| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Phan, D Miller, A Gopinath, M Lin, D Gunther, K Kiel, S Quintin, D Borg, Z Hasanpour-Segherlou, A Newman, Z Sorrentino, J Miller E, J Seibold, B Hoh, B Giasson, H Khoshboue. Parkinson's Paradox: Alpha-synuclein's Selective Strike on SNc Dopamine Neurons over VTA. bioRxiv : the preprint server for biology. 2025-04-16. PMID:40236072. |
while α-synuclein (αsyn) pathology is implicated in nigral dopamine neuron loss, the mechanisms by which αsyn affects neuronal activity and midbrain dopamine network connectivity prior to cell death remain unclear. |
2025-04-16 |
2025-04-18 |
mouse |
| Jessica M Phillips, Mohsen Afrasiabi, Niranjan A Kambi, Michelle J Redinbaugh, Summer Steely, Emily R Johnson, Xi Cheng, Maath Fayyad, Sounak Mohanta, Asia Carís, Charles B Mikell, Sima Mofakham, Yuri B Saalman. Primate thalamic nuclei select abstract rules and shape prefrontal dynamics. Neuron. 2025-04-15. PMID:40233749. |
md, a major recipient of midbrain dopamine input, was the first to represent information about behavioral outcomes. |
2025-04-15 |
2025-04-18 |
monkey |
| Smitha Bhaskar, Jeevan Gowda, Akshay Hegde, Surya Chandra Rao Thumu, Shreetama Banerjee, Helen M Bellchambers, Narendrakumar Ramanan, Paloma Merchan Sala, Kenneth Campbell, Stephanie Ware, Jyothi Prasanna, Anujith Kuma. Zic3 enables bimodal regulation of tyrosine hydroxylase expression in olfactory bulb and midbrain-derived neurons. Cell death discovery. vol 11. issue 1. 2025-04-11. PMID:40216742. |
tyrosine hydroxylase (th) is the rate-limiting enzyme involved in the biosynthesis of catecholamines such as dopamine, norepinephrine, and epinephrine expressed in various regions of the brain, including the olfactory bulb (ob) and midbrain (mb). |
2025-04-11 |
2025-04-14 |
mouse |
| Chunjing Wang, Yang Liu, Junyan Chang, Yiqin He, Pan Yang, Jingjing Fu, Wanying Du, Caiyun Ma, Gaofeng Liu, Yu Guo, Changqing Li. Genetically engineered BMSCs promote dopamine secretion and ameliorate motor dysfunction in a Parkinson's disease rat model. Scientific reports. vol 15. issue 1. 2025-04-11. PMID:40217082. |
importantly, da-bmscs promoted the reconstruction of midbrain dopamine pathways by upregulating striatal dopamine and 5-ht levels and downregulating the levels of inflammatory factors including il-6, tnf-α, and il-10. |
2025-04-11 |
2025-04-14 |
rat |
| Qing Guo, Zhao-Feng Li, Dong-Yan Hu, Pei-Jun Li, Kai-Nian Wu, Hui-Hui Fan, Jie Deng, Hong-Mei Wu, Xiong Zhang, Jian-Hong Zh. The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder. The EMBO journal. 2025-04-08. PMID:40195499. |
the selenocysteine-containing protein selenot maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder. |
2025-04-08 |
2025-04-10 |
mouse |
| Emily M Teichman, Jianping Hu, Hsiao-Yun Lin, Rachel L Fisher-Foye, Anthony Blando, Xiaoping Hu, H Ümit Kaniskan, Sarah E Montgomery, Min Cai, Lyonna F Parise, Jun Wang, Scott J Russo, Ming-Hu Han, Jian Jin, Carole More. Design and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotype. Molecular psychiatry. 2025-04-08. PMID:40199995. |
patients with mdd exhibit alterations in their dopamine (da) signaling pathways through the midbrain ventral tegmental area (vta). |
2025-04-08 |
2025-04-11 |
mouse |
| Hao Zhong, Kangrong Lu, Liping Wang, Wanshan Wang, Pengfei Wei, Xuemei Li. Subtle behavioral alterations in the spontaneous behaviors of MPTP mouse model of Parkinson's disease. Translational psychiatry. vol 15. issue 1. 2025-04-02. PMID:40175343. |
