| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinhe Liu, Lin Tian, Ruisi Cui, Heng Ruan, Xinwang L. Muscarinic receptors in the nucleus accumbens shell play different roles in context-induced or morphine-challenged expression of behavioral sensitization in rats. European journal of pharmacology. vol 819. 2018-08-06. PMID:29196177. |
the nucleus accumbens (nac), especially the shell of the nac, where the muscarinic receptors are expressed, is critical for craving and relapse. |
2018-08-06 |
2023-08-13 |
rat |
| Kirsty Bannister, Chaoling Qu, Edita Navratilova, Janice Oyarzo, Jennifer Yanhua Xie, Tamara King, Anthony H Dickenson, Frank Porrec. Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain. Pain. vol 158. issue 12. 2018-08-02. PMID:28832395. |
intravenous or intrathecal gbp reversed evoked mechanical hypersensitivity and produced conditioned place preference (cpp) and dopamine (da) release in the nucleus accumbens (nac) selectively in snl rats. |
2018-08-02 |
2023-08-13 |
rat |
| Aimilia Lydia Kalafateli, Daniel Vallöf, Julia Winsa Jörnulf, Markus Heilig, Elisabet Jerlha. A cannabinoid receptor antagonist attenuates ghrelin-induced activation of the mesolimbic dopamine system in mice. Physiology & behavior. vol 184. 2018-08-01. PMID:29221808. |
reward modulation involves the mesolimbic dopamine system, consisting of the ventral tegmental area (vta) dopamine neurons targeting nucleus accumbens (nac), a system that ghrelin activates through vta-dependent mechanisms. |
2018-08-01 |
2023-08-13 |
mouse |
| Peter J Hamilton, Dominika J Burek, Sonia I Lombroso, Rachael L Neve, Alfred J Robison, Eric J Nestler, Elizabeth A Helle. Cell-Type-Specific Epigenetic Editing at the Fosb Gene Controls Susceptibility to Social Defeat Stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 2. 2018-07-30. PMID:28462942. |
chronic social defeat stress regulates the expression of fosb in the nucleus accumbens (nac) to promote the cell-type-specific accumulation of Δfosb in the two medium spiny neuron (msn) subtypes in this region. |
2018-07-30 |
2023-08-13 |
mouse |
| Jessie Muir, Zachary S Lorsch, Charu Ramakrishnan, Karl Deisseroth, Eric J Nestler, Erin S Calipari, Rosemary C Bago. In Vivo Fiber Photometry Reveals Signature of Future Stress Susceptibility in Nucleus Accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 2. 2018-07-30. PMID:28589967. |
stress-induced alterations in the activity of reward-related brain regions, such as the nucleus accumbens (nac), are linked to the pathophysiology of depression. |
2018-07-30 |
2023-08-13 |
mouse |
| Sangyu Xu, Gishnu Das, Emily Hueske, Susumu Tonegaw. Dorsal Raphe Serotonergic Neurons Control Intertemporal Choice under Trade-off. Current biology : CB. vol 27. issue 20. 2018-07-30. PMID:28988863. |
similar effects were observed when we manipulated the serotonergic projections to the nucleus accumbens (nac). |
2018-07-30 |
2023-08-13 |
mouse |
| Guangfa Jiao, Guozhong Zhang, Haiying Wang, Weilin Zhao, Yanwei Cui, Yongjing Liu, Feng Gao, Fang Yuan, Yi Zhan. Glucose Intake Alters Expression of Neuropeptides Derived from Proopiomelanocortin in the Lateral Hypothalamus and the Nucleus Accumbens in Fructose Preference Rats. Neural plasticity. vol 2017. 2018-07-30. PMID:29250448. |
to study the neuroendocrine mechanism of sugar preference, we investigated the role of glucose feeding in the regulation of expression levels of neuropeptides derived from proopiomelanocortin (pomc) in the lateral hypothalamus (lh) and nucleus accumbens (nac) in fructose preference rats. |
2018-07-30 |
2023-08-13 |
rat |
| J M Wenzel, J F Chee. Endocannabinoid Regulation of Reward and Reinforcement through Interaction with Dopamine and Endogenous Opioid Signaling. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 1. 2018-07-26. PMID:28653666. |
indeed, ecb signaling in the ventral tegmental area stimulates activation of midbrain da cells and promotes da release in terminal regions such as the nucleus accumbens (nac). |
2018-07-26 |
2023-08-13 |
human |
| Yiyun Lin, Hui Gu, Linhong Jiang, Wei Xu, Chunqi Liu, Yan Li, Xinying Qian, Dandan Li, Zhuoling Li, Jing Hu, Huaqin Zhang, Wei Guo, Yinglan Zhao, Xiaobo Ce. Cocaine modifies brain lipidome in mice. Molecular and cellular neurosciences. vol 85. 2018-07-25. PMID:28830718. |
in this study, we used a lc-ms-based lipidomic approach to investigate the impact of cocaine on brain lipidome in two mouse models, cocaine-conditioned place preference (cpp) and hyperlocomotor models and the lipidome was profoundly modified in the nucleus accumbens (nac) and striatum respectively. |
2018-07-25 |
2023-08-13 |
mouse |
| Gregory C Sartor, Samuel K Powell, Dmitry Velmeshev, David Y Lin, Marco Magistri, Hannah J Wiedner, Andrea M Malvezzi, Nadja S Andrade, Mohammad A Faghihi, Claes Wahlested. Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens. Molecular and cellular neurosciences. vol 85. 2018-07-25. PMID:29055697. |
