| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huynh Nhu Mai, Sung Hoon Lee, Garima Sharma, Dae-Joong Kim, Naveen Sharma, Eun-Joo Shin, Duc Toan Pham, Quynh Dieu Trinh, Choon-Gon Jang, Seung-Yeol Nah, Ji Hoon Jeong, Hyoung-Chun Ki. Protein kinase Cδ knockout mice are protected from cocaine-induced hepatotoxicity. Chemico-biological interactions. vol 297. 2019-01-08. PMID:30393195. |
cocaine treatment significantly increased alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels in the serum of wt mice signifying the hepatic damage. |
2019-01-08 |
2023-08-13 |
mouse |
| Hsiao-Yun Wang, Hsiang-Chi Peng, Yi-Wen Chien, Ya-Ling Chen, Nien-Shan Lu, Suh-Ching Yan. Effects of Fish Oil on Lipid Metabolism and Its Molecular Biological Regulators in Chronic Ethanol-Fed Rats. Nutrients. vol 10. issue 7. 2019-01-07. PMID:29932129. |
when compared with c group, the plasma aspartate transaminase (ast) activity and hepatic steatosis and inflammatory cell infiltration were significantly higher, while plasma adiponectin level and hepatic amp-activated protein kinase α (ampkα) protein expression was significantly lower in the e group. |
2019-01-07 |
2023-08-13 |
rat |
| M Liu, R Zhou, X Wu, X Xu, M Su, B Yan. Clinicopathologic charcterization of sorafenib-induced endoplasmic reticulum stress in human liver cancer cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 69. issue 4. 2019-01-03. PMID:30415242. |
compared to non-treated control, blood contents of alanine transaminase (alt), aspartate transaminase (ast), alphafetoprotein (afp), fibroblast growth factor 21 (fgf21) were decreased in sor-treated hcc patients, while the level of interleukin 10 (il-10) were increased. |
2019-01-03 |
2023-08-13 |
human |
| Paolo Ricchi, Antonella Meloni, Anna Spasiano, Silvia Costantini, Alessia Pepe, Patrizia Cinque, Aldo Filos. The impact of liver steatosis on the ability of serum ferritin levels to be predictive of liver iron concentration in non-transfusion-dependent thalassaemia patients. British journal of haematology. vol 180. issue 5. 2019-01-02. PMID:29363758. |
patients with ls had significant higher levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), alt/ast ratio and ferritin than those without, but lic values were comparable. |
2019-01-02 |
2023-08-13 |
Not clear |
| Jinhyung Bae, Young Sil Min, Yoonjin Nam, Hyun Seok Lee, Uy Dong Soh. Humulus japonicus Extracts Protect Against Lipopolysaccharide/d-Galactosamine-Induced Acute Liver Injury in Rats. Journal of medicinal food. vol 21. issue 10. 2019-01-02. PMID:30334699. |
aspartate aminotransferase (ast), alanine aminotransferase (alt), and tumor necrosis factor-α (tnf-α) activities were also assayed to examine liver cell viability. |
2019-01-02 |
2023-08-13 |
human |
| Xue Shi, Yan Zhao, Chunchun Ding, Zhecheng Wang, Anlong Ji, Zhenlu Li, Dongcheng Feng, Yang Li, Dongyan Gao, Junjun Zhou, Xiaofeng Tian, Jihong Ya. Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of β-catenin nuclear accumulation by restoring SIRT1 in rats. Toxicology and applied pharmacology. vol 350. 2018-12-31. PMID:29729281. |
in this study, sala treatment significantly alleviated the accumulation of lipid droplets and reduced the plasma alanine aminotransferase (alt), aspartate aminotransferase (ast), total cholesterol (tc), triglyceride (tg), alcohol and ammonia levels in rats. |
2018-12-31 |
2023-08-13 |
rat |
| Shoichi Kageyama, Kojiro Nakamura, Takehiro Fujii, Bibo Ke, Rebecca A Sosa, Elaine F Reed, Nakul Datta, Ali Zarrinpar, Ronald W Busuttil, Jerzy W Kupiec-Weglinsk. Recombinant relaxin protects liver transplants from ischemia damage by hepatocyte glucocorticoid receptor: From bench-to-bedside. Hepatology (Baltimore, Md.). vol 68. issue 1. 2018-12-28. PMID:29350771. |
post-/pre-gr ratios at postoperative day 1 correlated negatively with serum aspartate aminotransferase (ast)/cleaved caspase-3 and positively with b-cell lymphoma-extra large (bcl-xl)/b-cell lymphoma 2 (bcl-2) levels. |
2018-12-28 |
2023-08-13 |
human |
