| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshihiko Yada, Katsuya Dezaki, Yusaku Iwasak. GLP-1 and ghrelin inversely regulate insulin secretion and action in pancreatic islets, vagal afferents and hypothalamus for controlling glycemia and feeding. American journal of physiology. Cell physiology. 2025-04-17. PMID:40241252. |
glp-1 and ghrelin inversely regulate insulin secretion and action in pancreatic islets, vagal afferents and hypothalamus for controlling glycemia and feeding. |
2025-04-17 |
2025-04-19 |
Not clear |
| Ekin Kaya, Evan Wegienka, Alexandra Akhtarzandi-Das, Hanh Do, Ada Eban-Rothschild, Gideon Rothschil. Food intake enhances hippocampal sharp wave-ripples. eLife. vol 14. 2025-04-14. PMID:40227932. |
metabolic control involves various nuclei within the hypothalamus, which receive information about the body's energy state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, and food-seeking behaviors. |
2025-04-14 |
2025-04-17 |
mouse |
| Romane Manceau, Pinçon Anthony, Cécile Hryhorczuk, Pauline Labbé, Nathalie Thorin-Trescases, Stephanie Fulton, Éric Thori. Sexually dimorphic effects of angiopoietin-like 2 on energy metabolism and hypothalamic neuropeptide regulation. International journal of obesity (2005). 2025-03-26. PMID:40133699. |
adipokines regulate body weight and metabolism by targeting the hypothalamus, influencing feeding, energy expenditure (ee) and insulin sensitivity. |
2025-03-26 |
2025-03-28 |
mouse |
| Saki Asano, Akitoshi Ogawa, Takahiro Osada, Satoshi Oka, Koji Nakajima, Yasushi Oshima, Sakae Tanaka, Hideyoshi Kaga, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Seiki Konish. Insulin Resistance-related Gray Matter Volume Reduction is Associated with the Default Mode Network. Juntendo medical journal. vol 71. issue 1. 2025-03-20. PMID:40109401. |
our results suggest that the reduction in gray matter volume associated with insulin resistance arises through metabolic homeostasis mechanisms in the hypothalamus. |
2025-03-20 |
2025-03-22 |
Not clear |
| Camila Astudillo-Guerrero, Alfonso H Paredes, Jorge Escobar, Daniela Fernandois, Rafael Barra, Gonzalo Cru. Metabolic control of ovarian function through the sympathetic nervous system: role of leptin. Frontiers in endocrinology. vol 15. 2025-02-18. PMID:39963180. |
some of these hormones are leptin, insulin, and glp-1 that act directly in the hypothalamus to activate the sympathetic nervous system. |
2025-02-18 |
2025-02-23 |
Not clear |
| Bin-Yang Long, Xipeng Liao, Xin Lian. The hypothalamus and pituitary gland regulate reproduction and are involved in the development of polycystic ovary syndrome. Neuroendocrinology. 2025-02-02. PMID:39894018. |
we find that the mechanisms by which the hypothalamus and pituitary regulate reproduction in girls are complex and are associated with altered sex hormone levels, obesity and insulin resistance. |
2025-02-02 |
2025-02-05 |
Not clear |
| Yiyi Zhu, Alexei Verkhratsky, Hui Chen, Chenju Y. Understanding glucose metabolism and insulin action at the blood-brain barrier: Implications for brain health and neurodegenerative diseases. Acta physiologica (Oxford, England). vol 241. issue 2. 2025-01-17. PMID:39822067. |
bbb nutrient sensing in the hypothalamus, along with insulin signaling, regulates systemic metabolism. |
2025-01-17 |
2025-01-20 |
Not clear |
| María Rodríguez, Eduardo Moltó, Rosario Serrano, Jorge Diaz-Rullo, Iván Parralejo, Diego Muñoz, Rosa María Andreu, Jennifer Seco, Nilda Gallardo, Antonio Andrés, Carmen Arribas, Cristina Pintad. Central Downregulation of S-Resistin Alleviates Inflammation in EWAT and Liver and Prevents Adipocyte Hypertrophy. Journal of the Endocrine Society. vol 9. issue 2. 2025-01-14. PMID:39807401. |
