| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Fuschillo, E Ascoli, G Franzese, F Campana, C Cello, M Galdi, S La Pia, C Cetrangol. Alzheimer's disease and acetylcholinesterase inhibitor agents: a two-year longitudinal study. Archives of gerontology and geriatrics. Supplement. issue 9. 2004-10-21. PMID:15207413. |
alzheimer's disease and acetylcholinesterase inhibitor agents: a two-year longitudinal study. |
2004-10-21 |
2023-08-12 |
Not clear |
| Bengt Winblad, Vesna Jeli. Long-term treatment of Alzheimer disease: efficacy and safety of acetylcholinesterase inhibitors. Alzheimer disease and associated disorders. vol 18 Suppl 1. 2004-09-30. PMID:15249842. |
long-term treatment of alzheimer disease: efficacy and safety of acetylcholinesterase inhibitors. |
2004-09-30 |
2023-08-12 |
Not clear |
| Howard Fillit, Jerrold Hil. The economic benefits of acetylcholinesterase inhibitors for patients with Alzheimer disease and associated dementias. Alzheimer disease and associated disorders. vol 18 Suppl 1. 2004-09-30. PMID:15249845. |
the economic benefits of acetylcholinesterase inhibitors for patients with alzheimer disease and associated dementias. |
2004-09-30 |
2023-08-12 |
Not clear |
| Roger M Lane, Miia Kivipelto, Nigel H Grei. Acetylcholinesterase and its inhibition in Alzheimer disease. Clinical neuropharmacology. vol 27. issue 3. 2004-09-27. PMID:15190239. |
acetylcholinesterase and its inhibition in alzheimer disease. |
2004-09-27 |
2023-08-12 |
Not clear |
| Dane R Liston, Jann A Nielsen, Anabella Villalobos, Douglas Chapin, Shawn B Jones, Sean T Hubbard, Ismail A Shalaby, Andres Ramirez, Deane Nason, W Frost Whit. Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease. European journal of pharmacology. vol 486. issue 1. 2004-09-22. PMID:14751402. |
pharmacology of selective acetylcholinesterase inhibitors: implications for use in alzheimer's disease. |
2004-09-22 |
2023-08-12 |
mouse |
| Dane R Liston, Jann A Nielsen, Anabella Villalobos, Douglas Chapin, Shawn B Jones, Sean T Hubbard, Ismail A Shalaby, Andres Ramirez, Deane Nason, W Frost Whit. Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease. European journal of pharmacology. vol 486. issue 1. 2004-09-22. PMID:14751402. |
the improved therapeutic index observed in mice with icopezil is due to a high degree of selectivity for acetylcholinesterase versus butyrylcholinesterase, suggesting that high selectivity for acetylcholinesterase may contribute to the clinically favourable tolerability profile of agents such as donepezil in alzheimer's disease patients. |
2004-09-22 |
2023-08-12 |
mouse |
| Neal E Slatkin, Michelle Rhine. Treatment of opiate-related sedation: utility of the cholinesterase inhibitors. The journal of supportive oncology. vol 1. issue 1. 2004-09-21. PMID:15352644. |
preliminary studies with donepezil, a centrally acting acetylcholinesterase (ache) inhibitor approved for use in alzheimer's disease, have suggested at least short-term benefit in treating opiate-related sedation. |
2004-09-21 |
2023-08-12 |
Not clear |
| Francesco Gambi, Marcella Reale, Carla Iarlori, Anatolia Salone, Lucia Toma, Carlo Paladini, Giovanna De Luca, Claudio Feliciani, Mirella Salvatore, Rosa M Salerno, Theoharis C Theoharides, Pio Conti, Michael Exton, Domenico Gamb. Alzheimer patients treated with an AchE inhibitor show higher IL-4 and lower IL-1 beta levels and expression in peripheral blood mononuclear cells. Journal of clinical psychopharmacology. vol 24. issue 3. 2004-09-07. PMID:15118486. |
the study evaluates the expression and production of cytokines in peripheral blood mononuclear cells of patients with alzheimer disease treated or not treated with acetylcholinesterase inhibitor, which enhances neuronal transmission. |
2004-09-07 |
2023-08-12 |
human |
| Francesco Gambi, Marcella Reale, Carla Iarlori, Anatolia Salone, Lucia Toma, Carlo Paladini, Giovanna De Luca, Claudio Feliciani, Mirella Salvatore, Rosa M Salerno, Theoharis C Theoharides, Pio Conti, Michael Exton, Domenico Gamb. Alzheimer patients treated with an AchE inhibitor show higher IL-4 and lower IL-1 beta levels and expression in peripheral blood mononuclear cells. Journal of clinical psychopharmacology. vol 24. issue 3. 2004-09-07. PMID:15118486. |
in contrast, il-4 levels and expression were significantly higher in alzheimer patients treated with the acetylcholinesterase inhibitor. |
2004-09-07 |
2023-08-12 |
human |
| David G Wilkinson, Paul T Francis, Elias Schwam, Jennifer Payne-Parris. Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy. Drugs & aging. vol 21. issue 7. 2004-08-27. PMID:15132713. |
