| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenneth E McCarson, Vanja Duric, Scott A Reisman, Michelle Winter, S J Enn. GABA(B) receptor function and subunit expression in the rat spinal cord as indicators of stress and the antinociceptive response to antidepressants. Brain research. vol 1068. issue 1. 2006-04-04. PMID:16368079. |
it was also discovered that repeated daily exposure to a thermal stimulus or immobilization stress increases gaba(b(1a)) expression in the lumbar spinal cord, with no commensurate change in thermal pain threshold or gaba(b) receptor sensitivity. |
2006-04-04 |
2023-08-12 |
rat |
| Guido Krause, Stefanie Lehmann, Mirko Lehmann, Ingo Freund, Erik Schreiber, Werner Bauman. Measurement of electrical activity of long-term mammalian neuronal networks on semiconductor neurosensor chips and comparison with conventional microelectrode arrays. Biosensors & bioelectronics. vol 21. issue 7. 2006-03-17. PMID:16006112. |
the gaba(a)-receptor blocker bicuculline was applied to both tissue cultures, the glycine-receptor blocker strychnine to spinal cord cultures. |
2006-03-17 |
2023-08-12 |
Not clear |
| Xu Zhang, Hua-Sheng Xia. Gene array analysis to determine the components of neuropathic pain signaling. Current opinion in molecular therapeutics. vol 7. issue 6. 2006-03-10. PMID:16370375. |
upregulation of the ca2+ channel alpha2/delta1 subunit, gamma-aminobutyric acid a receptor alpha5 subunit, na+ channels and nicotinic acetylcholine receptors in the drg and dorsal spinal cord indicates their potential roles in neuropathic pain control. |
2006-03-10 |
2023-08-12 |
Not clear |
| Kenneth E McCarson, Andrew Ralya, Scott A Reisman, S J Enn. Amitriptyline prevents thermal hyperalgesia and modifications in rat spinal cord GABA(B) receptor expression and function in an animal model of neuropathic pain. Biochemical pharmacology. vol 71. issue 1-2. 2006-02-03. PMID:16293232. |
amitriptyline prevents thermal hyperalgesia and modifications in rat spinal cord gaba(b) receptor expression and function in an animal model of neuropathic pain. |
2006-02-03 |
2023-08-12 |
rat |
| Kenneth E McCarson, Andrew Ralya, Scott A Reisman, S J Enn. Amitriptyline prevents thermal hyperalgesia and modifications in rat spinal cord GABA(B) receptor expression and function in an animal model of neuropathic pain. Biochemical pharmacology. vol 71. issue 1-2. 2006-02-03. PMID:16293232. |
using an animal model of neuropathic pain, behavioral and biochemical experiments were performed to assess the effects of this condition on pain threshold and gaba(b) receptor sensitivity and subunit gene expression in the rat lumbar spinal cord. |
2006-02-03 |
2023-08-12 |
rat |
| Kenneth E McCarson, Andrew Ralya, Scott A Reisman, S J Enn. Amitriptyline prevents thermal hyperalgesia and modifications in rat spinal cord GABA(B) receptor expression and function in an animal model of neuropathic pain. Biochemical pharmacology. vol 71. issue 1-2. 2006-02-03. PMID:16293232. |
the results indicate that partial sciatic nerve ligation decreases thermal and mechanical pain withdrawal latencies, and increases baclofen-stimulated [35s]gtpgammas binding and gaba(b) receptor subunit gene expression in the rat lumbar spinal cord, suggesting that neuropathic pain may be due, in part, to a deficiency in gabaergic transmission. |
2006-02-03 |
2023-08-12 |
rat |
| Kenneth E McCarson, Andrew Ralya, Scott A Reisman, S J Enn. Amitriptyline prevents thermal hyperalgesia and modifications in rat spinal cord GABA(B) receptor expression and function in an animal model of neuropathic pain. Biochemical pharmacology. vol 71. issue 1-2. 2006-02-03. PMID:16293232. |
