| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minoru Fujiki, Hidenori Kobayashi, Susumu Uchida, Ryo Inoue, Keisuke Ishi. Neuroprotective effect of donepezil, a nicotinic acetylcholine-receptor activator, on cerebral infarction in rats. Brain research. vol 1043. issue 1-2. 2005-07-08. PMID:15862539. |
this study evaluated the potential effect of donepezil, which is known as an acetylcholinesterase inhibitor used for treatment of alzheimer's disease, against cerebral infarction induced by permanent left middle cerebral artery (mca) occlusion. |
2005-07-08 |
2023-08-12 |
rat |
| Rebecca Rossom, Adityanjee, Maurice Dyske. Efficacy and tolerability of memantine in the treatment of dementia. The American journal of geriatric pharmacotherapy. vol 2. issue 4. 2005-06-28. PMID:15903287. |
until recently, acetylcholinesterase inhibitors were the only approved agents for the treatment of alzheimer's disease (ad). |
2005-06-28 |
2023-08-12 |
Not clear |
| Debby Van Dam, Bart Marescau, Sebastiaan Engelborghs, Thomas Cremers, Jan Mulder, Matthias Staufenbiel, Peter Paul De Dey. Analysis of cholinergic markers, biogenic amines, and amino acids in the CNS of two APP overexpression mouse models. Neurochemistry international. vol 46. issue 5. 2005-06-10. PMID:15737439. |
impairment of cholinergic transmission, the prominent neurochemical deficit in alzheimer brain, was examined; acetylcholinesterase and choline acetyltransferase activity levels were determined as markers of the cholinergic system. |
2005-06-10 |
2023-08-12 |
mouse |
| C Fuschillo, S La Pia, F Campana, A Pinto, L De Simon. Cognitive deficits in Alzheimer's disease: treatment with acetylcholinesterase inhibitor agents. Archives of gerontology and geriatrics. Supplement. vol 7. 2005-06-08. PMID:11431059. |
cognitive deficits in alzheimer's disease: treatment with acetylcholinesterase inhibitor agents. |
2005-06-08 |
2023-08-12 |
Not clear |
| Sam Medhat Salah, Anna Katharina Jäge. Screening of traditionally used Lebanese herbs for neurological activities. Journal of ethnopharmacology. vol 97. issue 1. 2005-05-26. PMID:15652288. |
aqueous, ethanol and ethyl acetate extracts of seven lebanese plants that are used traditionally for neurological disorders as alzheimer's disease, epilepsy and affective disorders as depression were tested for inhibition of acetylcholinesterase and affinity to the gaba(a)-benzodiazepine site and to the serotonin transporter. |
2005-05-26 |
2023-08-12 |
Not clear |
| Lynnette J Cook, Luk W Ho, Lin Wang, Edith Terrenoire, Carol Brayne, John Grimley Evans, John Xuereb, Nigel J Cairns, Dragana Turic, Paul Hollingworth, Pamela J Moore, Luke Jehu, Nicola Archer, Sarah Walter, Catherine Foy, Amanda Edmondson, John Powell, Simon Lovestone, Julie Williams, David C Rubinsztei. Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 132B. issue 1. 2005-05-12. PMID:15690550. |
consistent deficits in the cholinergic system are evident in the brains of alzheimer's disease (ad) patients, including reductions in the activities of acetylcholine, acetylcholinesterase (ache), and choline acetyltransferase (chat), increased butyrylcholinesterase (bche) activity, and a selective loss of nicotinic acetylcholine receptors (nachrs). |
2005-05-12 |
2023-08-12 |
Not clear |
| Tatsuya Kikuchi, Ming-Rong Zhang, Nobuo Ikota, Kiyoshi Fukushi, Toshimitsu Okamura, Kazutoshi Suzuki, Yasushi Arano, Toshiaki Iri. N-[18F] fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity. Journal of medicinal chemistry. vol 48. issue 7. 2005-05-05. PMID:15801847. |
the reduction of acetylcholinesterase (ache) activity in the brain has been measured in dementia disorders such as alzheimer's disease and dementia with lewy bodies using (11)c-labeled acetylcholine analogues, n-[(11)c]methylpiperidin-4-yl acetate and propionate, and positron emission tomography (pet). |
2005-05-05 |
2023-08-12 |
human |
| V Magnier, E Flipon, O Godefroy, O Ganry, D Dupuy-Sonntag, A Ros. [Acetylcholinesterase inhibitor treatment for Alzheimer's disease: the experience in Picardy]. Revue neurologique. vol 161. issue 2. 2005-05-03. PMID:15798520. |
[acetylcholinesterase inhibitor treatment for alzheimer's disease: the experience in picardy]. |
2005-05-03 |
2023-08-12 |
Not clear |
| M G M Olde Rikkert, S Lauque, L Frölich, B Vellas, W Dekker. The practice of obtaining approval from medical research ethics committees: a comparison within 12 European countries for a descriptive study on acetylcholinesterase inhibitors in Alzheimer's dementia. European journal of neurology. vol 12. issue 3. 2005-04-29. PMID:15693811. |
the practice of obtaining approval from medical research ethics committees: a comparison within 12 european countries for a descriptive study on acetylcholinesterase inhibitors in alzheimer's dementia. |
2005-04-29 |
2023-08-12 |
human |
| M G M Olde Rikkert, S Lauque, L Frölich, B Vellas, W Dekker. The practice of obtaining approval from medical research ethics committees: a comparison within 12 European countries for a descriptive study on acetylcholinesterase inhibitors in Alzheimer's dementia. European journal of neurology. vol 12. issue 3. 2005-04-29. PMID:15693811. |
