| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hikaru Mitori, Takeshi Izawa, Mitsuru Kuwamura, Masahiro Matsumoto, Jyoji Yamat. Developing Stage-dependent Retinal Toxicity Induced by l-glutamate in Neonatal Rats. Toxicologic pathology. vol 44. issue 8. 2017-12-12. PMID:28245157. |
the neurotransmitter glutamate causes excitotoxicity in the human retina. |
2017-12-12 |
2023-08-13 |
human |
| Hikaru Mitori, Takeshi Izawa, Mitsuru Kuwamura, Masahiro Matsumoto, Jyoji Yamat. Developing Stage-dependent Retinal Toxicity Induced by l-glutamate in Neonatal Rats. Toxicologic pathology. vol 44. issue 8. 2017-12-12. PMID:28245157. |
to elucidate the sensitivity to glutamate on various developing stage of retina, we investigated glutamate-induced retinal damage and glutamate target cells on each postnatal day (pnd). |
2017-12-12 |
2023-08-13 |
human |
| Ryan B MacDonald, Nachiket D Kashikar, Leon Lagnado, William A Harri. A Novel Tool to Measure Extracellular Glutamate in the Zebrafish Nervous System In Vivo. Zebrafish. vol 14. issue 3. 2017-11-02. PMID:28027028. |
tg(gfap:iglusnfr) is expressed on the glial membrane of müller glia cells in the retina, which rapidly respond to stimulation and the release of extracellular glutamate. |
2017-11-02 |
2023-08-13 |
zebrafish |
| Ursula Staubli, Natalie Rangel-Diaz, Miguel Alcantara, Yong-Xin Li, Jia-Ying Yang, Kai-Ming Zhang, Alan C Foste. Restoration of visual performance by d-serine in models of inner and outer retinal dysfunction assessed using sweep VEP measurements in the conscious rat and rabbit. Vision research. vol 127. 2017-10-20. PMID:27461280. |
the nmda subtype of glutamate receptor and its co-agonist d-serine play a key role in synaptic function in the central nervous system (cns), including visual cortex and retina. |
2017-10-20 |
2023-08-13 |
rat |
| Stella M K Glasauer, Robert Wäger, Matthias Gesemann, Stephan C F Neuhaus. mglur6b:EGFP Transgenic zebrafish suggest novel functions of metabotropic glutamate signaling in retina and other brain regions. The Journal of comparative neurology. vol 524. issue 12. 2017-09-13. PMID:27121676. |
mglur6b:egfp transgenic zebrafish suggest novel functions of metabotropic glutamate signaling in retina and other brain regions. |
2017-09-13 |
2023-08-13 |
zebrafish |
| Iris Haumann, Dirk Junghans, Max Anstötz, Michael Frotsche. Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina. PloS one. vol 12. issue 2. 2017-08-21. PMID:28235022. |
presynaptic localization of gluk5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina. |
2017-08-21 |
2023-08-13 |
mouse |
| Thomas J Wolfensberge. Macular Edema - Rationale for Therapy. Developments in ophthalmology. vol 58. 2017-08-16. PMID:28351053. |
novel treatments such as neuroprotective agents like nerve growth factors, somatostatins and antiapoptotic agents like calpain, the glutamate blocker memantine, and different caspase inhibitors may in the future inhibit neuronal cell death in the retina by separate pathways. |
2017-08-16 |
2023-08-13 |
Not clear |
| Katrin Franke, Philipp Berens, Timm Schubert, Matthias Bethge, Thomas Euler, Tom Bade. Inhibition decorrelates visual feature representations in the inner retina. Nature. vol 542. issue 7642. 2017-07-18. PMID:28178238. |
here, by imaging light-driven glutamate release from more than 13,000 bipolar cell axon terminals in the intact retina, we show that bipolar cell functional diversity is generated by the interplay of dendritic excitatory inputs and axonal inhibitory inputs. |
2017-07-18 |
2023-08-13 |
mouse |
| Sidney P Kuo, Gregory W Schwartz, Fred Riek. Nonlinear Spatiotemporal Integration by Electrical and Chemical Synapses in the Retina. Neuron. vol 90. issue 2. 2017-06-19. PMID:27068789. |
we found that release of glutamate from bipolar cells onto retinal ganglion cells (rgcs) was strongly shaped by gap-junction-mediated electrical coupling within the bipolar cell network of the mouse retina. |
2017-06-19 |
2023-08-13 |
mouse |
| E M Guimarães-Souza, O Perche, C W Morgans, R M Duvoisin, K C Calaz. Fragile X Mental Retardation Protein expression in the retina is regulated by light. Experimental eye research. vol 146. 2017-06-15. PMID:26719241. |
the retina is the first structure that participates in vision, and uses glutamate to transduce electromagnetic signals from light to electrochemical signals to neurons. |
2017-06-15 |
2023-08-13 |
mouse |
| Rebecca L Pfeiffer, Robert E Marc, Mineo Kondo, Hiroko Terasaki, Bryan W Jone. Müller cell metabolic chaos during retinal degeneration. Experimental eye research. vol 150. 2017-06-15. PMID:27142256. |
and while gs is believed to be the primary enzyme responsible for the conversion of glutamate to glutamine in the retina, alternative pathways appear to be unmasked in degenerating retina. |
