| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiu-Miao Li, Ri-Le Wendu, Jin Yao, Yan Ren, Yu-Xia Zhao, Guo-Fan Cao, Jiang Qin, Biao Ya. Abnormal glutamate metabolism in the retina of aquaporin 4 (AQP4) knockout mice upon light damage. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 6. 2015-01-05. PMID:24368741. |
however, the effect of aqp4 knockout on glutamate metabolism is still unclear in the retina. |
2015-01-05 |
2023-08-12 |
mouse |
| T Toimela, H Mäenpää, H Täht. Retinal müller cell culture. Alternatives to laboratory animals : ATLA. vol 28. issue 3. 2014-12-02. PMID:25419929. |
the main excitatory neurotransmitter in the retina is glutamate. |
2014-12-02 |
2023-08-13 |
Not clear |
| T Toimela, H Mäenpää, H Täht. Retinal müller cell culture. Alternatives to laboratory animals : ATLA. vol 28. issue 3. 2014-12-02. PMID:25419929. |
müller cells regulate the amount of glutamate in the synaptic regions of the neural network in the retina. |
2014-12-02 |
2023-08-13 |
Not clear |
| Lisa Nivison-Smith, Jacqueline Chua, Seong-Seng Tan, Michael Kalloniati. Amino acid signatures in the developing mouse retina. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 33. 2014-10-10. PMID:24368173. |
this study characterizes the developmental patterns of seven key amino acids: glutamate, γ-amino-butyric acid (gaba), glycine, glutamine, aspartate, alanine and taurine in the mouse retina. |
2014-10-10 |
2023-08-12 |
mouse |
| Ana María López-Colomé, Zila Martínez-Lozada, Alain M Guillem, Edith López, Arturo Orteg. Glutamate transporter-dependent mTOR phosphorylation in Müller glia cells. ASN neuro. vol 4. issue 5. 2014-09-02. PMID:22817638. |
glu (glutamate), the excitatory transmitter at the main signalling pathway in the retina, is critically involved in changes in the protein repertoire through the activation of signalling cascades, which regulate protein synthesis at transcriptional and translational levels. |
2014-09-02 |
2023-08-12 |
chicken |
| Wen Fan, Yiqiao Xing, Yongmei Zhong, Changzheng Chen, Yin She. Expression of NMDA receptor subunit 1 in the rat retina. Acta histochemica. vol 115. issue 1. 2014-08-12. PMID:22512920. |
n-methyl-d-aspartate receptors (nmdars) belong to the ionotropic glutamate receptors, which play key roles in neuronal communication in the retina. |
2014-08-12 |
2023-08-12 |
rat |
| Theresa Puthussery, Kumiko A Percival, Sowmya Venkataramani, Jacqueline Gayet-Primo, Ulrike Grünert, W Rowland Taylo. Kainate receptors mediate synaptic input to transient and sustained OFF visual pathways in primate retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 22. 2014-08-05. PMID:24872565. |
here we studied the glutamate receptors expressed by off-bipolar cells in slice preparations of macaque monkey retina, where the low (midget/parvocellular) and high-frequency (parasol/magnocellular) temporal channels are well characterized. |
2014-08-05 |
2023-08-13 |
monkey |
| Ya Fatou Njie-Mbye, Madhura Kulkarni-Chitnis, Catherine A Opere, Aaron Barrett, Sunny E Ohi. Lipid peroxidation: pathophysiological and pharmacological implications in the eye. Frontiers in physiology. vol 4. 2014-06-24. PMID:24379787. |
whereas isoprostanes attenuate dopamine release from mammalian neural retina, in vitro, these novel arachidonic acid metabolites exhibit a biphasic regulatory effect on glutamate release from retina and can regulate amino acid neurotransmitter metabolism without inducing cell death in the retina. |
2014-06-24 |
2023-08-12 |
Not clear |
| Makoto Ishikaw. Abnormalities in glutamate metabolism and excitotoxicity in the retinal diseases. Scientifica. vol 2013. 2014-06-24. PMID:24386591. |
in the physiological condition, glutamate acts as an excitatory neurotransmitter in the retina. |
2014-06-24 |
2023-08-12 |
Not clear |
| Bart G Borghuis, Loren L Looger, Susumu Tomita, Jonathan B Dem. Kainate receptors mediate signaling in both transient and sustained OFF bipolar cell pathways in mouse retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 18. 2014-06-23. PMID:24790183. |
in the retina, it has been proposed that distinct off cone bipolar cell types generate fast/transient and slow/sustained pathways by the differential expression of ampa- and kainate-type glutamate receptors, respectively. |
2014-06-23 |
2023-08-13 |
mouse |
| Ivan Anastassov, Harris Ripps, Richard L Chappel. Cytoprotection by endogenous zinc in the vertebrate retina. Journal of neurochemistry. vol 129. issue 2. 2014-05-27. PMID:24286124. |
we hypothesized that zinc feedback may serve to protect the retina from glutamate excitotoxicity, and conducted in vivo experiments on the retina of the skate (raja erinacea) to determine the effects of removing endogenous zinc by chelation. |
