All Relations between nucleus accumbens and nac

Publication Sentence Publish Date Extraction Date Species
Qingyao Kong, Xiaoyang Wu, Ming X. A Genetically Modified Skin Graft for Treating Alcohol Use Disorder and/or Polysubstance Abuse With Cocaine. Advances in drug and alcohol research. vol 1. 2024-02-23. PMID:38390403. we have developed and used a skin stem cell-based gene delivery platform and found that production of the glucagon-like peptide-1 (glp1) from the grafted genetically modified skin reduced development and reinstatement of alcohol-induced drug-taking and seeking, voluntary oral alcohol consumption and alcohol-induced increase in dopamine (da) levels in the nucleus accumbens (nac). 2024-02-23 2024-02-25 human
Yuka Kusui, Naotaka Izuo, Reika Tokuhara, Takashi Asano, Atsumi Nitt. Neuronal activation of nucleus accumbens by local methamphetamine administration induces cognitive impairment through microglial inflammation in mice. Journal of pharmacological sciences. vol 154. issue 3. 2024-02-23. PMID:38395513. meth causes neuronal hyperactivation in the nucleus accumbens (nac) by aberrantly releasing dopamine, which triggers dependence. 2024-02-23 2024-02-26 mouse
Hongyu Yang, Xiuning Zhang, Minglong Zhang, Yun Lu, Bing Xie, Shaoguang Sun, Hailei Yu, Bin Cong, Yixiao Luo, Chunling Ma, Di We. Roles of lncLingo2 and its derived miR-876-5p in the acquisition of opioid reinforcement. Addiction biology. vol 29. issue 2. 2024-02-21. PMID:38380802. in this study, we characterized lncrna transcriptome profiles in the nucleus accumbens (nac) of mice exhibiting morphine-conditioned place preference (cpp) and explored the prospective roles of novel differentially expressed lncrna, lnclingo2 and its derived mir-876-5p in the acquisition of opioids-associated behaviours. 2024-02-21 2024-02-23 mouse
C Medina-Saldivar, G V E Pardo, L F Pacheco-Otalor. Effect of MCH1, a fatty-acid amide hydrolase inhibitor, on the depressive-like behavior and gene expression of endocannabinoid and dopaminergic-signaling system in the mouse nucleus accumbens. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-02-21. PMID:38381881. this inhibition can modulate endocannabinoid and dopamine signaling in the nucleus accumbens (nac), potentially having an antidepressant-like effect. 2024-02-21 2024-02-24 mouse
Nicholas Pintori, Alessandro Piva, Francesca Mottarlini, Fernando Castillo Díaz, Coralie Maggi, Lucia Caffino, Fabio Fumagalli, Cristiano Chiamuler. Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint. The European journal of neuroscience. 2024-02-20. PMID:38378276. adult male sprague-dawley rats were exposed to ee for 22 h and the expression of critical elements of the glutamate synapse was measured 2 h after the end of ee in the medial prefrontal cortex (mpfc), nucleus accumbens (nac) and hippocampus (hipp) brain areas, which are critical for reward and memory. 2024-02-20 2024-02-23 rat
Conner W Wallace, Katherine M Holleran, Clare Y Slinkard, Samuel W Centanni, Sara R Jone. Kappa Opioid Receptors Negatively Regulate Real Time Spontaneous Dopamine Signals by Reducing Release and Increasing Uptake. bioRxiv : the preprint server for biology. 2024-02-19. PMID:38370660. to explore kor influences on real-time da fluctuations, we used the photosensor dlight1.2 with fiber photometry in the nucleus accumbens (nac) core of freely moving male and female c57bl/6 mice. 2024-02-19 2024-02-21 mouse
