| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Goldstein, J H Friedman, R Innis, J Seibyl, K Mare. Hemi-parkinsonism due to a midbrain arteriovenous malformation: dopamine transporter imaging. Movement disorders : official journal of the Movement Disorder Society. vol 16. issue 2. 2001-08-30. PMID:11295793. |
hemi-parkinsonism due to a midbrain arteriovenous malformation: dopamine transporter imaging. |
2001-08-30 |
2023-08-12 |
Not clear |
| G H Moll, S Hause, E Rüther, A Rothenberger, G Huethe. Early methylphenidate administration to young rats causes a persistent reduction in the density of striatal dopamine transporters. Journal of child and adolescent psychopharmacology. vol 11. issue 1. 2001-08-30. PMID:11322741. |
this experimental animal study describes the effects of methylphenidate administration (2 mg/kg/day) for 2 weeks to very young (prepubertal) and somewhat older (postpubertal) rats on the densities of dopamine, serotonin, and norepinephrine transporters in the striatum and in the midbrain. |
2001-08-30 |
2023-08-12 |
rat |
| G H Moll, S Hause, E Rüther, A Rothenberger, G Huethe. Early methylphenidate administration to young rats causes a persistent reduction in the density of striatal dopamine transporters. Journal of child and adolescent psychopharmacology. vol 11. issue 1. 2001-08-30. PMID:11322741. |
no alterations were found for the bmax values of [3h]-paroxetine and [3h]-nisoxetine binding, but the density of dopamine transporters (bmax values of [3h]-gbr binding) in the striatum (but not in the midbrain) was significantly reduced after early methylphenidate administration (by 25% at day 45), and this decline reached almost 50% at adulthood (day 70), that is, long after termination of the treatment. |
2001-08-30 |
2023-08-12 |
rat |
| W C Ouyang, Y C Wang, C J Hong, C Y Cheng, S J Tsa. Association study of angiotensin-converting enzyme gene polymorphism with schizophrenia and polydipsia. Neuropsychobiology. vol 44. issue 1. 2001-08-30. PMID:11408790. |
angiotensin-converting enzyme (ace) is a key enzyme in the renin-angiotensin system and can modulate dopamine turnover in the midbrain. |
2001-08-30 |
2023-08-12 |
human |
| D S Zahm, S Grosu, E A Williams, S Qin, A Béro. Neurons of origin of the neurotensinergic plexus enmeshing the ventral tegmental area in rat: retrograde labeling and in situ hybridization combined. Neuroscience. vol 104. issue 3. 2001-08-30. PMID:11440814. |
these results identify a novel brain substrate for control of midbrain dopamine levels, which affect reward mechanisms and motivation. |
2001-08-30 |
2023-08-12 |
rat |
| F Georges, G Aston-Jone. Potent regulation of midbrain dopamine neurons by the bed nucleus of the stria terminalis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11473131. |
potent regulation of midbrain dopamine neurons by the bed nucleus of the stria terminalis. |
2001-08-30 |
2023-08-12 |
rat |
| K H Holm, F Cicchetti, L Bjorklund, Z Boonman, P Tandon, L C Costantini, T W Deacon, X Huang, D F Chen, O Isacso. Enhanced axonal growth from fetal human bcl-2 transgenic mouse dopamine neurons transplanted to the adult rat striatum. Neuroscience. vol 104. issue 2. 2001-08-16. PMID:11377843. |
in this study, rats with complete striatal dopamine fiber denervation received embryonic day 14 mouse ventral mesencephalon cells overexpressing human bcl-2 or control wild-type ventral mesencephalon cells. |
2001-08-16 |
2023-08-12 |
mouse |
| T R Werkman, C G Kruse, H Nievelstein, S K Long, W J Wadma. In vitro modulation of the firing rate of dopamine neurons in the rat substantia nigra pars compacta and the ventral tegmental area by antipsychotic drugs. Neuropharmacology. vol 40. issue 7. 2001-08-09. PMID:11378163. |
an in vitro experimental midbrain slice preparation is described which allows simultaneous extracellular recordings of the (spontaneous) electrical activity of dopamine neurons in the rat substantia nigra (sn) and the ventral tegmental area (vta). |
2001-08-09 |
2023-08-12 |
rat |
| V P Chekhonin, V P Baklaushev, T B Dmitrieva, B M Kogan, E A Savchenko, S V Lebedev, I P Lazarenko, I V Man'kovskaya, T S Filatova, V V Belopaso. Complex analysis of efficiency of transplantation of embryonic nerve tissue to rats with hemiparkinsonism. Bulletin of experimental biology and medicine. vol 130. issue 12. 2001-08-02. PMID:11276317. |
transplantation of embryonic ventral mesencephalon into denervated striatum led to a more than 50% decrease in apomorphine-induced rotation, recovery of dopamine and dopac levels in the brain, and to an increase in dopac excretion and the dopac-dopamine ratio in daily urine of rats with hemiparkinsonism. |
2001-08-02 |
2023-08-12 |
rat |
| V P Chekhonin, V P Baklaushev, T B Dmitrieva, B M Kogan, E A Savchenko, S V Lebedev, I P Lazarenko, I V Man'kovskaya, T S Filatova, V V Belopaso. Complex analysis of efficiency of transplantation of embryonic nerve tissue to rats with hemiparkinsonism. Bulletin of experimental biology and medicine. vol 130. issue 12. 2001-08-02. PMID:11276317. |
a positive correlation between urinary excretion of dopac and brain concentration of dopamine was revealed in denervated rats after transplantation of ventral mesencephalon. |
