| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Farnaz Karimani, Afsaneh Asgari Taei, Neda Kaveh, Mohammad Rabiei Ghahfarokhi, Mohammad-Reza Abolghasemi-Dehaghani, Leila Dargah. Hippocampal sharp-wave ripples and hippocampal-prefrontal synchrony regulate memory-enhancing effects of intranasal insulin in an STZ-induced Alzheimer's model. Life sciences. 2024-10-03. PMID:39362588. |
hippocampal sharp-wave ripples and hippocampal-prefrontal synchrony regulate memory-enhancing effects of intranasal insulin in an stz-induced alzheimer's model. |
2024-10-03 |
2024-10-07 |
rat |
| Noriyasu Kamei, Kento Ikeda, Yuka Ohmoto, Seita Fujisaki, Ryusei Shirata, Maya Maki, Mika Miyata, Yuki Miyauchi, Nanaka Nishiyama, Mana Yamada, Yuna Ohigashi, Mariko Takeda-Morishit. Insulin-inspired hippocampal neuron-targeting technology for protein drug delivery. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 41. 2024-09-30. PMID:39348543. |
here, we genetically engineered insulin-fusion proteins, called hippocampal neuron-targeting (ht) proteins, for targeting protein drugs to hippocampal neurons because insulin tends to accumulate in the neuronal cell layers of the hippocampus. |
2024-09-30 |
2024-10-03 |
Not clear |
| Noriyasu Kamei, Kento Ikeda, Yuka Ohmoto, Seita Fujisaki, Ryusei Shirata, Maya Maki, Mika Miyata, Yuki Miyauchi, Nanaka Nishiyama, Mana Yamada, Yuna Ohigashi, Mariko Takeda-Morishit. Insulin-inspired hippocampal neuron-targeting technology for protein drug delivery. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 41. 2024-09-30. PMID:39348543. |
in vitro examinations clarified that insulin and ht proteins were internalized into the cultured hippocampal neurons through insulin receptor-mediated macropinocytosis. |
2024-09-30 |
2024-10-03 |
Not clear |
| Noriyasu Kamei, Kento Ikeda, Yuka Ohmoto, Seita Fujisaki, Ryusei Shirata, Maya Maki, Mika Miyata, Yuki Miyauchi, Nanaka Nishiyama, Mana Yamada, Yuna Ohigashi, Mariko Takeda-Morishit. Insulin-inspired hippocampal neuron-targeting technology for protein drug delivery. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 41. 2024-09-30. PMID:39348543. |
cysteines were key determinants of the delivery of ht proteins to hippocampal neurons, and insulin b chain mutant was most potent in delivering cargo proteins. |
2024-09-30 |
2024-10-03 |
Not clear |
| Da-Sol Kim, Suna Kang, Na-Rang Moon, Bae-Keun Shin, Sunmin Par. Zeaxanthin and Lutein Ameliorate Alzheimer's Disease-like Pathology: Modulation of Insulin Resistance, Neuroinflammation, and Acetylcholinesterase Activity in an Amyloid-β Rat Model. International journal of molecular sciences. vol 25. issue 18. 2024-09-28. PMID:39337316. |
the ad-con rats exhibited a higher aβ deposition, attenuated hippocampal insulin signaling (reduced phosphorylation of protein kinase b [pakt] and glycogen synthase kinase-3β [pgsk-3β]), increased neuroinflammation, elevated acetylcholinesterase activity, and memory deficits compared to the normal-con group. |
2024-09-28 |
2024-10-01 |
rat |
| Jian Liu, Hui Yang, Hong-Qing Zhao, Wei Li, Zhuo Liu, Yu-Hong Wan. [Protective effect and mechanism of Zuogui Jiangtang Jieyu Formula on damage to hippocampal synaptic microenvironment in rats with diabetes-related depression based on microglia-neuron crosstalk signal CD300f/TLR4]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 17. 2024-09-22. PMID:39307798. |
the results indicated that compared with that in the normal group, the total movement distance in open field experiments was reduced in the model group, and the immobility time in forced swimming experiments increased, with an elevated insulin level in serum, as well as tnf-α, il-1β, and ido levels in the hippocampus. |
2024-09-22 |
2024-09-26 |
rat |
