| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M E Cahill, D M Walker, A M Gancarz, Z J Wang, C K Lardner, R C Bagot, R L Neve, D M Dietz, E J Nestle. The dendritic spine morphogenic effects of repeated cocaine use occur through the regulation of serum response factor signaling. Molecular psychiatry. vol 23. issue 6. 2019-03-18. PMID:28555077. |
the nucleus accumbens (nac) is a primary brain reward region composed predominantly of medium spiny neurons (msns). |
2019-03-18 |
2023-08-13 |
Not clear |
| Léa Décarie-Spain, Sandeep Sharma, Cécile Hryhorczuk, Victor Issa-Garcia, Philip A Barker, Nathalie Arbour, Thierry Alquier, Stephanie Fulto. Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat. Molecular metabolism. vol 10. 2019-03-15. PMID:29454579. |
obesity arising from excessive intake of high-fat food provokes anxiodepressive behavior and elicits molecular adaptations in the nucleus accumbens (nac), a region well-implicated in the hedonic deficits associated with depression and in the control of food-motivated behavior. |
2019-03-15 |
2023-08-13 |
Not clear |
| Yusuf Hussain, Sairam Krishnamurth. Piracetam attenuates binge eating disorder related symptoms in rats. Pharmacology, biochemistry, and behavior. vol 169. 2019-03-15. PMID:29654794. |
increased levels of plasma corticosterone (cort), glutamate in nucleus accumbens (nac), hypothalamus (hyp) and prefrontal cortex (pfc) indicate stress and excitotoxicity. |
2019-03-15 |
2023-08-13 |
rat |
| M A van der Kooij, F Hollis, L Lozano, I Zalachoras, S Abad, O Zanoletti, J Grosse, I Guillot de Suduiraut, C Canto, C Sand. Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of dopamine D1 receptors. Molecular psychiatry. vol 23. issue 3. 2019-03-12. PMID:28727688. |
furthermore, mitochondrial function in the nucleus accumbens (nac) has been causally implicated in the link between anxiety and social competitiveness. |
2019-03-12 |
2023-08-13 |
rat |
| Irina N Krasnova, Maria Carla Gerra, Donna Walther, Subramaniam Jayanthi, Bruce Ladenheim, Michael T McCoy, Christie Brannock, Jean Lud Cade. Compulsive methamphetamine taking in the presence of punishment is associated with increased oxytocin expression in the nucleus accumbens of rats. Scientific reports. vol 7. issue 1. 2019-03-11. PMID:28827541. |
rats were euthanized one day after the second extinction test and the nucleus accumbens (nac) and dorsal striatum were collected to measure gene expression with microarray analysis. |
2019-03-11 |
2023-08-13 |
rat |
| Ernesto Solis, Keaton T Cameron-Burr, Yavin Shaham, Eugene A Kiyatki. Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 4. 2019-03-11. PMID:28849778. |
we used high-speed amperometry in freely moving rats to examine the effects of intravenous fentanyl at doses within the range of possible human intake (3-40 μg/kg) on oxygen and glucose levels in nucleus accumbens (nac). |
2019-03-11 |
2023-08-13 |
human |
| Nii A Addy, Eric J Nunes, Shannon M Hughley, Keri M Small, Sarah J Baracz, Joshua L Haight, Anjali M Rajadhyaksh. The L-type calcium channel blocker, isradipine, attenuates cue-induced cocaine-seeking by enhancing dopaminergic activity in the ventral tegmental area to nucleus accumbens pathway. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 12. 2019-03-11. PMID:29773910. |
dopamine (da) signaling in the nucleus accumbens (nac) core is necessary and sufficient for cue-induced drug-seeking. |
2019-03-11 |
2023-08-13 |
rat |
