| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mianzhi Tang, J Carlos Villaescusa, Sarah X Luo, Camilla Guitarte, Simonia Lei, Yasunori Miyamoto, Makoto M Taketo, Ernest Arenas, Eric J Huan. Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 27. 2010-08-16. PMID:20610763. |
signaling mechanisms involving wnt/beta-catenin and sonic hedgehog (shh) are known to regulate the development of ventral midbrain (vmb) dopamine neurons. |
2010-08-16 |
2023-08-12 |
mouse |
| Ryan M Drenan, Sharon R Grady, Andrew D Steele, Sheri McKinney, Natalie E Patzlaff, J Michael McIntosh, Michael J Marks, Julie M Miwa, Henry A Leste. Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 29. 2010-08-13. PMID:20660270. |
dopamine (da) release in striatum is governed by firing rates of midbrain da neurons, striatal cholinergic tone, and nicotinic ach receptors (nachrs) on da presynaptic terminals. |
2010-08-13 |
2023-08-12 |
mouse |
| D Galter, K Pernold, T Yoshitake, E Lindqvist, B Hoffer, J Kehr, N-G Larsson, L Olso. MitoPark mice mirror the slow progression of key symptoms and L-DOPA response in Parkinson's disease. Genes, brain, and behavior. vol 9. issue 2. 2010-08-10. PMID:20002202. |
the mitopark mouse, in which the mitochondrial transcription factor tfam is selectively removed in midbrain dopamine (da) neurons, is a genetic model for parkinson's disease (pd) that replicates the slow and progressive development of key symptoms. |
2010-08-10 |
2023-08-12 |
mouse |
| Dong-Youn Hwang, Dae-Sung Kim, Dong-Wook Ki. Human ES and iPS cells as cell sources for the treatment of Parkinson's disease: current state and problems. Journal of cellular biochemistry. vol 109. issue 2. 2010-08-05. PMID:20014069. |
a prerequisite for clinical application of hescs for pd is an efficient and strict differentiation of hescs into midbrain dopamine (mda) neuron-like cells, which would be directly translated into high effectiveness of the therapy with minimum risk of undesirable side effects. |
2010-08-05 |
2023-08-12 |
human |
| Enrique R Torre, Claire-Anne Gutekunst, Robert E Gros. Expression by midbrain dopamine neurons of Sema3A and 3F receptors is associated with chemorepulsion in vitro but a mild in vivo phenotype. Molecular and cellular neurosciences. vol 44. issue 2. 2010-08-02. PMID:20298787. |
expression by midbrain dopamine neurons of sema3a and 3f receptors is associated with chemorepulsion in vitro but a mild in vivo phenotype. |
2010-08-02 |
2023-08-12 |
mouse |
| Yan-Fang Xia, Elyssa B Margolis, Gregory O Hjelmsta. Substance P inhibits GABAB receptor signalling in the ventral tegmental area. The Journal of physiology. vol 588. issue Pt 9. 2010-07-29. PMID:20231139. |
sp activates neurokinin (nk) receptors, which excites midbrain dopamine (da) neurons and leads to increased da in target regions. |
2010-07-29 |
2023-08-12 |
Not clear |
| Susanne Nikolaus, Christina Antke, Markus Beu, Hans-Wilhelm Mülle. Cortical GABA, striatal dopamine and midbrain serotonin as the key players in compulsive and anxiety disorders--results from in vivo imaging studies. Reviews in the neurosciences. vol 21. issue 2. 2010-07-29. PMID:20614802. |
cortical gaba, striatal dopamine and midbrain serotonin as the key players in compulsive and anxiety disorders--results from in vivo imaging studies. |
2010-07-29 |
2023-08-12 |
Not clear |
| Wolfram Schult. Dopamine signals for reward value and risk: basic and recent data. Behavioral and brain functions : BBF. vol 6. 2010-07-15. PMID:20416052. |
previous lesion, electrical self-stimulation and drug addiction studies suggest that the midbrain dopamine systems are parts of the reward system of the brain. |
2010-07-15 |
2023-08-12 |
Not clear |
| Nicholas M Kanaan, Jeffrey H Kordower, Timothy J Collie. Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys. Neurobiology of aging. vol 31. issue 6. 2010-07-13. PMID:18715678. |
age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys. |
2010-07-13 |
2023-08-12 |
monkey |
| Nicholas M Kanaan, Jeffrey H Kordower, Timothy J Collie. Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys. Neurobiology of aging. vol 31. issue 6. 2010-07-13. PMID:18715678. |
aging remains the strongest risk factor for developing parkinson's disease (pd), and there is selective vulnerability in midbrain dopamine (da) neuron degeneration in pd. |
2010-07-13 |
2023-08-12 |
monkey |
| Nobutoshi Morimoto, Makiko Nagai, Kazunori Miyazaki, Yasuyuki Ohta, Tomoko Kurata, Yasushi Takehisa, Yoshio Ikeda, Tohru Matsuura, Masato Asanuma, Koji Ab. Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene. Journal of neuroscience research. vol 88. issue 8. 2010-07-12. PMID:20127819. |