of amitriptyline, a tricyclic antidepressant used for the treatment of neuropathic pain, for 1 week after surgery prevents the decline in thermal pain threshold, the increase in gaba(b2) gene expression, and development of increased gaba(b) receptor function in spinal cord resulting from nerve damage. |
2006-02-03 |
2023-08-12 |
rat |
| Kenneth E McCarson, Andrew Ralya, Scott A Reisman, S J Enn. Amitriptyline prevents thermal hyperalgesia and modifications in rat spinal cord GABA(B) receptor expression and function in an animal model of neuropathic pain. Biochemical pharmacology. vol 71. issue 1-2. 2006-02-03. PMID:16293232. |
these findings indicate that the efficacy of amitriptyline as a treatment for neuropathic pain may be related to an ability to maintain spinal cord gaba(b) receptor activity. |
2006-02-03 |
2023-08-12 |
rat |
| M A Pombal, Y Ruiz, M Rodríguez-Alonso, M C de Arriba, V Costas, R Alvarez, M Megía. Developmental changes of the GABA-immunoreactive fibers in the lamprey spinal cord. Brain research bulletin. vol 66. issue 4-6. 2006-01-31. PMID:16144617. |
the changes in distribution and number of gaba immunoreactive (gaba-ir) fibers from postembryonic stages to adulthood in the lamprey spinal cord white matter were studied by using immunocytochemical techniques. |
2006-01-31 |
2023-08-12 |
Not clear |
| Scott S Downing, Yan T Lee, David H Farb, Terrell T Gibb. Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation. British journal of pharmacology. vol 145. issue 7. 2006-01-17. PMID:15912137. |
consistent with this prediction, diazepam increased the efficacy of the gaba(a) receptor partial agonist kojic amine in chick spinal cord neurons. |
2006-01-17 |
2023-08-12 |
chicken |
| Luca Raiteri, Simona Zappettini, Sara Stigliani, Silvio Paluzzi, Maurizio Raiteri, Giambattista Bonann. Glutamate release induced by activation of glycine and GABA transporters in spinal cord is enhanced in a mouse model of amyotrophic lateral sclerosis. Neurotoxicology. vol 26. issue 5. 2005-12-22. PMID:15885796. |
glutamate release induced by activation of glycine and gaba transporters in spinal cord is enhanced in a mouse model of amyotrophic lateral sclerosis. |
2005-12-22 |
2023-08-12 |
mouse |
| Luca Raiteri, Simona Zappettini, Sara Stigliani, Silvio Paluzzi, Maurizio Raiteri, Giambattista Bonann. Glutamate release induced by activation of glycine and GABA transporters in spinal cord is enhanced in a mouse model of amyotrophic lateral sclerosis. Neurotoxicology. vol 26. issue 5. 2005-12-22. PMID:15885796. |
we studied the release of [3h]d-aspartate ([3h]d-asp) and endogenous glutamate evoked by glycine (gly) or gaba from spinal cord synaptosomes in mice expressing a mutant form of human sod1 with a gly93ala substitution ([sod1-g93a(+)]), a transgenic model of amyotrophic lateral sclerosis, in mice expressing the non-mutated form of human sod1 [sod1+], and in non-transgenic littermates [sod1(-)/g93a(-)]. |
2005-12-22 |
2023-08-12 |
mouse |
| Renata P Guedes, Melina I Marchi, Giordano G Viola, Léder L Xavier, Matilde Achaval, Wania A Partat. Somatostatin-, calcitonin gene-related peptide, and gamma-aminobutyric acid-like immunoreactivitity in the frog lumbosacral spinal cord: distribution and effects of sciatic nerve transection. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 138. issue 1. 2005-10-20. PMID:15142533. |
using immunohistochemistry and optical densitometry, somatostatin (som), calcitonin gene-related peptide (cgrp), and gamma-aminobutyric acid (gaba) were investigated in the lumbosacral spinal cord of the frog rana catesbeiana after sciatic nerve transection. |
2005-10-20 |
2023-08-12 |
Not clear |
| Toni L Jones, Sarah M Sweitzer, Michael C Peters, Steven P Wilson, David C Yeoman. GABAB receptors on central terminals of C-afferents mediate intersegmental Adelta-afferent evoked hypoalgesia. European journal of pain (London, England). vol 9. issue 3. 2005-08-02. PMID:15862472. |
