| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Josée-France Villemure, Lynda Adam, Nicola J Bevan, Katy Gearing, Sébastien Chénier, Michel Bouvie. Subcellular distribution of GABA(B) receptor homo- and hetero-dimers. The Biochemical journal. vol 388. issue Pt 1. 2009-09-25. PMID:15617512. |
gbrs (gaba(b) receptors; where gaba stands for gamma-aminobutyric acid) are g-protein-coupled receptors that mediate slow synaptic inhibition in the brain and spinal cord. |
2009-09-25 |
2023-08-12 |
Not clear |
| Jaehyung Kim, Sung Jin Kim, Heuiran Lee, Jin Woo Chan. Effective neuropathic pain relief through sciatic nerve administration of GAD65-expressing rAAV2. Biochemical and biophysical research communications. vol 388. issue 1. 2009-09-21. PMID:19643087. |
recently, we demonstrated that the administration of gad65-expressing raav2 to drg attenuates peripheral neuropathy by inducing gaba release in the spinal cord. |
2009-09-21 |
2023-08-12 |
Not clear |
| Jaehyung Kim, Sung Jin Kim, Heuiran Lee, Jin Woo Chan. Effective neuropathic pain relief through sciatic nerve administration of GAD65-expressing rAAV2. Biochemical and biophysical research communications. vol 388. issue 1. 2009-09-21. PMID:19643087. |
equally importantly, the gaba concentration in the spinal cord increased significantly after gad65 introduction, and pain symptoms were dramatically reduced and persistently controlled. |
2009-09-21 |
2023-08-12 |
Not clear |
| Ya-Yun Wang, Yan-Yan Wei, Jing Huang, Wei Wang, Nobuaiki Tamamaki, Yun-Qing Li, Sheng-Xi W. Expression patterns of 5-HT receptor subtypes 1A and 2A on GABAergic neurons within the spinal dorsal horn of GAD67-GFP knock-in mice. Journal of chemical neuroanatomy. vol 38. issue 1. 2009-09-18. PMID:19409978. |
5-ht plays an important role in gaba transmission at the spinal cord level. |
2009-09-18 |
2023-08-12 |
mouse |
| J-R Pape, S S Bertrand, P Lafon, M-F Odessa, M Chaigniau, J K Stiles, M Garre. Expression of GABA(A) receptor alpha3-, theta-, and epsilon-subunit mRNAs during rat CNS development and immunolocalization of the epsilon subunit in developing postnatal spinal cord. Neuroscience. vol 160. issue 1. 2009-08-17. PMID:19249336. |
expression of gaba(a) receptor alpha3-, theta-, and epsilon-subunit mrnas during rat cns development and immunolocalization of the epsilon subunit in developing postnatal spinal cord. |
2009-08-17 |
2023-08-12 |
rat |
| Claudia H Tambeli, Jon D Levine, Robert W Gea. Centralization of noxious stimulus-induced analgesia (NSIA) is related to activity at inhibitory synapses in the spinal cord. Pain. vol 143. issue 3. 2009-08-17. PMID:19375225. |
nsia was reversed by antagonists for two inhibitory receptors (gaba(b) and mu-opioid) but not by antagonists for either of the two excitatory receptors (nmda and mglur(5)), indicating that nsia is maintained by ongoing activity at inhibitory synapses in the spinal cord. |
2009-08-17 |
2023-08-12 |
rat |
| Windyanne Khristy, Noore J Ali, Arlene B Bravo, Ray de Leon, Roland R Roy, Hui Zhong, Nik J L London, V Reggie Edgerton, Niranjala J K Tillakaratn. Changes in GABA(A) receptor subunit gamma 2 in extensor and flexor motoneurons and astrocytes after spinal cord transection and motor training. Brain research. vol 1273. 2009-08-14. PMID:19358834. |
changes in gaba(a) receptor subunit gamma 2 in extensor and flexor motoneurons and astrocytes after spinal cord transection and motor training. |
2009-08-14 |
2023-08-12 |
human |
| Windyanne Khristy, Noore J Ali, Arlene B Bravo, Ray de Leon, Roland R Roy, Hui Zhong, Nik J L London, V Reggie Edgerton, Niranjala J K Tillakaratn. Changes in GABA(A) receptor subunit gamma 2 in extensor and flexor motoneurons and astrocytes after spinal cord transection and motor training. Brain research. vol 1273. 2009-08-14. PMID:19358834. |
gaba signaling plays an important role in the spinal cord response to injury and subsequent motor training. |
2009-08-14 |
2023-08-12 |
human |
| Windyanne Khristy, Noore J Ali, Arlene B Bravo, Ray de Leon, Roland R Roy, Hui Zhong, Nik J L London, V Reggie Edgerton, Niranjala J K Tillakaratn. Changes in GABA(A) receptor subunit gamma 2 in extensor and flexor motoneurons and astrocytes after spinal cord transection and motor training. Brain research. vol 1273. 2009-08-14. PMID:19358834. |
since benzodiazepines are commonly used to treat muscle spasticity in spinal cord injured subjects and the gamma2 subunit of the gaba(a) receptor is necessary for benzodiazepine binding, this subunit may be an important factor modulating sensorimotor function after an injury. |
2009-08-14 |
2023-08-12 |
human |
| Windyanne Khristy, Noore J Ali, Arlene B Bravo, Ray de Leon, Roland R Roy, Hui Zhong, Nik J L London, V Reggie Edgerton, Niranjala J K Tillakaratn. Changes in GABA(A) receptor subunit gamma 2 in extensor and flexor motoneurons and astrocytes after spinal cord transection and motor training. Brain research. vol 1273. 2009-08-14. PMID:19358834. |
since the gamma2 subunit is involved with gaba(a) receptor trafficking and synaptic clustering, it appears that this subunit could be an important component of the activity-dependent response of the spinal cord after a spinal injury. |