recent studies indicate that oxidative stress and disruption of mitochondrial homeostasis is a common mechanism for motor neuron degeneration in amyotrophic lateral sclerosis and the loss of midbrain dopamine neurons in parkinson's disease. |
2010-07-12 |
2023-08-12 |
mouse |
| V Roessner, T Sagvolden, T Dasbanerjee, F A Middleton, S V Faraone, S I Walaas, A Becker, A Rothenberger, N Boc. Methylphenidate normalizes elevated dopamine transporter densities in an animal model of the attention-deficit/hyperactivity disorder combined type, but not to the same extent in one of the attention-deficit/hyperactivity disorder inattentive type. Neuroscience. vol 167. issue 4. 2010-07-06. PMID:20211696. |
in this study, we first examined the expression of genes involved in dopamine signaling and metabolism in the dorsal striatum and ventral mesencephalon of these two rat strains, as well as three reference control strains (wky/nhsd, wk/hantac, and sd/ntac) using quantitative real time rt-pcr. |
2010-07-06 |
2023-08-12 |
rat |
| Garret D Stuber, Thomas S Hnasko, Jonathan P Britt, Robert H Edwards, Antonello Bonc. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 24. 2010-07-02. PMID:20554874. |
previous work has suggested that some midbrain dopamine neurons are themselves capable of glutamate corelease, but this phenomenon remains poorly understood. |
2010-07-02 |
2023-08-12 |
mouse |
| Garret D Stuber, Thomas S Hnasko, Jonathan P Britt, Robert H Edwards, Antonello Bonc. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 24. 2010-07-02. PMID:20554874. |
here, we expressed the light-activated cation channel channelrhodopsin-2 (chr2) in genetically defined midbrain dopamine neurons to stimulate exocytosis specifically from dopaminergic terminals in both the nucleus accumbens (nac) shell and dorsal striatum of brain slices from adult mice. |
2010-07-02 |
2023-08-12 |
mouse |
| L A Ruocco, U A Gironi Carnevale, C Treno, A G Sadile, D Melisi, C Arra, M Ibba, C Schirru, E Carbon. Prepuberal subchronic methylphenidate and atomoxetine induce different long-term effects on adult behaviour and forebrain dopamine, norepinephrine and serotonin in Naples high-excitability rats. Behavioural brain research. vol 210. issue 1. 2010-06-30. PMID:20156489. |
the high-performance liquid chromatography (hplc) tissue content assessment of dopamine, norepinephrine, serotonin and relative metabolites in the prefrontal cortex (pfc), cortical motor area (mc), dorsal striatum (ds), ventral striatum (vs), hippocampus and mesencephalon indicated that methylphenidate decreased (i) dopamine, dopac, norepinephrine, mhpg, 5-ht and 5-hiaa in the pfc, (ii) dopamine, dopac, hva, serotonin, 5-hiaa in the ds, (iii) dopamine, dopac, hva and mhpg (but increased norepinephrine) in the vs and (iv) norepinephrine, mhpg, serotonin and 5-hiaa in the hippocampus. |
2010-06-30 |
2023-08-12 |
rat |
| Ariel Graff-Guerrero, Laura Redden, Walid Abi-Saab, David A Katz, Sylvain Houle, Penny Barsoum, Anahita Bhathena, Ramesh Palaparthy, Mario D Saltarelli, Shitij Kapu. Blockade of [11C](+)-PHNO binding in human subjects by the dopamine D3 receptor antagonist ABT-925. The international journal of neuropsychopharmacology. vol 13. issue 3. 2010-06-24. PMID:19751545. |
dopamine d3 receptors are preferentially localized in the limbic system and midbrain, and thus may be involved in the pathophysiology of neuropsychiatry disorders. |
2010-06-24 |
2023-08-12 |
human |
| Ernest Arena. Towards stem cell replacement therapies for Parkinson's disease. Biochemical and biophysical research communications. vol 396. issue 1. 2010-06-18. PMID:20494130. |
first, the main symptoms of pd result from the loss of midbrain dopamine (da) neurons, but other cell types are also affected. |
2010-06-18 |
2023-08-12 |
human |
| M L Johnson, A E Day, C C Ho, Q D Walker, R Francis, C M Kuh. Androgen decreases dopamine neurone survival in rat midbrain. Journal of neuroendocrinology. vol 22. issue 4. 2010-06-17. PMID:20136692. |
androgen decreases dopamine neurone survival in rat midbrain. |
2010-06-17 |
2023-08-12 |
mouse |
| M L Johnson, C C Ho, A E Day, Q D Walker, R Francis, C M Kuh. Oestrogen receptors enhance dopamine neurone survival in rat midbrain. Journal of neuroendocrinology. vol 22. issue 4. 2010-06-17. PMID:20136693. |
oestrogen receptors enhance dopamine neurone survival in rat midbrain. |
2010-06-17 |
2023-08-12 |
mouse |
| Constantine James Konstantoulas, Malin Parmar, Meng L. FoxP1 promotes midbrain identity in embryonic stem cell-derived dopamine neurons by regulating Pitx3. Journal of neurochemistry. vol 113. issue 4. 2010-06-15. PMID:20175877. |
foxp1 promotes midbrain identity in embryonic stem cell-derived dopamine neurons by regulating pitx3. |
2010-06-15 |
2023-08-12 |
Not clear |