| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Mirella Hage, Cl\\xc3\\xa9ment Janot, Sylvie Salenave, Philippe Chanson, Peter Kamenick\\xc3\\xb. MANAGEMENT OF ENDOCRINE DISEASE: Etiology and outcome of acromegaly in patients with a paradoxical GH response to glucose. European journal of endocrinology. vol 184. issue 6. 2021-05-19. PMID:33830942.' |
management of endocrine disease: etiology and outcome of acromegaly in patients with a paradoxical gh response to glucose. |
2021-05-19 |
2023-08-13 |
Not clear |
| b' Mirella Hage, Cl\\xc3\\xa9ment Janot, Sylvie Salenave, Philippe Chanson, Peter Kamenick\\xc3\\xb. MANAGEMENT OF ENDOCRINE DISEASE: Etiology and outcome of acromegaly in patients with a paradoxical GH response to glucose. European journal of endocrinology. vol 184. issue 6. 2021-05-19. PMID:33830942.' |
to gain more insight on the pathogenesis of somatotroph pituitary adenomas, recent studies have focused on a subgroup of patients with acromegaly displaying a paradoxical growth hormone (gh) response during oral glucose tolerance test (ogtt). |
2021-05-19 |
2023-08-13 |
Not clear |
| b' Mirella Hage, Cl\\xc3\\xa9ment Janot, Sylvie Salenave, Philippe Chanson, Peter Kamenick\\xc3\\xb. MANAGEMENT OF ENDOCRINE DISEASE: Etiology and outcome of acromegaly in patients with a paradoxical GH response to glucose. European journal of endocrinology. vol 184. issue 6. 2021-05-19. PMID:33830942.' |
the paradoxical rise of gh after oral glucose intake occurs in about one-third of acromegaly patients and has been pathogenetically linked, by analogy to glucose-dependent insulinotropic polypeptide (gip)-dependent cushing's syndrome, to the ectopic expression of gip receptor (gipr) in somatotroph adenoma cells. |
2021-05-19 |
2023-08-13 |
Not clear |
| b' Mirella Hage, Cl\\xc3\\xa9ment Janot, Sylvie Salenave, Philippe Chanson, Peter Kamenick\\xc3\\xb. MANAGEMENT OF ENDOCRINE DISEASE: Etiology and outcome of acromegaly in patients with a paradoxical GH response to glucose. European journal of endocrinology. vol 184. issue 6. 2021-05-19. PMID:33830942.' |
acromegaly patients with a paradoxical gh response pattern seem to display higher insulin-like growth factor-1 (igf-1) concentrations and harbour smaller adenomas that are more often of the densely granulated phenotype. |
2021-05-19 |
2023-08-13 |
Not clear |
| b' Mirella Hage, Cl\\xc3\\xa9ment Janot, Sylvie Salenave, Philippe Chanson, Peter Kamenick\\xc3\\xb. MANAGEMENT OF ENDOCRINE DISEASE: Etiology and outcome of acromegaly in patients with a paradoxical GH response to glucose. European journal of endocrinology. vol 184. issue 6. 2021-05-19. PMID:33830942.' |
targeted therapy to antagonize gip receptor on gipr-expressing somatotroph adenomas could be a new treatment approach for acromegaly patients with a paradoxical pattern of gh response to ogtt. |
2021-05-19 |
2023-08-13 |
Not clear |
| Diego Andrés Cadena-Obando, Ilan Remba-Shapiro, Coralys Germania Abreu-Rosario, Moisés Mercad. [Acromegaly and it's cardiovascular implications]. Revista medica del Instituto Mexicano del Seguro Social. vol 59. issue 1. 2021-05-18. PMID:33667046. |
acromegaly is a chronic and slowly progressive disease that results from the hypersecretion of growth hormone (gh) and consequently insulin-like growth factor type 1 (igf-1), due to a gh-secreting pituitary adenoma in 95-98% of cases. |
2021-05-18 |
2023-08-13 |
Not clear |