| Ayano Shima, Moeko Noguchi-Shinohara, Shutaro Shibata, Yuta Usui, Yasuko Tatewaki, Benjamin Thyreau, Jun Hata, Tomoyuki Ohara, Takanori Honda, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Hisao Nishijo, Toshiharu Ninomiya, Kenjiro On. Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function. npj aging. vol 10. issue 1. 2024-09-09. PMID:39251602. |
we investigated associations of glycemic measures, and insulin resistance and secretion measures with hippocampal and subfield volumes. |
2024-09-09 |
2024-09-13 |
human |
| Qiaofeng Zhou, Xiying Guo, Tu Chen, Yumin Liu, Huimin Ji, Yixuan Sun, Xiaosong Yang, Changhan Ouyang, Xiufen Liu, Min Le. The neuroprotective role of celastrol on hippocampus in diabetic rats by inflammation restraint, insulin signaling adjustment, Aβ reduction and synaptic plasticity alternation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 179. 2024-09-04. PMID:39232386. |
the neuroprotective role of celastrol on hippocampus in diabetic rats by inflammation restraint, insulin signaling adjustment, aβ reduction and synaptic plasticity alternation. |
2024-09-04 |
2024-09-08 |
rat |
| Yuncong Xu, Yanxiao Li, Qiaojuan Yan, Xiangzhao Mao, Shaoqing Yang, Zhengqiang Jian. The Function and Mechanism of Laminaripentaose Prepared from Curdlan for the Amelioration of the Cognitive Dysfunctions in Obese Mice. Journal of agricultural and food chemistry. 2024-08-31. PMID:39215716. |
furthermore, lpa improved memory functions and reduced hippocampal insulin resistance and neuronal injury. |
2024-08-31 |
2024-09-04 |
mouse |
| Aliaa M Foda, Safinaz S Ibrahim, Sherehan M Ibrahim, Eman M Elba. Pterostilbene Ameliorates Cognitive Impairment in Polycystic Ovary Syndrome Rat Model through Improving Insulin Resistance via the IRS-1/PI3K/Akt/GSK-3β Pathway: A Comparative Study with Metformin. ACS chemical neuroscience. 2024-08-09. PMID:39119909. |
assessment of serum hormonal profile and hippocampal irs-1/pi3k/akt/gsk-3β insulin signaling pathway components were performed. |
2024-08-09 |
2024-08-12 |
rat |
| Reetta-Liina Armio, Heikki Laurikainen, Tuula Ilonen, Maija Walta, Elina Sormunen, Arvi Tolvanen, Raimo K R Salokangas, Nikolaos Koutsouleris, Lauri Tuominen, Jarmo Hietal. Longitudinal study on hippocampal subfields and glucose metabolism in early psychosis. Schizophrenia (Heidelberg, Germany). vol 10. issue 1. 2024-07-31. PMID:39085221. |
the smaller volume of hippocampal tail was associated with higher plasma insulin and insulin resistance in feps, at the one-year follow-up. |
2024-07-31 |
2024-08-03 |
Not clear |
| Miao Sun, Min Liu, Qingxiao Li, Siyuan Liu, Huikai Yang, Yuxiang Song, Mengyao Qu, Xiaoying Zhang, Yulong Ma, Weidong M. Insulin attenuates LPS-induced cognitive impairment and ferroptosis through regulation of glucose metabolism in hippocampus. CNS neuroscience & therapeutics. vol 30. issue 7. 2024-07-29. PMID:39073013. |
insulin attenuates lps-induced cognitive impairment and ferroptosis through regulation of glucose metabolism in hippocampus. |
2024-07-29 |
2024-08-02 |
mouse |
| Irina O Zakharova, Liubov V Bayunova, Daria K Avrova, Alina D Tretyakova, Alexander O Shpakov, Natalia F Avrov. The Autophagic and Apoptotic Death of Forebrain Neurons of Rats with Global Brain Ischemia Is Diminished by the Intranasal Administration of Insulin: Possible Mechanism of Its Action. Current issues in molecular biology. vol 46. issue 7. 2024-07-26. PMID:39057034. |
insulin administered intranasally activated the akt-kinase (activating the mtorc1 complex, which inhibits autophagy) and inhibited the amp-activated protein kinase (which activates autophagy) in the hippocampus and frontal cortex of rats with brain ischemia and reperfusion. |
2024-07-26 |
2024-07-28 |
rat |
