| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bernd Ibach, Ekkehard Hae. Acetylcholinesterase inhibition in Alzheimer's Disease. Current pharmaceutical design. vol 10. issue 3. 2004-04-16. PMID:14754384. |
acetylcholinesterase inhibition in alzheimer's disease. |
2004-04-16 |
2023-08-12 |
Not clear |
| Bernd Ibach, Ekkehard Hae. Acetylcholinesterase inhibition in Alzheimer's Disease. Current pharmaceutical design. vol 10. issue 3. 2004-04-16. PMID:14754384. |
although acetylcholinesterase inhibitors are no cure, these drugs can delay the progress of mental deterioration, reduce neuropsychiatric symptoms and therefore represent a rational therapeutic approach to the treatment of alzheimer's disease. |
2004-04-16 |
2023-08-12 |
Not clear |
| Horst J Koch, Alexander Szecsey, Ekkehard Hae. NMDA-antagonism (memantine): an alternative pharmacological therapeutic principle in Alzheimer's and vascular dementia. Current pharmaceutical design. vol 10. issue 3. 2004-04-16. PMID:14754385. |
due to its low potential of interaction, memantine can be combined with acetylcholinesterase inhibitors, the mainstay of current symptomatic treatment of alzheimer's disease and it is suited in elderly patients receiving multiple drug therapy. |
2004-04-16 |
2023-08-12 |
Not clear |
| Gustavo C Román, Susan J Roger. Donepezil: a clinical review of current and emerging indications. Expert opinion on pharmacotherapy. vol 5. issue 1. 2004-04-07. PMID:14680445. |
this article reviews the piperidine derivative, donepezil hydrochloride (e2020, aricept), a reversible central acetylcholinesterase inhibitor currently approved for treatment of mild-to-moderate alzheimer's disease. |
2004-04-07 |
2023-08-12 |
Not clear |
| Esperanza Arias, Eva Alés, Nelson H Gabilan, María F Cano-Abad, Mercedes Villarroya, Antonio G García, Manuela G Lópe. Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors. Neuropharmacology. vol 46. issue 1. 2004-04-05. PMID:14654102. |
galantamine is currently used to treat alzheimer's disease patients; it behaves as a mild blocker of acetylcholinesterase (ache) and has an allosteric modulating action on nicotinic acetylcholine receptors (nachrs). |
2004-04-05 |
2023-08-12 |
human |
| Marcella Reale, Carla Iarlori, Francesco Gambi, Claudio Feliciani, Anatolia Salone, Lucia Toma, Giovanna DeLuca, Mirella Salvatore, Pio Conti, Domenico Gamb. Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines. Journal of neuroimmunology. vol 148. issue 1-2. 2004-04-05. PMID:14975597. |
treatment with an acetylcholinesterase inhibitor in alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines. |
2004-04-05 |
2023-08-12 |
Not clear |
| T Darreh-Shori, E Hellström-Lindahl, C Flores-Flores, Z Z Guan, H Soreq, A Nordber. Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients. Journal of neurochemistry. vol 88. issue 5. 2004-03-30. PMID:15009666. |
long-lasting acetylcholinesterase splice variations in anticholinesterase-treated alzheimer's disease patients. |
2004-03-30 |
2023-08-12 |
Not clear |
| L R Fodero, S S Mok, D Losic, L L Martin, M I Aguilar, C J Barrow, B G Livett, D H Smal. Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones. Journal of neurochemistry. vol 88. issue 5. 2004-03-30. PMID:15009674. |
although there is a loss of acetylcholinesterase (ache) from both cholinergic and non-cholinergic neurones in the brain of alzheimer patients, the level of ache is increased around amyloid plaques. |
2004-03-30 |
2023-08-12 |
mouse |
| Susana López, Jaume Bastida, Francesc Viladomat, Carles Codin. Galanthamine pattern in Narcissus confusus plants. Planta medica. vol 69. issue 12. 2004-03-24. PMID:14750039. |
galanthamine is an amaryllidaceae-type alkaloid with acetylcholinesterase inhibitory activity which is used in the treatment of alzheimer's disease. |
2004-03-24 |
2023-08-12 |
Not clear |
| T Erkinjuntti, I Skoog, R Lane, C Andrew. Potential long-term effects of rivastigmine on disease progression may be linked to drug effects on vascular changes in Alzheimer brains. International journal of clinical practice. vol 57. issue 9. 2004-03-22. PMID:14686563. |
alzheimer's disease patients with hypertension or other vascular risk factors have been shown to receive greater symptomatic benefits than patients with strictly alzheimer's disease following short-term treatment with rivastigmine, an inhibitor of acetylcholinesterase and butyrylcholinesterase. |
2004-03-22 |
2023-08-12 |
human |
| S Brassen, G Adle. Short-term effects of acetylcholinesterase inhibitor treatment on EEG and memory performance in Alzheimer patients: an open, controlled trial. Pharmacopsychiatry. vol 36. issue 6. 2004-03-17. PMID:14663655. |
