| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E A Mayer, T Lembo, L Chan. Approaches to the modulation of abdominal pain. Canadian journal of gastroenterology = Journal canadien de gastroenterologie. vol 13 Suppl A. 1999-05-17. PMID:10202211. |
even though the precise mechanisms and sites underlying these alterations remain incompletely understood, plausible targets for the development of effective pharmacological treatments are receptors on peripheral terminals of visceral afferent nerves (opioids and serotonin), ion channels and receptors on dorsal horn neurons within the spinal cord (opioids, glutamate, calcitonin gene-related peptide and neurokinin-1), and supraspinal targets in the brainstem within the limbic system and in the prefrontal cortex (serotonin, catecholamines, dopamine and acetylcholine). |
1999-05-17 |
2023-08-12 |
Not clear |
| F Bymaster, K W Perry, D L Nelson, D T Wong, K Rasmussen, N A Moore, D O Calligar. Olanzapine: a basic science update. The British journal of psychiatry. Supplement. issue 37. 1999-05-10. PMID:10211140. |
microdialysis studies showed that olanzapine increased the extracellular levels of norepinephrine and dopamine, but not 5-ht, in the prefrontal cortex, and increased extracellular dopamine levels in the neostriatum and nucleus accumbens, areas of the brain associated with schizophrenia. |
1999-05-10 |
2023-08-12 |
Not clear |
| E A Mayer, L Chang, T Lemb. Brain-gut interactions: implications for newer therapy. The European journal of surgery. Supplement. : = Acta chirurgica. Supplement. issue 582. 1999-04-21. PMID:10029365. |
even though the precise mechanisms and sites underlying these alterations remain incompletely understood, plausible targets for the development of effective pharmacologic treatment are receptors on peripheral terminals of visceral afferent nerves (opioids, serotonin), ion channels and receptors on dorsal horn neurons within the spinal cord (opioids, glutamate, cgrp, nk-1) and supraspinal targets in the brainstem, within the limbic system and in the prefrontal cortex (serotonin, catecholamines, dopamine, acetylcholine). |
1999-04-21 |
2023-08-12 |
Not clear |
| J J Mann, M Oquendo, M D Underwood, V Arang. The neurobiology of suicide risk: a review for the clinician. The Journal of clinical psychiatry. vol 60 Suppl 2. 1999-03-18. PMID:10073382. |
postmortem studies of suicide victims also reveal decreased serotonin activity in the ventrolateral prefrontal cortex. |
1999-03-18 |
2023-08-12 |
Not clear |
| M Sugahara, H Shiraish. Synaptic density of the prefrontal cortex regulated by dopamine instead of serotonin in rats. Brain research. vol 814. issue 1-2. 1999-03-16. PMID:9838084. |
synaptic density of the prefrontal cortex regulated by dopamine instead of serotonin in rats. |
1999-03-16 |
2023-08-12 |
rat |
| M Sugahara, H Shiraish. Synaptic density of the prefrontal cortex regulated by dopamine instead of serotonin in rats. Brain research. vol 814. issue 1-2. 1999-03-16. PMID:9838084. |
we examined the synaptic density of the prefrontal cortex and parietal cortex of rats using dopamine (da) antagonists and agonists, as well as serotonin (5-ht) depleters and found a reduction in synaptic density in the prefrontal cortex lamina v-vi at a maximum of 20% with administration of a d1 antagonist (sch23390) and at a maximum of 30% with a d2 antagonist (ym09151). |
1999-03-16 |
2023-08-12 |
rat |
| M Sugahara, H Shiraish. Synaptic density of the prefrontal cortex regulated by dopamine instead of serotonin in rats. Brain research. vol 814. issue 1-2. 1999-03-16. PMID:9838084. |
administration of 5-ht depleter pcpa resulted in a 13.8% reduction of synaptic density in the parietal cortex, though there was no change identified in the synaptic density in the prefrontal cortex. |
1999-03-16 |
2023-08-12 |
rat |
| A Bortolozzi, R O Duffard, M Rubio, N Sturtz, A M Evangelista de Duffar. Regionally specific changes in central brain monoamine levels by 2,4-dichlorophenoxyacetic acid in acute treated rats. Neurotoxicology. vol 19. issue 6. 1999-03-16. PMID:9863773. |
we are demonstrating a correlation between rat behavior altered by the herbicide's treatment and the contents of 5-ht and da in brain areas, such as pfc, vta, sn, striatum, na, midbrain and cerebellum. |
1999-03-16 |
2023-08-12 |
rat |
| W M Abi-Saab, M Bubser, R H Roth, A Y Deutc. 5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 1. 1999-03-15. PMID:9885788. |
dopamine has been shown to activate these gabaergic interneurons, but there are no direct data on the effects of serotonin on gaba release in the prefrontal cortex. |
1999-03-15 |
2023-08-12 |
rat |
| W M Abi-Saab, M Bubser, R H Roth, A Y Deutc. 5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 1. 1999-03-15. PMID:9885788. |
these data indicate that serotonin, operating through a 5-ht2 receptor, acutely activates gabaergic interneurons in the prefrontal cortex. |
1999-03-15 |
2023-08-12 |
rat |