in a previous study, we demonstrated that s-resistin, an intracellular resistin isoform highly expressed in the hypothalamus and upregulated during aging, is important in the central control of energy homeostasis, affecting mainly the peripheral response to insulin by still unknown mechanisms. |
2025-01-14 |
2025-01-16 |
rat |
| Karoline Martins Dos Santos, Sandy E Saunders, Vagner R Antunes, Carie R Boychu. Insulin activates parasympathetic hepatic-related neurons of the paraventricular nucleus of the hypothalamus through mTOR signaling. Journal of neurophysiology. 2024-12-12. PMID:39665212. |
insulin activates parasympathetic hepatic-related neurons of the paraventricular nucleus of the hypothalamus through mtor signaling. |
2024-12-12 |
2024-12-14 |
Not clear |
| D V Sazonova, M A Perepelova, A S Shutova, L V Nikankina, G S Kolesnikova, E A Pigarova, L K Dzeranov. [Combination of macro-TSH and macroprolactinemia phenomena in a patient with autoimmune thyroiditis and vitiligo]. Problemy endokrinologii. vol 70. issue 5. 2024-11-07. PMID:39509634. |
the literature describes a variety of circulating autoantibodies involved in binding to pituitary hormones (prolactin (prl), thyroid-stimulating hormone (tsh), growth hormone, luteinizing, follicle-stimulating, and adrenocorticotropic hormones), hypothalamus (vasopressin and oxytocin), pancreas (insulin and glucagon) , parathyroid glands (parathyroid hormone), as well as with thyroid hormones. |
2024-11-07 |
2024-11-16 |
Not clear |
| Timothy D Allerton, James E Stampley, Zhen Li, Xiaoman Yu, Heather Quiariate, Jake E Doiron, Ginger White, Zach Wigger, Manas Ranjan Gartia, David J Lefer, Paul Soto, Brian A Irvin. Nitric oxide donors rescue metabolic and mitochondrial dysfunction in obese Alzheimer's model. Scientific reports. vol 14. issue 1. 2024-10-31. PMID:39478095. |
after 26 weeks of a high-fat diet, female app mice had higher adiposity, insulin resistance, and mitochondrial dysfunction (hypothalamus) than non-transgenic littermate (wild type) controls. |
2024-10-31 |
2024-11-02 |
mouse |
| María Nelly Flores-Hernández, Hilda Martínez-Coria, Héctor E López-Valdés, Marcela Arteaga-Silva, Isabel Arrieta-Cruz, Roger Gutiérrez-Juáre. Efficacy of a High-Protein Diet to Lower Glycemic Levels in Type 2 Diabetes Mellitus: A Systematic Review. International journal of molecular sciences. vol 25. issue 20. 2024-10-26. PMID:39456742. |
leucine (and other bcaas) improve glucose metabolism by directly signaling in the medio-basal hypothalamus (mbh), increasing liver insulin sensitivity. |
2024-10-26 |
2024-10-29 |
Not clear |
| Ekin Kaya, Evan Wegienka, Alexandra Akhtarzandi-Das, Hanh Do, Ada Eban-Rothschild, Gideon Rothschil. Food intake enhances hippocampal sharp wave-ripples. bioRxiv : the preprint server for biology. 2024-10-17. PMID:39416018. |
metabolic control involves various nuclei within the hypothalamus, which receive information about the body's energy state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, and food-seeking behaviors. |
2024-10-17 |
2024-10-19 |
mouse |
| Aniqa Tabassum, Sebastian Badulescu, Evanka Singh, Renee Asoro, Roger S McIntyre, Kayla M Teopiz, Cristian-Daniel Llach, Hiya Shah, Rodrigo B Mansu. Central effects of acute intranasal insulin on neuroimaging, cognitive, and behavioural outcomes: A systematic review. Neuroscience and biobehavioral reviews. 2024-09-27. PMID:39332547. |