short-term effects of acetylcholinesterase inhibitor treatment on eeg and memory performance in alzheimer patients: an open, controlled trial. |
2004-03-17 |
2023-08-12 |
Not clear |
| S Brassen, G Adle. Short-term effects of acetylcholinesterase inhibitor treatment on EEG and memory performance in Alzheimer patients: an open, controlled trial. Pharmacopsychiatry. vol 36. issue 6. 2004-03-17. PMID:14663655. |
acetylcholinesterase inhibitor treatment enhances cholinergic neurotransmission and may thus partially reverse eeg slowing and memory impairment in alzheimer patients within short time. |
2004-03-17 |
2023-08-12 |
Not clear |
| V Medrano, A Ferrándiz-López, J Girbes-Borrás, J Mallada-Frachín, S Fernández-Izquierdo, L Piqueras-Rodrígue. [The value of acetylcholinesterase inhibitor therapy in the serious phases of Alzheimer's disease]. Revista de neurologia. vol 36. issue 12. 2004-03-12. PMID:12833225. |
[the value of acetylcholinesterase inhibitor therapy in the serious phases of alzheimer's disease]. |
2004-03-12 |
2023-08-12 |
Not clear |
| Guido Rodriguez, Paolo Vitali, Michela Canfora, Piero Calvini, Nicola Girtler, Caterina De Leo, Arnoldo Piccardo, Flavio Nobil. Quantitative EEG and perfusional single photon emission computed tomography correlation during long-term donepezil therapy in Alzheimer's disease. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 115. issue 1. 2004-03-01. PMID:14706467. |
there is an increasing interest in the effects of the acetylcholinesterase inhibitors (acheis) in alzheimer's disease (ad), as investigated by means of objective, neurophysiological tools. |
2004-03-01 |
2023-08-12 |
Not clear |
| F Fagnani, A Lafuma, M Pechevis, A S Rigaud, L Traykov, M L Seux, F Forett. Donepezil for the treatment of mild to moderate Alzheimer's disease in France: the economic implications. Dementia and geriatric cognitive disorders. vol 17. issue 1-2. 2004-02-27. PMID:14560059. |
in the present study, the socioeconomic impact of the use of the acetylcholinesterase inhibitor donepezil in patients with mild to moderate alzheimer's disease (ad) living in france was examined. |
2004-02-27 |
2023-08-12 |
Not clear |
| Ashima Saxena, James M Fedorko, C R Vinayaka, Rohit Medhekar, Zoran Radić, Palmer Taylor, Oksana Lockridge, Bhupendra P Docto. Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases. European journal of biochemistry. vol 270. issue 22. 2004-02-06. PMID:14622273. |
e2020 (r,s)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl)piperidine hydrochloride is a piperidine-based acetylcholinesterase (ache) inhibitor that was approved for the treatment of alzheimer's disease in the united states. |
2004-02-06 |
2023-08-12 |
mouse |
| K Ranga Rama Krishnan, H Cecil Charles, P Murali Doraiswamy, Jacobo Mintzer, Richard Weisler, Xin Yu, Carlos Perdomo, John R Ieni, Sharon Roger. Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease. The American journal of psychiatry. vol 160. issue 11. 2004-01-29. PMID:14594748. |
the authors examined the effect of the acetylcholinesterase inhibitor donepezil on magnetic resonance markers of neurodegeneration in alzheimer's disease. |
2004-01-29 |
2023-08-12 |
Not clear |
| Alan M Palme. Cholinergic therapies for Alzheimer's disease: progress and prospects. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 7. 2004-01-22. PMID:14619403. |
cholinomimetic drugs are now available to treat the cognitive impairments associated with alzheimer's disease (ad), although evidence indicates that the effects of acetylcholinesterase (ache) inhibitors on measures of cognitive function may be secondary to an action on attentional mechanisms. |
2004-01-22 |
2023-08-12 |
Not clear |
| T Verhaeghe, L Diels, R de Vries, M De Meulder, J de Jon. Development and validation of a liquid chromatographic-tandem mass spectrometric method for the determination of galantamine in human heparinised plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 789. issue 2. 2004-01-06. PMID:12742124. |
galantamine is an acetylcholinesterase inhibitor, recently approved for the treatment of mild-to-moderate alzheimer's disease. |
2004-01-06 |
2023-08-12 |
human |
| Yeon-Kye Kim, Byung-Soo Koo, Dae-Jong Gong, Young-Choon Lee, Jeong-Heon Ko, Cheorl-Ho Ki. Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus. Journal of ethnopharmacology. vol 87. issue 2-3. 2003-12-29. PMID:12860300. |
in this study, the effects of oral administration of ppe on the extracellular acetylcholine concentration in the hippocampus of rats were evaluated, and compared to that of tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride), a well-known and centrally acting acetylcholinesterase (ache) inhibitor, which had been developed for the treatment of alzheimer's disease. |
2003-12-29 |
2023-08-12 |
rat |