| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L H Miner, S Schroeter, R D Blakely, S R Sesac. Ultrastructural localization of the serotonin transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to dopamine terminals. The Journal of comparative neurology. vol 427. issue 2. 2001-01-04. PMID:11054690. |
dopamine levels within the prefrontal cortex (pfc) can be manipulated by selective inhibitors of the serotonin transporter (sert). |
2001-01-04 |
2023-08-12 |
rat |
| S Nakad. [Effects of (+/-)-pindolol over increased extracellular 5-HT level induced by fluvoxamine: regional difference in effect among the raphe, dorsal hippocampus and prefrontal cortex as measured by in vivo microdialysis technique]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 20. issue 2. 2000-11-30. PMID:11062862. |
[effects of (+/-)-pindolol over increased extracellular 5-ht level induced by fluvoxamine: regional difference in effect among the raphe, dorsal hippocampus and prefrontal cortex as measured by in vivo microdialysis technique]. |
2000-11-30 |
2023-08-12 |
rat |
| S Nakad. [Effects of (+/-)-pindolol over increased extracellular 5-HT level induced by fluvoxamine: regional difference in effect among the raphe, dorsal hippocampus and prefrontal cortex as measured by in vivo microdialysis technique]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 20. issue 2. 2000-11-30. PMID:11062862. |
we have used freely moving rats to measure the extracellular level of 5-ht and dopamine (da) in the raphe, dorsal hippocampus and prefrontal cortex using an in vivo microdialysis technique. |
2000-11-30 |
2023-08-12 |
rat |
| Y Shirayama, K Hashimoto, M Iyo, K Watanabe, T Higuchi, Y Minab. 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-induced egr-1 mRNA in rat brain: pharmacological manipulation. European journal of pharmacology. vol 402. issue 3. 2000-11-28. PMID:10958887. |
furthermore, the expression of egr-1 mrna in the prefrontal cortex, striatum and hippocampal dentate gyrus after administration of mdma (10 mg/kg) was blocked significantly by pretreatment with nmda receptor antagonist (5r, 10s)-(+)-5-methyl-10,11-dihydro-5h-dibenzo[a,b]-cyclohepten-5, 10-imine ((+)-mk801; 1 mg/kg), dopamine d(1) receptor antagonist sch 23390 (1 mg/kg) or 5-ht uptake inhibitor paroxetine (5 mg/kg), but not by 5-ht(2a) receptor antagonist sr46349b (5 mg/kg). |
2000-11-28 |
2023-08-12 |
rat |
| Y Shirayama, K Hashimoto, M Iyo, K Watanabe, T Higuchi, Y Minab. 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-induced egr-1 mRNA in rat brain: pharmacological manipulation. European journal of pharmacology. vol 402. issue 3. 2000-11-28. PMID:10958887. |
these results suggest that mdma alters the expression of egr-1 mrna in several regions of rat brain, and that the expression of egr-1 mrna by mdma in the prefrontal cortex, striatum and hippocampal dentate gyrus appears to be mediated, at least in part, by nmda receptor, dopamine d(1) receptor and 5-ht transporter. |
2000-11-28 |
2023-08-12 |
rat |
| Y Noda, H Kamei, T Mamiya, H Furukawa, T Nabeshim. Repeated phencyclidine treatment induces negative symptom-like behavior in forced swimming test in mice: imbalance of prefrontal serotonergic and dopaminergic functions. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 4. 2000-11-01. PMID:10989264. |
5-ht utilization in the prefrontal cortex was increased, but dopamine utilization was decreased in mice showing pcp-induced enhancement of immobility. |
2000-11-01 |
2023-08-12 |
mouse |
| Y Noda, T Nabeshim. [Neuropsychopharmacological study on an animal model for negative symptom of schizophrenia induced by repeated phencyclidine treatment]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 120. issue 8. 2000-10-26. PMID:10946617. |
serotonin utilization in the prefrontal cortex was increased, but dopamine utilization was decreased in pcp-treated mice showing the enhancement of immobility. |
2000-10-26 |
2023-08-12 |
mouse |
| W Zhang, K W Perry, D T Wong, B D Potts, J Bao, G D Tollefson, F P Bymaste. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 3. 2000-10-11. PMID:10942849. |
to understand the mechanism of the clinical efficacy of olanzapine and fluoxetine combination therapy for treatment-resistant depression (trd), we studied the effects of olanzapine and other antipsychotics in combination with the selective serotonin uptake inhibitors fluoxetine or sertraline on neurotransmitter release in rat prefrontal cortex (pfc) using microdialysis. |
2000-10-11 |
2023-08-12 |
rat |
| W Zhang, K W Perry, D T Wong, B D Potts, J Bao, G D Tollefson, F P Bymaste. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 3. 2000-10-11. PMID:10942849. |
therefore, the large, sustained increase of [da](ex), [ne](ex), and [5-ht](ex) in pfc after olanzapine-fluoxetine treatment was unique and may contribute to the profound antidepressive effect of the olanzapine and fluoxetine therapy in trd. |
2000-10-11 |
2023-08-12 |
rat |
| S Lacosta, Z Merali, H Anisma. Central monoamine activity following acute and repeated systemic interleukin-2 administration. Neuroimmunomodulation. vol 8. issue 2. 2000-10-06. PMID:10965233. |