neuroimaging studies showed insulin affects brain activity, cerebral blood flow, and functional connectivity in regions like the hypothalamus, amygdala, and insula. |
2024-09-27 |
2024-10-01 |
Not clear |
| Forough Radfar, Mehdi Shahbazi, Shahzad Tahmasebi Boroujeni, Elahe Arab Ameri, Maryam Farahmandfa. Moderate aerobic training enhances the effectiveness of insulin therapy through hypothalamic IGF1 signaling in rat model of Alzheimer's disease. Scientific reports. vol 14. issue 1. 2024-07-10. PMID:38987609. |
we investigated the effects of treadmill exercise and intranasal insulin on learning and memory impairment and the expression of igf1, bdnf, and glut4 in hypothalamus. |
2024-07-10 |
2024-07-13 |
rat |
| Georgios Antasouras, Antonios Dakanalis, Maria Chrysafi, Sousana K Papadopoulou, Ioulia Trifonidi, Maria Spanoudaki, Olga Alexatou, Agathi Pritsa, Aikaterini Louka, Constantinos Giagini. Could Insulin Be a Better Regulator of Appetite/Satiety Balance and Body Weight Maintenance in Response to Glucose Exposure Compared to Sucrose Substitutes? Unraveling Current Knowledge and Searching for More Appropriate Choices. Medical sciences (Basel, Switzerland). vol 12. issue 2. 2024-06-26. PMID:38921683. |
moreover, insulin can exert an anorexigenic effect when inserted into the hypothalamus of the brain, in which a complex network of an appetite/hunger control system occurs. |
2024-06-26 |
2024-06-29 |
Not clear |
| Rachel A K Atkinson, Jessica M Collins, Jemeen Sreedharan, Anna E King, Carmen M Fernandez-Marto. Alterations to metabolic hormones in amyotrophic lateral sclerosis and frontotemporal dementia postmortem human tissue. Journal of neuropathology and experimental neurology. 2024-06-25. PMID:38917432. |
although regulation of metabolic processes in the cns is predominantly carried out within the hypothalamus, extra-hypothalamic cns areas contain metabolic hormone receptors, including those for leptin (lepr), insulin (insr), and neuropeptide y (npy), indicating that they may play a role in biological processes underlying pathogenic disease processes. |
2024-06-25 |
2024-06-29 |
human |
| Hooman Hatami, Vahid Reza Askari, Vafa Baradaran Rahimi, Md Saquib Hasnain, Amit Kumar Naya. The Dilemma of Insulin Delivery into the Brain: A Comprehensive Review. Current drug delivery. 2024-06-24. PMID:38910469. |
the ubiquitous distribution of insulin receptors on various brain cells, such as neurons, microglia, astrocytes, and oligodendrocytes, and their differential localization across various brain regions, including the hippocampus, hypothalamus, and olfactory bulb, collectively underscore the crucial involvement of insulin in the modulation of cerebral functions. |
2024-06-24 |
2024-06-26 |
human |
| Lucio Della Guardia, Andrew C Shi. Obesity-induced tissue alterations resist weight loss: A mechanistic review. Diabetes, obesity & metabolism. 2024-05-09. PMID:38720199. |
in the hypothalamus, obesity and overnutrition impair insulin and leptin signalling. |
2024-05-09 |
2024-05-27 |
Not clear |
| Russell T Turner, Adam J Branscum, Urszula T Iwanie. Long-duration leptin transgene expression in dorsal vagal complex does not alter bone parameters in female Sprague Dawley rats. Bone reports. vol 21. 2024-05-06. PMID:38706522. |
however, in contrast to hypothalamus, leptin transgene expression in the dvc had no effect on food intake, circulating insulin, ghrelin and glucose, nor on thermogenic energy expenditure. |
2024-05-06 |
2024-05-08 |
rat |