| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Zhang, S Cao, S Jin, J Cao, J Shen, B Pan, R Zhu, Y Y. Elevated aspartate aminotransferase and monocyte counts predict unfavorable prognosis in patients with malignant pleural mesothelioma. Neoplasma. vol 64. issue 1. 2019-04-22. PMID:27881012. |
significant prognostic factors on univariate analysis were performance status (ps), serum albumin, aspartate aminotransferase (ast), lactate dehydrogenase (ldh), alkaline phosphatase (alp), monocyte, platelet to lymphocyte ratio (plr), lymphocyte to monocyte ratio (lmr) and treatment strategy. |
2019-04-22 |
2023-08-13 |
Not clear |
| Semih Kalyon, Yasemin Gökden, Naciye Demirel, Burak Erden, Ayberk Türkyılma. Chanarin-Dorfman syndrome. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. vol 30. issue 1. 2019-04-22. PMID:30457558. |
a 38-year-old male patient was referred to our internal medicine clinic for consultation with laboratory findings as follows: high aspartate aminotransferase (ast; 203 u/l), alanine aminotransferase (alt; 151 u/l), gamma-glutamyl transferase (ggt; 167 u/l), creatine kinase (ck; 1127 u/l) levels and low platelet levels (108000). |
2019-04-22 |
2023-08-13 |
human |
| Ting Luo, Manlu Shen, Jiajie Zhou, Xiaoyu Wang, Jizhou Xia, Zhengwei Fu, Yuanxiang Ji. Chronic exposure to low doses of Pb induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels of mice. Environmental toxicology. vol 34. issue 4. 2019-04-22. PMID:30623991. |
while oral exposure to 0.03 or 0.1 mg/l pb for 15 weeks in male adult mice had no significant effect on body weights, pb exposure resulted in liver histopathological effects and increase of hepatic activities of aspartate aminotransferase (ast), alanine aminotransferase (alt), and alkaline phosphatase (alp). |
2019-04-22 |
2023-08-13 |
mouse |
| Hwa-Young Lee, Geum-Hwa Lee, Young Yoon, Han-Jung Cha. R. verniciflua and E. ulmoides Extract (ILF-RE) Protects against Chronic CCl₄-Induced Liver Damage by Enhancing Antioxidation. Nutrients. vol 11. issue 2. 2019-04-22. PMID:30759889. |
alanine transaminase (alt), aspartate transaminase (ast), gamma-glutamyl transpeptidase (ggt), and lipid peroxidation assays were performed, and total triglyceride, cholesterol, and ldl-cholesterol levels were quantified. |
2019-04-22 |
2023-08-13 |
rat |
| Anwar E Ahmed, Abeer N Alshukairi, Hamdan Al-Jahdali, Mody Alaqeel, Salma S Siddiq, Hanan A Alsaab, Ezzeldin A Sakr, Hamed A Alyahya, Munzir M Alandonisi, Alaa T Subedar, Nouf M Aloudah, Salim Baharoon, Majid A Alsalamah, Sameera Al Johani, Mohammed G Alghamd. Development of a risk-prediction model for Middle East respiratory syndrome coronavirus infection in dialysis patients. Hemodialysis international. International Symposium on Home Hemodialysis. vol 22. issue 4. 2019-04-18. PMID:29656480. |
independent predictors of mers-cov infection were identified, including chest pain (or = 24.194; p = 0.011), leukopenia (or = 6.080; p = 0.049), and elevated aspartate aminotransferase (ast) (or = 11.179; p = 0.013). |
2019-04-18 |
2023-08-13 |
Not clear |
| Yu-Ling Su, Guo Chen, Liang-Shi Chen, Jia-Zhou Li, Gang Wang, Jia-Yang He, Tian-Yong Zhan, Yan-Wei Li, Mu-Ting Yan, You-Hua Huang, Qi-Wei Qin, Xue-Ming Dan, Hong-Yan Su. Effects of antimicrobial peptides on serum biochemical parameters, antioxidant activity and non-specific immune responses in Epinephelus coioides. Fish & shellfish immunology. vol 86. 2019-04-16. PMID:30593900. |
results showed that the levels of total protein (tp), albumin (alb), alanine aminotransferase (alt), aspartate aminotransferase (ast), high-density lipoprotein cholesterol (hdl-c), low-density lipoprotein cholesterol (ldl-c) and blood glucose (glu) and lipopolysaccharide (lps) in the serum of e. coioides changed than those of the control group; compared to the control group, the levels of total antioxidant capacity (t-aoc), superoxide dismutase (sod), catalase (cat), malondialdehyde (mda) and lysozyme (lzm) levels in e. coioides fed with different dosages amp diets were also different; in addition, the mrna expression of tumor necrosis factor alpha (tnf-α), interleukin-1-beta (il-1β), and heat shock protein 90 (hsp90) in the tissues of e. coioides were measured, the three genes in the tissues examined were significantly upregulated. |
