| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Forough Radfar, Mehdi Shahbazi, Shahzad Tahmasebi Boroujeni, Elahe Arab Ameri, Maryam Farahmandfa. Moderate aerobic training enhances the effectiveness of insulin therapy through hypothalamic IGF1 signaling in rat model of Alzheimer's disease. Scientific reports. vol 14. issue 1. 2024-07-10. PMID:38987609. |
we investigated the effects of treadmill exercise and intranasal insulin on learning and memory impairment and the expression of igf1, bdnf, and glut4 in hypothalamus. |
2024-07-10 |
2024-07-13 |
rat |
| Georgios Antasouras, Antonios Dakanalis, Maria Chrysafi, Sousana K Papadopoulou, Ioulia Trifonidi, Maria Spanoudaki, Olga Alexatou, Agathi Pritsa, Aikaterini Louka, Constantinos Giagini. Could Insulin Be a Better Regulator of Appetite/Satiety Balance and Body Weight Maintenance in Response to Glucose Exposure Compared to Sucrose Substitutes? Unraveling Current Knowledge and Searching for More Appropriate Choices. Medical sciences (Basel, Switzerland). vol 12. issue 2. 2024-06-26. PMID:38921683. |
moreover, insulin can exert an anorexigenic effect when inserted into the hypothalamus of the brain, in which a complex network of an appetite/hunger control system occurs. |
2024-06-26 |
2024-06-29 |
Not clear |
| Rachel A K Atkinson, Jessica M Collins, Jemeen Sreedharan, Anna E King, Carmen M Fernandez-Marto. Alterations to metabolic hormones in amyotrophic lateral sclerosis and frontotemporal dementia postmortem human tissue. Journal of neuropathology and experimental neurology. 2024-06-25. PMID:38917432. |
although regulation of metabolic processes in the cns is predominantly carried out within the hypothalamus, extra-hypothalamic cns areas contain metabolic hormone receptors, including those for leptin (lepr), insulin (insr), and neuropeptide y (npy), indicating that they may play a role in biological processes underlying pathogenic disease processes. |
2024-06-25 |
2024-06-29 |
human |
| Hooman Hatami, Vahid Reza Askari, Vafa Baradaran Rahimi, Md Saquib Hasnain, Amit Kumar Naya. The Dilemma of Insulin Delivery into the Brain: A Comprehensive Review. Current drug delivery. 2024-06-24. PMID:38910469. |
the ubiquitous distribution of insulin receptors on various brain cells, such as neurons, microglia, astrocytes, and oligodendrocytes, and their differential localization across various brain regions, including the hippocampus, hypothalamus, and olfactory bulb, collectively underscore the crucial involvement of insulin in the modulation of cerebral functions. |
2024-06-24 |
2024-06-26 |
human |
| Lucio Della Guardia, Andrew C Shi. Obesity-induced tissue alterations resist weight loss: A mechanistic review. Diabetes, obesity & metabolism. 2024-05-09. PMID:38720199. |
in the hypothalamus, obesity and overnutrition impair insulin and leptin signalling. |
2024-05-09 |
2024-05-27 |
Not clear |
| Russell T Turner, Adam J Branscum, Urszula T Iwanie. Long-duration leptin transgene expression in dorsal vagal complex does not alter bone parameters in female Sprague Dawley rats. Bone reports. vol 21. 2024-05-06. PMID:38706522. |
however, in contrast to hypothalamus, leptin transgene expression in the dvc had no effect on food intake, circulating insulin, ghrelin and glucose, nor on thermogenic energy expenditure. |
2024-05-06 |
2024-05-08 |
rat |
| Mujeeb Adekunle Adedokun, Linus Anderson Enye, Elizabeth Toyin Akinluyi, Toheeb Adesumbo Ajibola, Edem Ekpenyong Ede. Black seed oil reverses chronic antibiotic-mediated depression and social behaviour deficits via modulation of hypothalamic mitochondrial-dependent markers and insulin expression. IBRO neuroscience reports. vol 16. 2024-02-21. PMID:38379607. |
moreover, chronic antibiotic exposure downregulated insulin expression in the hypothalamus. |
2024-02-21 |
2024-02-23 |
mouse |