| Amy C Janes, Maya Zegel, Kyoko Ohashi, Jennifer Betts, Elena Molokotos, David Olson, Lauren Moran, Diego A Pizzagall. Nicotine normalizes cortico-striatal connectivity in non-smoking individuals with major depressive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 12. 2019-03-11. PMID:29795403. |
specifically, mdd has been associated with reduced connectivity between the nucleus accumbens (nac) and rostral anterior cingulate cortex (racc) but enhanced connectivity between the dorsal striatum (ds) and dorsolateral prefrontal cortex (dlpfc). |
2019-03-11 |
2023-08-13 |
Not clear |
| Mahsaneh Vatankhah, Saeideh Karimi-Haghighi, Abdolrahman Sarihi, Abbas Haghparas. Intra-accumbal administration of AMN082, a metabotropic glutamate receptor type 7 allosteric agonist, inhibits the acquisition but not the expression of morphine-induced conditioned place preference in rats. Neuroscience letters. vol 681. 2019-03-11. PMID:29800675. |
the nucleus accumbens (nac) plays a primary role in opioid reward. |
2019-03-11 |
2023-08-13 |
rat |
| Joram D Mul, Marion Soto, Michael E Cahill, Rebecca E Ryan, Hirokazu Takahashi, Kawai So, Jia Zheng, Denise E Croote, Michael F Hirshman, Susanne E la Fleur, Eric J Nestler, Laurie J Goodyea. Voluntary wheel running promotes resilience to chronic social defeat stress in mice: a role for nucleus accumbens ΔFosB. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 9. 2019-03-11. PMID:29875450. |
chronic voluntary wheel running (vwr), a rodent model that mimics aspects of human physical exercise, induces the transcription factor Δfosb in the nucleus accumbens (nac), a key reward-related brain area. |
2019-03-11 |
2023-08-13 |
mouse |
| Max E Joffe, Brandon D Turner, Eric Delpire, Brad A Gruete. Genetic loss of GluN2B in D1-expressing cell types enhances long-term cocaine reward and potentiation of thalamo-accumbens synapses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 12. 2019-03-11. PMID:29982266. |
transient upregulation of glun2b-containing nmda receptors (r) in the nucleus accumbens (nac) is proposed as an intermediate to long-term ampar plasticity associated with persistent cocaine-related behaviors. |
2019-03-11 |
2023-08-13 |
mouse |
| Xiao-Bo Wu, Peng-Bo Jing, Zhi-Jun Zhang, De-Li Cao, Ming-Hui Gao, Bao-Chun Jiang, Yong-Jing Ga. Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 11. 2019-03-11. PMID:29993042. |
the nucleus accumbens (nac) is an important area in mediating pain sensation and depression. |
2019-03-11 |
2023-08-13 |
mouse |
| Ethan M Anderson, Erin B Larson, Daniel Guzman, Anne Marie Wissman, Rachael L Neve, Eric J Nestler, David W Sel. Overexpression of the Histone Dimethyltransferase G9a in Nucleus Accumbens Shell Increases Cocaine Self-Administration, Stress-Induced Reinstatement, and Anxiety. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 4. 2019-03-07. PMID:29217682. |
one epigenetic alteration involves reductions in levels of the histone dimethyltransferase g9a in nucleus accumbens (nac) after chronic cocaine administration. |
2019-03-07 |
2023-08-13 |
rat |
| S Mohammad Ahmadi Soleimani, Mohammad Hossein Mohamadi M A H, Mohammad Reza Raoufy, Hossein Azizi, Mohammad Nasehi, Mohammad Reza Zarrindas. Acute morphine administration alters the power of local field potentials in mesolimbic pathway of freely moving rats: Involvement of dopamine receptors. Neuroscience letters. vol 686. 2019-03-07. PMID:30219483. |
increasing number of evidence support the role of ventral tegmental area (vta) and nucleus accumbens (nac) in mediating the opiate effects as the two critical components of brain reward pathway. |
2019-03-07 |
2023-08-13 |
rat |
