| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marina Asiedu, Michael H Ossipov, Kai Kaila, Theodore J Pric. Acetazolamide and midazolam act synergistically to inhibit neuropathic pain. Pain. vol 148. issue 2. 2010-04-14. PMID:20007010. |
after peripheral nerve injury, a decrease in the expression of the k-cl cotransporter kcc2, a major neuronal cl(-) extruder, leads to pathologic alterations in gaba(a) and glycine receptor function in the spinal cord. |
2010-04-14 |
2023-08-12 |
Not clear |
| D Wolfe, M Mata, D J Fin. A human trial of HSV-mediated gene transfer for the treatment of chronic pain. Gene therapy. vol 16. issue 4. 2010-03-26. PMID:19242524. |
hsv vectors engineered to produce inhibitory neurotransmitters, including the delta opioid agonist peptide enkephalin, the mu opioid agonist peptide endomorphin-2 and glutamic acid decarboxylase (gad), to effect the release of gamma amino butyric acid (gaba) act to inhibit nociceptive neurotransmission at the first synapse between primary nociceptive and second-order neuron in the dorsal horn of the spinal cord. |
2010-03-26 |
2023-08-12 |
human |
| H J Waldvogel, K Baer, E Eady, K L Allen, R T Gilbert, H Mohler, M I Rees, L F B Nicholson, R L M Faul. Differential localization of gamma-aminobutyric acid type A and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: an immunohistochemical study. The Journal of comparative neurology. vol 518. issue 3. 2010-03-08. PMID:19950251. |
differential localization of gamma-aminobutyric acid type a and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: an immunohistochemical study. |
2010-03-08 |
2023-08-12 |
human |
| H J Waldvogel, K Baer, E Eady, K L Allen, R T Gilbert, H Mohler, M I Rees, L F B Nicholson, R L M Faul. Differential localization of gamma-aminobutyric acid type A and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: an immunohistochemical study. The Journal of comparative neurology. vol 518. issue 3. 2010-03-08. PMID:19950251. |
glyr and gaba(a)r are heteropentameric chloride ion channels that facilitate fast-response, inhibitory neurotransmission in the mammalian brain and spinal cord. |
2010-03-08 |
2023-08-12 |
human |
| H J Waldvogel, K Baer, E Eady, K L Allen, R T Gilbert, H Mohler, M I Rees, L F B Nicholson, R L M Faul. Differential localization of gamma-aminobutyric acid type A and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: an immunohistochemical study. The Journal of comparative neurology. vol 518. issue 3. 2010-03-08. PMID:19950251. |
we investigated the immunohistochemical distribution of gephyrin and the major gaba(a)r and glyr subunits in the human light microscopically in the rostral and caudal one-thirds of the pons, in the middle and caudal one-thirds of the medulla oblongata, and in the first cervical segment of the spinal cord. |
2010-03-08 |
2023-08-12 |
human |
| A Stil, S Liabeuf, C Jean-Xavier, C Brocard, J-C Viemari, L Vina. Developmental up-regulation of the potassium-chloride cotransporter type 2 in the rat lumbar spinal cord. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19699273. |
gaba(a) and glycine receptors are anions channels and the efficacy of inhibitory transmission in the spinal cord is largely determined by the gradient between intracellular and extracellular chloride concentrations. |
2010-02-12 |
2023-08-12 |
rat |
| K J Dougherty, M A Sawchuk, S Hochma. Phenotypic diversity and expression of GABAergic inhibitory interneurons during postnatal development in lumbar spinal cord of glutamic acid decarboxylase 67-green fluorescent protein mice. Neuroscience. vol 163. issue 3. 2010-01-14. PMID:19560523. |
here, we characterize the distribution of lumbar spinal cord gad67-gfp neurons at postnatal days (p) 0, 7, and 14, and adult based on their co-expression with gaba and determine the molecular phenotype of gad67-gfp neurons at p14 based on the expression of various neuropeptides, calcium binding proteins, and other markers. |
2010-01-14 |
2023-08-12 |
mouse |
| Yang-Can Duan, Bo Xu, Zhen Shi, Juan Gao, Shu-Juan Zhang, Wei Wang, Qi Chen, Guo-Qing Zh. Nucleus of solitary tract mediates cardiac sympathetic afferent reflex in rats. Pflugers Archiv : European journal of physiology. vol 459. issue 1. 2010-01-08. PMID:19629518. |
nine days after iontophoretic injection of biotin-dextran (a retrograde tracer) into the dorsal horn of upper thoracic spinal cord, biotin-dextran-labeled terminations were found in the vicinity of glutamic acid decarboxylase (a marker for gaba neurons) staining neurons. |
2010-01-08 |
2023-08-12 |
rat |
| Takaomi Tair. Intrathecal administration of GABA agonists in the vegetative state. Progress in brain research. vol 177. 2010-01-08. PMID:19818910. |
an analogue of gaba, baclofen, is an agonist of gaba-b receptor, and has very strong antispastic effect by acting to the posterior horn of the spinal cord. |
2010-01-08 |
2023-08-12 |
Not clear |