2014-05-27 |
2023-08-12 |
Not clear |
| Ivan Anastassov, Harris Ripps, Richard L Chappel. Cytoprotection by endogenous zinc in the vertebrate retina. Journal of neurochemistry. vol 129. issue 2. 2014-05-27. PMID:24286124. |
our results are a good indication that zinc, co-released with glutamate by photoreceptors, provides an auto-feedback system that plays an important cytoprotective role in the retina. |
2014-05-27 |
2023-08-12 |
Not clear |
| Shanti R Tummala, Adam Neinstein, Marie E Fina, Anuradha Dhingra, Noga Vard. Localization of Cacna1s to ON bipolar dendritic tips requires mGluR6-related cascade elements. Investigative ophthalmology & visual science. vol 55. issue 3. 2014-05-06. PMID:24519419. |
l-type voltage gated calcium channels in retina localize primarily at the presynaptic active zones of photoreceptors and bipolar cells where they modulate glutamate release. |
2014-05-06 |
2023-08-12 |
Not clear |
| Dongwook Lee, Myoung Sup Shim, Keun-Young Kim, You Hyun Noh, Heemin Kim, Sang Yeop Kim, Robert N Weinreb, Won-Kyu J. Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma. Investigative ophthalmology & visual science. vol 55. issue 2. 2014-04-14. PMID:24458150. |
to test whether a diet supplemented with coenzyme q10 (coq10) ameliorates glutamate excitotoxicity and oxidative stress-mediated retinal ganglion cell (rgc) degeneration by preventing mitochondrial alterations in the retina of glaucomatous dba/2j mice. |
2014-04-14 |
2023-08-12 |
mouse |
| Clairton F de Souza, Monica L Acosta, Philip J Polkinghorne, Charles N J McGhee, Michael Kalloniati. Amino acid immunoreactivity in normal human retina and after brachytherapy. Clinical & experimental optometry. vol 96. issue 5. 2014-04-07. PMID:23331319. |
the distribution pattern of glutamate, γ-amino butyric acid (gaba), glycine, glutamine and taurine, reflected patterns established in the primate retina. |
2014-04-07 |
2023-08-12 |
human |
| Rossella Russo, Federica Cavaliere, Giuseppe Pasquale Varano, Marco Milanese, Annagrazia Adornetto, Carlo Nucci, Giambattista Bonanno, Luigi Antonio Morrone, Maria Tiziana Corasaniti, Giacinto Bagett. Impairment of neuronal glutamate uptake and modulation of the glutamate transporter GLT-1 induced by retinal ischemia. PloS one. vol 8. issue 8. 2014-04-01. PMID:23936321. |
in the retina, glutamate transport is mainly operated by the glial glutamate transporter glast and the neuronal transporter glt-1. |
2014-04-01 |
2023-08-12 |
rat |
| Rossella Russo, Federica Cavaliere, Giuseppe Pasquale Varano, Marco Milanese, Annagrazia Adornetto, Carlo Nucci, Giambattista Bonanno, Luigi Antonio Morrone, Maria Tiziana Corasaniti, Giacinto Bagett. Impairment of neuronal glutamate uptake and modulation of the glutamate transporter GLT-1 induced by retinal ischemia. PloS one. vol 8. issue 8. 2014-04-01. PMID:23936321. |
these results support a role for neuronal transporters in glutamate accumulation observed in the retina following an ischemic event and suggest the presence of a glt-1 neuronal new alternative splice variant, induced in response to the detrimental stimulus. |
2014-04-01 |
2023-08-12 |
rat |
| K Namekata, A Kimura, K Kawamura, X Guo, C Harada, K Tanaka, T Harad. Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma. Cell death and differentiation. vol 20. issue 9. 2014-03-31. PMID:23852370. |
we previously reported that glutamate/aspartate transporter (glast) is a major glutamate transporter in the retina, and rgc degeneration due to glutamate neurotoxicity and oxidative stress is observed in glast-deficient (ko) mice. |
2014-03-31 |
2023-08-12 |
mouse |
| Nicole Schneider, Sönke Cordeiro, Jan-Philipp Machtens, Simona Braams, Thomas Rauen, Christoph Fahlk. Functional properties of the retinal glutamate transporters GLT-1c and EAAT5. The Journal of biological chemistry. vol 289. issue 3. 2014-03-17. PMID:24307171. |
in the mammalian retina, glutamate uptake is mediated by members of a family of glutamate transporters known as "excitatory amino acid transporters (eaats)." |
2014-03-17 |
2023-08-12 |
mouse |
| Takayuki Nakagawa, Shuji Kanek. SLC1 glutamate transporters and diseases: psychiatric diseases and pathological pain. Current molecular pharmacology. vol 6. issue 2. 2014-02-26. PMID:23876150. |
eaats are expressed in glial cells (eaat1/glast and eaat2/glt-1), neurons (eaat3/eaac1 and eaat4), and the retina (eaat5), where they precisely regulate extracellular glutamate levels at both synaptic and extrasynaptic sites. |
2014-02-26 |
2023-08-12 |
Not clear |