| I-Jung Tsai, Chia-Wen Chen, Shin-Yu Tsai, Pei-Yuan Wang, Eddy Owaga, Rong-Hong Hsie. Curcumin supplementation ameliorated vascular dysfunction and improved antioxidant status in rats fed a high-sucrose, high-fat diet. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 43. issue 7. 2018-12-24. PMID:29378153. |
after 8 weeks, the hsf diet significantly elevated levels of aspartate aminotransferase (ast), alanine aminotransferase (alt), insulin, homeostatic model assessment insulin resistance (homa-ir), low-density lipoprotein cholesterol (ldl-c), homocysteine (hcy), c-reactive protein (crp), vascular cell adhesion molecule 1 (vcam-1), and intercellular adhesion molecule 1 (icam-1) but significantly reduced levels of nitric oxide (no) and high-density lipoprotein cholesterol (hdl-c). |
2018-12-24 |
2023-08-13 |
rat |
| İlkay Aydogan, Mehmet Akif Karslı, Mehmet Başalan, Ebru Yıldırım, Miyase Çınar, Gökhan Şen, Tugce Süme. Effects of Supplemental Epigallocatechin Gallate in the Diet of Broilers Exposed to Fluoride Intoxication. Biological trace element research. vol 186. issue 1. 2018-12-24. PMID:29549531. |
alkaline phosphatase (alp), aspartate aminotransferase (ast), and total oxidant status (tos) levels in the f-treated groups were significantly higher, whereas the increase in total cholesterol levels was insignificant than those in the control group. |
2018-12-24 |
2023-08-13 |
Not clear |
| Hongming Lv, Xiaoye Fan, Lidong Wang, Haihua Feng, Xinxin C. Daphnetin alleviates lipopolysaccharide/d-galactosamine-induced acute liver failure via the inhibition of NLRP3, MAPK and NF-κB, and the induction of autophagy. International journal of biological macromolecules. vol 119. 2018-12-24. PMID:30031824. |
our findings suggested that daph treatment efficiently protected against lps/galn-induced alf by lessening the lethality, decreasing the alanine transaminase (alt) and aspartate aminotransferase (ast) levels, tumor necrosis factor (tnf)-α, interleukin (il)-1β, and il-6 secretion, malondialdehyde (mda) formation and myeloperoxidase (mpo) level, inhibiting nitric oxide synthase (inos), cyclooxygenase-2 (cox-2) protein expression, and increasing the glutathione (gsh) and superoxide dismutase (sod) contents. |
2018-12-24 |
2023-08-13 |
mouse |
| Weishi Liang, Dandan Zhang, Jiali Kang, Xubing Meng, Jingbo Yang, Lei Yang, Ning Xue, Qingyao Gao, Shuying Han, Xiangbo Go. Protective effects of rutin on liver injury in type 2 diabetic db/db mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2018-12-24. PMID:30138894. |
after administration of 120 mg/kg or 60 mg/kg rutin, to t2dm mice, rbg, oral glucose tolerance, alanine aminotransferase (alt) and aspartate aminotransferase (ast) in serum, and advanced glycation end products (ages) in vivo and vitro of different groups were detected. |
2018-12-24 |
2023-08-13 |
mouse |
| Rebeka D Major, Martin Kluge, Maximilian Jara, Maximilian Nösser, Rosa Horner, Joseph Gassner, Benjamin Struecker, Peter Tang, Steffen Lippert, Anja Reutzel-Selke, Dominik Geisel, Timm Denecke, Martin Stockmann, Johann Pratschke, Igor M Sauer, Nathanael Raschzo. The Predictive Value of the Maximal Liver Function Capacity Test for the Isolation of Primary Human Hepatocytes. Tissue engineering. Part C, Methods. vol 24. issue 3. 2018-12-21. PMID:29382276. |
from a total of 11 hepatocyte isolation procedures, metabolic parameters (albumin, urea, and aspartate aminotransferase or ast) were assessed during the hepatocyte cultivation period of 5 days. |
2018-12-21 |
2023-08-13 |
human |
| Ewa Podgorska, Martyna Sniegocka, Marianna Mycinska, Wojciech Trybus, Ewa Trybus, Anna Kopacz-Bednarska, Olga Wiechec, Martyna Krzykawska-Serda, Martyna Elas, Teodora Krol, Krystyna Urbanska, Andrzej Slominsk. Acute hepatologic and nephrologic effects of calcitriol in Syrian golden hamster (Mesocricetus auratus). Acta biochimica Polonica. vol 65. issue 3. 2018-12-21. PMID:30148509. |
there was also a trend for increased serum levels of aspartate aminotransferase (ast), but not of alanine aminotransferase (alt) or ggtp (gamma-glutamyl transpeptidase). |