2017-06-15 |
2023-08-13 |
Not clear |
| Li Guoping, Ye Xiang, Wu Jianfeng, Guo Dadong, Huang Jie, Jiang Wenjun, Guo Junguo, Bi Hongshen. Alterations of Glutamate and γ-Aminobutyric Acid Expressions in Normal and Myopic Eye Development in Guinea Pigs. Investigative ophthalmology & visual science. vol 58. issue 2. 2017-06-15. PMID:28241313. |
glutamate (glu) and γ-aminobutyric acid (gaba) are the major excitatory and inhibitory neurotransmitters in the retina, which can affect the development of both the eye and myopia. |
2017-06-15 |
2023-08-13 |
Not clear |
| Tingting Jiang, Qing Chang, Jiyang Cai, Jiawen Fan, Xiaozhe Zhang, Gezhi X. Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy. Oxidative medicine and cellular longevity. vol 2016. 2017-05-02. PMID:27143993. |
the retina of diabetic rats showed depletion of glutathione and downregulation of glutamate cysteine ligase (gcl). |
2017-05-02 |
2023-08-13 |
rat |
| Ana María López-Colomé, Edith López, Orquidia G Mendez-Flores, Arturo Orteg. Glutamate Receptor Stimulation Up-Regulates Glutamate Uptake in Human Müller Glia Cells. Neurochemical research. vol 41. issue 7. 2017-03-03. PMID:27017513. |
glutamate, the main excitatory amino acid in the vertebrate retina, is a well know activator of numerous signal transduction pathways, and has been critically involved in long-term synaptic changes acting through ionotropic and metabotropic glutamate receptors. |
2017-03-03 |
2023-08-13 |
human |
| Ana María López-Colomé, Edith López, Orquidia G Mendez-Flores, Arturo Orteg. Glutamate Receptor Stimulation Up-Regulates Glutamate Uptake in Human Müller Glia Cells. Neurochemical research. vol 41. issue 7. 2017-03-03. PMID:27017513. |
within the retina, müller glia cells are in close proximity to glutamatergic synapses and participate in the recycling of glutamate through the glutamate/glutamine shuttle. |
2017-03-03 |
2023-08-13 |
human |
| Aleksandra Araszkiewicz, Dorota Zozulinska-Ziolkiewic. Retinal Neurodegeneration in the Course of Diabetes-Pathogenesis and Clinical Perspective. Current neuropharmacology. vol 14. issue 8. 2017-01-17. PMID:26915422. |
in this review, we discuss the mechanisms leading to the neurodegeneration of the retina in diabetic patients including: low-grade inflammatory process, oxidative stress, activation of polymorphonuclear neutrophils, glutamate excitotoxicity and imbalance in the neuroprotective factors. |
2017-01-17 |
2023-08-13 |
Not clear |
| Kaihong Zeng, Na Yang, Duozi Wang, Suping Li, Jian Ming, Jing Wang, Xuemei Yu, Yi Song, Xue Zhou, Yongtao Yan. Resveratrol Prevents Retinal Dysfunction by Regulating Glutamate Transporters, Glutamine Synthetase Expression and Activity in Diabetic Retina. Neurochemical research. vol 41. issue 5. 2016-12-13. PMID:26677078. |
resveratrol prevents retinal dysfunction by regulating glutamate transporters, glutamine synthetase expression and activity in diabetic retina. |
2016-12-13 |
2023-08-13 |
rat |
| Kaihong Zeng, Na Yang, Duozi Wang, Suping Li, Jian Ming, Jing Wang, Xuemei Yu, Yi Song, Xue Zhou, Yongtao Yan. Resveratrol Prevents Retinal Dysfunction by Regulating Glutamate Transporters, Glutamine Synthetase Expression and Activity in Diabetic Retina. Neurochemical research. vol 41. issue 5. 2016-12-13. PMID:26677078. |
this study investigated the effects of resveratrol (rsv) on retinal functions, glutamate transporters (glast) and glutamine synthetase (gs) expression in diabetic rats retina, and on glutamate uptake, gs activity, glast and gs expression in high glucose-cultured müller cells. |
2016-12-13 |
2023-08-13 |
rat |
| Jun Zhang, Ronald S Petralia, Ya-Xian Wang, Jeffrey S Diamon. High-Resolution Quantitative Immunogold Analysis of Membrane Receptors at Retinal Ribbon Synapses. Journal of visualized experiments : JoVE. issue 108. 2016-12-13. PMID:26967746. |
although a high-resolution quantitative analysis of glutamate receptors at central synapses is widely employed, this approach has had only limited success in the retina. |
2016-12-13 |
2023-08-13 |
Not clear |
| Nancy Scardua Binda, Charles Porto Petruceli Carayon, Rafael Mourão Agostini, Ana Cristina do Nascimento Pinheiro, Marta Nascimento Cordeiro, Marco Aurélio Romano Silva, Juliana Figueira Silva, Elizete Maria Rita Pereira, Claudio Antonio da Silva Junior, Célio José de Castro Junior, Andre Luiz Sena Guimarães, Marcus Vinicius Gome. PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina. Toxins. vol 8. issue 3. 2016-12-13. PMID:26978403. |
nmda-induced cytotoxicity of the retina increased the release of glutamate, reactive oxygen species (ros) production and oxidative stress. |
2016-12-13 |
2023-08-13 |
rat |