| Elke Ziegler, M Bodusch, Y Song, K Jahn, H Wolfes, S Steinlechner, R Dengler, J Bufler, K Krampf. Interaction of androsterone and progesterone with inhibitory ligand-gated ion channels: a patch clamp study. Naunyn-Schmiedeberg's archives of pharmacology. vol 380. issue 4. 2009-12-11. PMID:19705103. |
gamma-aminobutyric acid receptor type a (gaba(a)) receptor channels mediate fast inhibitory neurotransmission throughout the central nervous system while the expression of ionotropic glycine receptors is mainly restricted to the spinal cord and brain stem. |
2009-12-11 |
2023-08-12 |
Not clear |
| T Nishiyam. Interaction between midazolam and serotonin in spinally mediated antinociception in rats. Journal of anesthesia. vol 23. issue 2. 2009-12-07. PMID:19444565. |
intrathecal administration of serotonin (5-ht) is antinociceptive through the involvement of spinal cord gamma-aminobutyric acid (gaba) receptors. |
2009-12-07 |
2023-08-12 |
rat |
| T Nishiyam. Interaction between midazolam and serotonin in spinally mediated antinociception in rats. Journal of anesthesia. vol 23. issue 2. 2009-12-07. PMID:19444565. |
therefore, 5-ht would interact with the gaba agonist, midazolam, which is well known to exert spinally mediated antinociception in the spinal cord. |
2009-12-07 |
2023-08-12 |
rat |
| Tomoki Nishiyam. Interaction between midazolam and epibatidine in spinally mediated antinociception in rats. Journal of anesthesia. vol 23. issue 3. 2009-12-07. PMID:19685117. |
both gamma-aminobutyric acid (gaba)(a) receptors and nicotinic cholinergic receptors have important roles in antinociception in the spinal cord. |
2009-12-07 |
2023-08-12 |
rat |
| Tomoki Nishiyam. Interaction between midazolam and epibatidine in spinally mediated antinociception in rats. Journal of anesthesia. vol 23. issue 3. 2009-12-07. PMID:19685117. |
the antinociceptive effects of midazolam (a gaba(a) agonist) and epibatidine (a nicotinic cholinergic agonist) in the spinal cord have been reported. |
2009-12-07 |
2023-08-12 |
rat |
| Colin S Goodchild, Anton Kolosov, Licheng Geng, Lara L Winter, Ray Nadeso. Prevention and reversal of morphine tolerance by the analgesic neuroactive steroid alphadolone. Pain medicine (Malden, Mass.). vol 10. issue 5. 2009-11-02. PMID:19682273. |
alphadolone is a neuroactive steroid that causes antinociception in rats and analgesia in humans by interaction with spinal cord gaba(a) receptors. |
2009-11-02 |
2023-08-12 |
rat |
| Giambattista Bonanno, Elena Fumagalli, Marco Milanese, Simona Zappettini, Tiziana Mennin. Release of [3H]D-aspartate induced by K+-stimulation is increased in the cervical spinal cord of the wobbler mouse: a model of motor neuron disease. Neurochemistry international. vol 55. issue 5. 2009-10-26. PMID:19576518. |
the ca2+-dependent exocytotic release of [3h]d-aspartate and [3h]gaba evoked by 15 mm kcl depolarization was studied in wobbler mice, an animal model of selective motor neuron degeneration in the cervical tract of the spinal cord. |
2009-10-26 |
2023-08-12 |
mouse |
| Giambattista Bonanno, Elena Fumagalli, Marco Milanese, Simona Zappettini, Tiziana Mennin. Release of [3H]D-aspartate induced by K+-stimulation is increased in the cervical spinal cord of the wobbler mouse: a model of motor neuron disease. Neurochemistry international. vol 55. issue 5. 2009-10-26. PMID:19576518. |
the kcl-induced release of [3h]gaba from cervical and lumbar spinal cord synaptosomes was unmodified at 4 weeks of age while it was moderately but significantly reduced in wobbler mice at 12 weeks, selectively in the cervical spinal cord. |
2009-10-26 |
2023-08-12 |
mouse |
| Seo-Yeon Yoon, Dae-Hyun Roh, Hyoung-Sig Seo, Suk-Yun Kang, Ho-Jae Han, Alvin J Beitz, Jang-Hern Le. Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors. British journal of pharmacology. vol 157. issue 4. 2009-10-15. PMID:19422393. |
as both the sigma-1 receptor and the gaba(a) receptor play important roles in spinal pain transmission, the present study was designed to examine whether intrathecally injected dheas or dhea affect nociceptive signalling at the spinal cord level. |
2009-10-15 |
2023-08-12 |
mouse |
| N I Kalinina, G G Kurchavyi, D V Amakhin, N P Veselki. Differences in the activation of inhibitory motoneuron receptors in the frog Rana ridibunda by GABA and glycine and their interaction. Neuroscience and behavioral physiology. vol 39. issue 8. 2009-10-05. PMID:19779830. |
intracellular recording of potentials was used in isolated spinal cord segments from the frog rana ridibunda to compare the inhibitory effects of gaba and glycine on the motoneuron membrane. |
2009-10-05 |
2023-08-12 |
Not clear |
| Achim Schmidtko, Ceng Luo, Wei Gao, Gerd Geisslinger, Rohini Kuner, Irmgard Tegede. Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. Pain. vol 139. issue 3. 2009-09-28. PMID:18701217. |
these results suggest that synapsin ii is involved in the regulation of glutamate and gaba release in the spinal cord after nerve injury, and that a imbalance between glutamatergic and gabaergic synaptic transmission contributes to the manifestation of neuropathic pain. |
2009-09-28 |
2023-08-12 |
mouse |