| W M Abi-Saab, M Bubser, R H Roth, A Y Deutc. 5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 1. 1999-03-15. PMID:9885788. |
these data further suggest that there may be convergent regulation of interneurons by dopamine and serotonin in the prefrontal cortex. |
1999-03-15 |
2023-08-12 |
rat |
| K Etou, T Kuroki, T Kawahara, Y Yonezawa, N Tashiro, H Uchimur. Ceruletide inhibits phencyclidine-induced dopamine and serotonin release in rat prefrontal cortex. Pharmacology, biochemistry, and behavior. vol 61. issue 4. 1999-03-01. PMID:9802838. |
ceruletide inhibits phencyclidine-induced dopamine and serotonin release in rat prefrontal cortex. |
1999-03-01 |
2023-08-12 |
rat |
| K Etou, T Kuroki, T Kawahara, Y Yonezawa, N Tashiro, H Uchimur. Ceruletide inhibits phencyclidine-induced dopamine and serotonin release in rat prefrontal cortex. Pharmacology, biochemistry, and behavior. vol 61. issue 4. 1999-03-01. PMID:9802838. |
produced a greater increase in extracellular dopamine (da) levels in the prefrontal cortex than in the striatum, while pcp increased the extracellular 5-hydroxytryptamine (serotonin; 5-ht) levels in the prefrontal cortex but not the striatum, as determined by in vivo microdialysis in awake, freely moving rats. |
1999-03-01 |
2023-08-12 |
rat |
| K Etou, T Kuroki, T Kawahara, Y Yonezawa, N Tashiro, H Uchimur. Ceruletide inhibits phencyclidine-induced dopamine and serotonin release in rat prefrontal cortex. Pharmacology, biochemistry, and behavior. vol 61. issue 4. 1999-03-01. PMID:9802838. |
), administered 60 min prior to pcp, significantly attenuated the pcp-induced increase in the extracellular levels of da and 5-ht in the prefrontal cortex, but not in the striatum. |
1999-03-01 |
2023-08-12 |
rat |
| K Etou, T Kuroki, T Kawahara, Y Yonezawa, N Tashiro, H Uchimur. Ceruletide inhibits phencyclidine-induced dopamine and serotonin release in rat prefrontal cortex. Pharmacology, biochemistry, and behavior. vol 61. issue 4. 1999-03-01. PMID:9802838. |
these results suggest that ceruletide may differentially modulate basal and pcp-induced release of da and 5-ht in the prefrontal cortex. |
1999-03-01 |
2023-08-12 |
rat |
| R Lewis, S Kapur, C Jones, J DaSilva, G M Brown, A A Wilson, S Houle, R B Zipursk. Serotonin 5-HT2 receptors in schizophrenia: a PET study using [18F]setoperone in neuroleptic-naive patients and normal subjects. The American journal of psychiatry. vol 156. issue 1. 1999-01-27. PMID:9892300. |
several postmortem studies have reported a decreased density of serotonin 5-ht2 receptors in the prefrontal cortex in schizophrenia. |
1999-01-27 |
2023-08-12 |
human |
| P A Broderick, M F Pierce. Clozapine, haloperidol, and the D4 antagonist PNU-101387G: in vivo effects on mesocortical, mesolimbic, and nigrostriatal dopamine and serotonin release. Journal of neural transmission (Vienna, Austria : 1996). vol 105. issue 6-7. 1999-01-26. PMID:9826116. |
with in vivo microvoltammetry, the dopamine (da) receptor antagonists, clozapine (d4/d2), haloperidol (d2) and the selective d4 antagonist, pnu-101387g, were evaluated for their effects on da and serotonin (5-ht) release within a10 neuronal terminal fields [mesocortical, prefrontal cortex (pfc), mesolimbic, nucleus accumbens, (nacc)] and within a9 neuronal terminal fields [nigrostriatal, caudate putamen (cpu)], in chloral hydrate anesthetized rats. |
1999-01-26 |
2023-08-12 |
rat |
| P A Broderick, M F Pierce. Clozapine, haloperidol, and the D4 antagonist PNU-101387G: in vivo effects on mesocortical, mesolimbic, and nigrostriatal dopamine and serotonin release. Journal of neural transmission (Vienna, Austria : 1996). vol 105. issue 6-7. 1999-01-26. PMID:9826116. |
haloperidol significantly (p < 0.001) increased da release within pfc, dramatically and significantly (p < 0.001) increased da release within cpu, but not within nacc; haloperidol had a small but statistically significant (p < 0.05) increase on 5-ht release within pfc [only at the highest dose studied (2.5 mg/kg)] and within cpu [only at the lowest dose studied 1.0 mg/kg) (p < 0.05)]. |
1999-01-26 |
2023-08-12 |
rat |
| S Zalcman, L Murray, D G Dyck, A H Greenberg, D M Nanc. Interleukin-2 and -6 induce behavioral-activating effects in mice. Brain research. vol 811. issue 1-2. 1999-01-12. PMID:9804916. |
we demonstrated that whereas il-2 increased hypothalamic and hippocampal norepinephrine (ne) utilization, and da turnover in the prefrontal cortex, il-6 induced profound elevations of serotonin (5-ht) and mesocortical dopamine (da) activity in the hippocampus and prefrontal cortex [s. zalcman, j.m. |
1999-01-12 |
2023-08-12 |
mouse |
| E H Jaff. Ca2+ dependency of serotonin and dopamine release from CNS slices of chronically isolated rats. Psychopharmacology. vol 139. issue 3. 1998-12-28. PMID:9784082. |
these isolated rats enabled the study of kcl-induced release of 5-ht and da from nucleus accumbens, prefrontal cortex and hippocampal slices. |
1998-12-28 |
2023-08-12 |
rat |