| Mitra-Sadat Sadat-Shirazi, Mohammad-Reza Zarrindast, Hamidreza Daneshparvar, Ali Ziaie, Monir Fekri, Enayatollah Abbasnezhad, Ghorbangol Ashabi, Solmaz Khalifeh, Nasim Vousoogh. Alteration of dopamine receptors subtypes in the brain of opioid abusers: A postmortem study in Iran. Neuroscience letters. vol 687. 2019-03-07. PMID:30268777. |
mrna expression and protein level of dopamine receptors in the ventral tegmental area (vta), nucleus accumbens (nac) and amygdala were assessed. |
2019-03-07 |
2023-08-13 |
human |
| Ana Del C Vaquer-Alicea, Rafael Vázquez-Torres, Marcos Devarie-Hornedo, Juan C Vicenty-Padilla, Bermary Santos-Vera, Cristina María-Ríos, Maria E Vélez-Hernández, Todd Sacktor, Carlos A Jiménez-River. aPKC-Mediated Persistent Increase in AMPA/NMDA Ratio in the VTA Participates in the Neuroadaptive Signal Necessary to Induce NAc Synaptic Plasticity After Cocaine Administration. Neuroscience. vol 392. 2019-03-06. PMID:30243909. |
persistence of early cocaine-evoked neuroadaptations in the ventral tegmental area (vta) is necessary for later synaptic alterations in the nucleus accumbens (nac), suggesting a temporal sequence of neuroplastic changes between these two areas. |
2019-03-06 |
2023-08-13 |
Not clear |
| Marian T Sepulveda-Orengo, Kati L Healey, Ronald Kim, Alyson C Auriemma, Jennifer Rojas, Nicholas Woronoff, Rachel Hyppolite, Kathryn J Reissne. Riluzole Impairs Cocaine Reinstatement and Restores Adaptations in Intrinsic Excitability and GLT-1 Expression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 6. 2019-03-04. PMID:28990593. |
riluzole also reversed the cocaine-induced suppression of the high-affinity glutamate transporter 1 (eaat2/glt-1) in the nucleus accumbens (nac). |
2019-03-04 |
2023-08-13 |
rat |
| Paige M Dingess, Amit Thakar, Zhaojie Zhang, Francis W Flynn, Travis E Brow. High-Salt Exposure During Perinatal Development Enhances Stress Sensitivity. Developmental neurobiology. vol 78. issue 11. 2019-02-27. PMID:30136369. |
using a combination of cellular and behavioral approaches, we examined the impact of maternal salt intake during the perinatal period on structural plasticity in the prefrontal cortex (pfc) and nucleus accumbens (nac) in weanling and adult offspring as well as reward- and stress-driven behaviors in adult offspring. |
2019-02-27 |
2023-08-13 |
rat |
| Akiko Shimamoto, Virginie Rappeneau, Havisha Munjal, Tonie Farris, Christopher Davis, Alicia Wilson, Malcolm Edwards, Cindy Moore, Collin Reynolds, Charles K Meshu. Glutamate-Glutamine Transfer and Chronic Stress-Induced Sex Differences in Cocaine Responses. Neuroscience. vol 391. 2019-02-27. PMID:30240589. |
our previous findings revealed sex-dependent changes in extracellular levels of glutamate (glu) and glutamine (gln) in the nucleus accumbens (nac) in long-evans rats that were exposed to 21 days of chronic social defeat stress (csds), which models md. |
2019-02-27 |
2023-08-13 |
rat |
| Igor Bazov, Daniil Sarkisyan, Olga Kononenko, Hiroyuki Watanabe, Tatiana Yakovleva, Anita C Hansson, Wolfgang H Sommer, Rainer Spanagel, Georgy Bakalki. Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics. Molecular neurobiology. vol 55. issue 8. 2019-02-26. PMID:29383684. |
a main molecular addiction hypothesis is that the upregulation of the dynorphin (dyn)/κ-opioid receptor (kor) system in the nucleus accumbens (nac) of alcohol-dependent individuals causes the imbalance in activity of d1- and d2 dopamine receptor (dr) expressing neural circuits that results in dysphoria. |
2019-02-26 |
2023-08-13 |
human |