| Vinicius Matheus Knihs, Fabíola Branco Filippin-Monteir. GLP1R (glucagon-like-peptide-1 incretin receptor), diabetes and obesity phenotypes: An in silico approach revealed new pathogenic variants. Diabetes & metabolic syndrome. vol 18. issue 2. 2024-02-16. PMID:38364583. |
upon stimulation by its agonist, the glucagon-like peptide-1, the receptor plays a role in glucose metabolism, enhancing insulin secretion, and regulating appetite in the hypothalamus. |
2024-02-16 |
2024-02-19 |
human |
| Mi-Na Wang, Miao-Xin Zhai, Yi-Tong Wang, Qiu-Fu Dai, Lu Liu, Luo-Peng Zhao, Qiu-Yu Xia, Shen Li, Bin L. Mechanism of Acupuncture in Treating Obesity: Advances and Prospects. The American journal of Chinese medicine. 2024-02-14. PMID:38351701. |
acupuncture is an effective alternative for obesity, it modulates the hypothalamus, sympathetic activity and parasympathetic activity, obesity-related hormones (leptin, ghrelin, insulin, and cck), the brain-gut axis, inflammatory status, adipose tissue browning, muscle blood flow, hypoxia, and reactive oxygen species (ros) to influence metabolism, eating behavior, motivation, cognition, and the reward system. |
2024-02-14 |
2024-02-16 |
human |
| Sandra Pereira, Laura N Castellani, Chantel Kowalchuk, Khaled Alganem, Xiaolu Zhang, William G Ryan, Raghunath Singh, Sally Wu, Emily Au, Roshanak Asgariroozbehani, Sri Mahavir Agarwal, Adria Giacca, Robert E Mccullumsmith, Margaret K Hah. Olanzapine's effects on hypothalamic transcriptomics and kinase activity. Psychoneuroendocrinology. vol 163. 2024-02-10. PMID:38340539. |
hypothalamus samples from rats were collected following the pancreatic euglycemic clamp, thereby allowing us to study endpoints under steady state conditions for plasma glucose and insulin. |
2024-02-10 |
2024-02-14 |
rat |
| Ya-Tin Lin, Kuan-Hsuan Wu, Jie-Jhu Jhang, Jie-Lan Jhang, Zachary Yu, Sze-Chi Tsai, Jin-Chung Chen, Po-Hung Hsu, Hui-Yun L. Hypothalamic NPFFR2 attenuates central insulin signaling and its knockout diminishes metabolic dysfunction in mouse models of diabetes mellitus. Clinical nutrition (Edinburgh, Scotland). vol 43. issue 3. 2024-02-01. PMID:38301284. |
the hypothalamus is a crucial brain region that mediates the effects of insulin and leptin signals on peripheral metabolic functions. |
2024-02-01 |
2024-02-04 |
mouse |
| Ya-Tin Lin, Kuan-Hsuan Wu, Jie-Jhu Jhang, Jie-Lan Jhang, Zachary Yu, Sze-Chi Tsai, Jin-Chung Chen, Po-Hung Hsu, Hui-Yun L. Hypothalamic NPFFR2 attenuates central insulin signaling and its knockout diminishes metabolic dysfunction in mouse models of diabetes mellitus. Clinical nutrition (Edinburgh, Scotland). vol 43. issue 3. 2024-02-01. PMID:38301284. |
previous research has shown that insulin signals in the hypothalamus act via multiple neuronal circuits and anabolic/catabolic pathways that converge on the vagus nerve and sympathetic fibers to coordinate energy metabolism in peripheral organs. |
2024-02-01 |
2024-02-04 |
mouse |
| Xiaoxue Yang, Wenwen Ding, Ziyi Chen, Kaiyi Lai, Ying Li. The role of autophagy in insulin resistance and glucolipid metabolism and potential use of autophagy modulating natural products in the treatment of type 2 diabetes mellitus. Diabetes/metabolism research and reviews. vol 40. issue 1. 2024-01-30. PMID:38287719. |
an enhanced autophagic activity, either by activating the adenosine monophosphate-activated protein kinase and sirtuin-1 signalling pathways or inhibiting the mechanistic target of rapamycin complex 1 signalling pathway, can effectively improve insulin resistance and balance glucolipid metabolism in key tissues like the hypothalamus, skeletal muscle, liver, and adipose tissue. |
2024-01-30 |
2024-02-01 |
Not clear |
| Gonçalo M Melo, Adriana M Capucho, Joana F Sacramento, José Ponce-de-Leão, Marcos V Fernandes, Inês F Almeida, Fátima O Martins, Silvia V Cond. Overnutrition during Pregnancy and Lactation Induces Gender-Dependent Dysmetabolism in the Offspring Accompanied by Heightened Stress and Anxiety. Nutrients. vol 16. issue 1. 2024-01-11. PMID:38201896. |