to determine if this central gaba(b) receptor activation occurs at pre-synaptic primary afferent terminals or postsynaptic spinal cord neurons, the dorsal hind paws of mice were infected with a recombinant herpes simplex virus type 1 (hsv-1) designed to selectively knock down expression of the gaba(b1a) receptor subunit (pagb1a) in primary afferents or a control virus encoding the e. coli lacz gene (pz). |
2005-08-02 |
2023-08-12 |
mouse |
| Luca Raiteri, Sara Stigliani, Laura Patti, Cesare Usai, Giovanna Bucci, Alberto Diaspro, Maurizio Raiteri, Giambattista Bonann. Activation of gamma-aminobutyric acid GAT-1 transporters on glutamatergic terminals of mouse spinal cord mediates glutamate release through anion channels and by transporter reversal. Journal of neuroscience research. vol 80. issue 3. 2005-07-26. PMID:15789377. |
activation of gamma-aminobutyric acid gat-1 transporters on glutamatergic terminals of mouse spinal cord mediates glutamate release through anion channels and by transporter reversal. |
2005-07-26 |
2023-08-12 |
mouse |
| Luca Raiteri, Sara Stigliani, Laura Patti, Cesare Usai, Giovanna Bucci, Alberto Diaspro, Maurizio Raiteri, Giambattista Bonann. Activation of gamma-aminobutyric acid GAT-1 transporters on glutamatergic terminals of mouse spinal cord mediates glutamate release through anion channels and by transporter reversal. Journal of neuroscience research. vol 80. issue 3. 2005-07-26. PMID:15789377. |
the effects of gamma-aminobutyric acid (gaba) on the release of glutamate from mouse spinal cord nerve endings have been studied using superfused synaptosomes. |
2005-07-26 |
2023-08-12 |
mouse |
| Luca Raiteri, Sara Stigliani, Laura Patti, Cesare Usai, Giovanna Bucci, Alberto Diaspro, Maurizio Raiteri, Giambattista Bonann. Activation of gamma-aminobutyric acid GAT-1 transporters on glutamatergic terminals of mouse spinal cord mediates glutamate release through anion channels and by transporter reversal. Journal of neuroscience research. vol 80. issue 3. 2005-07-26. PMID:15789377. |
gaba, up to 30 microm, was unable to augment significantly the basal release of [3h]glycine from spinal cord synaptosomes, indicating selectivity for glutamatergic transmission. |
2005-07-26 |
2023-08-12 |
mouse |
| Luca Raiteri, Sara Stigliani, Laura Patti, Cesare Usai, Giovanna Bucci, Alberto Diaspro, Maurizio Raiteri, Giambattista Bonann. Activation of gamma-aminobutyric acid GAT-1 transporters on glutamatergic terminals of mouse spinal cord mediates glutamate release through anion channels and by transporter reversal. Journal of neuroscience research. vol 80. issue 3. 2005-07-26. PMID:15789377. |
it is concluded that gaba gat-1 transporters and glutamate transporters coexist on the same spinal cord glutamatergic terminals. |
2005-07-26 |
2023-08-12 |
mouse |
| S J Enn. GABAB receptor agonists and antagonists: pharmacological properties and therapeutic possibilities. Expert opinion on investigational drugs. vol 6. issue 10. 2005-07-14. PMID:15989503. |
gamma-aminobutyric acid (gaba), an inhibitory neurotransmitter, is widely distributed throughout the brain and spinal cord. |
2005-07-14 |
2023-08-12 |
Not clear |
| Hong-Mei Zhang, De-Pei Li, Shao-Rui Chen, Hui-Lin Pa. M2, M3, and M4 receptor subtypes contribute to muscarinic potentiation of GABAergic inputs to spinal dorsal horn neurons. The Journal of pharmacology and experimental therapeutics. vol 313. issue 2. 2005-07-05. PMID:15640398. |
to determine the role of receptor subtypes in the muscarinic agonist-induced synaptic gaba release, spontaneous inhibitory postsynaptic currents (sipscs) were recorded in lamina ii neurons using whole-cell voltage-clamp recordings in rat spinal cord slices. |
2005-07-05 |
2023-08-12 |
rat |