Nan Song, Zhenhong Liu, Yan Gao, Shanshan Lu, Shenglian Yang, Chao Yua. NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA. Molecular psychiatry. 2024-02-16. PMID:38361128. mdd can be associated with abnormalities in the reward-system-dopaminergic mesolimbic pathway, in which the nucleus accumbens (nac) and ventral tegmental area (vta) play major roles. 2024-02-16 2024-02-18 mouse
Julien Castel, Guangping Li, Oriane Onimus, Emma Leishman, Patrice D Cani, Heather Bradshaw, Ken Mackie, Amandine Everard, Serge Luquet, Giuseppe Gangaross. NAPE-PLD in the ventral tegmental area regulates reward events, feeding and energy homeostasis. Molecular psychiatry. 2024-02-16. PMID:38361126. reward-dependent behaviors depend on dopamine (da) transmission between the ventral tegmental area (vta) and the nucleus accumbens (nac), which conveys reward-values and scales reinforced behaviors. 2024-02-16 2024-02-18 Not clear
Xiaoxi Zhao, Aqian Hu, Yanyan Wang, Tianshu Zhao, Xiaojun Xian. Paraventricular thalamus to nucleus accumbens circuit activation decreases long-term relapse of alcohol-seeking behaviour in male mice. Pharmacology, biochemistry, and behavior. 2024-02-15. PMID:38360104. the pathway from the anterior paraventricular thalamus (pvt) to the shell of the nucleus accumbens (nac) has been reported as an essential regulatory pathway for processing aversion and is also closely associated with substance addiction. 2024-02-15 2024-02-18 mouse
Bo-Han He, Ya-Hui Yang, Bo-Wen Hsiao, Wan-Ting Lin, Yi-Fang Chuang, Shih-Yun Chen, Fu-Chin Li. Foxp2 is Required for Nucleus Accumbens-mediated Multifaceted Limbic Function. Neuroscience. 2024-02-14. PMID:38354901. although foxp2 has been well studied in the dorsal striatum, its function in the nucleus accumbens (nac) of the ventral striatum remains elusive. 2024-02-14 2024-02-17 mouse
Mariah F Hazlett, Victoria L Hall, Esha Patel, Aaron Halvorsen, Nicole Calakos, Anne E Wes. The Perineuronal Net Protein Brevican Acts in Nucleus Accumbens Parvalbumin-expressing Interneurons of Adult Mice to Regulate Excitatory Synaptic Inputs and Motivated Behaviors. Biological psychiatry. 2024-02-12. PMID:38346480. experience-dependent functional adaptation of nucleus accumbens (nac) circuitry underlies the development and expression of reward-motivated behaviors. 2024-02-12 2024-02-15 mouse
Jonathan J Chow, Kayla M Pitts, Ansel Schoenbaum, Kauê M Costa, Geoffrey Schoenbaum, Yavin Shaha. Different effects of peer-sex on operant responding for social interaction and striatal dopamine activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-02-12. PMID:38346894. next, we transfected grab-da2m and implanted optic fibers into nucleus accumbens (nac) core and dorsomedial striatum (dms). 2024-02-12 2024-02-15 rat
Giulia Poggi, Giorgio Bergamini, Redas Dulinskas, Lorraine Madur, Alexandra Greter, Christian Ineichen, Amael Dagostino, Diana Kúkeľová, Hannes Sigrist, Klaus D Bornemann, Bastian Hengerer, Christopher R Pryc. Engagement of basal amygdala-nucleus accumbens glutamate neurons in the processing of rewarding or aversive social stimuli. The European journal of neuroscience. 2024-02-07. PMID:38326849. basal amygdala (ba) neurons projecting to nucleus accumbens (nac) core/shell are primarily glutamatergic and are integral to the circuitry of emotional processing. 2024-02-07 2024-02-10 mouse
