| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| U Ungerstedt, M Herrera-Marschitz, L Ståhle, U Tossman, T Zetterströ. Functional classification of different dopamine receptors. Psychopharmacology. Supplementum. vol 2. 1985-07-24. PMID:3159010. |
on the basis of results obtained following systemic and local treatment with picrotoxin it seems probable that d-2 receptors are located on gaba interneurons in the striatum. |
1985-07-24 |
2023-08-11 |
Not clear |
| R S Flint, J M Murphy, W J McBrid. Release of endogenous dopamine, 3,4-dihydroxyphenylacetic acid, and amino acid transmitters from rat striatal slices. Neurochemical research. vol 10. issue 4. 1985-07-23. PMID:2860579. |
the release of endogenous dopamine (da) and 3,4-dihydroxyphenylacetic acid (dopac) was measured in superfused striatal slices of the rat and the results compared with data obtained for the release of endogenous (a) da and dopac in the cerebral cortex, nucleus accumbens and thalamus; (b) 5-hydroxytryptamine (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), gaba, and glutamate in the striatum; and (c) gaba, glutamate and 5-ht in the cerebral cortex. |
1985-07-23 |
2023-08-11 |
rat |
| R S Flint, J M Murphy, W J McBrid. Release of endogenous dopamine, 3,4-dihydroxyphenylacetic acid, and amino acid transmitters from rat striatal slices. Neurochemical research. vol 10. issue 4. 1985-07-23. PMID:2860579. |
on the other hand, in the striatum, 16 mm mg2+ inhibited the ca2+-dependent, 60 mm k+-stimulated release of gaba and glutamate. |
1985-07-23 |
2023-08-11 |
rat |
| F Nicoletti, J L Mee. Estradiol benzoate decreases nigral GABAergic activity in male rats. Brain research. vol 332. issue 1. 1985-06-25. PMID:2986760. |
hypophysectomy decreased gaba content and gad activity in sn and gaba content in striatum. |
1985-06-25 |
2023-08-11 |
rat |
| M A Matin, K Hussai. Striatal neurochemical changes and motor dysfunction in mipafox-treated animals. Methods and findings in experimental and clinical pharmacology. vol 7. issue 2. 1985-06-19. PMID:2859406. |
the animals developed motor dysfunction-muscle twitchings, fasciculations and slight ataxia towards the end of the experimental period; the motor dysfunction was accompanied by neurochemical changes in the corpus striatum which included significantly reduced levels of cholinesterase, neurotoxicesterase, dopamine and gaba. |
1985-06-19 |
2023-08-11 |
rat |
| H Benet, K Fujimori, I K H. The basal ganglia in chlordecone-induced neurotoxicity in the mouse. Neurotoxicology. vol 6. issue 1. 1985-06-18. PMID:2581191. |
included are the effects of chlordecone on motor coordination, levels of biogenic amines, uptake of catecholamines and gaba, release of 3h-dopamine from striatal slices, newly synthesized dopamine, levels of dopamine metabolites in striatum, total and protein-bound ca++ in discrete areas of brain, and distribution of chlordecone in discrete areas of brain. |
1985-06-18 |
2023-08-11 |
mouse |
| T Nishikawa, B Scatto. Inhibitory influence of GABA on central serotonergic transmission. Raphé nuclei as the neuroanatomical site of the GABAergic inhibition of cerebral serotonergic neurons. Brain research. vol 331. issue 1. 1985-06-14. PMID:2985201. |
acute injection of the gamma-aminobutyric acid (gaba) mimetics progabide, aminooxyacetic acid, gamma-acetylenic gaba and dipropylacetamide reduced 5-hydroxytryptophan (5-htp) accumulation in serotonergic nerve terminal regions (prefrontal cortex, olfactory tubercle, septum, striatum, hypothalamus, hippocampus, substantia nigra, cerebellum and spinal cord) as well as in corresponding cell body areas (raphé dorsalis, medianus, pontis and magnus). |
1985-06-14 |
2023-08-11 |
Not clear |
| T Nishikawa, B Scatto. Inhibitory influence of GABA on central serotonergic transmission. Raphé nuclei as the neuroanatomical site of the GABAergic inhibition of cerebral serotonergic neurons. Brain research. vol 331. issue 1. 1985-06-14. PMID:2985201. |
local infusion of high concentrations of gaba or gaba mimetics into the striatum, septum or substantia nigra failed to modify 5-htp accumulation in these areas. |
1985-06-14 |
2023-08-11 |
Not clear |
| S Lindgren, N E Andé. Effect of the normal nerve impulse flow on the synthesis and utilization of GABA in the rat substantia nigra. Journal of neural transmission. vol 61. issue 1-2. 1985-05-03. PMID:3981161. |
the concentrations of gaba, glutamate, serine, glutamine, threonine, glycine and taurine in the substantia nigra and in the corpus striatum of the rat were determined electrochemically following condensation with o-phthalaldehyde-beta-mercaptoethanol and reverse-phase, high performance liquid chromatography. |
1985-05-03 |
2023-08-11 |
rat |
| S Lindgren, N E Andé. Effect of the normal nerve impulse flow on the synthesis and utilization of GABA in the rat substantia nigra. Journal of neural transmission. vol 61. issue 1-2. 1985-05-03. PMID:3981161. |
the concentrations of taurine in the substantia nigra and of gaba in the corpus striatum were initially lowered and later elevated following this lesion. |
1985-05-03 |
2023-08-11 |
rat |
