| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C R Abraham, P C Mullen, T Tucker-Zhou, C D Chen, E Zeldic. Klotho Is a Neuroprotective and Cognition-Enhancing Protein. Vitamins and hormones. vol 101. 2017-10-30. PMID:27125744. |
we recently demonstrated that klotho protects hippocampal neurons from amyloid and glutamate toxicity via the activation of an antioxidant enzymatic system suggesting klotho is a neuroprotective protein. |
2017-10-30 |
2023-08-13 |
mouse |
| Crystal Bostrom, Suk-Yu Yau, Namat Majaess, Mariana Vetrici, Joana Gil-Mohapel, Brian R Christi. Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome. Neuroscience and biobehavioral reviews. vol 68. 2017-10-24. PMID:27345143. |
this review provides an overview of the neuropathology of fragile-x syndrome, highlighting how structural and synaptic deficits in hippocampal subregions, including the ca1 exhibiting exaggerated metabotropic glutamate receptor dependent long-term depression and the dentate gyrus displaying hypofunction of n-methyl-d-aspartate receptors, contribute to cognitive impairments associated with this neurodevelopmental disorder. |
2017-10-24 |
2023-08-13 |
Not clear |
| Pamela J Yao, Ronald S Petralia, Mark P Mattso. Sonic Hedgehog Signaling and Hippocampal Neuroplasticity. Trends in neurosciences. vol 39. issue 12. 2017-10-20. PMID:27865563. |
activation of shh receptors in the dendrites of hippocampal neurons engages a trans-neuronal signaling pathway that accelerates axon outgrowth and enhances glutamate release from presynaptic terminals. |
2017-10-20 |
2023-08-13 |
Not clear |
| Carla Nasca, Benedetta Bigio, Danielle Zelli, Paolo de Angelis, Timothy Lau, Masahiro Okamoto, Hideyo Soya, Jason Ni, Lars Brichta, Paul Greengard, Rachael L Neve, Francis S Lee, Bruce S McEwe. Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress. Neuron. vol 96. issue 2. 2017-10-20. PMID:29024663. |
role of the astroglial glutamate exchanger xct in ventral hippocampus in resilience to stress. |
2017-10-20 |
2023-08-13 |
mouse |
| Carla Nasca, Benedetta Bigio, Danielle Zelli, Paolo de Angelis, Timothy Lau, Masahiro Okamoto, Hideyo Soya, Jason Ni, Lars Brichta, Paul Greengard, Rachael L Neve, Francis S Lee, Bruce S McEwe. Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress. Neuron. vol 96. issue 2. 2017-10-20. PMID:29024663. |
we demonstrate that stress differentially regulates glutamate homeostasis in the dorsal and ventral hippocampus and identify a role for the astroglial xct in ventral dentate gyrus (vdg) in stress and antidepressant responses. |
2017-10-20 |
2023-08-13 |
mouse |
| Sarah Hescham, Ali Jahanshahi, Judith V Schweimer, Stephen N Mitchell, Guy Carter, Arjan Blokland, Trevor Sharp, Yasin Teme. Fornix deep brain stimulation enhances acetylcholine levels in the hippocampus. Brain structure & function. vol 221. issue 8. 2017-10-10. PMID:26597361. |
interestingly, hippocampal glutamate levels did not change compared to baseline. |
2017-10-10 |
2023-08-13 |
rat |
| Cecilia Csölle, Mária Baranyi, Gabriella Zsilla, Agnes Kittel, Flóra Gölöncsér, Peter Illes, Edit Papp, E Sylvester Vizi, Beáta Sperlág. Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. PloS one. vol 8. issue 6. 2017-10-06. PMID:23805233. |
the activation of p2rx7 resulted in the concentration-dependent release of [(3)h]glutamate in p2rx7+/+ but not p2rx7-/- mice, and the nr2b subunit mrna and protein was upregulated in the hippocampus of p2rx7-/- mice. |
2017-10-06 |
2023-08-12 |
mouse |
| Cecilia Csölle, Mária Baranyi, Gabriella Zsilla, Agnes Kittel, Flóra Gölöncsér, Peter Illes, Edit Papp, E Sylvester Vizi, Beáta Sperlág. Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. PloS one. vol 8. issue 6. 2017-10-06. PMID:23805233. |
in conclusion there are several potential mechanisms for the antidepressant phenotype of p2rx7-/- mice, such as the absence of p2rx7-mediated glutamate release, elevated basal bdnf production, enhanced neurogenesis and increased 5-ht bioavailability in the hippocampus. |
2017-10-06 |
2023-08-12 |
mouse |
