| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Millan, S Hjorth, R Samanin, R Schreiber, R Jaffard, B De Ladonchamps, S Veiga, B Goument, J L Peglion, M Spedding, M Brocc. S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: II. Modulation of hippocampal serotonin release in relation to potential anxiolytic properties. The Journal of pharmacology and experimental therapeutics. vol 282. issue 1. 1997-08-07. PMID:9223550. |
s 15535 dose-dependently (0.3-3.0) reduced dialysate concentrations of 5-ht in the hippocampus of anesthetized rats. |
1997-08-07 |
2023-08-12 |
mouse |
| L E Schechte. The potassium channel blockers 4-aminopyridine and tetraethylammonium increase the spontaneous basal release of [3H]5-hydroxytryptamine in rat hippocampal slices. The Journal of pharmacology and experimental therapeutics. vol 282. issue 1. 1997-08-07. PMID:9223563. |
the potassium channel blockers 4-aminopyridine and tetraethylammonium increase the spontaneous basal release of [3h]5-hydroxytryptamine in rat hippocampal slices. |
1997-08-07 |
2023-08-12 |
rat |
| L E Schechte. The potassium channel blockers 4-aminopyridine and tetraethylammonium increase the spontaneous basal release of [3H]5-hydroxytryptamine in rat hippocampal slices. The Journal of pharmacology and experimental therapeutics. vol 282. issue 1. 1997-08-07. PMID:9223563. |
this study examined the in vitro effects of the "classical" potassium channel blockers 4-aminopyridine (4-ap) and tetraethylammonium (tea) on the spontaneous basal release of [3h]5-hydroxytryptamine ([3h]5-ht) from rat hippocampal slices using an automated superfusion apparatus. |
1997-08-07 |
2023-08-12 |
rat |
| L E Schechte. The potassium channel blockers 4-aminopyridine and tetraethylammonium increase the spontaneous basal release of [3H]5-hydroxytryptamine in rat hippocampal slices. The Journal of pharmacology and experimental therapeutics. vol 282. issue 1. 1997-08-07. PMID:9223563. |
taken together, the results demonstrate that potassium channel blockade can enhance the spontaneous basal release of [3h]5-ht in rat hippocampal slices. |
1997-08-07 |
2023-08-12 |
rat |
| D Marazziti, A Rossi, L Palego, G Giannaccini, A Naccarato, A Lucacchini, G B Cassan. [3H]ketanserin binding in human brain postmortem. Neurochemical research. vol 22. issue 6. 1997-08-06. PMID:9178960. |
this study aimed at comparing the binding characteristics of [3h]ketanserin, a high-affinity serotonin 2a (5-ht2a) receptor antagonist, in the prefrontal cortex, hippocampus and striatum of human brain post-mortem. |
1997-08-06 |
2023-08-12 |
human |
| O C Meijer, T J Cole, W Schmid, G Schütz, M Joëls, E R De Kloe. Regulation of hippocampal 5-HT1A receptor mRNA and binding in transgenic mice with a targeted disruption of the glucocorticoid receptor. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191104. |
we describe hippocampal 5-ht(1a) receptor mrna regulation in mice that have a targeted disruption of the glucocorticoid receptor gene. |
1997-08-05 |
2023-08-12 |
mouse |
| O C Meijer, T J Cole, W Schmid, G Schütz, M Joëls, E R De Kloe. Regulation of hippocampal 5-HT1A receptor mRNA and binding in transgenic mice with a targeted disruption of the glucocorticoid receptor. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191104. |
5-ht(1a) receptor mrna levels as well as binding of [3h]8-oh-dpat, were measured in the hippocampus of heterozygous and homozygous gr-deficient mice and in wild-type control mice. |
1997-08-05 |
2023-08-12 |
mouse |
| O C Meijer, T J Cole, W Schmid, G Schütz, M Joëls, E R De Kloe. Regulation of hippocampal 5-HT1A receptor mRNA and binding in transgenic mice with a targeted disruption of the glucocorticoid receptor. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191104. |
the 5-ht(1a) receptor mrna levels were responsive to corticosterone, as adrenalectomy led to increased levels of hippocampal 5-ht(1a) receptor mrna both in wild-type as in heterozygous knockout mice. |
1997-08-05 |
2023-08-12 |
mouse |
| O C Meijer, T J Cole, W Schmid, G Schütz, M Joëls, E R De Kloe. Regulation of hippocampal 5-HT1A receptor mRNA and binding in transgenic mice with a targeted disruption of the glucocorticoid receptor. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191104. |
these results support a suppressive control of b over 5-ht(1a) receptor expression in the hippocampus of the mouse, which is predominantly mediated via the mineralocorticoid receptor. |
1997-08-05 |
2023-08-12 |
mouse |
| S Takeo, H Hayashi, K Miyake, K Takagi, M Tadokoro, N Takagi, S Oshikaw. Effects of delayed treatment with nebracetam on neurotransmitters in brain regions after microsphere embolism in rats. British journal of pharmacology. vol 121. issue 3. 1997-08-04. PMID:9179389. |
the levels of acetylcholine, dopamine, noradrenaline, 5-hydroxytryptamine (5-ht) and their metabolites in the cerebral cortex, striatum and hippocampus of animals with microsphere embolism were determined by high performance liquid chromatography (h.p.l.c.) |
1997-08-04 |
2023-08-12 |
rat |
