| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Borsini, A Mancinelli, V D'Aranno, S Evangelista, A Mel. On the role of endogenous GABA in the forced swimming test in rats. Pharmacology, biochemistry, and behavior. vol 29. issue 2. 1988-06-09. PMID:3362921. |
after 5 hr from single dosing, 25 mg/kg aoaa increased gaba levels less than 50 mg/kg aoaa in the brainstem, nucleus accumbens, frontal cortex and striatum, and increased it to same extent in the other areas. |
1988-06-09 |
2023-08-11 |
rat |
| R M Pos. Time course of clinical effects of carbamazepine: implications for mechanisms of action. The Journal of clinical psychiatry. vol 49 Suppl. 1988-05-12. PMID:3280560. |
these effects might include carbamazepine's ability to increase acetylcholine in the striatum, decrease probenecid-induced levels of csf homovanillic acid (hva) in man and dopamine turnover in animals, decrease csf norepinephrine in manic patients, inhibit adenylate cyclase activity (in response to norepinephrine, dopamine, adenosine, or ouabain), decrease gaba turnover, or act as a vasopressin agonist. |
1988-05-12 |
2023-08-11 |
Not clear |
| J Korf, H C Klein, K Venema, F Postem. Increases in striatal and hippocampal impedance and extracellular levels of amino acids by cardiac arrest in freely moving rats. Journal of neurochemistry. vol 50. issue 4. 1988-04-21. PMID:2894408. |
fifteen minutes after cardiac arrest, the levels of gaba were 617 and 774% of the resting release in the striatum and hippocampus, respectively. |
1988-04-21 |
2023-08-11 |
rat |
| T R Winder, G Y Minuk, E J Sargeant, T P Selan. gamma-Aminobutyric acid (GABA) and sepsis-related encephalopathy. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 15. issue 1. 1988-04-21. PMID:3345457. |
in order to determine whether disturbances in gaba homeostasis might play a role in the pathogenesis of sepsis-related encephalopathy, serum and brain tissue gaba concentrations from six areas of the brain (cortex, diencephalon, striatum, hippocampus, midbrain, and pons-medulla) were determined in a rat model of bacterial sepsis (cecal ligation and perforation). |
1988-04-21 |
2023-08-11 |
rat |
| I Kanazawa, S Kwak, H Sasaki, O Muramoto, T Mizutani, A Hori, N Nukin. Studies on neurotransmitter markers of the basal ganglia in Pick's disease, with special reference to dopamine reduction. Journal of the neurological sciences. vol 83. issue 1. 1988-04-12. PMID:2450180. |
gaba and substance p levels in the substantia nigra and the globus pallidus were generally decreased, corresponding to the moderate to severe loss of small neurones in the striatum. |
1988-04-12 |
2023-08-11 |
Not clear |
| D W Ellison, M F Beal, M F Mazurek, J R Malloy, E D Bird, J B Marti. Amino acid neurotransmitter abnormalities in Huntington's disease and the quinolinic acid animal model of Huntington's disease. Brain : a journal of neurology. vol 110 ( Pt 6). 1988-03-07. PMID:2892568. |
concentrations of gamma-aminobutyric acid (gaba), glutamate, aspartate, and taurine were measured in postmortem tissue from the brains of patients with huntington's disease (hd) and in the quinolinic acid (qa) lesioned rat striatum. |
1988-03-07 |
2023-08-11 |
rat |
| D W Ellison, M F Beal, M F Mazurek, J R Malloy, E D Bird, J B Marti. Amino acid neurotransmitter abnormalities in Huntington's disease and the quinolinic acid animal model of Huntington's disease. Brain : a journal of neurology. vol 110 ( Pt 6). 1988-03-07. PMID:2892568. |
significant reductions in both gaba and glutamate were found in hd striatum. |
1988-03-07 |
2023-08-11 |
rat |
| M Guttma. Receptors in the basal ganglia. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 14. issue 3 Suppl. 1988-01-13. PMID:2824009. |
the striatum has receptors for dopamine, gaba and benzodiazepines, acetylcholine, opiates, substance p, glutamate and cholecystokinin. |
1988-01-13 |
2023-08-11 |
Not clear |
| W Löscher, W S Schwar. Further evidence for abnormal GABAergic circuits in amygdala-kindled rats. Brain research. vol 420. issue 2. 1987-12-22. PMID:2823978. |
compared to controls, gaba synthesis was reduced in the ipsilateral (stimulated) amygdala and in corpus striatum and substantia nigra. |
1987-12-22 |
2023-08-11 |
rat |
| W Löscher, W S Schwar. Further evidence for abnormal GABAergic circuits in amygdala-kindled rats. Brain research. vol 420. issue 2. 1987-12-22. PMID:2823978. |
gaba receptor binding was decreased in amygdala and substantia nigra but significantly increased in the striatum. |
1987-12-22 |
