| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter Kamenický, Luigi Maione, Philippe Chanso. Cardiovascular complications of acromegaly. Annales d'endocrinologie. vol 82. issue 3-4. 2021-05-28. PMID:33168155. |
acromegaly is a chronic disease due to growth hormone (gh) and insulin-like growth factor 1 (igf-1) excess. |
2021-05-28 |
2023-08-13 |
Not clear |
| V Amodru, P Petrossians, A Colao, B Delemer, L Maione, S J C M M Neggers, B Decoudier, P Kamenicky, F Castinetti, V Hana, R Pivonello, D Carvalho, T Brue, A Beckers, P Chanson, T Cun. Discordant biological parameters of remission in acromegaly do not increase the risk of hypertension or diabetes: a study with the Liege Acromegaly Survey database. Endocrine. vol 70. issue 1. 2021-05-27. PMID:32562181. |
acromegaly is a rare disease due to growth hormone (gh)-secreting pituitary adenoma. |
2021-05-27 |
2023-08-13 |
Not clear |
| Denise Costa, Filippo Ceccato, Rosa Lauretta, Valeria Mercuri, Tania D'Amico, Corrado De Vito, Carla Scaroni, Marialuisa Appetecchia, Patrizia Gargiul. The prevalence of secondary neoplasms in acromegalic patients: possible preventive and/or protective role of metformin. International journal of clinical oncology. vol 26. issue 6. 2021-05-25. PMID:33713207. |
acromegaly is a rare disease due to chronic growth hormone (gh) excess and the consequent increase in insulin-like growth factor-1 (igf-1) levels. |
2021-05-25 |
2023-08-13 |
Not clear |
| b' Mirella Hage, Cl\\xc3\\xa9ment Janot, Sylvie Salenave, Philippe Chanson, Peter Kamenick\\xc3\\xb. MANAGEMENT OF ENDOCRINE DISEASE: Etiology and outcome of acromegaly in patients with a paradoxical GH response to glucose. European journal of endocrinology. vol 184. issue 6. 2021-05-19. PMID:33830942.' |
management of endocrine disease: etiology and outcome of acromegaly in patients with a paradoxical gh response to glucose. |
2021-05-19 |
2023-08-13 |
Not clear |
| b' Mirella Hage, Cl\\xc3\\xa9ment Janot, Sylvie Salenave, Philippe Chanson, Peter Kamenick\\xc3\\xb. MANAGEMENT OF ENDOCRINE DISEASE: Etiology and outcome of acromegaly in patients with a paradoxical GH response to glucose. European journal of endocrinology. vol 184. issue 6. 2021-05-19. PMID:33830942.' |
to gain more insight on the pathogenesis of somatotroph pituitary adenomas, recent studies have focused on a subgroup of patients with acromegaly displaying a paradoxical growth hormone (gh) response during oral glucose tolerance test (ogtt). |
2021-05-19 |
2023-08-13 |
Not clear |
| b' Mirella Hage, Cl\\xc3\\xa9ment Janot, Sylvie Salenave, Philippe Chanson, Peter Kamenick\\xc3\\xb. MANAGEMENT OF ENDOCRINE DISEASE: Etiology and outcome of acromegaly in patients with a paradoxical GH response to glucose. European journal of endocrinology. vol 184. issue 6. 2021-05-19. PMID:33830942.' |
the paradoxical rise of gh after oral glucose intake occurs in about one-third of acromegaly patients and has been pathogenetically linked, by analogy to glucose-dependent insulinotropic polypeptide (gip)-dependent cushing's syndrome, to the ectopic expression of gip receptor (gipr) in somatotroph adenoma cells. |
2021-05-19 |
2023-08-13 |
Not clear |
| b' Mirella Hage, Cl\\xc3\\xa9ment Janot, Sylvie Salenave, Philippe Chanson, Peter Kamenick\\xc3\\xb. MANAGEMENT OF ENDOCRINE DISEASE: Etiology and outcome of acromegaly in patients with a paradoxical GH response to glucose. European journal of endocrinology. vol 184. issue 6. 2021-05-19. PMID:33830942.' |
