| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Changhan Ouyang, Lianjun Guo, Qing Lu, Xulin Xu, Hongxing Wan. Enhanced activity of GABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum. Neuroscience letters. vol 420. issue 2. 2007-08-10. PMID:17531382. |
using push-pull perfusion technique, we investigated the regulatory role of gamma-aminobutyric acid (gaba) and its receptors in modifying the amount of glutamate in rat striatum with ischemia. |
2007-08-10 |
2023-08-12 |
rat |
| Changhan Ouyang, Lianjun Guo, Qing Lu, Xulin Xu, Hongxing Wan. Enhanced activity of GABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum. Neuroscience letters. vol 420. issue 2. 2007-08-10. PMID:17531382. |
the present study demonstrates that the excessive release of glutamate or the overly activated glutamate receptor, triggered by cerebral ischemia, can be down-regulated by exogenous gaba or by increased activity of gaba receptors, especially the presynaptic gaba(b) receptors, which might be one of the important mechanisms to protect against striatum neuronal damage from over stimulation by excessive glutamate during ischemia. |
2007-08-10 |
2023-08-12 |
rat |
| Xiaodong Bie, Yueqing Chen, Jinn Han, Haibin Dai, Haitong Wan, Tongfeng Zha. Effects of gastrodin on amino acids after cerebral ischemia-reperfusion injury in rat striatum. Asia Pacific journal of clinical nutrition. vol 16 Suppl 1. 2007-06-14. PMID:17392124. |
the levels of glutamic acid (glu), aspartic acid (asp), gamma-aminobutyric acid (gaba), taurine (tau) in striatum in the rats of the 3 groups were measured with the method of microdialysis-hplc techniques. |
2007-06-14 |
2023-08-12 |
rat |
| Qiang Chen, Tong H Lee, William C Wetsel, Qi-An Sun, Yingmiao Liu, Colin Davidson, Xueying Xiong, Everett H Ellinwood, Xiuwu Zhan. Reversal of cocaine sensitization-induced behavioral sensitization normalizes GAD67 and GABAA receptor alpha2 subunit expression, and PKC zeta activity. Biochemical and biophysical research communications. vol 356. issue 3. 2007-06-06. PMID:17382295. |
these results suggest that reversal of cocaine-induced behavioral sensitization is associated with reversal of region-specific changes in gaba function and pkc activity in the striatum. |
2007-06-06 |
2023-08-12 |
rat |
| Kleopatra Fragioudaki, Elias D Kouvelas, Rosella Cristiani, Panagiotis Giompres, Paola Bagnoli, Adamantia Mitsaco. Expression of amino acid receptors and neural peptides in the weaver mouse brain. Brain research. vol 1140. 2007-06-01. PMID:16626633. |
in the present study, we conducted: (i) in situ hybridization in order to investigate the expression of kainate and gaba(a) receptor subunits and the pre-proenkephalin and prodynorphin peptides in the brain of weaver mouse (a genetic model of dopamine deficiency) and (ii) immunocytochemistry in order to study the somatostatin-positive cells in weaver striatum. |
2007-06-01 |
2023-08-12 |
mouse |
| Kleopatra Fragioudaki, Elias D Kouvelas, Rosella Cristiani, Panagiotis Giompres, Paola Bagnoli, Adamantia Mitsaco. Expression of amino acid receptors and neural peptides in the weaver mouse brain. Brain research. vol 1140. 2007-06-01. PMID:16626633. |
our results indicated: (i) increases in mrna levels of ka2 and glur6 kainate receptor subunits, of alpha(4) and beta(3) gaba(a) receptor subunits and of pre-proenkephalin and prodynorphin in 6-month-old weaver striatum; (ii) a decrease in alpha(1) and beta(2) gaba(a) subunit mrnas in 6-month-old weaver globus pallidus; (iii) increases in ka2, alpha(4) and beta(3) and decreases in alpha(2) and beta(2) mrnas in the 6-month-old weaver somatosensory cortex; and (iv) an increase in somatostatin-immunopositive cells in 3-month-old weaver striatum. |
2007-06-01 |
2023-08-12 |
mouse |
| Kleopatra Fragioudaki, Elias D Kouvelas, Rosella Cristiani, Panagiotis Giompres, Paola Bagnoli, Adamantia Mitsaco. Expression of amino acid receptors and neural peptides in the weaver mouse brain. Brain research. vol 1140. 2007-06-01. PMID:16626633. |