2019-04-16 |
2023-08-13 |
cat |
| Katsuhito Watanabe, Shingo Oda, Akiko Matsubara, Sho Akai, Tsuyoshi Yoko. Establishment and characterization of a mouse model of rhabdomyolysis by coadministration of statin and fibrate. Toxicology letters. vol 307. 2019-04-15. PMID:30853469. |
the plasma levels of cpk and aspartate aminotransferase (ast) were prominently increased, and the increase in plasma mir-206-3p and mir-133-3p levels, not the increase of mir-122-5p and mir-208-3p levels, suggested skeletal muscle-specific toxicity. |
2019-04-15 |
2023-08-13 |
mouse |
| Solmaz Karimi, Saeid Reza Khatami, Negar Azarpira, Hamid Galehdari, Sara Pakba. Investigate of AQP gene expression in the liver of mice after ischemia-reperfusion. Molecular biology reports. vol 45. issue 6. 2019-04-11. PMID:30143973. |
serum and liver tissue samples were collected for evaluation of alanine aminotransferase (alt), aspartate aminotransferase (ast) and liver histopathology. |
2019-04-11 |
2023-08-13 |
mouse |
| Xuerong Zhao, Lianhong Yin, Lingling Fang, Lina Xu, Pengyuan Sun, Ming Xu, Kexin Liu, Jinyong Pen. Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway. International immunopharmacology. vol 65. 2019-04-08. PMID:30390593. |
in addition, dioscin significantly declined the levels of alanine transaminase (alt), aspartate transaminase (ast), creatinine (cr), blood urea nitrogen (bun), malondialdehyde (mda) and myeloperoxidase (mpo), increased the levels of superoxide dismutase (sod) in rats and mice. |
2019-04-08 |
2023-08-13 |
mouse |
| Masataka Kusunoki, Yukie Natsume, Tetsuro Miyata, Kazuhiko Tsutsumi, Yoshiharu Oshid. Effects of Concomitant Administration of a Dipeptidyl Peptidase-4 Inhibitor in Japanese Patients with Type 2 Diabetes Showing Relatively Good Glycemic Control Under Treatment with a Sodium Glucose Co-Transporter 2 Inhibitor. Drug research. vol 68. issue 12. 2019-04-05. PMID:29966149. |
however, decreases of the serum aspartate aminotransferase (ast), alanine aminotransferase (alt), γ-glutamyltransferase (γ-gtp) and uric acid were observed in this group. |
2019-04-05 |
2023-08-13 |
Not clear |
| Jiangning Yin, Hanqing Wang, Guoyuan L. Umbelliferone alleviates hepatic injury in diabetic db/db mice via inhibiting inflammatory response and activating Nrf2-mediated antioxidant. Bioscience reports. vol 38. issue 4. 2019-04-05. PMID:29967293. |
at 28 days after drug administration, blood samples were obtained for the analysis of lipids and enzymes related to hepatic function, including alanine aminotransferase (alt), aspartate aminotransaminase (ast) and total cholesterol (tc) and triglyceride (tg). |
2019-04-05 |
2023-08-13 |
mouse |
| Jingzhuo Tian, Jingjing Zhu, Yan Yi, Chunying Li, Yushi Zhang, Yong Zhao, Chen Pan, Shixie Xiang, Xiaolong Li, Guiqin Li, John W Newman, Xiaoyi Feng, Jing Liu, Jiayin Han, Lianmei Wang, Yue Gao, Michael R La Frano, Aihua Lian. Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. Scientific reports. vol 7. issue 1. 2019-04-03. PMID:28827769. |
the 300 mg/kg geniposide caused liver injury evidenced by pathological changes and increases in serum alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp) and γ-glutamytransferase (γ-gt). |
2019-04-03 |
2023-08-13 |
rat |
| Farzad Shidfar, Samaneh Sadat Bahrololumi, Saeid Doaei, Assieh Mohammadzadeh, Maryam Gholamalizadeh, Ali Mohammadimanes. The Effects of Extra Virgin Olive Oil on Alanine Aminotransferase, Aspartate Aminotransferase, and Ultrasonographic Indices of Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients Undergoing Low Calorie Diet. Canadian journal of gastroenterology & hepatology. vol 2018. 2019-04-03. PMID:29850450. |
this study aimed to examine the effect of virgin olive oil on alanine aminotransferase (alt) and aspartate aminotransferase (ast) and the severity of steatosis in the nafld patients undergoing a weight-loss diet. |
2019-04-03 |
2023-08-13 |
Not clear |