2009-08-14 |
2023-08-12 |
human |
| D V Amakhin, N P Veselki. [Characteristics and interactions between glycine- and GABA-mediated responses of the frog spinal cord neurons]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 95. issue 4. 2009-07-01. PMID:19505034. |
interactions between gaba and glycine receptors in dissociated neurons from the frog spinal cord lumbar enlargement were analyzed by using whole-cell patch-clamp technique. |
2009-07-01 |
2023-08-12 |
Not clear |
| D V Amakhin, N P Veselki. [Characteristics and interactions between glycine- and GABA-mediated responses of the frog spinal cord neurons]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 95. issue 4. 2009-07-01. PMID:19505034. |
these results suggest that the frog spinal cord neurons express a population of inhibitory amino acid receptors that can bind either glycine or gaba. |
2009-07-01 |
2023-08-12 |
Not clear |
| C Cervetto, G Taccol. GABAA and strychnine-sensitive glycine receptors modulate N-methyl-D-aspartate-evoked acetylcholine release from rat spinal motoneurons: a possible role in neuroprotection. Neuroscience. vol 154. issue 4. 2009-06-29. PMID:18554813. |
these data suggest that glutamatergic overload of receptors located onto spinal cord motoneurons might be decreased by activating gaba(a) and glycine receptors. |
2009-06-29 |
2023-08-12 |
rat |
| Lihua Wang, Emma Spary, Jim Deuchars, Susan A Deuchar. Tonic GABAergic inhibition of sympathetic preganglionic neurons: a novel substrate for sympathetic control. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 47. 2009-06-09. PMID:19020037. |
recording from identified spns in the intermediolateral cell column (iml) of rat spinal cord slices, application of the gaba receptor antagonist bicuculline, but not gabazine, elicited a change in voltage that lasted for the duration of application. |
2009-06-09 |
2023-08-12 |
rat |
| W-X Yuan, S-R Chen, H Chen, H-L Pa. Stimulation of alpha(1)-adrenoceptors reduces glutamatergic synaptic input from primary afferents through GABA(A) receptors and T-type Ca(2+) channels. Neuroscience. vol 158. issue 4. 2009-05-20. PMID:19068225. |
collectively, these findings suggest that activation of alpha(1)-adrenoceptors in the spinal cord increases synaptic gaba release, which attenuates glutamatergic input from primary afferents mainly through gaba(a) receptors and t-type ca(2+) channels. |
2009-05-20 |
2023-08-12 |
rat |
| Cristina Romei, Elisa Luccini, Maurizio Raiteri, Luca Raiter. GABA(B) presynaptic receptors modulate glycine exocytosis from mouse spinal cord and hippocampus glycinergic nerve endings. Pharmacological research. vol 59. issue 3. 2009-04-23. PMID:19135152. |
gaba(b) presynaptic receptors modulate glycine exocytosis from mouse spinal cord and hippocampus glycinergic nerve endings. |
2009-04-23 |
2023-08-12 |
mouse |
| Cristina Romei, Elisa Luccini, Maurizio Raiteri, Luca Raiter. GABA(B) presynaptic receptors modulate glycine exocytosis from mouse spinal cord and hippocampus glycinergic nerve endings. Pharmacological research. vol 59. issue 3. 2009-04-23. PMID:19135152. |
we here investigate on the existence and the pharmacological profile of gaba(b) receptors regulating glycine release in mouse spinal cord and hippocampus. |
2009-04-23 |
2023-08-12 |
mouse |
| Cristina Romei, Elisa Luccini, Maurizio Raiteri, Luca Raiter. GABA(B) presynaptic receptors modulate glycine exocytosis from mouse spinal cord and hippocampus glycinergic nerve endings. Pharmacological research. vol 59. issue 3. 2009-04-23. PMID:19135152. |
the effect of 3 microm (-)-baclofen in the spinal cord was prevented by the gaba(b) receptor antagonists cgp 52432 (ic(50)=22.6+/-2.15 microm) and cgp 35348 (ic(50)=5.99+/-1.21 microm), whereas phaclofen was ineffective. |
2009-04-23 |
2023-08-12 |
mouse |
| Cristina Romei, Elisa Luccini, Maurizio Raiteri, Luca Raiter. GABA(B) presynaptic receptors modulate glycine exocytosis from mouse spinal cord and hippocampus glycinergic nerve endings. Pharmacological research. vol 59. issue 3. 2009-04-23. PMID:19135152. |
it is concluded that: (i) glycinergic nerve terminals in spinal cord and hippocampus possess gaba(b) receptors mediating inhibition of the evoked glycine exocytosis; (ii) the pharmacological profiles of the receptors are qualitatively similar in the two regions; (iii) low concentrations of gaba(b) antagonists appear able to preferentially inhibit the receptors located on hippocampal glycinergic nerve endings. |
2009-04-23 |
2023-08-12 |
mouse |
| In-Sun Choi, Jin-Hwa Cho, Seok-Gwon Jeong, Jung-Soo Hong, Sang-Jung Kim, Jun Kim, Maan-Gee Lee, Byung-Ju Choi, Il-Sung Jan. GABA(B) receptor-mediated presynaptic inhibition of glycinergic transmission onto substantia gelatinosa neurons in the rat spinal cord. Pain. vol 138. issue 2. 2009-01-26. PMID:18258370. |
gaba(b) receptor-mediated presynaptic inhibition of glycinergic transmission onto substantia gelatinosa neurons in the rat spinal cord. |
2009-01-26 |
2023-08-12 |
rat |