| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eiji Sugiyama, Ashwin N Skelly, Makoto Suematsu, Yuki Sugiur. In situ imaging of monoamine localization and dynamics. Pharmacology & therapeutics. vol 208. 2021-03-22. PMID:31931099. |
moreover, ims can reveal regionally segregated monoamine fluctuations, such as rapid dopamine fluctuation within the nucleus accumbens (nac) subregion during pain sensation. |
2021-03-22 |
2023-08-13 |
Not clear |
| Ru Yang, Xixi Zhao, Jun Liu, Xufeng Yao, Feng Hou, Yikai Xu, Qianjin Fen. Functional connectivity changes of nucleus Accumbens Shell portion in left mesial temporal lobe epilepsy patients. Brain imaging and behavior. vol 14. issue 6. 2021-03-22. PMID:32318911. |
growing evidence has supported that the nucleus accumbens (nac), especially its shell portion, has been involved in epileptogenesis. |
2021-03-22 |
2023-08-13 |
human |
| Shannon L Cole, Jeffrey J Olne. Dissecting Mechanisms of Motivation within the Nucleus Accumbens Using Optogenetics. Methods in molecular biology (Clifton, N.J.). vol 2191. 2021-03-22. PMID:32865753. |
the chapter also provides examples of behavioral testing protocols using optogenetics to localize psychological functions in the nucleus accumbens (nac), a brain region involved in the production of motivated behaviors. |
2021-03-22 |
2023-08-13 |
Not clear |
| Andrew M Youssef, Ke Peng, Pearl Kijoo Kim, Alyssa Lebel, Navil F Sethna, Corey Kronman, David Zurakowski, David Borsook, Laura E Simon. Pain stickiness in pediatric complex regional pain syndrome: A role for the nucleus accumbens. Neurobiology of pain (Cambridge, Mass.). vol 9. 2021-03-21. PMID:33732954. |
our results show: (1) on admission, pain nonresponders had decreased grey matter density (gmd) within the nucleus accumbens (nac) and reduced rfc strength between the nac and the dorsolateral prefrontal cortex vs. responders; (2) connectivity strength was positively correlated with change in pain intensity from admission to discharge; (3) compared with pain-free controls, grey matter and rfc differences emerged only among pain nonresponders; and (4) using a discriminative model, combining gmd and rfc strengths assessed at admission showed the highest prediction estimate (87%) on potential for pain improvement, warranting testing in a de novo sample. |
2021-03-21 |
2023-08-13 |
Not clear |
| Megan E Fox, Ramesh Chandra, Miriam S Menken, Emily J Larkin, Hyungwoo Nam, Michel Engeln, T Chase Francis, Mary Kay Lob. Dendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior. Molecular psychiatry. vol 25. issue 5. 2021-03-16. PMID:30120419. |
preclinical evidence suggests that medium spiny neurons (msns) in the nucleus accumbens (nac) undergo structural plasticity; however, the molecular mechanism and behavioral significance is poorly understood. |
2021-03-16 |
2023-08-13 |
mouse |
| Katalin Eszter Ibos, Éva Bodnár, Zsolt Bagosi, Zsolt Bozsó, Gábor Tóth, Gyula Szabó, Krisztina Csabaf. Kisspeptin-8 Induces Anxiety-Like Behavior and Hypolocomotion by Activating the HPA Axis and Increasing GABA Release in the Nucleus Accumbens in Rats. Biomedicines. vol 9. issue 2. 2021-03-16. PMID:33503835. |
gaba release from the nucleus accumbens (nac) and dopamine release from the ventral tegmental area (vta) and nac were measured via ex vivo superfusion. |
2021-03-16 |
2023-08-13 |
rat |
| Wendy J Lynch, Anousheh Bakhti-Suroosh, Jean M Abel, Camilla Davi. Shifts in the neurobiological mechanisms motivating cocaine use with the development of an addiction-like phenotype in male rats. Psychopharmacology. vol 238. issue 3. 2021-03-15. PMID:33241478. |
the development of addiction is accompanied by a shift in the mechanisms motivating cocaine use from nucleus accumbens (nac) dopamine d |