| Diego Andrés Cadena-Obando, Ilan Remba-Shapiro, Coralys Germania Abreu-Rosario, Moisés Mercad. [Acromegaly and it's cardiovascular implications]. Revista medica del Instituto Mexicano del Seguro Social. vol 59. issue 1. 2021-05-18. PMID:33667046. |
the cardiovascular complications of acromegaly go from arterial hypertension to a peculiar form of cardiomyopathy and are the result of the long-standing exposure to high gh and igf-1 levels. |
2021-05-18 |
2023-08-13 |
Not clear |
| Kazuhide Takada, Mari Sasano, Satoshi Hayakaw. A legendary sumo wrestler with gigantism or acromegaly? The case of Ikezuki Geitazaemon (1827-1850). Medical hypotheses. vol 144. 2021-05-14. PMID:33254497. |
here, we hypothesize that the legendary japanese sumo wrestler could have had gigantism or acromegaly, which are disorders caused by the hypersecretion of growth hormone (gh). |
2021-05-14 |
2023-08-13 |
Not clear |
| Adriana P Kuker, Wei Shen, Zhezhen Jin, Simran Singh, Jun Chen, Jeffrey N Bruce, Pamela U Fred. Body Composition Changes with Long-term Pegvisomant Therapy of Acromegaly. Journal of the Endocrine Society. vol 5. issue 3. 2021-05-14. PMID:33553983. |
in active acromegaly, the lipolytic and insulin antagonistic effects of growth hormone (gh) excess alter adipose tissue (at) deposition, reduce body fat, and increase insulin resistance. |
2021-05-14 |
2023-08-13 |
Not clear |
| Adriana P Kuker, Wei Shen, Zhezhen Jin, Simran Singh, Jun Chen, Jeffrey N Bruce, Pamela U Fred. Body Composition Changes with Long-term Pegvisomant Therapy of Acromegaly. Journal of the Endocrine Society. vol 5. issue 3. 2021-05-14. PMID:33553983. |
pegvisomant treats acromegaly by blocking gh receptor (ghr) signal transduction and lowering insulin-like growth factor 1 (igf-1) levels. |
2021-05-14 |
2023-08-13 |
Not clear |
| Daisuke Kamakura, Katsunori Fukutake, Kazumasa Nakamura, Shintaro Tsuge, Keiji Hasegawa, Naobumi Tochigi, Akihito Wada, Tetsuo Mikami, Hiroshi Takahash. Acromegaly presenting with myelopathy due to ossification of posterior longitudinal ligament: a case report. BMC musculoskeletal disorders. vol 22. issue 1. 2021-05-14. PMID:33853563. |
acromegaly is a rare disease caused by high serum levels of growth hormone (gh) and insulin-like growth factor 1 (igf-1), often originating from a pituitary adenoma. |
2021-05-14 |
2023-08-13 |
Not clear |
| b' Iulia Florentina Burcea, Valeria Nicoleta N\\xc4\\x83stase, Anca Maria C\\xc3\\xaempean, Amalia Raluca Ceau\\xc8\\x99u, Ionela Baciu, Cristina C\\xc4\\x83p\\xc4\\x83\\xc8\\x9b\\xc3\\xaen\\xc4\\x83, Roxana Dusceac, Simona G\\xc4\\x83loiu, Dan Niculescu, \\xc8\\x98erban Radian, Raluca Trif\\xc4\\x83nescu, Anda Dumitra\\xc8\\x99cu, Lauren\\xc8\\x9biu C\\xc4\\x83t\\xc4\\x83lin Coco\\xc8\\x99il\\xc4\\x83, Marius Raica, C\\xc4\\x83t\\xc4\\x83lina Poian\\xc4\\x8. Clinicopathological Features of Growth Hormone-producing Pituitary Adenomas and Correlation With Preoperative Laboratory Findings. Anticancer research. vol 41. issue 5. 2021-05-13. PMID:33952498.' |
the histopathological variability of each type of pituitary adenoma (pa) that causes growth hormone (gh) excess influences the phenotype, radiological characteristics and therapy response of acromegaly patients. |
2021-05-13 |
2023-08-13 |
Not clear |
| Fatmah S Alhawya. Mortality in Acromegalic Patients: Etiology, Trends, and Risk Factors. Cureus. vol 13. issue 4. 2021-05-08. PMID:33959447. |
this review also found that exposure to radiotherapy, old age, hypopituitarism, active acromegaly, and high growth hormone (gh) levels are significant predictors of mortality in acromegalic patients. |