midbrain dopamine (da) neurons are essential for regulating movement, emotion, and reward, with their dysfunction closely linked to parkinson's disease (pd). |
2025-04-02 |
2025-04-04 |
mouse |
| Shannon D Almeida, Sameera Hammigi Ramesh, Govardhan Katta Radhakrishna, Golla Sireesha, Soundarya Ramesh, Bandral Sunil Kumar, Basavana Gowda Hosur Dinesh, Srinivas Ganjipete, Sunil Nagaraj, Panneerselvam Theivendren, Kumarappan Chidambaram, Selvaraj Kunjiappan, Damodar Nayak Ammunje, Parasuraman Pavada. Development and evaluation of S-carboxymethyl-L-cystine-loaded solid lipid nanoparticles for Parkinson's disease in murine and zebrafish models. Scientific reports. vol 15. issue 1. 2025-03-29. PMID:40158023. |
parkinson's disease (pd) is an advanced neurodegenerative condition distinguished by the rapid decline of dopamine neurons in the midbrain, leading to an imbalance in dopamine and acetylcholine levels, precipitating associated symptoms. |
2025-03-29 |
2025-04-02 |
rat |
| The people behind the papers - Laura Lahti and Thomas Perlmann. Development (Cambridge, England). vol 152. issue 6. 2025-03-26. PMID:40136082. |
midbrain dopamine (mda) neuron degeneration is a major cause of parkinson's disease, so understanding the mechanisms underpinning mda neuron production could help inform future treatments. |
2025-03-26 |
2025-03-28 |
Not clear |
| Weifeng Xu, Meiting Wang, Xiaodan Li, Rongyan He, Ren-Bo Ding, Jiaolin Bao, Dongting Zhangsun, Sulan Lu. α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice. Marine drugs. vol 23. issue 3. 2025-03-26. PMID:40137295. |
a significant contributor to nicotine addiction is its interaction with α6β2* nachrs located on midbrain dopaminergic neurons, which leads to an increase in dopamine (da) release. |
2025-03-26 |
2025-03-28 |
mouse |
| Weifeng Xu, Meiting Wang, Xiaodan Li, Rongyan He, Ren-Bo Ding, Jiaolin Bao, Dongting Zhangsun, Sulan Lu. α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice. Marine drugs. vol 23. issue 3. 2025-03-26. PMID:40137295. |
in this study, we aimed to investigate the effectiveness of α-ctx txib in countering nicotine-induced behavioral sensitization and moderating the impact of nicotine on dopamine accumulation in the midbrain. |
2025-03-26 |
2025-03-28 |
mouse |
| Maria Mancini, Takuya Hikima, Paul Witkovsky, Jyoti C Patel, Dominic W Stone, Alison H Affinati, Margaret E Ric. Leptin activates dopamine and GABA neurons in the substantia nigra via a local pars compacta-pars reticulata circuit. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2025-03-24. PMID:40127936. |
whole-cell recording in ex vivo midbrain slices from male wild-type mice showed that leptin activates snc dopamine neurons directly and increases somatodendritic dopamine release. |
2025-03-24 |
2025-03-27 |
mouse |
| Thaís Antonia Alves Fernandes, Aurore Tourville, Ismaila Ciss, Rafaela Ribeiro Silva, Bianca Andretto de Mattos, Maurício Dos Santos Pereira, Maxime Oblaza, Jean-Michel Brunel, Laurent Ferrié, Rita Raisman-Vozari, Bruno Figadère, Elaine Del-Bel, Patrick Pierre Miche. Oxytetracycline and its Non-Antibiotic Derivative DOT Protect Midbrain Dopamine Neurons from Iron-Driven Oxidative Damage. Neurotoxicity research. vol 43. issue 2. 2025-03-22. PMID:40119187. |
oxytetracycline and its non-antibiotic derivative dot protect midbrain dopamine neurons from iron-driven oxidative damage. |
2025-03-22 |
2025-03-25 |
mouse |
| Mingxin Ding, Porter L Tomsick, Ryan A Young, Shantanu P Jadha. Ventral tegmental area dopamine neural activity switches simultaneously with rule representations in the medial prefrontal cortex and hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2025-03-17. PMID:40097186. |