| Jing-Jen Lin, Yeuk-Chuen Liu, Chun-Ju Chang, Min-Hsiung Pan, Mong-Fong Lee, Bonnie Sun Pa. Hepatoprotective mechanism of freshwater clam extract alleviates non-alcoholic fatty liver disease: elucidated in vitro and in vivo models. Food & function. vol 9. issue 12. 2019-04-03. PMID:30411763. |
in tilapia fed with high-fat diet (hfd), fcre mitigated nonalcoholic steatohepatitis (nash), which was evidenced by decreased levels of plasma aspartate transaminase (ast) and alanine transaminase (alt), in addition to reduced total cholesterol and accumulation of triacylglycerols, particularly those of saturated and monounsaturated fatty acids. |
2019-04-03 |
2023-08-13 |
mouse |
| Shing-Hwa Liu, Chen-Yuan Chiu, Lin-Hui Huang, Meng-Tsan Chian. Resistant Maltodextrin Ameliorates Altered Hepatic Lipid Homeostasis via Activation of AMP-Activated Protein Kinase in a High-Fat Diet-Fed Rat Model. Nutrients. vol 11. issue 2. 2019-04-03. PMID:30699992. |
the results showed that the increased plasma aspartate aminotransferase (ast) and alanine aminotransferase (alt) activities, the increased hepatic triglyceride and total cholesterol levels, and fatty liver in hf-diet-fed rats were significantly decreased after supplementation with rmd. |
2019-04-03 |
2023-08-13 |
rat |
| Lili Wu, Yulian Chen, Han Liu, Zhikun Zhan, Zhi Liang, Tao Zhang, Zheng Cai, Ling Ye, Menghua Liu, Jie Zhao, Shuwen Liu, Lan Tan. Emodin-induced hepatotoxicity was exacerbated by probenecid through inhibiting UGTs and MRP2. Toxicology and applied pharmacology. vol 359. 2019-04-01. PMID:30248416. |
in toxicokinetics-toxicodynamics (tk-td) study, aspartate aminotransferase (ast) and systemic exposure (area under the serum concentration-time curve, auc) of emodin and its glucuronide were significantly increased in rats after co-administrated with emodin and probenecid for 28 consecutive days. |
2019-04-01 |
2023-08-13 |
rat |
| Zhuoan Bai, Tongjun Ren, Yuzhe Han, Md Mostafizur Rahman, Yanan Hu, Zequn Li, Zhiqiang Jian. Influences of dietary selenomethionine exposure on tissue accumulation, blood biochemical profiles, gene expression and intestinal microbiota of Carassius auratus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 218. 2019-04-01. PMID:30528703. |
serum contents of alanine transaminase (alt), aspartate transaminase (ast) and alkaline phosphatase (alp) in fish exposed to se-met20 group was significantly highest among se-met exposure groups. |
2019-04-01 |
2023-08-13 |
Not clear |
| Xin-Xin Li, Zhi-Hui Jiang, Bo Zhou, Chen Chen, Xiao-Ying Zhan. Hepatoprotective effect of gastrodin against alcohol-induced liver injury in mice. Journal of physiology and biochemistry. vol 75. issue 1. 2019-03-29. PMID:30242628. |
gastrodin treatment reduced the activities of serum alanine aminotransferase (alt) and aspartate aminotransferase (ast), decreased hepatic malondialdehyde (mda) content, and increased hepatic superoxide dismutase (sod), glutathione peroxidase (gpx), and catalase (cat) activities in a dose-dependent manner. |
2019-03-29 |
2023-08-13 |
mouse |
| Y Zhang, Y Zhang, J Li, Y Chen, L Han, Q He, J Chu, K Li. The role of hepatic antioxidant capacity and hepatobiliary transporter in liver injury induced by isopsoralen in zebrafish larvae. Human & experimental toxicology. vol 38. issue 1. 2019-03-28. PMID:29774767. |
the mortality, liver morphology changes, levels of alanine aminotransferase (alt) and aspartate aminotransferase (ast), liver histopathology and mrna levels of liver injury-related genes in zebrafish larvae were measured. |
2019-03-28 |
2023-08-13 |
zebrafish |
| Elham Karimi-Sales, Abbas Ebrahimi-Kalan, Mohammad Reza Alipou. Preventive effect of trans-chalcone on non-alcoholic steatohepatitis: Improvement of hepatic lipid metabolism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-03-28. PMID:30551380. |
liver and blood samples were collected and serum levels of alkaline phosphatase (alp), aspartate aminotransferase (ast), alanine aminotransferase (alt), triglyceride, total cholesterol, low-density lipoprotein (ldl)-cholesterol, and high-density lipoprotein (hdl)-cholesterol, as well as hepatic levels of srebp-1c, srebp-2, fas, ppar-α, and ppar-γ2, were measured. |
2019-03-28 |
2023-08-13 |
rat |