as well, serotonin (5-hydroxytryptamine; 5-ht) levels were altered within the hippocampus and prefrontal cortex, and dopamine turnover was reduced within the caudate and substantia nigra. |
2000-10-06 |
2023-08-12 |
mouse |
| Z de Saint Hilaire, M Orosco, C Rouch, A Python, S Nicolaidi. Neuromodulation of the prefrontal cortex during sleep: a microdialysis study in rats. Neuroreport. vol 11. issue 8. 2000-10-05. PMID:10852212. |
to test the hypothesis that biogenic amines of the prefrontal cortex are involved in state-dependent cortical and behavioural activation, changes in extracellular levels of serotonin (5-ht), dopamine (da), and noradrenaline (na) were determined during the sleep-wake cycle in freely moving rats using microdialysis probes with parallel eeg recording. |
2000-10-05 |
2023-08-12 |
rat |
| Z de Saint Hilaire, M Orosco, C Rouch, A Python, S Nicolaidi. Neuromodulation of the prefrontal cortex during sleep: a microdialysis study in rats. Neuroreport. vol 11. issue 8. 2000-10-05. PMID:10852212. |
however, da and hva showed dramatic changes announcing the transition between sws and w. during paradoxical sleep (ps), da and 5-ht showed complex changes, the direction of which depended on whether ps was followed by sws or w. biogenic amines of the prefrontal cortex are probably involved in cortical and behavioural activation. |
2000-10-05 |
2023-08-12 |
rat |
| T Byrne, L E Baker, A Polin. MDMA and learning: effects of acute and neurotoxic exposure in the rat. Pharmacology, biochemistry, and behavior. vol 66. issue 3. 2000-10-05. PMID:10899362. |
although mdma significantly reduced 5-ht and 5-hiaa levels in the striatum and prefrontal cortex, mean performance of rats exposed to mdma did not differ from that of rats exposed to vehicle. |
2000-10-05 |
2023-08-12 |
rat |
| H Rollema, Y Lu, A W Schmidt, J S Sprouse, S H Zor. 5-HT(1A) receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex. Biological psychiatry. vol 48. issue 3. 2000-09-21. PMID:10924666. |
5-ht(1a) receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex. |
2000-09-21 |
2023-08-12 |
rat |
| H Takahashi, Y Takada, N Nagai, T Urano, A Takad. Serotonergic neurons projecting to hippocampus activate locomotion. Brain research. vol 869. issue 1-2. 2000-08-25. PMID:10865074. |
thus, using microdialysis and microinjection techniques, we examined the relationship between serotonin (5-ht) levels in striatum, hippocampus or prefrontal cortex (pfc) and motor activity in rats. |
2000-08-25 |
2023-08-12 |
rat |
| H Takahashi, Y Takada, N Nagai, T Urano, A Takad. Serotonergic neurons projecting to hippocampus activate locomotion. Brain research. vol 869. issue 1-2. 2000-08-25. PMID:10865074. |
of monoamine oxidase inhibitor, tranylcypromine (tc), significantly elevated 5-ht levels in the striatum, hippocampus and pfc accompanied by a parallel increase in motor activity of the rats. |
2000-08-25 |
2023-08-12 |
rat |
| S Puglisi-Allegra, S Cabib, T Pascucci, R Ventura, F Cali, V Roman. Dramatic brain aminergic deficit in a genetic mouse model of phenylketonuria. Neuroreport. vol 11. issue 6. 2000-07-17. PMID:10817622. |
results indicated a significant reduction of 5-ht levels and metabolism in prefrontal cortex (pfc), cingulate cortex (cg), nucleus accumbens (nac), caudate putamen (cp), hippocampus (hip) and amygdala (amy). |
2000-07-17 |
2023-08-12 |
mouse |
| J Farisse, F Héry, N Barden, M Héry, P Boulengue. Central 5-HT(1) and 5-HT(2) binding sites in transgenic mice with reduced glucocorticoid receptor number. Brain research. vol 862. issue 1-2. 2000-06-21. PMID:10799679. |
transgenic mice bearing a transgene coding for a glucocorticoid receptor antisense mrna, which partially blocks glucocorticoid receptor expression, were used in order to clarify the role of glucocorticoid receptors in the regulation of 5-ht(1a), 5-ht(1nona) and 5-ht(2) binding sites labelled by quantitative autoradiography in the frontal and prefrontal cortex, striatum, hypothalamus, amygdala and raphe nuclei. |
2000-06-21 |
2023-08-12 |
mouse |
| G K Aghajanian, G J Mare. Serotonin model of schizophrenia: emerging role of glutamate mechanisms. Brain research. Brain research reviews. vol 31. issue 2-3. 2000-05-17. PMID:10719157. |
in the prefrontal cortex, 5-ht(2a)-receptors stimulation increases the release of glutamate, as indicated by a marked increase in the frequency of excitatory postsynaptic potentials/currents (epsps/epscs) in the apical dendritic region of layer v pyramidal cells; this effect is blocked by inhibitory group ii/iii metabotropic glutamate agonists acting presynaptically and by an ampa/kainate glutamate antagonist, acting postsynaptically at non-nmda glutamate receptors. |
2000-05-17 |
2023-08-12 |
Not clear |
| M Sakaue, P Somboonthum, B Nishihara, Y Koyama, H Hashimoto, A Baba, T Matsud. Postsynaptic 5-hydroxytryptamine(1A) receptor activation increases in vivo dopamine release in rat prefrontal cortex. British journal of pharmacology. vol 129. issue 5. 2000-05-04. PMID:10696105. |
postsynaptic 5-hydroxytryptamine(1a) receptor activation increases in vivo dopamine release in rat prefrontal cortex. |
2000-05-04 |
2023-08-12 |
rat |