| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H R Olpe, H Schellenberg, W P Koell. Rotational behavior induced in rats by intranigral application of GABA-related drugs and GABA antagonists. European journal of pharmacology. vol 45. issue 3. 1978-01-27. PMID:562761. |
gaba and gaba-related drugs such as muscimol, gamma-hydroxybutyric acid and baclofen injected unilaterally into the substantia nigra of rats elicited contraversive turning. |
1978-01-27 |
2023-08-11 |
rat |
| T Segawa, Y Nakata, H Yajima, K Kitagaw. Further observation on the lack of active uptake system for substance P in the central nervous system. Japanese journal of pharmacology. vol 27. issue 4. 1978-01-27. PMID:926460. |
crude mitochondrial p2 fractions from bovine hypothalamus and substantia nigra, slices from rabbit spinal cord and mesencephalon and glial fractions from rabbit brain were incubated with [3h]-substance p and the uptake was measured and compared with those for 5-ht and gaba. |
1978-01-27 |
2023-08-11 |
rabbit |
| K G Lloyd, O Hornykiewic. Effect of chronic neuroleptic or L-DOPA administration on GABA levels in the rat substantia nigra. Life sciences. vol 21. issue 10. 1978-01-27. PMID:927011. |
effect of chronic neuroleptic or l-dopa administration on gaba levels in the rat substantia nigra. |
1978-01-27 |
2023-08-11 |
rat |
| K G Lloy. CNS compensation to dopamine neuron loss in Parkinson's disease. Advances in experimental medicine and biology. vol 90. 1978-01-27. PMID:930746. |
postmortem examination of parkinson's disease brains and study of animal models indicate that the following mechanisms may contribute to this cns compensation: 1) a decrease in striatal cholinergic activity, in an attempt to maintain a critical da:ach balance; and 2) a decrease in activity of gaba neurons in the striatum and substantia nigra, resulting in an increased firing rate of nigral dopamine cells. |
1978-01-27 |
2023-08-11 |
Not clear |
| J L Waddingto. Induction of rotational behaviour by intranigral baclofen suggests possible GABA-agonist activity. Experientia. vol 33. issue 10. 1977-11-30. PMID:561703. |
these results mimic those following unilateral elevation of gaba levels in the substantia nigra and suggest that baclofen may have some gaba agonist activity following intracerebral injection. |
1977-11-30 |
2023-08-11 |
rat |
| G Racagni, F Bruno, F Cattabeni, A Maggi, A M Di Giulio, M Parenti, A Groppett. Functional interaction between rat substantia nigra and striatum: GABA and dopamine interrelation. Brain research. vol 134. issue 2. 1977-10-31. PMID:890495. |
functional interaction between rat substantia nigra and striatum: gaba and dopamine interrelation. |
1977-10-31 |
2023-08-11 |
rat |
| R W Horton, C J Pycoc. Circling behavior in rodents following an imbalance of basal ganglia GABA concentrations. Pharmacology, biochemistry, and behavior. vol 6. issue 5. 1977-10-14. PMID:331345. |
unilateral focal injection of the gaba - transaminase inhibitor, ethanolamine o-sulphate, into one substantia nigra or globus pallidus of rats or the striatum of mice induces spontaneous and drug-induced circling behaviour. |
1977-10-14 |
2023-08-11 |
mouse |
| C C Mao, D L Cheney, E Marco, A Revuelta, E Cost. Turnover times of gamma-aminobutyric acid and acetylcholine in nucleus caudatus, nucleus accumbens, globus pallidus and substantia nigra: effects of repeated administration of haloperidol. Brain research. vol 132. issue 2. 1977-10-14. PMID:890488. |
turnover times of gamma-aminobutyric acid and acetylcholine in nucleus caudatus, nucleus accumbens, globus pallidus and substantia nigra: effects of repeated administration of haloperidol. |
1977-10-14 |
2023-08-11 |
Not clear |
| C C Mao, E Marco, A Revuelta, L Bertilsson, E Cost. The turnover rate of gamma-aminobutyric acid in the nuclei of telencephalon: implications in the pharmacology of antipsychotics and of a minor tranquilizer. Biological psychiatry. vol 12. issue 3. 1977-08-12. PMID:17436. |
the turnover rate of gaba is measured in substantia nigra, globus pallidus, n. accumbens, and striatum of rats injected with muscimol, a potent gaba agonist, and diazepam. |
1977-08-12 |
2023-08-11 |
rat |
| C C Mao, E Marco, A Revuelta, L Bertilsson, E Cost. The turnover rate of gamma-aminobutyric acid in the nuclei of telencephalon: implications in the pharmacology of antipsychotics and of a minor tranquilizer. Biological psychiatry. vol 12. issue 3. 1977-08-12. PMID:17436. |
haloperidol decreases gaba turnover in caudate but does not affect that in substantia nigra, whereas clozapine increases gaba turnover in both areas. |
