| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cecile Martinat, Shoshana Shendelman, Alan Jonason, Thomas Leete, M Flint Beal, Lichuan Yang, Thomas Floss, Asa Abeliovic. Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism. PLoS biology. vol 2. issue 11. 2006-02-03. PMID:15502868. |
the hallmark of parkinson's disease (pd) is the selective loss of dopamine neurons in the ventral midbrain. |
2006-02-03 |
2023-08-12 |
Not clear |
| Shoshana Shendelman, Alan Jonason, Cecile Martinat, Thomas Leete, Asa Abeliovic. DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation. PLoS biology. vol 2. issue 11. 2006-02-03. PMID:15502874. |
parkinson's disease (pd) pathology is characterized by the degeneration of midbrain dopamine neurons (dns) ultimately leading to a progressive movement disorder in patients. |
2006-02-03 |
2023-08-12 |
Not clear |
| Ingrid Strömberg, Carmelina Gemma, Jennifer Vila, Paula C Bickfor. Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system. Experimental neurology. vol 196. issue 2. 2006-01-25. PMID:16176814. |
the model of 6-hydroxydopamine (6-ohda) injected into the dorsal striatum of normal rats, causes a progressive loss of dopamine neurons in the ventral mesencephalon. |
2006-01-25 |
2023-08-12 |
rat |
| C Daniel Salzman, Marina A Belova, Joseph J Pato. Beetles, boxes and brain cells: neural mechanisms underlying valuation and learning. Current opinion in neurobiology. vol 15. issue 6. 2006-01-20. PMID:16271457. |
neurons in the basal ganglia, in midbrain dopamine areas, in frontal and parietal cortices and in other brain areas, all modulate their activity in relation to aspects of learning. |
2006-01-20 |
2023-08-12 |
monkey |
| Fernando Cardozo-Pelaez, David P Cox, Celeste Boli. Lack of the DNA repair enzyme OGG1 sensitizes dopamine neurons to manganese toxicity during development. Gene expression. vol 12. issue 4-6. 2006-01-20. PMID:16358418. |
in addition, the reduction of dopamine in caudate putamen correlated with the accumulation of oxo8dg in midbrain. |
2006-01-20 |
2023-08-12 |
mouse |
| Michael F Salvatore, Brent Fisher, Stewart P Surgener, Greg A Gerhardt, Tracey Rouaul. Neurochemical investigations of dopamine neuronal systems in iron-regulatory protein 2 (IRP-2) knockout mice. Brain research. Molecular brain research. vol 139. issue 2. 2006-01-17. PMID:16051392. |
to further characterize the dopamine (da) systems of irp-2 -/- mice, we harvested cns tissue from age-matched wild type and irp-2 -/- (16-19 months) and analyzed the protein levels of tyrosine hydroxylase (th), dopamine transporter (dat), vesicular monoamine transporter (vmat2), and da levels in dorsal striatum, ventral striatum (including the core and shell of nucleus accumbens), and midbrain. |
2006-01-17 |
2023-08-12 |
mouse |
| B K Yee, R Keist, L von Boehmer, R Studer, D Benke, N Hagenbuch, Y Dong, R C Malenka, J-M Fritschy, H Bluethmann, J Feldon, H Möhler, U Rudolp. A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 47. 2006-01-12. PMID:16284244. |
as a result of the loss of alpha3 gaba(a) receptors, the gaba-induced whole-cell current recorded from midbrain dopamine neurons was significantly reduced. |
2006-01-12 |
2023-08-12 |
mouse |
| S McArthur, E McHale, J W Dalley, J C Buckingham, G E Gillie. Altered mesencephalic dopaminergic populations in adulthood as a consequence of brief perinatal glucocorticoid exposure. Journal of neuroendocrinology. vol 17. issue 8. 2005-12-23. PMID:16011483. |
these findings are the first to demonstrate permanent changes in the cytoarchitecture within midbrain dopamine nuclei after perinatal exposure to stress hormones and implicate altered functionality. |
2005-12-23 |
2023-08-12 |
rat |
| N M Hula, M F Huliĭ, N K Kharchenko, T M Horid'ko, V M Marhityc. [Neuroprotective effect of N-acylethanolamines in chronic morphine dependence. III. Influence on the content of neurotransmitters in the rat brain]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). vol 77. issue 1. 2005-12-23. PMID:16335268. |
a significant decrease of dopamine levels was found in the hypothalamus, midbrain and cortex of rats with morphine dependence. |
2005-12-23 |
2023-08-12 |
rat |
| Chiho Sumi-Ichinose, Fumi Urano, Atsushi Shimomura, Takashi Sato, Kazuhisa Ikemoto, Hiroaki Shiraishi, Takao Senda, Hiroshi Ichinose, Takahide Nomur. Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities. Journal of neurochemistry. vol 95. issue 3. 2005-12-13. PMID:16135092. |