Yue Zhang, Jingwen Gao, Na Li, Peng Xu, Shimeng Qu, Jinqian Cheng, Mingrui Wang, Xueru Li, Yaheng Song, Fan Xiao, Xinyu Yang, Jihong Liu, Hao Hong, Ronghao Mu, Xiaotian Li, Youmei Wang, Hui Xu, Yuan Xie, Tianming Gao, Guangji Wang, Jiye A. Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy. Acta pharmaceutica Sinica. B. vol 14. issue 2. 2024-02-07. PMID:38322327. studies have suggested that the nucleus accumbens (nac) is implicated in the pathophysiology of major depression; however, the regulatory strategy that targets the nac to achieve an exclusive and outstanding anti-depression benefit has not been elucidated. 2024-02-07 2024-02-09 mouse
Sydney P Weiner, Carolina Vasquez, Soomin Song, Kaiyang Zhao, Omar Ali, Danielle Rosenkilde, Robert C Froemke, Kenneth D Car. Sex difference in the effect of environmental enrichment on food restriction-induced persistence of cocaine conditioned place preference and mechanistic underpinnings. Addiction neuroscience. vol 10. 2024-02-07. PMID:38323217. mechanistic studies provided evidence of decreased basal dopamine (da) transmission, adaptive upregulation of signaling downstream of d1 da receptor stimulation, synaptic upscaling and incorporation of calcium-permeable ampa receptors (cp-ampars) in medium spiny neurons (msns) of nucleus accumbens (nac). 2024-02-07 2024-02-09 rat
Catarina Deseyve, Ana Verónica Domingues, Tawan T A Carvalho, Gisela Armada, Raquel Correia, Natacha Vieitas-Gaspar, Marcelina Wezik, Luísa Pinto, Nuno Sousa, Bárbara Coimbra, Ana João Rodrigues, Carina Soares-Cunh. Nucleus accumbens neurons dynamically respond to appetitive and aversive associative learning. Journal of neurochemistry. 2024-02-06. PMID:38317429. this association is partially mediated by the nucleus accumbens (nac), a key brain region of the reward circuit that is mainly composed by gabaergic medium spiny neurons (msns), that express either dopamine receptor d1 or d2. 2024-02-06 2024-02-09 mouse
Lindsey Wilson, McKenna Klausner, Stacey Chuang, Smruti Patel, Wayne E Prat. An examination of the effects of nucleus accumbens core nociceptin on appetitive and consummatory motivation for food. Behavioural brain research. 2024-02-05. PMID:38316167. the nucleus accumbens (nac) is a critical region for regulating the appetitive and consummatory aspects of motivated behavior. 2024-02-05 2024-02-09 rat
Ying Yu, Xuemei Li, Teng Teng, Yuqian He, Yuanliang Jiang, Xueer Liu, Xinyu Zhou, Yong Luo, Peng Xi. Comparative analysis of the nucleus accumbens transcriptional features in multiple depressive animal models. Behavioural brain research. 2024-02-03. PMID:38309372. the nucleus accumbens (nac), an essential brain area for the pathophysiology of depression, and its underlying neural mechanisms remain unclear. 2024-02-03 2024-02-06 rat
R Heijkoop, J F Lalanza, M Solanas, A Álvarez-Monell, A Subias-Gusils, R M Escorihuela, E M S Snoere. Changes in reward-induced neural activity upon Cafeteria Diet consumption. Physiology & behavior. 2024-02-02. PMID:38307359. to this end, rats were exposed to a 6-week diet with either standard chow, or ad libitum daily access to caf diet, 30% restricted but daily access to caf diet, or one-day-a-week (intermittent) ad libitum access to caf diet, after which c-fos expression in the nucleus accumbens (nac), prefrontal cortex (pfc), and ventral tegmental area (vta) following consumption of a caf reward of choice was examined. 2024-02-02 2024-02-05 rat
Robin Nguyen, Sanghavy Sivakumaran, Evelyn K Lambe, Jun Chul Ki. Ventral hippocampal cholecystokinin interneurons gate contextual reward memory. iScience. vol 27. issue 2. 2024-02-02. PMID:38303709. here, we demonstrate that the encoding of context-reward memory requires a ventral hippocampus (vhpc) to nucleus accumbens (nac) circuit that is gated by cholecystokinin (cck) interneurons. 2024-02-02 2024-02-04 Not clear