we found that 22% of the genes examined contain nats and that expression of homer1 natural antisense transcript (homer1-as) was altered in the nucleus accumbens (nac) of mice 2h and 10days following repeated cocaine administration. |
2018-07-25 |
2023-08-13 |
mouse |
| Mitra Heshmati, Hossein Aleyasin, Caroline Menard, Daniel J Christoffel, Meghan E Flanigan, Madeline L Pfau, Georgia E Hodes, Ashley E Lepack, Lucy K Bicks, Aki Takahashi, Ramesh Chandra, Gustavo Turecki, Mary Kay Lobo, Ian Maze, Sam A Golden, Scott J Russ. Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 5. 2018-07-25. PMID:29339486. |
behavioral coping strategies are critical for active resilience to stress and depression; here we describe a role for neuroligin-2 (nlgn-2) in the nucleus accumbens (nac). |
2018-07-25 |
2023-08-13 |
mouse |
| Xiao Han, Man-Yi Jing, Tai-Yun Zhao, Ning Wu, Rui Song, Jin L. Role of dopamine projections from ventral tegmental area to nucleus accumbens and medial prefrontal cortex in reinforcement behaviors assessed using optogenetic manipulation. Metabolic brain disease. vol 32. issue 5. 2018-07-23. PMID:28523568. |
the nucleus accumbens (nac) and medial prefrontal cortices (mpfc) are the main projections from the vta. |
2018-07-23 |
2023-08-13 |
mouse |
| Paul M Klenowsk. Emerging role for the medial prefrontal cortex in alcohol-seeking behaviors. Addictive behaviors. vol 77. 2018-07-23. PMID:28992574. |
animal studies have begun to dissect the role of the mpfc circuitry in alcohol-seeking behavior and withdrawal, and have identified a key role for projections to sub-cortical sites including the extended amygdala and the nucleus accumbens (nac). |
2018-07-23 |
2023-08-13 |
Not clear |
| Anthony Purgianto, Michael E Weinfeld, Marina E Wol. Prolonged withdrawal from cocaine self-administration affects prefrontal cortex- and basolateral amygdala-nucleus accumbens core circuits but not accumbens GABAergic local interneurons. Addiction biology. vol 22. issue 6. 2018-07-16. PMID:27457780. |
after prolonged withdrawal (1-2 months), when craving is high, expression of incubation depends on strengthening of excitatory inputs to medium spiny neurons (msn) of the nucleus accumbens (nac). |
2018-07-16 |
2023-08-13 |
rat |
| Kejing Yuan, Huan Sheng, Jiaojiao Song, Li Yang, Dongyang Cui, Qianqian Ma, Wen Zhang, Bin Lai, Ming Chen, Ping Zhen. Morphine treatment enhances glutamatergic input onto neurons of the nucleus accumbens via both disinhibitory and stimulating effect. Addiction biology. vol 22. issue 6. 2018-07-16. PMID:27549902. |
the nucleus accumbens (nac) is an important site where morphine treatment produces its reinforcing effect on reward. |
2018-07-16 |
2023-08-13 |
Not clear |
| Sophie Laguesse, Nadege Morisot, Khanhky Phamluong, Dorit Ro. Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents. Addiction biology. vol 22. issue 6. 2018-07-16. PMID:27766766. |
we previously reported that the kinase akt is activated in the nucleus accumbens (nac) of rodents in response to excessive consumption of alcohol. |
2018-07-16 |
2023-08-13 |
mouse |
| Ronald Kim, Marian T Sepulveda-Orengo, Kati L Healey, Emily A Williams, Kathryn J Reissne. Regulation of glutamate transporter 1 (GLT-1) gene expression by cocaine self-administration and withdrawal. Neuropharmacology. vol 128. 2018-07-13. PMID:28919080. |
downregulation of the astroglial glutamate transporter glt-1 is observed in the nucleus accumbens (nac) following administration of multiple drugs of abuse. |
2018-07-13 |
2023-08-13 |
rat |
| Robert J Wickham, Eric J Nunes, Shannon Hughley, Phillip Silva, Sofia N Walton, Jinwoo Park, Nii A Add. Evaluating oral flavorant effects on nicotine self-administration behavior and phasic dopamine signaling. Neuropharmacology. vol 128. 2018-07-13. PMID:28943284. |
oral administration of 10% sucrose or 0.32% saccharin, but not 0.005% menthol, increased phasic da release in the nucleus accumbens (nac). |
2018-07-13 |
2023-08-13 |
rat |
| Julia Morud, Joakim Strandberg, Anna Andrén, Mia Ericson, Bo Söderpalm, Louise Adermar. Progressive modulation of accumbal neurotransmission and anxiety-like behavior following protracted nicotine withdrawal. Neuropharmacology. vol 128. 2018-07-13. PMID:28986279. |
we have previously shown that neurotransmission in the nucleus accumbens (nac), a key brain region with respect to drug reinforcement and relapse, is suppressed for as long as seven months after a brief period of nicotine treatment. |
2018-07-13 |
2023-08-13 |
rat |
| Hailong Li, Jessica M Illenberger, Kristen A McLaurin, Charles F Mactutus, Rosemarie M Booz. Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology. Journal of visualized experiments : JoVE. issue 133. 2018-07-13. PMID:29658920. |
using a novel rna in situ hybridization assay, the current study identified dopamine drd1α receptor and tyrosine hydroxylase (th) rna expression from da-related circuitry in the nucleus accumbens (nac) area and substantia nigra region (snr), respectively. |
2018-07-13 |
2023-08-13 |
rat |