the study that was evaluated is the ictus study, which studies the impact of treatment with acetylcholinesterase inhibitors (ache-i) on europeans with mildly or moderately severe alzheimer's disease (ad). |
2005-04-29 |
2023-08-12 |
human |
| E G Jordá, E Verdaguer, A Jiménez, A M Canudas, V Rimbau, P Camps, D Muñoz-Torrero, A Camins, M Pallà. (+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration. Journal of Alzheimer's disease : JAD. vol 6. issue 6. 2005-04-26. PMID:15665397. |
acetylcholinesterase inhibitors (achei) are among the drugs most widely used in the treatment of alzheimer's disease. |
2005-04-26 |
2023-08-12 |
Not clear |
| Wanda Lipczyńska-Łojkowska, Danuta Ryglewicz, Tomasz Jedrzejczak, Teresa Jakubowska, Sławomira Kotapka-Minc, Halina Sienkiewicz-Jarosz, Anna Bochyńsk. [The effect of rivastigmine on cognitive functions and regional cerebral blood flow in Alzheimer's disease and vascular dementia: follow-up for 2 years]. Neurologia i neurochirurgia polska. vol 38. issue 6. 2005-04-19. PMID:15654671. |
the aim of the work was to investigate the effect of treatment with rivastigmine, one of the inhibitors of acetylcholinesterase (ache-i) on the regional cerebral perfusion (rcbf) and the cognitive functions of the brain in patients with alzheimer's disease (ad) and vascular dementia (vad). |
2005-04-19 |
2023-08-12 |
Not clear |
| Hugo Geerts, Pierre-Olivier Guillaumat, Christopher Grantham, Wilhelmina Bode, Katelijne Anciaux, Sohel Sacha. Brain levels and acetylcholinesterase inhibition with galantamine and donepezil in rats, mice, and rabbits. Brain research. vol 1033. issue 2. 2005-04-13. PMID:15694923. |
galantamine is a rather weak acetylcholinesterase (ache) inhibitor, currently approved for the symptomatic treatment of alzheimer's disease, with possible additional allosteric potentiating effects at the nicotinic ach receptor (nachr). |
2005-04-13 |
2023-08-12 |
mouse |
| Nibaldo C Inestrosa, Juan Paulo Sagal, Marcela Colombre. Acetylcholinesterase interaction with Alzheimer amyloid beta. Sub-cellular biochemistry. vol 38. 2005-04-12. PMID:15709485. |
acetylcholinesterase interaction with alzheimer amyloid beta. |
2005-04-12 |
2023-08-12 |
rat |
| Robert van Reekum, Donald T Stuss, Laurie Ostrande. Apathy: why care? The Journal of neuropsychiatry and clinical neurosciences. vol 17. issue 1. 2005-04-11. PMID:15746478. |
strong evidence of efficacy exists for acetylcholinesterase inhibitors in alzheimer's disease, and for atypical antipsychotics in schizophrenia. |
2005-04-11 |
2023-08-12 |
Not clear |
| Sandra Bond Chapman, Myron F Weiner, Audette Rackley, Linda S Hynan, Jennifer Zient. Effects of cognitive-communication stimulation for Alzheimer's disease patients treated with donepezil. Journal of speech, language, and hearing research : JSLHR. vol 47. issue 5. 2005-03-31. PMID:15603468. |
this randomized study evaluated the combined effect of a cognitive-communication program plus an acetylcholinesterase inhibitor (donepezil; donepezil-plus-stimulation group; n = 26), as compared with donepezil alone (donepezil-only group; n = 28) in 54 patients with mild to moderate alzheimer's disease (ad; mini-mental status examination score of 12- 28) ranging in age from 54 to 91 years. |
2005-03-31 |
2023-08-12 |
human |
| N I Bohnen, D I Kaufer, R Hendrickson, L S Ivanco, B J Lopresti, R A Koeppe, C C Meltzer, G Constantine, J G Davis, C A Mathis, S T Dekosky, R Y Moor. Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 76. issue 3. 2005-03-15. PMID:15716518. |
degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in alzheimer's disease. |
2005-03-15 |
2023-08-12 |
human |
| N I Bohnen, D I Kaufer, R Hendrickson, L S Ivanco, B J Lopresti, R A Koeppe, C C Meltzer, G Constantine, J G Davis, C A Mathis, S T Dekosky, R Y Moor. Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. vol 76. issue 3. 2005-03-15. PMID:15716518. |
to determine in vivo cortical acetylcholinesterase (ache) activity and cognitive effects in subjects with mild alzheimer's disease (ad, n = 14) prior to and after 12 weeks of donepezil therapy. |
2005-03-15 |
2023-08-12 |
human |
| Dong Shao, Chunyan Zou, Cheng Luo, Xican Tang, Yuanchao L. Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry letters. vol 14. issue 18. 2005-03-07. PMID:15324879. |
synthesis and evaluation of tacrine-e2020 hybrids as acetylcholinesterase inhibitors for the treatment of alzheimer's disease. |
2005-03-07 |
2023-08-12 |
Not clear |
| Z-X She. Brain cholinesterases: I. The clinico-histopathological and biochemical basis of Alzheimer's disease. Medical hypotheses. vol 63. issue 2. 2005-02-24. PMID:15236793. |
in alzheimer's disease (ad), the histopathological characteristics are initially and primarily associated with the degeneration of the acetylcholinesterase (ache) system in various brain regions. |
2005-02-24 |
2023-08-12 |
Not clear |