| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fatima Ezzahra Laghchioua, Carlos F M da Silva, Diana C G A Pinto, José A S Cavaleiro, Ricardo F Mendes, Filipe A Almeida Paz, Maria A F Faustino, El Mostapha Rakib, M Graça P M S Neves, Florbela Pereira, Nuno M M Mour. Design of Promising Thiazoloindazole-Based Acetylcholinesterase Inhibitors Guided by Molecular Docking and Experimental Insights. ACS chemical neuroscience. 2024-07-22. PMID:39037949. |
since acetylcholinesterase (ache) is a critical enzyme in the nervous system, responsible for breaking down the neurotransmitter acetylcholine, its inhibition holds a significant interest in the treatment of various neurological disorders. |
2024-07-22 |
2024-07-25 |
Not clear |
| Nicole Baumgarth, Antonio Cembellin Prieto, Zheng Luo, Heather Kulag. B cells modulate lung antiviral inflammatory responses via the neurotransmitter acetylcholine. Research square. 2024-07-09. PMID:38978583. |
here, b cells expressing choline acetyl transferase (chat), an enzyme required for production of the metabolite and neurotransmitter acetylcholine (ach) are identified as such regulators of the immediate early response to influenza a virus. |
2024-07-09 |
2024-07-12 |
mouse |
| Yaqian Tang, Caibao Lin, Chongrong Ke, Yong Tao, Jianzhong Huang, Xinwei Yan. [Advances in the synthesis of cytidine-5'-diphosphate choline]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 40. issue 6. 2024-06-24. PMID:38914484. |
cytidine-5'-diphosphate choline (cdp-choline) plays a crucial role in the formation of the phospholipid bilamolecular layer in cell membranes and the stabilization of the neurotransmitter system, acting as a precursor to phosphatidylcholine and acetylcholine. |
2024-06-24 |
2024-06-27 |
Not clear |
| Octavian Vasiliu, Beatrice Budeanu, Mihai-Ștefan Cătănesc. The New Horizon of Antipsychotics beyond the Classic Dopaminergic Hypothesis-The Case of the Xanomeline-Trospium Combination: A Systematic Review. Pharmaceuticals (Basel, Switzerland). vol 17. issue 5. 2024-05-25. PMID:38794180. |
xanomeline-trospium (karxt) is a drug combination that is based on the essential role played by acetylcholine in the regulation of cognitive processes and the interactions between this neurotransmitter and other signaling pathways in the central nervous system, with a potential role in the onset of schizophrenia, alzheimer's disease, and substance use disorders. |
2024-05-25 |
2024-05-27 |
Not clear |
| Mingyu Zhu, Lili Cui, Guanglin Liu, Pengpeng Yu, Qingyuan Hu, Huan Chen, Hongwei Ho. UHPLC-MS/MS combined with microdialysis for simultaneous determination of nicotine and neurotransmitter metabolites in the rat hippocampal brain region: application to pharmacokinetic and pharmacodynamic study. Analytical methods : advancing methods and applications. 2024-05-13. PMID:38738307. |
nicotine crosses the blood-brain barrier and interacts with nicotinic acetylcholine receptors, initiating a cascade of neurotransmitter effects with potential therapeutic implications for neurodegenerative conditions such as alzheimer's and parkinson's disease. |
2024-05-13 |
2024-05-27 |
rat |
| Yi Zhang, Gonghui Ge, Xiangyang Xu, Jinhui W. Ensemble-Based Virtual Screening Led to the Discovery of Novel Lead Molecules as Potential NMBAs. Molecules (Basel, Switzerland). vol 29. issue 9. 2024-05-11. PMID:38731447. |
nicotinic acetylcholine receptors (nachrs) are ligand-gated ion channels; nmbas can induce muscle paralysis by preventing the neurotransmitter acetylcholine (ach) from binding to nachrs situated on the postsynaptic membranes. |
2024-05-11 |
2024-05-27 |
Not clear |
| Maria-Christina Zerva, Christos Triantafylloudis, Vassilis Paspaliaris, Efthimios M C Skoulakis, Katerina Papanikolopoulo. Choline Metabolites Reverse Differentially the Habituation Deficit and Elevated Memory of Tau Null Drosophila. Cells. vol 13. issue 9. 2024-05-10. PMID:38727282. |
aberrantly modified tau protein and neurotransmitter imbalance, predominantly involving acetylcholine, have been linked to these symptoms. |
2024-05-10 |
2024-05-27 |
drosophila_melanogaster |
| Maria-Christina Zerva, Christos Triantafylloudis, Vassilis Paspaliaris, Efthimios M C Skoulakis, Katerina Papanikolopoulo. Choline Metabolites Reverse Differentially the Habituation Deficit and Elevated Memory of Tau Null Drosophila. Cells. vol 13. issue 9. 2024-05-10. PMID:38727282. |
in drosophila, we have shown that dtau loss specifically enhances associative long-term olfactory memory, impairs foot shock habituation, and deregulates proteins involved in the regulation of neurotransmitter levels, particularly acetylcholine. |
2024-05-10 |
2024-05-27 |
drosophila_melanogaster |
| Maria-Christina Zerva, Christos Triantafylloudis, Vassilis Paspaliaris, Efthimios M C Skoulakis, Katerina Papanikolopoulo. Choline Metabolites Reverse Differentially the Habituation Deficit and Elevated Memory of Tau Null Drosophila. Cells. vol 13. issue 9. 2024-05-10. PMID:38727282. |