acromegaly patients with a paradoxical gh response pattern seem to display higher insulin-like growth factor-1 (igf-1) concentrations and harbour smaller adenomas that are more often of the densely granulated phenotype. |
2021-05-19 |
2023-08-13 |
Not clear |
| b' Mirella Hage, Cl\\xc3\\xa9ment Janot, Sylvie Salenave, Philippe Chanson, Peter Kamenick\\xc3\\xb. MANAGEMENT OF ENDOCRINE DISEASE: Etiology and outcome of acromegaly in patients with a paradoxical GH response to glucose. European journal of endocrinology. vol 184. issue 6. 2021-05-19. PMID:33830942.' |
targeted therapy to antagonize gip receptor on gipr-expressing somatotroph adenomas could be a new treatment approach for acromegaly patients with a paradoxical pattern of gh response to ogtt. |
2021-05-19 |
2023-08-13 |
Not clear |
| Diego Andrés Cadena-Obando, Ilan Remba-Shapiro, Coralys Germania Abreu-Rosario, Moisés Mercad. [Acromegaly and it's cardiovascular implications]. Revista medica del Instituto Mexicano del Seguro Social. vol 59. issue 1. 2021-05-18. PMID:33667046. |
acromegaly is a chronic and slowly progressive disease that results from the hypersecretion of growth hormone (gh) and consequently insulin-like growth factor type 1 (igf-1), due to a gh-secreting pituitary adenoma in 95-98% of cases. |
2021-05-18 |
2023-08-13 |
Not clear |
| Diego Andrés Cadena-Obando, Ilan Remba-Shapiro, Coralys Germania Abreu-Rosario, Moisés Mercad. [Acromegaly and it's cardiovascular implications]. Revista medica del Instituto Mexicano del Seguro Social. vol 59. issue 1. 2021-05-18. PMID:33667046. |
the cardiovascular complications of acromegaly go from arterial hypertension to a peculiar form of cardiomyopathy and are the result of the long-standing exposure to high gh and igf-1 levels. |
2021-05-18 |
2023-08-13 |
Not clear |
| Kazuhide Takada, Mari Sasano, Satoshi Hayakaw. A legendary sumo wrestler with gigantism or acromegaly? The case of Ikezuki Geitazaemon (1827-1850). Medical hypotheses. vol 144. 2021-05-14. PMID:33254497. |
here, we hypothesize that the legendary japanese sumo wrestler could have had gigantism or acromegaly, which are disorders caused by the hypersecretion of growth hormone (gh). |
2021-05-14 |
2023-08-13 |
Not clear |
| Adriana P Kuker, Wei Shen, Zhezhen Jin, Simran Singh, Jun Chen, Jeffrey N Bruce, Pamela U Fred. Body Composition Changes with Long-term Pegvisomant Therapy of Acromegaly. Journal of the Endocrine Society. vol 5. issue 3. 2021-05-14. PMID:33553983. |
in active acromegaly, the lipolytic and insulin antagonistic effects of growth hormone (gh) excess alter adipose tissue (at) deposition, reduce body fat, and increase insulin resistance. |
2021-05-14 |
2023-08-13 |
Not clear |
| Adriana P Kuker, Wei Shen, Zhezhen Jin, Simran Singh, Jun Chen, Jeffrey N Bruce, Pamela U Fred. Body Composition Changes with Long-term Pegvisomant Therapy of Acromegaly. Journal of the Endocrine Society. vol 5. issue 3. 2021-05-14. PMID:33553983. |
pegvisomant treats acromegaly by blocking gh receptor (ghr) signal transduction and lowering insulin-like growth factor 1 (igf-1) levels. |
2021-05-14 |
2023-08-13 |
Not clear |
| Daisuke Kamakura, Katsunori Fukutake, Kazumasa Nakamura, Shintaro Tsuge, Keiji Hasegawa, Naobumi Tochigi, Akihito Wada, Tetsuo Mikami, Hiroshi Takahash. Acromegaly presenting with myelopathy due to ossification of posterior longitudinal ligament: a case report. BMC musculoskeletal disorders. vol 22. issue 1. 2021-05-14. PMID:33853563. |
