All Relations between hypothalamus and insulin

Publication Sentence Publish Date Extraction Date Species
Russell T Turner, Adam J Branscum, Urszula T Iwanie. Long-duration leptin transgene expression in dorsal vagal complex does not alter bone parameters in female Sprague Dawley rats. Bone reports. vol 21. 2024-05-06. PMID:38706522. however, in contrast to hypothalamus, leptin transgene expression in the dvc had no effect on food intake, circulating insulin, ghrelin and glucose, nor on thermogenic energy expenditure. 2024-05-06 2024-05-08 rat
Mujeeb Adekunle Adedokun, Linus Anderson Enye, Elizabeth Toyin Akinluyi, Toheeb Adesumbo Ajibola, Edem Ekpenyong Ede. Black seed oil reverses chronic antibiotic-mediated depression and social behaviour deficits via modulation of hypothalamic mitochondrial-dependent markers and insulin expression. IBRO neuroscience reports. vol 16. 2024-02-21. PMID:38379607. moreover, chronic antibiotic exposure downregulated insulin expression in the hypothalamus. 2024-02-21 2024-02-23 mouse
Vinicius Matheus Knihs, Fabíola Branco Filippin-Monteir. GLP1R (glucagon-like-peptide-1 incretin receptor), diabetes and obesity phenotypes: An in silico approach revealed new pathogenic variants. Diabetes & metabolic syndrome. vol 18. issue 2. 2024-02-16. PMID:38364583. upon stimulation by its agonist, the glucagon-like peptide-1, the receptor plays a role in glucose metabolism, enhancing insulin secretion, and regulating appetite in the hypothalamus. 2024-02-16 2024-02-19 human
Mi-Na Wang, Miao-Xin Zhai, Yi-Tong Wang, Qiu-Fu Dai, Lu Liu, Luo-Peng Zhao, Qiu-Yu Xia, Shen Li, Bin L. Mechanism of Acupuncture in Treating Obesity: Advances and Prospects. The American journal of Chinese medicine. 2024-02-14. PMID:38351701. acupuncture is an effective alternative for obesity, it modulates the hypothalamus, sympathetic activity and parasympathetic activity, obesity-related hormones (leptin, ghrelin, insulin, and cck), the brain-gut axis, inflammatory status, adipose tissue browning, muscle blood flow, hypoxia, and reactive oxygen species (ros) to influence metabolism, eating behavior, motivation, cognition, and the reward system. 2024-02-14 2024-02-16 human
Sandra Pereira, Laura N Castellani, Chantel Kowalchuk, Khaled Alganem, Xiaolu Zhang, William G Ryan, Raghunath Singh, Sally Wu, Emily Au, Roshanak Asgariroozbehani, Sri Mahavir Agarwal, Adria Giacca, Robert E Mccullumsmith, Margaret K Hah. Olanzapine's effects on hypothalamic transcriptomics and kinase activity. Psychoneuroendocrinology. vol 163. 2024-02-10. PMID:38340539. hypothalamus samples from rats were collected following the pancreatic euglycemic clamp, thereby allowing us to study endpoints under steady state conditions for plasma glucose and insulin. 2024-02-10 2024-02-14 rat
Ya-Tin Lin, Kuan-Hsuan Wu, Jie-Jhu Jhang, Jie-Lan Jhang, Zachary Yu, Sze-Chi Tsai, Jin-Chung Chen, Po-Hung Hsu, Hui-Yun L. Hypothalamic NPFFR2 attenuates central insulin signaling and its knockout diminishes metabolic dysfunction in mouse models of diabetes mellitus. Clinical nutrition (Edinburgh, Scotland). vol 43. issue 3. 2024-02-01. PMID:38301284. the hypothalamus is a crucial brain region that mediates the effects of insulin and leptin signals on peripheral metabolic functions. 2024-02-01 2024-02-04 mouse
Ya-Tin Lin, Kuan-Hsuan Wu, Jie-Jhu Jhang, Jie-Lan Jhang, Zachary Yu, Sze-Chi Tsai, Jin-Chung Chen, Po-Hung Hsu, Hui-Yun L. Hypothalamic NPFFR2 attenuates central insulin signaling and its knockout diminishes metabolic dysfunction in mouse models of diabetes mellitus. Clinical nutrition (Edinburgh, Scotland). vol 43. issue 3. 2024-02-01. PMID:38301284. previous research has shown that insulin signals in the hypothalamus act via multiple neuronal circuits and anabolic/catabolic pathways that converge on the vagus nerve and sympathetic fibers to coordinate energy metabolism in peripheral organs. 2024-02-01 2024-02-04 mouse