based on these surprising results, we decided to use our well-established genetic model to understand how habituation deficits and memory performance correlate with different aspects of choline physiology as an essential component of the neurotransmitter acetylcholine, the lipid phosphatidylcholine, and the osmoregulator betaine. |
2024-05-10 |
2024-05-27 |
drosophila_melanogaster |
| Ali Hassan, Lidong Kang, Kaixiong Zhang, Lei Wang, Xianjiao Qin, Guobin Fang, Yongyue Lu, Qiuying Huan. Effect of entomopathogenic fungi on behavior and physiology of Solenopsis invicta (Hymenoptera, Formicidae). Journal of economic entomology. 2024-04-18. PMID:38634604. |
the activity of acetylcholinesterase, which hydrolyses the important neurotransmitter acetylcholine, also decreased after fungal application compared to the control. |
2024-04-18 |
2024-04-20 |
Not clear |
| Juan David Villeda-González, José Luis Gómez-Olivares, Luis Arturo Baiza-Gutma. New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase. Journal of cellular physiology. 2024-04-12. PMID:38605655. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ach), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. |
2024-04-12 |
2024-04-14 |
Not clear |
| Gumpeny R Sridhar, Lakshmi Gumpen. Emerging significance of butyrylcholinesterase. World journal of experimental medicine. vol 14. issue 1. 2024-04-09. PMID:38590305. |
its other functions include the ability to hydrolyze acetylcholine, the cholinergic neurotransmitter in the brain, when its primary hydrolytic enzyme, acetylcholinesterase, is absent. |
2024-04-09 |
2024-04-11 |
human |
| Jae Yeon Park, Seong Doo Kang, Yun Gon Son, Ju Yeon Kim, Gihwan Lee, Kwang Dong Kim, Sang Won Lee, Jeong Yoon Ki. Eucalyptus globulus leaf-isolated isorhapontin serves as a natural insecticide via acetylcholinesterase inhibition. Pesticide biochemistry and physiology. vol 200. 2024-04-08. PMID:38582576. |
acetylcholinesterase (ache) inhibitors cause insect death by preventing the hydrolysis of the neurotransmitter acetylcholine, which overstimulates the nervous system. |
2024-04-08 |
2024-04-10 |
Not clear |
| A Saud, V Krishnaraju, A Taha, K Kalpana, V Malarkodi, S Durgaramani, V Vinoth Prabhu, F A Saleh, S Ezhilarasa. Potential acetylcholinesterase inhibitors to treat Alzheimer's disease. European review for medical and pharmacological sciences. vol 28. issue 6. 2024-04-03. PMID:38567612. |
a lack of the brain neurotransmitter acetylcholine has been related to the etiology of alzheimer's disease. |
2024-04-03 |
2024-04-05 |
Not clear |
| Arash Salehi, Behzad Zolfaghari, Mahmoud Aghaei, Hajar Sirous, Morteza Sadeghi, Mohammad Reza Gholami, Parham Reisi, Mustafa Ghanadia. New amide and diterpene alkaloids with anticholinesterase activity from Delphinium cyphoplectrum roots. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2024-03-18. PMID:38498253. |
the cholinergic hypothesis posits a robust correlation between the onset of alzheimer's disease and a pronounced deficit in acetylcholine, a pivotal neurotransmitter crucial for the central cholinergic nervous system's function, pivotal for memory and learning. |
2024-03-18 |
2024-03-21 |
Not clear |
| Xiujuan Huang, Yuanyuan Cheng, Qi Zhou, Yifeng Tu, Jilin Ya. A simple fluorescence detection of acetylcholinesterase with peroxidase-like catalysis from iodide. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 313. 2024-03-15. PMID:38490124. |
acetylcholinesterase (ache) is an important enzyme in the central and peripheral nervous system that regulates the balance of the neurotransmitter acetylcholine. |
2024-03-15 |
2024-03-18 |
Not clear |
| Natalia G Vallianou, Dimitris Kounatidis, Sotiria Psallida, Fotis Panagopoulos, Theodora Stratigou, Eleni Geladari, Irene Karampela, Dimitrios Tsilingiris, Maria Dalamag. The Interplay Between Dietary Choline and Cardiometabolic Disorders: A Review of Current Evidence. Current nutrition reports. 2024-03-01. PMID:38427291. |
choline is an essential nutrient for human health and cellular homeostasis as it is necessary for the synthesis of lipid cell membranes, lipoproteins, and the synthesis of the neurotransmitter acetylcholine. |
2024-03-01 |
2024-03-03 |
human |
| Joana Ribeiro, Henrique Araújo-Silva, Mário Fernandes, Joilna Alves da Silva, Francisco das Chagas L Pinto, Otília Deusdenia L Pessoa, Hélcio Silva Santos, Jane Eire Silva Alencar de Menezes, Andreia C Gome. Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo. Natural products and bioprospecting. vol 14. issue 1. 2024-02-22. PMID:38383833. |
a crucial hallmark associated with this disease is associated with the deficiency of the brain neurotransmitter acetylcholine, due to an affected acetylcholinesterase (ache) activity. |
2024-02-22 |
2024-02-24 |
zebrafish |
| Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ach). |
2024-02-10 |
2024-02-12 |
Not clear |
| F Javier Luque, Diego Muñoz-Torrer. Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets. Accounts of chemical research. 2024-02-09. PMID:38333993. |
conspectusthe enzyme acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine (ach) at cholinergic synapses of the peripheral and central nervous system. |
2024-02-09 |
2024-02-11 |
human |