acromegaly is a rare disease caused by high serum levels of growth hormone (gh) and insulin-like growth factor 1 (igf-1), often originating from a pituitary adenoma. |
2021-05-14 |
2023-08-13 |
Not clear |
| b' Iulia Florentina Burcea, Valeria Nicoleta N\\xc4\\x83stase, Anca Maria C\\xc3\\xaempean, Amalia Raluca Ceau\\xc8\\x99u, Ionela Baciu, Cristina C\\xc4\\x83p\\xc4\\x83\\xc8\\x9b\\xc3\\xaen\\xc4\\x83, Roxana Dusceac, Simona G\\xc4\\x83loiu, Dan Niculescu, \\xc8\\x98erban Radian, Raluca Trif\\xc4\\x83nescu, Anda Dumitra\\xc8\\x99cu, Lauren\\xc8\\x9biu C\\xc4\\x83t\\xc4\\x83lin Coco\\xc8\\x99il\\xc4\\x83, Marius Raica, C\\xc4\\x83t\\xc4\\x83lina Poian\\xc4\\x8. Clinicopathological Features of Growth Hormone-producing Pituitary Adenomas and Correlation With Preoperative Laboratory Findings. Anticancer research. vol 41. issue 5. 2021-05-13. PMID:33952498.' |
the histopathological variability of each type of pituitary adenoma (pa) that causes growth hormone (gh) excess influences the phenotype, radiological characteristics and therapy response of acromegaly patients. |
2021-05-13 |
2023-08-13 |
Not clear |
| Fatmah S Alhawya. Mortality in Acromegalic Patients: Etiology, Trends, and Risk Factors. Cureus. vol 13. issue 4. 2021-05-08. PMID:33959447. |
this review also found that exposure to radiotherapy, old age, hypopituitarism, active acromegaly, and high growth hormone (gh) levels are significant predictors of mortality in acromegalic patients. |
2021-05-08 |
2023-08-13 |
Not clear |
| Fernanda Nastri Gouvêa, Caio Santos Pennacchi, Najla Doutel Assaf, Luana de Oliveira Branco, Paula Barbosa Costa, Patrícia Alves Dos Reis, Sofia Borin-Crivellent. Acromegaly in dogs and cats. Annales d'endocrinologie. vol 82. issue 2. 2021-05-07. PMID:33727117. |
acromegaly is an endocrine disease that leads to elevated production and secretion of growth hormone (gh). |
2021-05-07 |
2023-08-13 |
Not clear |
| Fernanda Nastri Gouvêa, Caio Santos Pennacchi, Najla Doutel Assaf, Luana de Oliveira Branco, Paula Barbosa Costa, Patrícia Alves Dos Reis, Sofia Borin-Crivellent. Acromegaly in dogs and cats. Annales d'endocrinologie. vol 82. issue 2. 2021-05-07. PMID:33727117. |
the present review aims to provide a relevant animal model of acromegaly with an update on the therapeutic approach that may help clinicians to consider the gh axis-igf-1 system, its pathogenesis and the clinical signs induced by this hormonal disorder. |
2021-05-07 |
2023-08-13 |
Not clear |
| Lucia Riccio, Carmine Antonio Donofrio, Giovanni Tomacelli, Roberto De Blasi, Alessandro Melatin. Ectopic GH-secreting pituitary adenoma of the clivus: systematic literature review of a challenging tumour. Pituitary. vol 23. issue 4. 2021-05-03. PMID:32504302. |
acromegaly is usually due to growth hormone (gh)-secreting pituitary adenomas, but it may be exceptionally caused by gh-secreting ectopic pituitary adenomas (epa). |
2021-05-03 |
2023-08-13 |
Not clear |
| Han Yang, Huiwen Tan, He Huang, Jianwei L. Advances in Research on the Cardiovascular Complications of Acromegaly. Frontiers in oncology. vol 11. 2021-04-21. PMID:33869029. |
although the underlying pathophysiology has not been fully elucidated, the spontaneous overproduction of gh and igf-1, increasing age, prolonged duration of disease and the coexistence of other cardiovascular risk factors are crucial to cardiac complications in patients with acromegaly. |
2021-04-21 |
2023-08-13 |
Not clear |