we suggest that: (i) in striatum, the alterations are induced by the induction of the transcription factor deltafosb (for glur6, pre-proenkephalin and prodynorphin mrnas) and the suppression of transcription factors like ngf-ib (nerve growth factor inducible b; for the ka2 mrna), in response to dopamine depletion; (ii) in striatum and cortex, the alterations in the expression of the gaba(a) subunits indicate an increase of extrasynaptic versus a decrease of synaptic gaba(a) receptors; and (iii) in globus pallidus, the increased striatopallidal gabaergic transmission leads to a decrease in the number of gaba(a) receptors. |
2007-06-01 |
2023-08-12 |
mouse |
| Lei Wang, Timothy J Maher, Richard J Wurtma. Oral L-glutamine increases GABA levels in striatal tissue and extracellular fluid. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 4. 2007-05-17. PMID:17218538. |
these data suggest that gaba synthesis in, and release from, rat striatum may be regulated in part by circulating glutamine. |
2007-05-17 |
2023-08-12 |
rat |
| Chien-Lu Liu, Yi-Ruu Lin, Ming-Huan Chan, Hwei-Hsien Che. Effects of toluene exposure during brain growth spurt on GABA(A) receptor-mediated functions in juvenile rats. Toxicological sciences : an official journal of the Society of Toxicology. vol 95. issue 2. 2007-04-05. PMID:17108153. |
the relative abundance of the mrnas encoding various subunits of gaba(a) receptor (alpha1, alpha2, alpha4, alpha5, alpha6, beta2, beta3, gamma2s, gamma2l) was examined in four brain regions (hippocampus, striatum, cortex, and cerebellum) by semiquantitative reverse transcription-pcr. |
2007-04-05 |
2023-08-12 |
rat |
| Elizabeth Hernández-Echeagaray, Carlos Cepeda, Marjorie A Ariano, Mary Kay Lobo, David R Sibley, Michael S Levin. Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype. Neurochemical research. vol 32. issue 2. 2007-03-28. PMID:17031565. |
we conclude that d(1) receptors are the main d1-like receptor subtype involved in the modulation of gaba currents and that d(5) receptors contribute to the normal expression of these currents in the striatum. |
2007-03-28 |
2023-08-12 |
mouse |
| Lynette J Tippett, Henry J Waldvogel, Sally J Thomas, Virginia M Hogg, Willeke van Roon-Mom, Beth J Synek, Ann M Graybiel, Richard L M Faul. Striosomes and mood dysfunction in Huntington's disease. Brain : a journal of neurology. vol 130. issue Pt 1. 2007-02-01. PMID:17040921. |
we report here a significant association between pronounced mood dysfunction in huntington's disease patients and differential loss of the gaba(a) receptor marker in striosomes of the striatum. |
2007-02-01 |
2023-08-12 |
Not clear |
| Lynette J Tippett, Henry J Waldvogel, Sally J Thomas, Virginia M Hogg, Willeke van Roon-Mom, Beth J Synek, Ann M Graybiel, Richard L M Faul. Striosomes and mood dysfunction in Huntington's disease. Brain : a journal of neurology. vol 130. issue Pt 1. 2007-02-01. PMID:17040921. |
we suggest that variation in clinical symptomatology in huntington's disease is associated with variation in the relative abnormality of gaba(a) receptor expression in the striosome and matrix compartments of the striatum, and that striosome-related circuits may modulate mood functioning. |
2007-02-01 |
2023-08-12 |
Not clear |
| Tiziana Antonelli, Kjell Fuxe, Luigi Agnati, Elisa Mazzoni, Sergio Tanganelli, Maria Cristina Tomasini, Luca Ferrar. Experimental studies and theoretical aspects on A2A/D2 receptor interactions in a model of Parkinson's disease. Relevance for L-dopa induced dyskinesias. Journal of the neurological sciences. vol 248. issue 1-2. 2007-01-23. PMID:16765381. |
the a2a agonist cgs21680 and/or the d2-like agonist quinpirole were perfused via reverse microdialysis into the da denervated striatum and the effects on globus pallidus (gp) extracellular gaba levels were evaluated. |