Xiaoxue Yang, Wenwen Ding, Ziyi Chen, Kaiyi Lai, Ying Li. The role of autophagy in insulin resistance and glucolipid metabolism and potential use of autophagy modulating natural products in the treatment of type 2 diabetes mellitus. Diabetes/metabolism research and reviews. vol 40. issue 1. 2024-01-30. PMID:38287719. an enhanced autophagic activity, either by activating the adenosine monophosphate-activated protein kinase and sirtuin-1 signalling pathways or inhibiting the mechanistic target of rapamycin complex 1 signalling pathway, can effectively improve insulin resistance and balance glucolipid metabolism in key tissues like the hypothalamus, skeletal muscle, liver, and adipose tissue. 2024-01-30 2024-02-01 Not clear
Gonçalo M Melo, Adriana M Capucho, Joana F Sacramento, José Ponce-de-Leão, Marcos V Fernandes, Inês F Almeida, Fátima O Martins, Silvia V Cond. Overnutrition during Pregnancy and Lactation Induces Gender-Dependent Dysmetabolism in the Offspring Accompanied by Heightened Stress and Anxiety. Nutrients. vol 16. issue 1. 2024-01-11. PMID:38201896. the offspring were analyzed at postnatal days 21 and 28 and at 2 months old (pd21, pd28, and pd60) for their metabolic profiles (weight, fasting glycemia insulin sensitivity, and glucose tolerance) and euthanized for brain collection to evaluate metabolism and inflammation in the hypothalamus, hippocampus, and prefrontal cortex using western blot markers of synaptic dynamics. 2024-01-11 2024-01-13 rat
Sarah Pemberton, Demi C Galindo, Michael W Schwartz, William A Banks, Elizabeth M Rhe. Endocytosis of insulin at the blood-brain barrier. Frontiers in drug delivery. vol 2. 2023-11-08. PMID:37936681. we found clathrin-mediated mechanisms responsible for insulin surface binding in isolated brain microvessels while caveolin-mediated endocytosis may mediate bbb insulin transport specifically in the hypothalamus. 2023-11-08 2023-11-20 mouse
Yao Zhao, Surabhi Bhutani, Thorsten Kahn. Appetite-regulating hormones modulate odor perception and odor-evoked activity in hypothalamus and olfactory cortices. Chemical senses. 2023-10-05. PMID:37796827. we found that a hormonal composite measure, capturing variance relating positively to insulin and negatively to ghrelin, correlated inversely with odor intensity ratings and fmri responses to odorized vs. clean air in the hypothalamus, ot, and aon. 2023-10-05 2023-10-07 human
Yao Zhao, Surabhi Bhutani, Thorsten Kahn. Appetite-regulating hormones modulate odor perception and odor-evoked activity in hypothalamus and olfactory cortices. Chemical senses. 2023-10-05. PMID:37796827. these results demonstrate that high (low) blood plasma concentrations of insulin (ghrelin) decrease perceived odor intensity and odor-evoked activity in the cortical targets of the medial and intermediate striae of the olfactory tract, as well as the hypothalamus. 2023-10-05 2023-10-07 human
Saki Asano, Akitoshi Ogawa, Takahiro Osada, Satoshi Oka, Koji Nakajima, Yasushi Oshima, Sakae Tanaka, Hideyoshi Kaga, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Seiki Konish. Reduced gray matter volume in the default-mode network associated with insulin resistance. Cerebral cortex (New York, N.Y. : 1991). 2023-09-27. PMID:37757477. furthermore, we found a significant correlation in these networks between insulin resistance-related gray matter volume reduction and network paraventricular nucleus of the hypothalamus resting-state functional connectivity. 2023-09-27 2023-10-07 human
