| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer A Dinieri, Christina L Nemeth, Aram Parsegian, Tiffany Carle, Vsevolod V Gurevich, Eugenia Gurevich, Rachael L Neve, Eric J Nestler, William A Carlezo. Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 6. 2009-03-06. PMID:19211892. |
the transcription factor camp response element-binding protein (creb) within the nucleus accumbens (nac) plays an important role in regulating mood. |
2009-03-06 |
2023-08-12 |
mouse |
| Jeffery H Penzner, Daria L Thompson, Cory Arth, Jaclyn K Fowler, Alexis W Ary, Karen K Szumlinsk. Protracted 'anti-addictive' effects of adolescent phenylpropanolamine exposure in C57BL/6J mice. Addiction biology. vol 13. issue 3-4. 2009-03-05. PMID:18331369. |
exposure to the once highly prevalent over-the-counter (otc) sympathomimetic phenylpropanolamine (ppa; +/--norephedrine) during pre-adolescence alters the developmental trajectory of catecholamine and amino acid neurotransmitter systems in the nucleus accumbens (nac) that culminate in a 'pro-addictive' phenotype in adulthood. |
2009-03-05 |
2023-08-12 |
mouse |
| R C R Martinez, A R Oliveira, C E Macedo, V A Molina, M L Brandã. Involvement of dopaminergic mechanisms in the nucleus accumbens core and shell subregions in the expression of fear conditioning. Neuroscience letters. vol 446. issue 2-3. 2009-02-27. PMID:18835326. |
the involvement of dopamine (da) mechanisms in the nucleus accumbens (nac) in fear conditioning has been proposed by many studies that have challenged the view that the nac is solely involved in the modulation of appetitive processes. |
2009-02-27 |
2023-08-12 |
rat |
| Lars V Kristiansen, Michael J Bannon, James H Meador-Woodruf. Expression of transcripts for myelin related genes in postmortem brain from cocaine abusers. Neurochemical research. vol 34. issue 1. 2009-02-23. PMID:18357522. |
chronic abuse of cocaine is known to cause neuroadaptive changes in the nucleus accumbens (nac) and ventral tegmental area (vta). |
2009-02-23 |
2023-08-12 |
human |
| Mei Huang, Zhu Li, Jin Dai, Mohammed Shahid, Erik H F Wong, Herbert Y Meltze. Asenapine increases dopamine, norepinephrine, and acetylcholine efflux in the rat medial prefrontal cortex and hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 12. 2009-02-20. PMID:18418367. |
atypical antipsychotic drugs, which are more potent direct acting antagonists of brain serotonin (5-ht)(2a) than dopamine (da) d(2) receptors, preferentially enhance da and acetylcholine (ach) efflux in the rat medial prefrontal cortex (mpfc) and hippocampus (hip), compared with the nucleus accumbens (nac). |
2009-02-20 |
2023-08-12 |
rat |
| Nadia Chaudhri, Lacey L Sahuque, Jackson J Cone, Patricia H Jana. Reinstated ethanol-seeking in rats is modulated by environmental context and requires the nucleus accumbens core. The European journal of neuroscience. vol 28. issue 11. 2009-02-20. PMID:19046372. |
we also determined whether pharmacologically inactivating the nucleus accumbens (nac), a key structure in relapse circuitry, would attenuate reinstated etoh-seeking. |
2009-02-20 |
2023-08-12 |
rat |
| Taku Nagai, Toshitaka Nabeshima, Kiyofumi Yamad. Basic and translational research on proteinase-activated receptors: regulation of nicotine reward by the tissue plasminogen activator (tPA) - plasmin system via proteinase-activated receptor 1. Journal of pharmacological sciences. vol 108. issue 4. 2009-02-19. PMID:19098386. |
we show that the tissue plasminogen activator (tpa) - plasmin system regulates nicotine-induced reward and dopamine release in the nucleus accumbens (nac) by activating proteinase-activated receptor 1 (par(1)). |
2009-02-19 |
2023-08-12 |
mouse |
| Ahmed A Othman, Amy H Newman, Natalie D Eddingto. The novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse. Journal of pharmaceutical sciences. vol 97. issue 12. 2009-02-10. PMID:18425847. |
effect of ga2-50 on the extracelluar nucleus accumbens (nac) dopamine levels and on cocaine's induced dopamine elevation was evaluated using intracerebral microdialysis. |
2009-02-10 |
2023-08-12 |
human |
| Fei He, Hao Guan, Zhijing Zhao, Xinfang Miao, Qin Zhou, Lihong Li, Dongmei Huang, Anheng Liu, Danmin Mia. Evaluation of short-term psychological functions in opiate addicts after ablating the nucleus accumbens via stereotactic surgery. Stereotactic and functional neurosurgery. vol 86. issue 5. 2009-02-06. PMID:18841037. |
to investigate the short-term psychological function of opiate addicts who have undergone ablative stereotactic surgery targeting the nucleus accumbens (nac) for alleviating opiate drug psychological dependence. |
2009-02-06 |
2023-08-12 |
Not clear |
| Myonghwan Kim, Eunkyu Au, Rachael Neve, Bong-June Yoo. AMPA receptor trafficking in the dorsal striatum is critical for behavioral sensitization to cocaine in juvenile mice. Biochemical and biophysical research communications. vol 379. issue 1. 2009-02-06. PMID:19070590. |
while the role for the nucleus accumbens (nac) shell and core in addiction has been extensively studied, the function of the dorsal striatum is not clear. |
2009-02-06 |
2023-08-12 |
mouse |
