are effective against progressive degeneration of neuronal cells. |
2004-04-23 |
2023-08-12 |
rat |
| Shigeru Akasofu, Takashi Kosasa, Manami Kimura, Atsuhiko Kubot. Protective effect of donepezil in a primary culture of rat cortical neurons exposed to oxygen-glucose deprivation. European journal of pharmacology. vol 472. issue 1-2. 2004-04-23. PMID:12860473. |
in this study, we investigated the neuroprotective effects of donepezil and other acetylcholinesterase inhibitors used for treatment of alzheimer's disease, i.e., galantamine, rivastigmine, and tacrine. |
2004-04-23 |
2023-08-12 |
rat |
| Si-lang Zhou, Jun-pao Chen, Xiao-wen Tu, Dong-lin Cao, Dai-jun Yua. [Effects of basic fibroblast growth factor on rat models of Alzheimer disease]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA. vol 23. issue 6. 2004-04-16. PMID:12810391. |
to study the effects of basic fibroblast growth factor (bfgf) on the praxiology and cerebral acetylcholinesterase (ache) fiber density of kainic acid-lesioned rat models of alzheimer disease (ad). |
2004-04-16 |
2023-08-12 |
rat |