1977-08-12 |
2023-08-11 |
rat |
| C C Mao, E Marco, A Revuelta, L Bertilsson, E Cost. The turnover rate of gamma-aminobutyric acid in the nuclei of telencephalon: implications in the pharmacology of antipsychotics and of a minor tranquilizer. Biological psychiatry. vol 12. issue 3. 1977-08-12. PMID:17436. |
it is suggested that an increase of gaba turnover and perhaps of gaba release in striatum and substantia nigra may account for the lack of tardive dyskinesia and extrapyramidal side effects of clozapine. |
1977-08-12 |
2023-08-11 |
rat |
| K G Iloyd, L Shemen, O Hornykiewic. Distribution of high affinity sodium-independent [3H]gamma-aminobutyric acid [3H]GABA binding in the human brain: alterations in Parkinson's disease. Brain research. vol 127. issue 2. 1977-07-18. PMID:861759. |
the binding of [3h]gaba to membranes from the substantia nigra, thalamus and internal or external pallidum was lower than for the above regions. |
1977-07-18 |
2023-08-11 |
human |
| K G Iloyd, L Shemen, O Hornykiewic. Distribution of high affinity sodium-independent [3H]gamma-aminobutyric acid [3H]GABA binding in the human brain: alterations in Parkinson's disease. Brain research. vol 127. issue 2. 1977-07-18. PMID:861759. |
in membranes prepared from parkinsonian patients [3h]gaba binding was greatly decreased in the substantia nigra, but not in other brain areas examined. |
1977-07-18 |
2023-08-11 |
human |
| M L Tappaz, M J Brownstein, I J Kopi. Glutamate decarboxylase (GAD) and gamma-aminobutyric acid (GABA) in discrete nuclei of hypothalamus and substantia nigra. Brain research. vol 125. issue 1. 1977-06-11. PMID:856403. |
glutamate decarboxylase (gad) and gamma-aminobutyric acid (gaba) in discrete nuclei of hypothalamus and substantia nigra. |
1977-06-11 |
2023-08-11 |
rat |
| M L Tappaz, M J Brownstein, I J Kopi. Glutamate decarboxylase (GAD) and gamma-aminobutyric acid (GABA) in discrete nuclei of hypothalamus and substantia nigra. Brain research. vol 125. issue 1. 1977-06-11. PMID:856403. |
the distribution of l-glutamate decarboxylase activity (gad) and gamma-aminobutyric acid (gaba) was investigated in the hypothalamic nuclei and in parts of the substantia nigra in the rat. |
1977-06-11 |
2023-08-11 |
rat |
| T M Jessell, L L Iverse. Inhibition of substance P release from the isolated rat substantia nigra by GABA [proceedings]. British journal of pharmacology. vol 59. issue 3. 1977-05-20. PMID:843724. |
inhibition of substance p release from the isolated rat substantia nigra by gaba [proceedings]. |
1977-05-20 |
2023-08-11 |
rat |
| L Bertilsson, C C Mao, E Cost. Application of principles of steady-state kinetics to the estimation of gamma-aminobutyric acid turnover rate in nuclei of rat brain. The Journal of pharmacology and experimental therapeutics. vol 200. issue 2. 1977-04-15. PMID:839439. |
the results showed that in the five brain areas studied, substantia nigra contained the highest gaba concentration, followed by globus pallidus, n. accumbens, deep cerebellar nuclei, n. caudatus and cerebellar cortex. |
1977-04-15 |
2023-08-11 |
rat |
| L Bertilsson, C C Mao, E Cost. Application of principles of steady-state kinetics to the estimation of gamma-aminobutyric acid turnover rate in nuclei of rat brain. The Journal of pharmacology and experimental therapeutics. vol 200. issue 2. 1977-04-15. PMID:839439. |
the concentrations of glutamate and gaba were comparable in some nuclei (substantia nigra and globus pallidus), but not in others. |
1977-04-15 |
2023-08-11 |
rat |
| L Bertilsson, C C Mao, E Cost. Application of principles of steady-state kinetics to the estimation of gamma-aminobutyric acid turnover rate in nuclei of rat brain. The Journal of pharmacology and experimental therapeutics. vol 200. issue 2. 1977-04-15. PMID:839439. |
the turnover rates of gaba in substantia nigra, globus pallidus, n. caudatus and n. accumbens were calculated by applying principles of steady-state kinetics to the changes with time in the 13c enrichment of glutamic acid and gaba. |
1977-04-15 |
2023-08-11 |
rat |
| L Bertilsson, C C Mao, E Cost. Application of principles of steady-state kinetics to the estimation of gamma-aminobutyric acid turnover rate in nuclei of rat brain. The Journal of pharmacology and experimental therapeutics. vol 200. issue 2. 1977-04-15. PMID:839439. |
in substantia nigra, n. accumbens and n. caudatus, the percentage of 13c incorporation into glutamic acid and gaba reached its maximum 10 to 15 minutes after the infusion. |
1977-04-15 |
2023-08-11 |
rat |