| S Takeo, H Hayashi, K Miyake, K Takagi, M Tadokoro, N Takagi, S Oshikaw. Effects of delayed treatment with nebracetam on neurotransmitters in brain regions after microsphere embolism in rats. British journal of pharmacology. vol 121. issue 3. 1997-08-04. PMID:9179389. |
although the microsphere embolism induced significant changes in most of the neurotransmitters and some of their metabolites in the brain regions, the delayed treatment with nebracetam partially restored only the hippocampal 5-ht and the striatal dopamine metabolite contents on the 3rd day. |
1997-08-04 |
2023-08-12 |
rat |
| S Takeo, H Hayashi, K Miyake, K Takagi, M Tadokoro, N Takagi, S Oshikaw. Effects of delayed treatment with nebracetam on neurotransmitters in brain regions after microsphere embolism in rats. British journal of pharmacology. vol 121. issue 3. 1997-08-04. PMID:9179389. |
the hippocampal in vivo 5-ht synthesis, but not the striatal dopamine synthesis, was attenuated in rats with microsphere embolism on the 3rd day, but was restored by treatment with nebracetam. |
1997-08-04 |
2023-08-12 |
rat |
| J L Yau, J Noble, J R Seck. Site-specific regulation of corticosteroid and serotonin receptor subtype gene expression in the rat hippocampus following 3,4-methylenedioxymethamphetamine: role of corticosterone and serotonin. Neuroscience. vol 78. issue 1. 1997-08-01. PMID:9135093. |
site-specific regulation of corticosteroid and serotonin receptor subtype gene expression in the rat hippocampus following 3,4-methylenedioxymethamphetamine: role of corticosterone and serotonin. |
1997-08-01 |
2023-08-12 |
rat |
| J L Yau, J Noble, J R Seck. Site-specific regulation of corticosteroid and serotonin receptor subtype gene expression in the rat hippocampus following 3,4-methylenedioxymethamphetamine: role of corticosterone and serotonin. Neuroscience. vol 78. issue 1. 1997-08-01. PMID:9135093. |
abnormal interactions between serotonin (5-hydroxytryptamine) and glucocorticoids, notably in the hippocampus, may underpin neuroendocrine, affective and cognitive dysfunction in depression and ageing. |
1997-08-01 |
2023-08-12 |
rat |
| J L Yau, J Noble, J R Seck. Site-specific regulation of corticosteroid and serotonin receptor subtype gene expression in the rat hippocampus following 3,4-methylenedioxymethamphetamine: role of corticosterone and serotonin. Neuroscience. vol 78. issue 1. 1997-08-01. PMID:9135093. |
to determine the roles of 5-hydroxytryptamine and corticosterone in the short-term control of hippocampal receptor gene expression, we used 3,4-methylenedioxymethamphetamine (20 mg/kg), which causes acute release of both 5-hydroxytryptamine and corticosterone. |
1997-08-01 |
2023-08-12 |
rat |
| J L Yau, J Noble, J R Seck. Site-specific regulation of corticosteroid and serotonin receptor subtype gene expression in the rat hippocampus following 3,4-methylenedioxymethamphetamine: role of corticosterone and serotonin. Neuroscience. vol 78. issue 1. 1997-08-01. PMID:9135093. |
3,4-methylenedioxymethamphetamine increased mineralocorticoid receptor messenger rna expression throughout the hippocampus after 16 h. in rats with fixed glucocorticoid levels (adrenalectomy plus corticosterone pellets) this effect was lost in ca1-4, suggesting corticosterone-mediation, but maintained in the dentate gyrus, indicating 5-hydroxytryptamine involvement. |
1997-08-01 |
2023-08-12 |
rat |
| J L Yau, J Noble, J R Seck. Site-specific regulation of corticosteroid and serotonin receptor subtype gene expression in the rat hippocampus following 3,4-methylenedioxymethamphetamine: role of corticosterone and serotonin. Neuroscience. vol 78. issue 1. 1997-08-01. PMID:9135093. |
5-hydroxytryptamine1a receptor messenger rna expression was decreased in ca1 in both groups of rats, but increased in the dentate gyrus only in corticosterone-fixed rats, suggesting 5-hydroxytryptamine differentially regulates expression of this gene within hippocampal subfields. |
1997-08-01 |
2023-08-12 |
rat |
| J L Yau, J Noble, J R Seck. Site-specific regulation of corticosteroid and serotonin receptor subtype gene expression in the rat hippocampus following 3,4-methylenedioxymethamphetamine: role of corticosterone and serotonin. Neuroscience. vol 78. issue 1. 1997-08-01. PMID:9135093. |
these results show the complexity and intricate subregional-specificity of 5-hydroxytryptamine and corticosterone interactions upon hippocampal corticosteroid and 5-hydroxytryptamine receptor gene expression. |
1997-08-01 |
2023-08-12 |
rat |
| M Asikainen, J Toppila, L Alanko, D J Ward, D Stenberg, T Porkka-Heiskane. Sleep deprivation increases brain serotonin turnover in the rat. Neuroreport. vol 8. issue 7. 1997-07-31. PMID:9189895. |
sd significantly increased the 5-hiaa/5-ht ratio in frontal cortex, hippocampus, hypothalamus and brain stem, indicating increased 5-ht turnover in those areas. |
1997-07-31 |
2023-08-12 |
rat |
| J W Dailey, M E Reith, Q S Yan, M Y Li, P C Job. Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: dose response relationships. Neuroscience letters. vol 227. issue 1. 1997-07-30. PMID:9178847. |
anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: dose response relationships. |
1997-07-30 |
2023-08-12 |
rat |