| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Sakaue, P Somboonthum, B Nishihara, Y Koyama, H Hashimoto, A Baba, T Matsud. Postsynaptic 5-hydroxytryptamine(1A) receptor activation increases in vivo dopamine release in rat prefrontal cortex. British journal of pharmacology. vol 129. issue 5. 2000-05-04. PMID:10696105. |
the present study describes the effect of 5-¿3-[[(2s)-1,4-benzodioxan-2ylmethyl]amino]propoxy¿-1, 3-benzodioxole hcl (mkc-242), a highly potent and selective 5-ht(1a) receptor agonist, on dopamine release in the prefrontal cortex using microdialysis in the freely moving rat. |
2000-05-04 |
2023-08-12 |
rat |
| M Sakaue, P Somboonthum, B Nishihara, Y Koyama, H Hashimoto, A Baba, T Matsud. Postsynaptic 5-hydroxytryptamine(1A) receptor activation increases in vivo dopamine release in rat prefrontal cortex. British journal of pharmacology. vol 129. issue 5. 2000-05-04. PMID:10696105. |
the effect of mkc-242 in the prefrontal cortex was antagonized by pretreatment with the selective 5-ht(1a) receptor antagonist, n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl)cyclohe xanecarboxamide (way100635; 1 mg kg(-1), i.p.). |
2000-05-04 |
2023-08-12 |
rat |
| M Sakaue, P Somboonthum, B Nishihara, Y Koyama, H Hashimoto, A Baba, T Matsud. Postsynaptic 5-hydroxytryptamine(1A) receptor activation increases in vivo dopamine release in rat prefrontal cortex. British journal of pharmacology. vol 129. issue 5. 2000-05-04. PMID:10696105. |
fluoxetine, a selective serotonin reuptake inhibitor, increased dopamine release in the prefrontal cortex, but not in the nucleus accumbens, while buspirone, a 5-ht(1a) receptor agonist, increased dopamine release in both brain regions. |
2000-05-04 |
2023-08-12 |
rat |
| L Palego, A Giromella, D Marazziti, G Giannaccini, F Borsini, F Bigazzi, A G Naccarato, A Lucacchini, G B Cassano, M R Mazzon. Lack of stereoselectivity of 8-hydroxy-2(di-N-propylamino)tetralin-mediated inhibition of forskolin-stimulated adenylyl cyclase activity in human pre- and post-synaptic brain regions. Neurochemistry international. vol 36. issue 3. 2000-03-02. PMID:10676857. |
the stereoselectivity of the serotonin1a (5-ht1a) receptor compound 8-hydroxy-2(di-n-propylamino)tetralin (8-oh-dpat) on forskolin-stimulated adenylyl cyclase activity was investigated in membranes from human 5-ht pre-synaptic (raphe nuclei) and post-synaptic (hippocampus and prefrontal cortex) regions of autopsy brains. |
2000-03-02 |
2023-08-12 |
human |
| G J Marek, R A Wright, D D Schoepp, J A Monn, G K Aghajania. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 292. issue 1. 2000-01-27. PMID:10604933. |
physiological antagonism between 5-hydroxytryptamine(2a) and group ii metabotropic glutamate receptors in prefrontal cortex. |
2000-01-27 |
2023-08-12 |
Not clear |
| G J Marek, R A Wright, D D Schoepp, J A Monn, G K Aghajania. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 292. issue 1. 2000-01-27. PMID:10604933. |
in prefrontal cortex, 5-hydroxytryptamine(2a) (5-ht(2a)) receptors have been linked to the action of hallucinogens and atypical antidepressant/antipsychotic drugs. |
2000-01-27 |
2023-08-12 |
Not clear |
| G J Marek, R A Wright, D D Schoepp, J A Monn, G K Aghajania. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 292. issue 1. 2000-01-27. PMID:10604933. |
these findings suggest a close coupling between mglu2/3 and 5-ht(2a) receptors in the prefrontal cortex that may be relevant for novel therapeutic approaches in the treatment of neuropsychiatric syndromes such as depression and schizophrenia. |
2000-01-27 |
2023-08-12 |
Not clear |
| M Matsumoto, H Togashi, K Mori, K Ueno, A Miyamoto, M Yoshiok. Characterization of endogenous serotonin-mediated regulation of dopamine release in the rat prefrontal cortex. European journal of pharmacology. vol 383. issue 1. 2000-01-13. PMID:10556679. |
endogenous serotonin (5-hydroxytryptamine, 5-ht)-mediated regulation of dopamine release in the rat prefrontal cortex was pharmacologically characterized using in vivo microdialysis. |
2000-01-13 |
2023-08-12 |
rat |
| M Matsumoto, H Togashi, K Mori, K Ueno, A Miyamoto, M Yoshiok. Characterization of endogenous serotonin-mediated regulation of dopamine release in the rat prefrontal cortex. European journal of pharmacology. vol 383. issue 1. 2000-01-13. PMID:10556679. |
in other words, 5-ht(6) receptors may play, in part, a significant role in the functional interaction between the dopaminergic and serotonergic neuronal system in the rat prefrontal cortex. |
2000-01-13 |
2023-08-12 |
rat |
| A Degl'Innocenti, H Agren, M Sjögren, O Zachrisson, L Bäckma. [Executive functions and serotonin activity in patients with depression. A connection mirrors the influence of serotonin on prefrontal cortex]. Lakartidningen. vol 96. issue 45. 2000-01-11. PMID:10596531. |
a connection mirrors the influence of serotonin on prefrontal cortex]. |
2000-01-11 |
2023-08-12 |
Not clear |
| D C McIntyre, P Kent, S Hayley, Z Merali, H Anisma. Influence of psychogenic and neurogenic stressors on neuroendocrine and central monoamine activity in fast and slow kindling rats. Brain research. vol 840. issue 1-2. 1999-11-22. PMID:10517953. |