| Rita A Fuchs, Donna R Ramirez, Guinevere H Bel. Nucleus accumbens shell and core involvement in drug context-induced reinstatement of cocaine seeking in rats. Psychopharmacology. vol 200. issue 4. 2009-01-29. PMID:18597075. |
the nucleus accumbens (nac) is a functionally heterogeneous brain region with respect to its involvement in cocaine-seeking behavior triggered by drug-associated explicit conditioned stimuli, foot shock stress, or cocaine itself in the reinstatement animal model of drug relapse. |
2009-01-29 |
2023-08-12 |
rat |
| Nicole M Vittoz, Brooke Schmeichel, Craig W Berridg. Hypocretin /orexin preferentially activates caudomedial ventral tegmental area dopamine neurons. The European journal of neuroscience. vol 28. issue 8. 2009-01-26. PMID:18973582. |
recent studies indicate that hcrt selectively increases dopamine (da) neurotransmission within the prefrontal cortex (pfc) and the shell subregion of the nucleus accumbens (nas), but not the core subregion of the nucleus accumbens (nac). |
2009-01-26 |
2023-08-12 |
Not clear |
| Ryan K Bachtell, David W Sel. Renewed cocaine exposure produces transient alterations in nucleus accumbens AMPA receptor-mediated behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 48. 2009-01-26. PMID:19036973. |
withdrawal from repeated cocaine is associated with increased synaptic and extrasynaptic ampa receptor (ampar) expression in nucleus accumbens (nac) neurons and enhanced behavioral sensitivity to ampar stimulation. |
2009-01-26 |
2023-08-12 |
Not clear |
| Wei-Lun Sun, Luyi Zhou, Ruhal Hazim, Vanya Quinones-Jenab, Shirzad Jena. Effects of dopamine and NMDA receptors on cocaine-induced Fos expression in the striatum of Fischer rats. Brain research. vol 1243. 2009-01-21. PMID:18822274. |
in this study, we show that a single cocaine administration (30 mg/kg) time-dependently increases erk phosphorylation, c-fos and fosb protein expression, and mkp-1 phosphorylation (p-mkp-1), in the caudate-putamen (cpu) and nucleus accumbens (nac) of fischer rats. |
2009-01-21 |
2023-08-12 |
rat |
| Donita L Robinson, Regina M Carell. Distinct subsets of nucleus accumbens neurons encode operant responding for ethanol versus water. The European journal of neuroscience. vol 28. issue 9. 2009-01-21. PMID:18973602. |
subsets of nucleus accumbens (nac) neurons process information about operant responses for drugs as well as natural rewards (food and water) by excitations and inhibitions in firing rate time-locked to the operant response. |
2009-01-21 |
2023-08-12 |
rat |
| Xiao-Qing Peng, Xia Li, Jeremy G Gilbert, Arlene C Pak, Charles R Ashby, Jonathan D Brodie, Stephen L Dewey, Eliot L Gardner, Zheng-Xiong X. Gamma-vinyl GABA inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats by a non-dopaminergic mechanism. Drug and alcohol dependence. vol 97. issue 3. 2009-01-06. PMID:18063319. |
in vivo microdialysis data indicated that the same doses of gvg dose-dependently elevate extracellular gaba levels in the nucleus accumbens (nac). |
2009-01-06 |
2023-08-12 |
rat |
| Xiao-Qing Peng, Xia Li, Jie Li, P Veeraraghavan Ramachandran, Pravin D Gagare, Debarshi Pratihar, Charles R Ashby, Eliot L Gardner, Zheng-Xiong X. Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in rats. Drug and alcohol dependence. vol 97. issue 3. 2009-01-06. PMID:18065162. |
in the present study, we investigated the effects of gabapentin on intravenous cocaine self-administration and cocaine-triggered reinstatement of drug-seeking behavior, as well as on cocaine-enhanced dopamine (da) in the nucleus accumbens (nac). |
2009-01-06 |
2023-08-12 |
rat |
| Soon-Eng Ta. Roles of hippocampal NMDA receptors and nucleus accumbens D1 receptors in the amphetamine-produced conditioned place preference in rats. Brain research bulletin. vol 77. issue 6. 2008-12-29. PMID:18929625. |
there are glutamatergic projections from the hippocampus to the nucleus accumbens (nac), which regulate da transmission in this structure. |
2008-12-29 |
2023-08-12 |
rat |
| Ainhoa Bilbao, Jan Rodriguez Parkitna, David Engblom, Stéphanie Perreau-Lenz, Carles Sanchis-Segura, Miriam Schneider, Witold Konopka, Magdalena Westphal, Gerome Breen, Sylvane Desrivieres, Matthias Klugmann, Camila Guindalini, Homero Vallada, Ronaldo Laranjeira, Fernando Rodriguez de Fonseca, Gunter Schumann, Günther Schütz, Rainer Spanage. Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 45. 2008-12-23. PMID:19001277. |
the persistent nature of addiction has been associated with activity-induced plasticity of neurons within the striatum and nucleus accumbens (nac). |
2008-12-23 |
2023-08-12 |
mouse |
| Emma S J Robinson, Jeffrey W Dalley, David E H Theobald, Jeffrey C Glennon, Marie A Pezze, Emily R Murphy, Trevor W Robbin. Opposing roles for 5-HT2A and 5-HT2C receptors in the nucleus accumbens on inhibitory response control in the 5-choice serial reaction time task. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 10. 2008-12-22. PMID:18046307. |
the present study investigates the loci of effects mediated by 5-ht(2a) and 5-ht(2c) receptors in attention and inhibitory response control using microinfusions targeted at the nucleus accumbens (nac), prelimbic cortex (pl) and infralimbic cortex (il). |
2008-12-22 |
2023-08-12 |
rat |