2018-12-21 |
2023-08-13 |
Not clear |
| Y Shimizu, T Mashima-Nemoto, M Hazawa, Y Taira, I Taira, I Ishida, K Isod. The hepatoprotective effect of lycopene on Con A-induced liver injury in mice. Die Pharmazie. vol 73. issue 7. 2018-12-20. PMID:30001773. |
the results showed that con a administration increased histopathological damage, and the levels of aspartate aminotransferase (ast), alanine aminotransferase (alt), interleukin (il)-6, interferon (ifn)-γ and tumor necrosis factor (tnf)-α were increased in serum samples whereas the levels of these compounds were significantly decreased in the con a and lycopene group compared to the con a group. |
2018-12-20 |
2023-08-13 |
mouse |
| Fang Xie, Xiang Fei, Ming-Bo Zhang, Yan Zhang, Hong-Wei Wang, Jie Tang, Wen-Bo Tang, Yu-Kun Lu. Quantitative Evaluation of Hepatic Microvascular Perfusion after Ischemia-Reperfusion Injury in Rabbits by Contrast-Enhanced Ultrasound Perfusion Imaging. Ultrasound in medicine & biology. vol 44. issue 5. 2018-12-19. PMID:29478786. |
prolonged ischemia upregulated intracellular adhesion molecule-1 (icam-1), alanine transaminase (alt) and aspartate transaminase (ast) levels. |
2018-12-19 |
2023-08-13 |
Not clear |
| Yi-Hao Yen, Fang-Ying Kuo, Kwong-Ming Kee, Kuo-Chin Chang, Ming-Chao Tsai, Tsung-Hui Hu, Sheng-Nan Lu, Jing-Houng Wang, Chao-Hung Hung, Chien-Hung Che. APRI and FIB-4 in the evaluation of liver fibrosis in chronic hepatitis C patients stratified by AST level. PloS one. vol 13. issue 6. 2018-12-19. PMID:29953518. |
the aspartate aminotransferase (ast)-to-platelet ratio index (apri) and fibrosis-4 index (fib-4) are commonly used compound surrogates for advanced fibrosis in chronic hepatitis c (chc) patients. |
2018-12-19 |
2023-08-13 |
Not clear |
| Tianci Bu, Changyuan Wang, Qiang Meng, Xiaokui Huo, Huijun Sun, Pengyuan Sun, Siqi Zheng, Xiaodong Ma, Zhihao Liu, Kexin Li. Hepatoprotective effect of rhein against methotrexate-induced liver toxicity. European journal of pharmacology. vol 834. 2018-12-18. PMID:30031796. |
rhein significantly reduced the elevation of alanine aminotransferase (alt) and aspartate aminotransferase (ast) caused by mtx in rat serum and improved liver morphological damage induced by mtx. |
2018-12-18 |
2023-08-13 |
human |
| Ali Emami, Behnaz Bazargani-Gilan. Effect of oral CoQ Food & function. vol 9. issue 8. 2018-12-18. PMID:30058646. |
in this study, we examined the effects of 14-day coenzyme q10 (coq10) supplementation and precooling strategy on the serum levels of nadph-oxidase (nox), hydrogen peroxide (h2o2), lactic acid (la), creatine kinase (ck), 8-isoprostane (8-iso pgf2α), 8-hydroxy-2-deoxyguanosine (8-ohdg), aspartate aminotransferase (ast), protein carbonyls (pc), alanine aminotransferase (alt), and gamma-glutamyl transferase (ggt) in adolescent elite swimmers. |
2018-12-18 |
2023-08-13 |
Not clear |
| Tianhua Fu, Haijun Li, Yan Zhao, Enbo Cai, Hongyan Zhu, Pingya Li, Jinping Li. Hepatoprotective effect of α-mangostin against lipopolysaccharide/d-galactosamine-induced acute liver failure in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-18. PMID:30119260. |
the results showed that α-mg could attenuate lps/d-galn-induced liver pathological injury, and decrease the hepatic malondialdehyde (mda) level, serum alanine aminotransferase (alt), aspartate transaminase (ast), tumor necrosis factor (tnf-α), interleukin-1β and 6 (il-1β, il-6) levels and recovery hepatic glutathione (gsh), superoxide dismutase (sod), catalase (cat) activities. |
2018-12-18 |
2023-08-13 |
mouse |
| Guang-Meng Xu, Tao Zan, Hong-Yan Li, Jin-Feng Han, Zhong-Min Liu, Ju Huang, Li-Hua Dong, Hai-Na Zhan. Betulin inhibits lipopolysaccharide/D-galactosamine-induced acute liver injury in mice through activating PPAR-γ. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-18. PMID:30119266. |
the results indicated that betulin dramatically decreased liver pathologic changes, myeloperoxidase (mpo) activity, serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels. |
2018-12-18 |
2023-08-13 |
mouse |