2021-03-15 |
2023-08-13 |
rat |
| Brittany L Smith, Collin J Laaker, Kelsey R Lloyd, Adam R Hiltz, Teresa M Reye. Adolescent microglia play a role in executive function in male mice exposed to perinatal high fat diet. Brain, behavior, and immunity. vol 84. 2021-03-12. PMID:31765789. |
we then measured gene expression in adult male pfc, nucleus accumbens (nac), and amygdala (amg), examining targets related to synaptic function, reward, and inflammation. |
2021-03-12 |
2023-08-13 |
mouse |
| C E Strong, D P Hagarty, A Brea Guerrero, K J Schoepfer, S M Cajuste, M Kabba. Chemogenetic selective manipulation of nucleus accumbens medium spiny neurons bidirectionally controls alcohol intake in male and female rats. Scientific reports. vol 10. issue 1. 2021-03-09. PMID:33154463. |
the nucleus accumbens (nac), considered the hub of reward circuitry, is comprised of two medium spiny neuron (msn) subtypes that are classified by their enrichment of dopamine 1 (d1) or 2 (d2) receptors. |
2021-03-09 |
2023-08-13 |
rat |
| Jing Wang, Simin Lai, Guodong Li, Ting Zhou, Biao Wang, Fang Cao, Teng Chen, Xia Zhang, Yanjiong Che. Microglial activation contributes to depressive-like behavior in dopamine D3 receptor knockout mice. Brain, behavior, and immunity. vol 83. 2021-03-08. PMID:31626970. |
we previously demonstrated that the dopamine d3 receptor (d3r) inhibitor, ngb2904, increases susceptibility to depressive-like symptoms, elevates pro-inflammatory cytokine expression, and alters brain-derived neurotrophic factor (bdnf) levels in mesolimbic dopaminergic regions, including the medial prefrontal cortex (mpfc), nucleus accumbens (nac), and ventral tegmental area (vta) in mice. |
2021-03-08 |
2023-08-13 |
mouse |
| Joo Han Lee, Efrain A Ribeiro, Jeongseop Kim, Bumjin Ko, Hope Kronman, Yun Ha Jeong, Jong Kyoung Kim, Patricia H Janak, Eric J Nestler, Ja Wook Koo, Joung-Hun Ki. Dopaminergic Regulation of Nucleus Accumbens Cholinergic Interneurons Demarcates Susceptibility to Cocaine Addiction. Biological psychiatry. vol 88. issue 10. 2021-03-08. PMID:32622465. |
cholinergic interneurons (chins) in the nucleus accumbens (nac) play critical roles in processing information related to reward. |
2021-03-08 |
2023-08-13 |
Not clear |
| Jessie Muir, Yiu Chung Tse, Eshaan S Iyer, Julia Biris, Vedrana Cvetkovska, Joëlle Lopez, Rosemary C Bago. Ventral Hippocampal Afferents to Nucleus Accumbens Encode Both Latent Vulnerability and Stress-Induced Susceptibility. Biological psychiatry. vol 88. issue 11. 2021-03-08. PMID:32682566. |
in rodents, nucleus accumbens (nac) afferents from the ventral hippocampus (vhip) are implicated in stress-induced susceptibility, but little is known about how this pathway might encode future vulnerability or specific behavioral phenotypes. |
2021-03-08 |
2023-08-13 |
Not clear |
| Guiyun Wu, Xiaoying Xu, Fang Ye, Haihua Sh. Effects of processed Aconiti tuber on the extinction and reinstatement of morphine-induced conditioned place preference in rats. Journal of ethnopharmacology. vol 267. 2021-03-02. PMID:33129945. |
the dynorphin level in rats' nucleus accumbens (nac) is detected as a target of the dynorphin/kappa opioid receptor (kor) system for the possible mechanism. |
2021-03-02 |
2023-08-13 |
rat |
| Patricia Novaes Soares, Rosiane Aparecida Miranda, Iala Milene Bertasso, Carla Bruna Pietrobon, Vanessa Silva Tavares Rodrigues, Elaine de Oliveira, Alex Christian Manhães, Egberto Gaspar de Moura, Patricia Cristina Lisbo. Late effects of early weaning on food preference and the dopaminergic and endocannabinoid systems in male and female rats. Journal of developmental origins of health and disease. 2021-03-02. PMID:33650480. |