| R M Beckstead, K S Kerse. Immunohistochemical demonstration of differential substance P-, met-enkephalin-, and glutamic-acid-decarboxylase-containing cell body and axon distributions in the corpus striatum of the cat. The Journal of comparative neurology. vol 232. issue 4. 1985-04-26. PMID:2579980. |
the immunohistochemical localization of neuronal cell bodies and axons reactive for substance p (sp) and methionine-enkephalin (me) was investigated in the corpus striatum of the adult cat brain and compared with that of glutamate decarboxylase (gad), synthetic enzyme for gamma-aminobutyric acid. |
1985-04-26 |
2023-08-11 |
cat |
| M Saeed Dar, W R Woole. The effect of acute ethanol on dopamine metabolism and other neurotransmitters in the hypothalamus and the corpus striatum of mice. Journal of neural transmission. vol 60. issue 3-4. 1985-04-18. PMID:6151966. |
the effect of acute ethanol on the levels of ne, da and its metabolites dopac and hva, as well as on the levels of gaba, in the corpus striatum and hypothalamus were investigated in mice in the first two hours after acute ethanol administration. |
1985-04-18 |
2023-08-12 |
mouse |
| M Saeed Dar, W R Woole. The effect of acute ethanol on dopamine metabolism and other neurotransmitters in the hypothalamus and the corpus striatum of mice. Journal of neural transmission. vol 60. issue 3-4. 1985-04-18. PMID:6151966. |
the concentration of ne and gaba in the hypothalamus and the corpus striatum was unchanged at any time period after ethanol. |
1985-04-18 |
2023-08-12 |
mouse |
| M S Dar, W R Woole. GABA mediation of the central effects of acute and chronic ethanol in mice. Pharmacology, biochemistry, and behavior. vol 22. issue 1. 1985-03-27. PMID:4038803. |
in the acute studies ethanol had a biphasic effect on aoaa-induced gaba accumulation in the hypothalamus and corpus striatum: low doses prevented and a slightly higher dose was without effect on gaba accumulation. |
1985-03-27 |
2023-08-11 |
mouse |
| b' H H Hennies, W A G\\xc3\\xbcnzler, L Floh\\xc3\\xa. Influence of supidimide on brain neurotransmitter systems of rats and mice. Arzneimittel-Forschung. vol 34. issue 11. 1985-03-14. PMID:6084511.' |
with the above restrictions, the following parameters can be rated as not influenced by supidimide: levels of tryptophan in rat brain and serum (free and total); 5-ht biosynthesis in vivo (rat brain; 5-ht accumulation after monoamine oxidase (mao) blockade); activity of mao-a and mao-b (rat brain mitochondria); uptake of 5-ht, ne and da (rat synaptosomes); 5-ht receptor binding ( [3h]-lsd binding assay in rat cortical membranes); tyrosine hydroxylase activity (rat adrenal glands); catechol-o-methyl transferase (comt) (rat liver); ne binding to central alpha 1- and alpha 2-receptors (rat brain; radioligand assay with [3h]-dihydroergocryptine, [3h]-prazosin and [3h]-wb 4101 (2',6'-dimethoxy-(g-3h]-phenoxy]-ethylaminomethylbenzo-1,4-dioxane ); da levels (whole rat brain and striata); dihydroxyphenylacetic acid (dopac) levels (whole rat brain without cerebellum and striata); elevated dopac levels after pretreatment with haloperidol; da-dependent adenylate cyclase in vitro (rat striatum); d2 receptor binding ( [3h]-spiperone binding assay, rat striatum); gaba levels (mouse brain); gaba transaminase activity (mouse brain stem); sodium-independent [3h]-gaba receptor binding (rat brain) and benzodiazepine binding (rat cortical membranes, [3h]-diazepam binding assay). |
1985-03-14 |
2023-08-12 |
mouse |
| C Geula, D Asdouria. Circling and bodily asymmetry induced by injection of GABA agonists and antagonists into the superior colliculus. Pharmacology, biochemistry, and behavior. vol 21. issue 6. 1985-03-05. PMID:6522415. |
these results demonstrate that dlsc gaba produces circling and asymmetry, and suggest that the dlsc as well as the mrf serve as output stations for the expression of circling behavior initiated at the striatum. |
1985-03-05 |
2023-08-12 |
Not clear |
| G Gianutsos, P D Suzda. Evidence for down-regulation of GABA receptors following long-term gamma-butyrolactone. Naunyn-Schmiedeberg's archives of pharmacology. vol 328. issue 1. 1985-02-21. PMID:6096730. |
the binding of gaba to its putative receptor was reduced in the gbl group as evidenced by a decrease in the bmax in the cerebral cortex, cerebellum, and striatum, but not in the hippocampus. |
1985-02-21 |
2023-08-12 |
mouse |
| H H Kornhuber, J Kornhuber, J S Kim, M E Kornhube. [A biochemical theory of schizophrenia]. Der Nervenarzt. vol 55. issue 11. 1985-02-04. PMID:6151120. |
the classical and the new atypical neuroleptic drugs show differential effects on glutamate and gaba in the brain tissue of the striatum and in the cerebrospinal fluid. |
1985-02-04 |
2023-08-12 |
Not clear |
| H H Kornhuber, J Kornhuber, J S Kim, M E Kornhube. [A biochemical theory of schizophrenia]. Der Nervenarzt. vol 55. issue 11. 1985-02-04. PMID:6151120. |
haloperidol, on the other hand, enhances the gaba level in the striatum in a dose-related manner. |
1985-02-04 |
2023-08-12 |
Not clear |
| C Reavill, P Jenner, C D Marsde. Gamma-aminobutyric acid and basal ganglia outflow pathways. Ciba Foundation symposium. vol 107. 1985-01-24. PMID:6094124. |
neurons containing gamma-aminobutyric acid (gaba) are important outflow pathways from the striatum to the pallidal complex and substantia nigra. |
1985-01-24 |
2023-08-12 |
rat |