biopterin and dopamine contents, and th activity in the striatum were poorly restored compared with those in the midbrain. |
2005-12-13 |
2023-08-12 |
mouse |
| J-M Taymans, H K Kia, H J Groenewegen, J E Leysen, X Langloi. Bilateral control of brain activity by dopamine D1 receptors: evidence from induction patterns of regulator of G protein signaling 2 and c-fos mRNA in D1-challenged hemiparkinsonian rats. Neuroscience. vol 134. issue 2. 2005-11-15. PMID:15964700. |
gene induction assays were used to identify activated regions from midbrain to forebrain in unilaterally 6-hydroxydopamine lesioned (hemiparkinsonian) rats challenged with the full dopamine d1-type agonist skf82958 (3 mg/kg, 0.5 and 2 h). |
2005-11-15 |
2023-08-12 |
rat |
| Don M Gash, Zhiming Zhang, Yi Ai, Richard Grondin, Robert Coffey, Greg A Gerhard. Trophic factor distribution predicts functional recovery in parkinsonian monkeys. Annals of neurology. vol 58. issue 2. 2005-10-31. PMID:16049934. |
glial cell line-derived neurotrophic factor (gdnf) promotes the survival, growth, and regeneration of dopamine neurons in the midbrain that degenerate in parkinson's disease. |
2005-10-31 |
2023-08-12 |
monkey |
| Don M Gash, Zhiming Zhang, Yi Ai, Richard Grondin, Robert Coffey, Greg A Gerhard. Trophic factor distribution predicts functional recovery in parkinsonian monkeys. Annals of neurology. vol 58. issue 2. 2005-10-31. PMID:16049934. |
significant increases were evident in the number of midbrain dopamine neurons immunopositive for tyrosine hydroxylase in both the substantia nigra and ventral tegmental area. |
2005-10-31 |
2023-08-12 |
monkey |
| Qing-song Liu, Lu Pu, Mu-ming Po. Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons. Nature. vol 437. issue 7061. 2005-10-27. PMID:16222299. |
repeated cocaine exposure in vivo facilitates ltp induction in midbrain dopamine neurons. |
2005-10-27 |
2023-08-12 |
rat |
| Qing-song Liu, Lu Pu, Mu-ming Po. Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons. Nature. vol 437. issue 7061. 2005-10-27. PMID:16222299. |
in midbrain slices from rats treated with saline or a single dose of cocaine, ltp could not be induced in vta dopamine neurons unless gaba-mediated inhibition was reduced by bicuculline or picrotoxin. |
2005-10-27 |
2023-08-12 |
rat |
| Jan Lewerenz, Bartosz Zurowski, Lars Jenicke, Tobias Bäumer, Andrew J Lees, Alexander Müncha. Lesion of the dorsorostral midbrain sparing the nigrostriatal tract mimics axial rigidity seen in progressive supranuclear palsy. Movement disorders : official journal of the Movement Disorder Society. vol 20. issue 8. 2005-10-19. PMID:15838851. |
we suggest that dorsorostral midbrain pathology rather than dopamine deficiency due to degeneration of nigrostriatal dopaminergic neurons or basal ganglia nuclei might be responsible for axial rigidity in extension. |
2005-10-19 |
2023-08-12 |
Not clear |
| Ying Chen, Keith Phillips, Gareth Minton, Emanuele She. GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area. British journal of pharmacology. vol 144. issue 7. 2005-09-29. PMID:15711597. |
in this study, we assessed the ability of cgp7930 to modulate the baclofen-induced depression of dopamine (da) neuron activity via the activation of gaba(b) receptors in the ventral tegmental area in rat midbrain slices. |
2005-09-29 |
2023-08-12 |
rat |
| R Ramakrishnan, D Kempuraj, K Prabhakaran, A R Jayakumar, R S Devi, N Suthanthirarajan, A Namasivaya. A short-term diabetes induced changes of catecholamines and p38-MAPK in discrete areas of rat brain. Life sciences. vol 77. issue 15. 2005-09-29. PMID:16009379. |
in this study, we investigated the effects of acute diabetes on the levels of dopamine (da), norepinephrine (ne), epinephrine (e) and p38-mitogen-activated protein kinase (p38-mapk) in striatum (st), hippocampus (hc), hypothalamus (ht), midbrain (mb), pons medulla (pm), cerebellum (cb) and cerebral cortex (ccx). |
2005-09-29 |
2023-08-12 |
rat |
| Shankar J Chinta, Julie K Anderse. Dopaminergic neurons. The international journal of biochemistry & cell biology. vol 37. issue 5. 2005-09-09. PMID:15743669. |
dopaminergic neurons of the midbrain are the main source of dopamine (da) in the mammalian central nervous system. |
2005-09-09 |
2023-08-12 |
human |
| Hannah M Bayer, Paul W Glimche. Midbrain dopamine neurons encode a quantitative reward prediction error signal. Neuron. vol 47. issue 1. 2005-09-07. PMID:15996553. |
midbrain dopamine neurons encode a quantitative reward prediction error signal. |
2005-09-07 |
2023-08-12 |
human |