| Igor Henrique Rodrigues de Paiva, Rodrigo Soares da Silva, Ingrid Prata Mendonça, José Roberto Botelho de Souza, Christina Alves Peixot. Semaglutide Attenuates Anxious and Depressive-Like Behaviors and Reverses the Cognitive Impairment in a Type 2 Diabetes Mellitus Mouse Model Via the Microbiota-Gut-Brain Axis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-07-23. PMID:39042202. |
additionally, semaglutide treatment protected synaptic plasticity and reversed the hippocampal neuroinflammation induced by hfd fed, improving activation of the insulin pathway, demonstrating the protective effects of semaglutide. |
2024-07-23 |
2024-07-25 |
mouse |
| Camila A E F Cardinali, Yandara A Martins, Ruan C M Moraes, Andressa P Costa, Mayke B Alencar, Ariel M Silber, Andrea S Torrã. Exploring the Therapeutic Potential of Benfotiamine in a Sporadic Alzheimer's-Like Disease Rat Model: Insights into Insulin Signaling and Cognitive function. ACS chemical neuroscience. 2024-07-15. PMID:39007352. |
we attribute these effects to bft's ability to modulate glucose transporters type 1 and 3 (glut1 and glut3) in the hippocampus, inhibit gsk3 activity in the hippocampus, and modulate the insulin signaling in the hippocampus and entorhinal cortex, as well as reduce the activation of apoptotic pathways (bax) in the hippocampus. |
2024-07-15 |
2024-07-18 |
rat |
| Natasha Ivanova, Milena Atanasova, Dora Terzieva, Katerina Georgieva, Jana Tchekalarov. The Role of Piromelatine on Peripheral and Hippocampal Insulin Resistance in Rat Offspring Exposed to Chronic Maternal Stress. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000130. |
the role of piromelatine on peripheral and hippocampal insulin resistance in rat offspring exposed to chronic maternal stress. |
2024-07-13 |
2024-07-15 |
rat |
| Natasha Ivanova, Milena Atanasova, Dora Terzieva, Katerina Georgieva, Jana Tchekalarov. The Role of Piromelatine on Peripheral and Hippocampal Insulin Resistance in Rat Offspring Exposed to Chronic Maternal Stress. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000130. |
prenatally stressed offspring of both sexes indicated enhanced plasma glucose and serum insulin concentrations, increased homa-ir, and decreased hippocampal glut4 only in male rats. |
2024-07-13 |
2024-07-15 |
rat |
| Nathan R Kerr, Chandler W Mossman, Chih-Hsuan Chou, Joshua M Bunten, Taylor J Kelty, Thomas E Childs, R Scott Rector, W David Arnold, Laurel A Grisanti, Xiangwei Du, Frank W Boot. Hindlimb immobilization induces insulin resistance and elevates mitochondrial ROS production in the hippocampus of female rats. Journal of applied physiology (Bethesda, Md. : 1985). 2024-07-04. PMID:38961821. |
hindlimb immobilization induces insulin resistance and elevates mitochondrial ros production in the hippocampus of female rats. |
2024-07-04 |
2024-07-10 |
rat |
| Maryam Moosavi, Roksana Soukhaklari, Saeid Bagheri-Mohammadi, Bita Firouzan, Pegah Javadpour, Rasoul Ghasem. Nanocurcumin prevents memory impairment, hippocampal apoptosis, Akt and CaMKII-α signaling disruption in the central STZ model of Alzheimer's disease in rat. Behavioural brain research. 2024-06-28. PMID:38942084. |
these findings might suggest that nanocurcumin can restore memory deficit, hippocampal apoptosis as well as akt and camkii-α signaling disruption associated with brain insulin resistance. |
2024-06-28 |
2024-07-01 |
rat |
| Iraj Sadri, Saeid Dabbagh Nikookheslat, Pouran Karimi, Mostafa Khani, Sanaz Nadim. Aerobic exercise training improves memory function through modulation of brain-derived neurotrophic factor and synaptic proteins in the hippocampus and prefrontal cortex of type 2 diabetic rats. Journal of diabetes and metabolic disorders. vol 23. issue 1. 2024-06-27. PMID:38932906. |
defective insulin signaling in the brain may disrupt hippocampal neuroplasticity resulting in learning and memory impairments. |
2024-06-27 |
2024-06-29 |
rat |