at pn180, ew males showed lower type 2 dopamine receptor (d2r) in the nucleus accumbens (nac) and dorsal striatum, while ew females had lower tyrosine hydroxylase in the ventral tegmental area and nac, d1r in the nac, and d2r in the prefrontal cortex. |
2021-03-02 |
2023-08-13 |
rat |
| Meltem Weger, Daniel Alpern, Antoine Cherix, Sriparna Ghosal, Jocelyn Grosse, Julie Russeil, Rolf Gruetter, E Ronald de Kloet, Bart Deplancke, Carmen Sand. Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress. Scientific reports. vol 10. issue 1. 2021-02-26. PMID:33110158. |
here, we performed a genome-wide transcriptomic study to examine mitochondrial gene expression in the prefrontal cortex (pfc) and nucleus accumbens (nac) of mice exposed to multimodal chronic restraint stress. |
2021-02-26 |
2023-08-13 |
mouse |
| Omer Horovitz, Ziv Ardi, Shiri Karni Ashkenazi, Gilad Ritov, Rachel Anunu, Gal Richter-Levi. Network Neuromodulation of Opioid and GABAergic Receptors Following a Combination of "Juvenile" and "Adult Stress" in Rats. International journal of molecular sciences. vol 21. issue 15. 2021-02-22. PMID:32751453. |
two weeks following behavioral assessment in adulthood, gabaar α1 and α2 subunits and κ opioid receptor expression levels were measured in the medial prefrontal cortex (mpfc), nucleus accumbens (nac), amygdala, and periaqueductal gray (pag). |
2021-02-22 |
2023-08-13 |
rat |
| In Soo Ryu, Oc-Hee Kim, Young Eun Lee, Ji Sun Kim, Zhan-Hui Li, Tae Wan Kim, Ri-Na Lim, Young Ju Lee, Jae Hoon Cheong, Hee Jin Kim, Yong Sup Lee, Scott C Steffensen, Bong Hyo Lee, Joung-Wook Seo, Eun Young Jan. The Abuse Potential of Novel Synthetic Phencyclidine Derivative 1-(1-(4-Fluorophenyl)Cyclohexyl)Piperidine (4'-F-PCP) in Rodents. International journal of molecular sciences. vol 21. issue 13. 2021-02-19. PMID:32610694. |
using western immunoblotting, we also investigated the expression of dopamine (da)-related proteins and da-receptor-mediated downstream signaling cascades in the nucleus accumbens (nac) of 4'-f-pcp-self-administering rats. |
2021-02-19 |
2023-08-13 |
mouse |
| Elena Sildatke, Thomas Schüller, Theo O J Gründler, Markus Ullsperger, Veerle Visser-Vandewalle, Daniel Huys, Jens Kuh. Error-Related Activity in Striatal Local Field Potentials and Medial Frontal Cortex: Evidence From Patients With Severe Opioid Abuse Disorder. Frontiers in human neuroscience. vol 14. 2021-02-19. PMID:33597851. |
here we attempted to identify the involvement of the nucleus accumbens (nac) in the aforementioned performance monitoring processes. |
2021-02-19 |
2023-08-13 |
Not clear |
| Bok Soon Go, Sunil Sirohi, Brendan M Walke. The role of matrix metalloproteinase-9 in negative reinforcement learning and plasticity in alcohol dependence. Addiction biology. vol 25. issue 2. 2021-02-16. PMID:30648329. |
subsequently, rat brains were extracted after initial or stable escalated alcohol self-administration phases of acute withdrawal and analyzed by immunoblot to detect mmp-2, -3, and -9 levels in the anterior cingulate cortex (acc), bed nucleus of the stria terminalis, central amygdala (cea), hippocampus, and nucleus accumbens (nac). |
2021-02-16 |
2023-08-13 |
rat |
| Shuang-Qi Gao, Hai Zhang, Jin-Gang He, Hui-Ling Zheng, Pei-Wei Zhang, Jun-Feng Xu, Zu-Cheng Shen, Huan-Huan Zhao, Fang Wang, Zhuang-Li Hu, Jian-Guo Che. Neuronal HMGB1 in nucleus accumbens regulates cocaine reward memory. Addiction biology. vol 25. issue 2. 2021-02-16. PMID:31056833. |
here, we show that cocaine exposure induced the translocation and release of hmgb1 in the nucleus accumbens (nac) neurons. |
2021-02-16 |
2023-08-13 |
Not clear |