there is substantial evidence that the cholinesterase inhibitors, including donepezil, galantamine and rivastigmine, decrease acetylcholinesterase activity in a number of brain regions in patients with alzheimer's disease. |
2004-08-27 |
2023-08-12 |
Not clear |
| David G Wilkinson, Paul T Francis, Elias Schwam, Jennifer Payne-Parris. Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy. Drugs & aging. vol 21. issue 7. 2004-08-27. PMID:15132713. |
it seems clear that whatever the subsidiary modes of action, clinical evidence supporting acetylcholinesterase inhibition as the mechanism by which cholinesterase inhibitors treat the symptoms of alzheimer's disease is accumulating. |
2004-08-27 |
2023-08-12 |
Not clear |
| Rachel Sayer, Emma Law, Peter J Connelly, Kieran C Bree. Association of a salivary acetylcholinesterase with Alzheimer's disease and response to cholinesterase inhibitors. Clinical biochemistry. vol 37. issue 2. 2004-08-25. PMID:14725939. |
association of a salivary acetylcholinesterase with alzheimer's disease and response to cholinesterase inhibitors. |
2004-08-25 |
2023-08-12 |
human |
| Renee L Hayslett, Yousef Tizab. Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. Pharmacology, biochemistry, and behavior. vol 76. issue 3-4. 2004-08-24. PMID:14643839. |
donepezil is an acetylcholinesterase inhibitor approved for use in mild to moderate alzheimer's disease. |
2004-08-24 |
2023-08-12 |
mouse |
| Thierry Voisin, Emma Reynish, Florence Portet, Howard Feldman, Bruno Vella. What are the treatment options for patients with severe Alzheimer's disease? CNS drugs. vol 18. issue 9. 2004-08-23. PMID:15222774. |
post-hoc analyses of rivastigmine and galantamine in patients with more advanced alzheimer's disease have supported the hypothesis that acetylcholinesterase inhibitors are likely be efficacious in this subgroup. |
2004-08-23 |
2023-08-12 |
Not clear |
| Yaping Pan, Xianghua Xu, Xiaoliang Wan. Rivastigmine blocks voltage-activated K+ currents in dissociated rat hippocampal neurons. British journal of pharmacology. vol 140. issue 5. 2004-08-13. PMID:14504131. |
rivastigmine is an acetylcholinesterase inhibitor used in alzheimer's disease therapy. |
2004-08-13 |
2023-08-12 |
rat |
| Sultan Darvesh, Rakesh C Arora, Earl Martin, David Magee, David A Hopkins, J Andrew Armou. Cholinesterase inhibitors modify the activity of intrinsic cardiac neurons. Experimental neurology. vol 188. issue 2. 2004-08-10. PMID:15246845. |
cholinesterase inhibitors used to treat the symptoms of alzheimer's disease (ad) inhibit both acetylcholinesterase (ache) and butyrylcholinesterase (buche), albeit to different degrees. |
2004-08-10 |
2023-08-12 |
Not clear |
| Yuhao Ren, Peter J Houghton, Robert C Hider, Melanie-Jayne R Howe. Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza. Planta medica. vol 70. issue 3. 2004-08-09. PMID:15114495. |
acetylcholinesterase (ache, ec 3.1.1.7) inhibitors are the only registered drugs used to treat alzheimer's disease (ad). |
2004-08-09 |
2023-08-12 |
Not clear |
| Alessandra Lugaresi, Angelo Di Iorio, Carla Iarlori, Marcella Reale, Giovanna De Luca, Eleonora Sparvieri, Alessia Michetti, Pio Conti, Domenico Gambi, Giuseppe Abate, Roberto Paganell. IL-4 in vitro production is upregulated in Alzheimer's disease patients treated with acetylcholinesterase inhibitors. Experimental gerontology. vol 39. issue 4. 2004-08-02. PMID:15050302. |
il-4 in vitro production is upregulated in alzheimer's disease patients treated with acetylcholinesterase inhibitors. |
2004-08-02 |
2023-08-12 |
Not clear |
| L Froelich, H-J Gertz, R Heun, I Heuser, K Jendroska, J Kornhuber, A Kurz, T Mueller-Thomsen, F Ries, C Waechtler, M Metz, C Goebe. Donepezil for Alzheimer's disease in clinical practice--The DONALD Study. A multicenter 24-week clinical trial in Germany. Dementia and geriatric cognitive disorders. vol 18. issue 1. 2004-07-28. PMID:15084792. |
this multicenter open-label clinical trial was designed to investigate the safety and efficacy of donepezil, a selective acetylcholinesterase inhibitor, in the treatment of alzheimer's disease (ad) in routine clinical practice in germany. |
2004-07-28 |
2023-08-12 |
Not clear |
| F E de Leeuw, J van Gij. [Vascular dementia]. Nederlands tijdschrift voor geneeskunde. vol 148. issue 24. 2004-07-26. PMID:15224429. |
acetylcholinesterase inhibitors may slow down cognitive decline not only in some patients with alzheimer's disease but also in patients with vascular dementia. |
2004-07-26 |
2023-08-12 |
human |