although both stressors influenced norepinephrine (ne), dopamine (da) and/or serotonin (5-ht) activity in brain regions typically associated with stressors (e.g., locus coeruleus, paraventricular nucleus of the hypothalamus, nucleus accumbens, prefrontal cortex), considerable amine alterations were evident in the medial and basolateral amygdala nuclei, but not in the central nucleus. |
1999-11-22 |
2023-08-12 |
rat |
| X M Li, K W Perry, D T Won. Difference in the in vivo influence of serotonin1A autoreceptors on serotonin release in prefrontal cortex and dorsal hippocampus of the same rat treated with fluoxetine. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513599. |
difference in the in vivo influence of serotonin1a autoreceptors on serotonin release in prefrontal cortex and dorsal hippocampus of the same rat treated with fluoxetine. |
1999-11-02 |
2023-08-12 |
rat |
| X M Li, K W Perry, D T Won. Difference in the in vivo influence of serotonin1A autoreceptors on serotonin release in prefrontal cortex and dorsal hippocampus of the same rat treated with fluoxetine. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513599. |
the investigational approach used in the present study was to detect extracellular 5-ht concentrations in two terminal areas, prefrontal cortex (pfc) and dorsal hippocampus (dhp), which are mainly innervated by the 5-ht neurons located in the drn and mrn respectively. |
1999-11-02 |
2023-08-12 |
rat |
| X M Li, K W Perry, D T Won. Difference in the in vivo influence of serotonin1A autoreceptors on serotonin release in prefrontal cortex and dorsal hippocampus of the same rat treated with fluoxetine. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513599. |
fluoxetine (10 mg/kg, s.c.) alone produced a smaller increase in the extracellular 5-ht concentration in the pfc than dhp of the same rat (maximal 5-ht concentrations were 183% and 223% of the baseline values in pfc and dhp respectively). |
1999-11-02 |
2023-08-12 |
rat |
| X M Li, K W Perry, D T Won. Difference in the in vivo influence of serotonin1A autoreceptors on serotonin release in prefrontal cortex and dorsal hippocampus of the same rat treated with fluoxetine. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513599. |
however, an antagonist of 5-ht1a receptors, way100635, subsequently injected (s.c.) at 1 mg/kg brought the 5-ht concentrations to similar levels in the pfc (332%) and dhp (308%). |
1999-11-02 |
2023-08-12 |
rat |
| X M Li, K W Perry, D T Won. Difference in the in vivo influence of serotonin1A autoreceptors on serotonin release in prefrontal cortex and dorsal hippocampus of the same rat treated with fluoxetine. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513599. |
since the 5-ht concentrations immediately before the injection of way100635 were lower in the pfc (102%) than dhp (186%), way100635 induced a larger 5-ht net increase in the pfc (332%-102%=230%) than dhp (308%-186%=122%). |
1999-11-02 |
2023-08-12 |
rat |
| X M Li, K W Perry, D T Won. Difference in the in vivo influence of serotonin1A autoreceptors on serotonin release in prefrontal cortex and dorsal hippocampus of the same rat treated with fluoxetine. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513599. |
in conclusion, the present study demonstrated that the antagonist of 5-ht1a receptors, way100635, produced a more robust potentiation in the fluoxetine-induced 5-ht increases in the pfc than dhp. |
1999-11-02 |
2023-08-12 |
rat |
| X M Li, K W Perry, D T Won. Difference in the in vivo influence of serotonin1A autoreceptors on serotonin release in prefrontal cortex and dorsal hippocampus of the same rat treated with fluoxetine. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513599. |
since pfc and dhp are predominately innervated by 5-ht neurons located in the drn and mrn respectively, this result may indicate a functional difference between the 5-ht1a autoreceptors located on the cell bodies of 5-ht neurons in the drn and mrn. |
1999-11-02 |
2023-08-12 |
rat |
| A Mendlin, F J Martín, B L Jacob. Dopaminergic input is required for increases in serotonin output produced by behavioral activation: an in vivo microdialysis study in rat forebrain. Neuroscience. vol 93. issue 3. 1999-10-21. PMID:10473255. |
accordingly, we examined the effects of d2 receptor blockade or unilateral dopamine depletion on behaviorally induced increases in extracellular serotonin levels in the corpus striatum and prefrontal cortex of freely moving rats using in vivo microdialysis. |
1999-10-21 |
2023-08-12 |
rat |
| A Mendlin, F J Martín, B L Jacob. Dopaminergic input is required for increases in serotonin output produced by behavioral activation: an in vivo microdialysis study in rat forebrain. Neuroscience. vol 93. issue 3. 1999-10-21. PMID:10473255. |
tail pinch-induced increases in serotonin levels (39+/-3% and 53+/-5% in the corpus striatum and prefrontal cortex, respectively), but not the accompanying behavioral changes, were blocked by local application of the d2 receptor antagonist raclopride (10 microm). |
1999-10-21 |
2023-08-12 |
rat |