2021-05-08 |
2023-08-13 |
Not clear |
| Fernanda Nastri Gouvêa, Caio Santos Pennacchi, Najla Doutel Assaf, Luana de Oliveira Branco, Paula Barbosa Costa, Patrícia Alves Dos Reis, Sofia Borin-Crivellent. Acromegaly in dogs and cats. Annales d'endocrinologie. vol 82. issue 2. 2021-05-07. PMID:33727117. |
acromegaly is an endocrine disease that leads to elevated production and secretion of growth hormone (gh). |
2021-05-07 |
2023-08-13 |
Not clear |
| Fernanda Nastri Gouvêa, Caio Santos Pennacchi, Najla Doutel Assaf, Luana de Oliveira Branco, Paula Barbosa Costa, Patrícia Alves Dos Reis, Sofia Borin-Crivellent. Acromegaly in dogs and cats. Annales d'endocrinologie. vol 82. issue 2. 2021-05-07. PMID:33727117. |
the present review aims to provide a relevant animal model of acromegaly with an update on the therapeutic approach that may help clinicians to consider the gh axis-igf-1 system, its pathogenesis and the clinical signs induced by this hormonal disorder. |
2021-05-07 |
2023-08-13 |
Not clear |
| Lucia Riccio, Carmine Antonio Donofrio, Giovanni Tomacelli, Roberto De Blasi, Alessandro Melatin. Ectopic GH-secreting pituitary adenoma of the clivus: systematic literature review of a challenging tumour. Pituitary. vol 23. issue 4. 2021-05-03. PMID:32504302. |
acromegaly is usually due to growth hormone (gh)-secreting pituitary adenomas, but it may be exceptionally caused by gh-secreting ectopic pituitary adenomas (epa). |
2021-05-03 |
2023-08-13 |
Not clear |
| Han Yang, Huiwen Tan, He Huang, Jianwei L. Advances in Research on the Cardiovascular Complications of Acromegaly. Frontiers in oncology. vol 11. 2021-04-21. PMID:33869029. |
although the underlying pathophysiology has not been fully elucidated, the spontaneous overproduction of gh and igf-1, increasing age, prolonged duration of disease and the coexistence of other cardiovascular risk factors are crucial to cardiac complications in patients with acromegaly. |
2021-04-21 |
2023-08-13 |
Not clear |
| Sauradeep Sarkar, Ari G Chack. Surgery for Acromegaly. Neurology India. vol 68. issue Supplement. 2021-04-14. PMID:32611892. |
growth hormone (gh) hypersecretion from a pituitary adenoma results in acromegaly, an endocrinological disorder with multiple systemic manifestations that presents several unique challenges in terms of perioperative management and long term outcomes. |
2021-04-14 |
2023-08-13 |
Not clear |
| Kensaku Fukunaga, Hitomi Imachi, Seisuke Sato, Toshihiro Kobayashi, Yuki Yoshioka, Takanobu Saheki, Natsuki Ban, Kurumi Urushihara, Jingya Lyu, Tao Dong, Ryou Ishikawa, Kyuichi Kadota, Reiji Haba, Naoko Inoshita, Koji Mura. Successful Therapy Using Pasireotide Long-acting Release for Cushing's Disease Merged with Biochemical Acromegaly. Internal medicine (Tokyo, Japan). vol 60. issue 7. 2021-04-14. PMID:33162471. |
five years later, she was diagnosed with recurrent cushing's disease and biochemical acromegaly because of elevated levels of serum growth hormone (gh), plasma insulin-like growth factor-1, plasma adrenocorticotropic hormone (acth), and the 24-hour urinary excretion of free cortisol. |
2021-04-14 |
2023-08-13 |
Not clear |
| Amit Akirov, Hiba Masri-Iraqi, Idit Dotan, Ilan Shimo. The Biochemical Diagnosis of Acromegaly. Journal of clinical medicine. vol 10. issue 5. 2021-04-08. PMID:33803429. |
the most important assays for the biochemical diagnosis and management of acromegaly are growth hormone (gh) and insulin-like growth factor-1 (igf-1). |
2021-04-08 |
2023-08-13 |
Not clear |