2001-08-02 |
2023-08-12 |
rat |
| K Tajiri, K Emori, M Murata, K Tanaka, M Suzuki, T Uehara, T Sumiyoshi, C R Ashby, M Kurach. Intracerebroventricular administration of NMDA-R1 antisense oligodeoxynucleotide significantly alters the activity of ventral tegmental area dopamine neurons: an electrophysiological study. Synapse (New York, N.Y.). vol 40. issue 4. 2001-07-26. PMID:11309843. |
in this study, we determined the activity of midbrain dopamine (da) neurons in male albino rats following the intracerebroventricular (i.c.v.) |
2001-07-26 |
2023-08-12 |
rat |
| A Tozzi, E Guatteo, L Caputi, G Bernardi, N B Mercur. Group I mGluRs coupled to G proteins are regulated by tyrosine kinase in dopamine neurons of the rat midbrain. Journal of neurophysiology. vol 85. issue 6. 2001-07-26. PMID:11387395. |
group i mglurs coupled to g proteins are regulated by tyrosine kinase in dopamine neurons of the rat midbrain. |
2001-07-26 |
2023-08-12 |
rat |
| A Tozzi, E Guatteo, L Caputi, G Bernardi, N B Mercur. Group I mGluRs coupled to G proteins are regulated by tyrosine kinase in dopamine neurons of the rat midbrain. Journal of neurophysiology. vol 85. issue 6. 2001-07-26. PMID:11387395. |
here we investigated, using whole cell patch-clamp recordings in combination with fluorimetric measurements of intracellular calcium concentration ([ca(2+)](i)), the metabolic pathways involved in the responses induced by group i mglurs in dopamine neurons of the rat midbrain. |
2001-07-26 |
2023-08-12 |
rat |
| J B Eells, J E Rives, S K Yeung, V M Nikode. In vitro regulated expression of tyrosine hydroxylase in ventral midbrain neurons from Nurr1-null mouse pups. Journal of neuroscience research. vol 64. issue 4. 2001-07-19. PMID:11340638. |
disruption of the nurr1 gene in mice by homologous recombination abolishes synthesis of dopamine (da) and expression of da biosynthetic enzymes, including tyrosine hydroxylase (th), in the ventral midbrain without affecting the synthesis of da in other areas of the brain. |
2001-07-19 |
2023-08-12 |
mouse |
| K Sawamoto, N Nakao, K Kobayashi, N Matsushita, H Takahashi, K Kakishita, A Yamamoto, T Yoshizaki, T Terashima, F Murakami, T Itakura, H Okan. Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 11. 2001-07-19. PMID:11353855. |
to visualize and isolate live dopamine (da)-producing neurons in the embryonic ventral mesencephalon, we generated transgenic mice expressing green fluorescent protein (gfp) under the control of the rat tyrosine hydroxylase gene promoter. |
2001-07-19 |
2023-08-12 |
mouse |
| M T Bardo, P M Robinet, B A Mattingly, J E Margulie. Effect of 6-hydroxydopamine or repeated amphetamine treatment on mesencephalic mRNA levels for AMPA glutamate receptor subunits in the rat. Neuroscience letters. vol 302. issue 2-3. 2001-07-12. PMID:11290405. |
expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (ampa) subunit mrnas were assayed in the ventral mesencephalon of rats that received either a unilateral microinjection of the dopamine neurotoxin 6-hydroxydopamine (6-ohda; experiment 1) or repeated treatment with amphetamine (experiment 2). |
2001-07-12 |
2023-08-12 |
rat |
| Y Minabe, K Hashimoto, K I Watanabe, C R Ashb. Acute and repeated administration of the selective 5-HT(2A) receptor antagonist M100907 significantly alters the activity of midbrain dopamine neurons: an in vivo electrophysiological study. Synapse (New York, N.Y.). vol 40. issue 2. 2001-07-05. PMID:11252021. |
acute and repeated administration of the selective 5-ht(2a) receptor antagonist m100907 significantly alters the activity of midbrain dopamine neurons: an in vivo electrophysiological study. |
2001-07-05 |
2023-08-12 |
rat |
| S J Cragg, C Nicholson, J Kume-Kick, L Tao, M E Ric. Dopamine-mediated volume transmission in midbrain is regulated by distinct extracellular geometry and uptake. Journal of neurophysiology. vol 85. issue 4. 2001-07-05. PMID:11287497. |
somatodendritic release of dopamine (da) in midbrain is, at least in part, nonsynaptic; moreover, midbrain da receptors are predominantly extrasynaptic. |
2001-07-05 |
2023-08-12 |
Not clear |
| M Rubinstein, C Cepeda, R S Hurst, J Flores-Hernandez, M A Ariano, T L Falzone, L B Kozell, C K Meshul, J R Bunzow, M J Low, M S Levine, D K Grand. Dopamine D4 receptor-deficient mice display cortical hyperexcitability. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 11. 2001-06-21. PMID:11356863. |
the dopamine d(4) receptor (d(4)r) is predominantly expressed in the frontal cortex (fc), a brain region that receives dense input from midbrain dopamine (da) neurons and is associated with cognitive and emotional processes. |
2001-06-21 |
2023-08-12 |
mouse |
| B P Bergstrom, P A Garri. Utility of a tripolar stimulating electrode for eliciting dopamine release in the rat striatum. Journal of neuroscience methods. vol 87. issue 2. 2001-06-14. PMID:11230817. |
taken together, these results suggested that the tripolar stimulating electrode is well suited for studying the regulation of midbrain dopamine neurons in vivo. |
2001-06-14 |
2023-08-12 |
rat |