Saki Asano, Akitoshi Ogawa, Takahiro Osada, Satoshi Oka, Koji Nakajima, Yasushi Oshima, Sakae Tanaka, Hideyoshi Kaga, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Seiki Konish. Reduced gray matter volume in the default-mode network associated with insulin resistance. Cerebral cortex (New York, N.Y. : 1991). 2023-09-27. PMID:37757477. these results suggest that insulin resistance-related gray matter volume reduction in the default-mode and limbic networks emerged through metabolic homeostasis mechanisms in the hypothalamus. 2023-09-27 2023-10-07 human
Julia Matuszewska, Joanna Nowacka-Woszuk, Anna Radziejewska, Emilia Grzęda, Ewa Pruszynska-Oszmałek, Łukasz Dylewski, Agata Chmurzynska, Joanna H Sliwowsk. Maternal cafeteria diet and reproductive functions in offspring. Biology of reproduction. 2023-09-04. PMID:37665248. we found that caf offspring had: lower weight and altered body composition; increased cholesterol and triglycerides levels, sex-specific changes in glucose and insulin levels; sex-dependent changes in sirt1/kiss1 mrna ratio in the hypothalamus, sex-specific alterations in kiss1 and sirt1 mrna in the liver with more diversity in males; a delayed puberty onset in females. 2023-09-04 2023-09-07 rat
Fan Yang, Shuang Zhao, Pingqing Wang, Wei Xian. Hypothalamic neuroendocrine integration of reproduction and metabolism in mammals. The Journal of endocrinology. vol 258. issue 3. 2023-08-10. PMID:37561042. changes in the nutritional status of the body cause fluctuations in the levels of peripheral metabolic hormone signals, such as leptin, insulin, and ghrelin, which provide feedback to the hypothalamus and integrate to coordinate metabolism and fertility. 2023-08-10 2023-08-16 Not clear
Caio Henrique Mazucanti, Vernon Kennedy, Hasitha U Premathilake, Maire E Doyle, Jane Tian, Qing-Rong Liu, Jennifer O'Connell, Simonetta Camandola, Josephine M Ega. AAV5-mediated manipulation of insulin expression in choroid plexus has long-term metabolic and behavioral consequences. Cell reports. vol 42. issue 8. 2023-07-29. PMID:37515772. transcriptomic changes in the hypothalamus, especially in synapse-related processes, are also seen in mice overexpressing insulin in cp. 2023-07-29 2023-08-14 mouse
Caio Henrique Mazucanti, Vernon Kennedy, Hasitha U Premathilake, Maire E Doyle, Jane Tian, Qing-Rong Liu, Jennifer O'Connell, Simonetta Camandola, Josephine M Ega. AAV5-mediated manipulation of insulin expression in choroid plexus has long-term metabolic and behavioral consequences. Cell reports. vol 42. issue 8. 2023-07-29. PMID:37515772. last, activation of gq signaling in cp leads to acute akt phosphorylation in neurons of the arcuate nucleus, indicating a direct action of cp-derived insulin on the hypothalamus. 2023-07-29 2023-08-14 mouse
Tamara Dakic, Tanja Jevdjovic, Iva Lakic, Aleksandra Ruzicic, Nebojsa Jasnic, Sinisa Djurasevic, Jelena Djordjevic, Predrag Vujovi. The Expression of Insulin in the Central Nervous System: What Have We Learned So Far? International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047558. considering that both insulin mrna and insulin were detected in the central nervous system (cns), it is now known that this hormone is also synthesized in several brain regions, including the hypothalamus, hippocampus, cerebral and cerebellar cortex, and olfactory bulb. 2023-04-13 2023-08-14 Not clear
Jyoti C Patel, Kenneth D Carr, Margaret E Ric. Actions and Consequences of Insulin in the Striatum. Biomolecules. vol 13. issue 3. 2023-03-29. PMID:36979453. in the brain, insulin has well-established actions in the hypothalamus, as well as at the level of mesolimbic dopamine neurons in the midbrain. 2023-03-29 2023-08-14 Not clear