the offspring were analyzed at postnatal days 21 and 28 and at 2 months old (pd21, pd28, and pd60) for their metabolic profiles (weight, fasting glycemia insulin sensitivity, and glucose tolerance) and euthanized for brain collection to evaluate metabolism and inflammation in the hypothalamus, hippocampus, and prefrontal cortex using western blot markers of synaptic dynamics. |
2024-01-11 |
2024-01-13 |
rat |
| Sarah Pemberton, Demi C Galindo, Michael W Schwartz, William A Banks, Elizabeth M Rhe. Endocytosis of insulin at the blood-brain barrier. Frontiers in drug delivery. vol 2. 2023-11-08. PMID:37936681. |
we found clathrin-mediated mechanisms responsible for insulin surface binding in isolated brain microvessels while caveolin-mediated endocytosis may mediate bbb insulin transport specifically in the hypothalamus. |
2023-11-08 |
2023-11-20 |
mouse |
| Yao Zhao, Surabhi Bhutani, Thorsten Kahn. Appetite-regulating hormones modulate odor perception and odor-evoked activity in hypothalamus and olfactory cortices. Chemical senses. 2023-10-05. PMID:37796827. |
we found that a hormonal composite measure, capturing variance relating positively to insulin and negatively to ghrelin, correlated inversely with odor intensity ratings and fmri responses to odorized vs. clean air in the hypothalamus, ot, and aon. |
2023-10-05 |
2023-10-07 |
human |
| Yao Zhao, Surabhi Bhutani, Thorsten Kahn. Appetite-regulating hormones modulate odor perception and odor-evoked activity in hypothalamus and olfactory cortices. Chemical senses. 2023-10-05. PMID:37796827. |
these results demonstrate that high (low) blood plasma concentrations of insulin (ghrelin) decrease perceived odor intensity and odor-evoked activity in the cortical targets of the medial and intermediate striae of the olfactory tract, as well as the hypothalamus. |
2023-10-05 |
2023-10-07 |
human |
| Saki Asano, Akitoshi Ogawa, Takahiro Osada, Satoshi Oka, Koji Nakajima, Yasushi Oshima, Sakae Tanaka, Hideyoshi Kaga, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Seiki Konish. Reduced gray matter volume in the default-mode network associated with insulin resistance. Cerebral cortex (New York, N.Y. : 1991). 2023-09-27. PMID:37757477. |
furthermore, we found a significant correlation in these networks between insulin resistance-related gray matter volume reduction and network paraventricular nucleus of the hypothalamus resting-state functional connectivity. |
2023-09-27 |
2023-10-07 |
human |
| Saki Asano, Akitoshi Ogawa, Takahiro Osada, Satoshi Oka, Koji Nakajima, Yasushi Oshima, Sakae Tanaka, Hideyoshi Kaga, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Seiki Konish. Reduced gray matter volume in the default-mode network associated with insulin resistance. Cerebral cortex (New York, N.Y. : 1991). 2023-09-27. PMID:37757477. |
these results suggest that insulin resistance-related gray matter volume reduction in the default-mode and limbic networks emerged through metabolic homeostasis mechanisms in the hypothalamus. |
2023-09-27 |
2023-10-07 |
human |
| Julia Matuszewska, Joanna Nowacka-Woszuk, Anna Radziejewska, Emilia Grzęda, Ewa Pruszynska-Oszmałek, Łukasz Dylewski, Agata Chmurzynska, Joanna H Sliwowsk. Maternal cafeteria diet and reproductive functions in offspring. Biology of reproduction. 2023-09-04. PMID:37665248. |
we found that caf offspring had: lower weight and altered body composition; increased cholesterol and triglycerides levels, sex-specific changes in glucose and insulin levels; sex-dependent changes in sirt1/kiss1 mrna ratio in the hypothalamus, sex-specific alterations in kiss1 and sirt1 mrna in the liver with more diversity in males; a delayed puberty onset in females. |
2023-09-04 |
2023-09-07 |
rat |