2007-01-23 |
2023-08-12 |
Not clear |
| Tiziana Antonelli, Kjell Fuxe, Luigi Agnati, Elisa Mazzoni, Sergio Tanganelli, Maria Cristina Tomasini, Luca Ferrar. Experimental studies and theoretical aspects on A2A/D2 receptor interactions in a model of Parkinson's disease. Relevance for L-dopa induced dyskinesias. Journal of the neurological sciences. vol 248. issue 1-2. 2007-01-23. PMID:16765381. |
cgs21680 alone produced in the da denervated striatum a transient rise of gp gaba levels. |
2007-01-23 |
2023-08-12 |
Not clear |
| Tiziana Antonelli, Kjell Fuxe, Luigi Agnati, Elisa Mazzoni, Sergio Tanganelli, Maria Cristina Tomasini, Luca Ferrar. Experimental studies and theoretical aspects on A2A/D2 receptor interactions in a model of Parkinson's disease. Relevance for L-dopa induced dyskinesias. Journal of the neurological sciences. vol 248. issue 1-2. 2007-01-23. PMID:16765381. |
quinpirole perfused alone into the da denervated striatum reduced gp gaba levels, which was not only counteracted by coperfused cgs21680, but led to an enhancement of the gaba levels, which was larger than that seen with cgs21680 alone. |
2007-01-23 |
2023-08-12 |
Not clear |
| Giuseppe Di Giovanni, Vincenzo Di Matteo, Massimo Pierucci, Arcangelo Benigno, Ennio Esposit. Serotonin involvement in the basal ganglia pathophysiology: could the 5-HT2C receptor be a new target for therapeutic strategies? Current medicinal chemistry. vol 13. issue 25. 2006-12-05. PMID:17073648. |
in fact, serotonergic terminals have been reported to make synaptic contacts with dopamine (da)-containing neurons and gamma-aminobutyric acid (gaba)-containing neurons in the striatum, globus pallidus, subthalamus and substantia nigra. |
2006-12-05 |
2023-08-12 |
human |
| Jordi Gomez-Ramirez, Tom H Johnston, Naomi P Visanji, Susan H Fox, Jonathan M Brotchi. Histamine H3 receptor agonists reduce L-dopa-induced chorea, but not dystonia, in the MPTP-lesioned nonhuman primate model of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 21. issue 6. 2006-11-14. PMID:16532454. |
histamine h3 heteroreceptors can reduce glutamate and gamma-aminobutyric acid (gaba) transmission in the striatum and substantia nigra reticulata, respectively. |
2006-11-14 |
2023-08-12 |
marmoset |
| S J Enna, Scott A Reisman, John A Stanfor. CGP 56999A, a GABA(B) receptor antagonist, enhances expression of brain-derived neurotrophic factor and attenuates dopamine depletion in the rat corpus striatum following a 6-hydroxydopamine lesion of the nigrostriatal pathway. Neuroscience letters. vol 406. issue 1-2. 2006-11-03. PMID:16890350. |
cgp 56999a, a gaba(b) receptor antagonist, enhances expression of brain-derived neurotrophic factor and attenuates dopamine depletion in the rat corpus striatum following a 6-hydroxydopamine lesion of the nigrostriatal pathway. |
2006-11-03 |
2023-08-12 |
human |
| S J Enna, Scott A Reisman, John A Stanfor. CGP 56999A, a GABA(B) receptor antagonist, enhances expression of brain-derived neurotrophic factor and attenuates dopamine depletion in the rat corpus striatum following a 6-hydroxydopamine lesion of the nigrostriatal pathway. Neuroscience letters. vol 406. issue 1-2. 2006-11-03. PMID:16890350. |
in contrast, as compared to animals receiving saline only, daily treatment with the gaba(b) receptor antagonist significantly attenuated the 6-hydroxydopamine-induced decline in da and increased the expression of bdnf in the ipsilateral striatum. |
2006-11-03 |
2023-08-12 |
human |
| I T Demchenko, C A Piantados. Nitric oxide amplifies the excitatory to inhibitory neurotransmitter imbalance accelerating oxygen seizures. Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc. vol 33. issue 3. 2006-08-08. PMID:16869530. |
interstitial no and amino acids: aspartate (asp), glutamate (glu) and gamma-aminobutyric acid (gaba) were determined in the striatum by microdialysis coupled with hplc. |
2006-08-08 |
2023-08-12 |
rat |