midbrain dopamine (da) activity is key in reward seeking behavior and learning. |
2025-03-17 |
2025-03-20 |
rat |
| Bahareh Tolooshams, Sara Matias, Hao Wu, Simona Temereanca, Naoshige Uchida, Venkatesh N Murthy, Paul Masset, Demba B. Interpretable deep learning for deconvolutional analysis of neural signals. Neuron. 2025-03-13. PMID:40081364. |
we uncover multiplexed salience and reward prediction error signals from midbrain dopamine neurons, perform simultaneous event detection and characterization in somatosensory thalamus recordings, and characterize the heterogeneity of neural responses in the piriform cortex and across striatum during unstructured, naturalistic experiments. |
2025-03-13 |
2025-03-16 |
Not clear |
| Hui-Ru Chen, Tao Wang, Jing Shao, Hui-Min Zhu, Chi-Zhang, Ting Zhao, Li-Hua Xu, Min Wang, Jing-Jing Li, Qi-Long Zhu, Xi-Meng Qi, De-Xiang Xu, Bo Wang, Xiu-Hong Men. Paternal fenvalerate exposure causes depressive-like behaviour by altering Grb10 gene DNA methylation in adolescent offspring. Ecotoxicology and environmental safety. vol 292. 2025-03-05. PMID:40043501. |
the level of dopamine was reduced in the midbrain of fenvalerate-exposed adolescent offspring. |
2025-03-05 |
2025-03-08 |
Not clear |
| Hui-Ru Chen, Tao Wang, Jing Shao, Hui-Min Zhu, Chi-Zhang, Ting Zhao, Li-Hua Xu, Min Wang, Jing-Jing Li, Qi-Long Zhu, Xi-Meng Qi, De-Xiang Xu, Bo Wang, Xiu-Hong Men. Paternal fenvalerate exposure causes depressive-like behaviour by altering Grb10 gene DNA methylation in adolescent offspring. Ecotoxicology and environmental safety. vol 292. 2025-03-05. PMID:40043501. |
tyrosine hydroxylase (th), a rate limiting enzyme for dopamine synthesis, was significantly reduced in the midbrain of adolescent offspring exposed to fenvalerate. |
2025-03-05 |
2025-03-08 |
Not clear |
| Leah C Beauchamp, Laura J Ellett, Sydney M A Juan, Xiang M Liu, Cameron P J Hunt, Clare L Parish, Laura H Jacobson, Claire E Shepherd, Glenda M Halliday, Ashley I Bush, Laura J Vella, David I Finkelstein, Kevin J Barnha. Evidence of COMT dysfunction in the olfactory bulb in Parkinson's disease. Acta neuropathologica. vol 149. issue 1. 2025-03-02. PMID:40024917. |
in contrast to the loss of dopaminergic neurons in the midbrain, we observed an increase in tyrosine hydroxylase-positive neurons in the parkinson's disease olfactory bulb, suggesting a potential role for dopamine in the hyposmia associated with the condition. |
2025-03-02 |
2025-03-05 |
human |
| Alexis Kalu, Swapan K Ra. Epigallocatechin-3-Gallate, Quercetin, and Kaempferol for Treatment of Parkinson's Disease Through Prevention of Gut Dysbiosis and Attenuation of Multiple Molecular Mechanisms of Pathogenesis. Brain sciences. vol 15. issue 2. 2025-02-26. PMID:40002477. |
parkinson's disease (pd) is a neurodegenerative condition in which degeneration mostly occurs in the dopamine (da)-producing neurons within the substantia nigra in the midbrain. |
2025-02-26 |
2025-02-28 |
Not clear |
| Laura Lahti, Nikolaos Volakakis, Linda Gillberg, Behzad Yaghmaeian Salmani, Katarína Tiklová, Nigel Kee, Hilda Lundén-Miguel, Maarten Werkman, Michael Piper, Richard Gronostajski, Thomas Perlman. Sox9 and Nfi transcription factors regulate the timing of neurogenesis and ependymal maturation in dopamine progenitors. Development (Cambridge, England). 2025-02-25. PMID:39995267. |
here we analyse how the midbrain dopamine neuron (mda) progenitors transition into cell cycle arrest (g0) and begin to mature into ependymal cells. |
2025-02-25 |
2025-02-27 |
Not clear |