2023-08-11 |
rat |
| A R Green, M C Minchin, N D Vincen. Inhibition of GABA release from slices prepared from several brain regions of rats at various times following a convulsion. British journal of pharmacology. vol 92. issue 1. 1987-12-16. PMID:3664084. |
1 a method is described for the measurement of the k+-evoked release of endogenous gamma-aminobutyric acid (gaba) from slices of rat cortex, hippocampus and striatum. |
1987-12-16 |
2023-08-11 |
rat |
| A R Green, M C Minchin, N D Vincen. Inhibition of GABA release from slices prepared from several brain regions of rats at various times following a convulsion. British journal of pharmacology. vol 92. issue 1. 1987-12-16. PMID:3664084. |
2 in tissue prepared 30 min following an electroconvulsive shock, k+-evoked gaba release (above basal release) was inhibited by 45% in cortex, 50% in hippocampus and 75% in striatum. |
1987-12-16 |
2023-08-11 |
rat |
| A R Green, N D Vincen. The effect of repeated electroconvulsive shock on GABA synthesis and release in regions of rat brain. British journal of pharmacology. vol 92. issue 1. 1987-12-16. PMID:3664087. |
1 the release of endogenous gamma-aminobutyric acid (gaba) from slices of rat cortex, hippocampus and striatum prepared both 30 min and 24 h after the last of a series of electroconvulsive shocks (5 seizures given spread out over 10 days) has been investigated. |
1987-12-16 |
2023-08-11 |
rat |
| A R Green, N D Vincen. The effect of repeated electroconvulsive shock on GABA synthesis and release in regions of rat brain. British journal of pharmacology. vol 92. issue 1. 1987-12-16. PMID:3664087. |
however, 30 min after the last convulsion, k+-evoked gaba release above basal release was inhibited in both hippocampus (20%) and striatum (33%) but not in the cortex. |
1987-12-16 |
2023-08-11 |
rat |
| A R Green, N D Vincen. The effect of repeated electroconvulsive shock on GABA synthesis and release in regions of rat brain. British journal of pharmacology. vol 92. issue 1. 1987-12-16. PMID:3664087. |
3 in confirmation of an earlier report, chronic electroconvulsive shock was found to increase basal gaba content in striatum and inhibit synthesis by 34%. |
1987-12-16 |
2023-08-11 |
rat |
| A R Green, N D Vincen. The effect of repeated electroconvulsive shock on GABA synthesis and release in regions of rat brain. British journal of pharmacology. vol 92. issue 1. 1987-12-16. PMID:3664087. |
5 it is proposed that repeated electroconvulsive shocks lead to a substantial inhibition of release in the striatum and hippocampus and a long-term inhibition of gaba synthesis in these regions. |
1987-12-16 |
2023-08-11 |
rat |
| A R Green, A Metz, M C Minchin, N D Vincen. Inhibition of the rate of GABA synthesis in regions of rat brain following a convulsion. British journal of pharmacology. vol 92. issue 1. 1987-12-16. PMID:3664092. |
1 the rate of synthesis of gamma-aminobutyric acid (gaba) in the cortex, hippocampus and striatum of rat brain was assessed by measuring the linear rate of accumulation of gaba following injection of amino-oxyacetic acid (aoaa). |
1987-12-16 |
2023-08-11 |
rat |
| M W Warenycia, G M McKenzie, M Murphy, J C Szer. The effects of cortical ablation on multiple unit activity in the striatum following dexamphetamine. Neuropharmacology. vol 26. issue 8. 1987-11-18. PMID:2889162. |
on the other hand, cortical ablations did not alter the content of either the gamma-aminobutyric acid or glutamine of the striatum. |
1987-11-18 |
2023-08-11 |
rat |
| H Hagberg, P Andersson, I Kjellmer, K Thiringer, M Thordstei. Extracellular overflow of glutamate, aspartate, GABA and taurine in the cortex and basal ganglia of fetal lambs during hypoxia-ischemia. Neuroscience letters. vol 78. issue 3. 1987-10-22. PMID:2888062. |
abolished evoked potentials and reduced cerebral blood flow, marked extracellular elevations of glutamate (3- to 11-fold), aspartate (3- to 7-fold), gamma-aminobutyric acid (gaba) (3- to 5-fold) and taurine (3- to 18-fold) occurred, the higher values representing striatum. |
1987-10-22 |
2023-08-11 |
Not clear |
| N E Andén, S Lindgren, A Magnusso. Regional differences in the changes in rat brain GABA concentrations post mortem and following inhibition of the synthesis and metabolism. Pharmacology & toxicology. vol 60. issue 5. 1987-09-22. PMID:3615349. |
some other regions (cerebellum, cuneate nucleus, corpus striatum, hippocampus) were included where the cellular localization of gaba is less certain. |
1987-09-22 |
2023-08-11 |
rat |