| A C Pereira, J D Gray, J F Kogan, R L Davidson, T G Rubin, M Okamoto, J H Morrison, B S McEwe. Age and Alzheimer's disease gene expression profiles reversed by the glutamate modulator riluzole. Molecular psychiatry. vol 22. issue 2. 2017-10-03. PMID:27021815. |
the glutamate modulator, riluzole, which was recently shown to improve memory performance in aged rats, prevented many of the hippocampal age-related gene expression changes. |
2017-10-03 |
2023-08-13 |
human |
| Nikhil J Pandya, Remco V Klaassen, Roel C van der Schors, Johan A Slotman, Adriaan Houtsmuller, August B Smit, Ka Wan L. Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex. Proteomics. vol 16. issue 20. 2017-10-02. PMID:27392515. |
group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex. |
2017-10-02 |
2023-08-13 |
mouse |
| Hong-Tao Wang, Fu-Lian Huang, Zhao-Lan Hu, Wen-Juan Zhang, Xiao-Qing Qiao, Yan-Qing Huang, Ru-Ping Dai, Fang Li, Chang-Qi L. Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline. Neurotoxicity research. vol 31. issue 4. 2017-10-02. PMID:28092020. |
here, we used the early-life social isolation (esi) model of early-life stress in rats to characterize development of depressive-like behavior, the role of microglia, levels of histone methylation, as well as expression of glutamate receptor subunits in the hippocampus. |
2017-10-02 |
2023-08-13 |
rat |
| P De Rossi, E Harde, J P Dupuis, L Martin, N Chounlamountri, M Bardin, C Watrin, C Benetollo, K Pernet-Gallay, H J Luhmann, J Honnorat, G Malleret, L Groc, A Acker-Palmer, P A Salin, C Meissire. A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior. Molecular psychiatry. vol 21. issue 12. 2017-09-21. PMID:26728568. |
vegf increases the postsynaptic responses mediated by the n-methyl-d-aspartate type of glutamate receptors (glunrs) in hippocampal neurons. |
2017-09-21 |
2023-08-13 |
Not clear |
| Yan-Mei Ma, Gordon Ibeanu, Li-Yao Wang, Jian-Zhong Zhang, Yue Chang, Jian-Da Dong, P Andy Li, Li Jin. Selenium suppresses glutamate-induced cell death and prevents mitochondrial morphological dynamic alterations in hippocampal HT22 neuronal cells. BMC neuroscience. vol 18. issue 1. 2017-09-18. PMID:28103798. |
in this study glutamate exposed murine hippocampal neuronal ht22 cell was used as a model to investigate the underlying mechanisms of selenium-dependent protection against mitochondria damage. |
2017-09-18 |
2023-08-13 |
Not clear |
| Hua Chai, Blanca Diaz-Castro, Eiji Shigetomi, Emma Monte, J Christopher Octeau, Xinzhu Yu, Whitaker Cohn, Pradeep S Rajendran, Thomas M Vondriska, Julian P Whitelegge, Giovanni Coppola, Baljit S Khak. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron. vol 95. issue 3. 2017-09-14. PMID:28712653. |
here, we used multiple integrated approaches, including rna sequencing (rna-seq), mass spectrometry, electrophysiology, immunohistochemistry, serial block-face-scanning electron microscopy, morphological reconstructions, pharmacogenetics, and diffusible dye, calcium, and glutamate imaging, to directly compare adult striatal and hippocampal astrocytes under identical conditions. |
2017-09-14 |
2023-08-13 |
Not clear |
| Naima Calderón, Luis Betancourt, Luis Hernández, Pedro Rad. A ketogenic diet modifies glutamate, gamma-aminobutyric acid and agmatine levels in the hippocampus of rats: A microdialysis study. Neuroscience letters. vol 642. 2017-09-08. PMID:28189745. |
a ketogenic diet modifies glutamate, gamma-aminobutyric acid and agmatine levels in the hippocampus of rats: a microdialysis study. |
2017-09-08 |
2023-08-13 |
rat |
| Naima Calderón, Luis Betancourt, Luis Hernández, Pedro Rad. A ketogenic diet modifies glutamate, gamma-aminobutyric acid and agmatine levels in the hippocampus of rats: A microdialysis study. Neuroscience letters. vol 642. 2017-09-08. PMID:28189745. |
in the present report, we have used microdialysis coupled to capillary electrophoresis to monitor microdialysate levels of gaba, glutamate and agmatine in the hippocampus of rats submitted to a kd for 15days compared to rats on a normal rat chow diet. |
2017-09-08 |
2023-08-13 |
rat |
| Jochen Martin Decker, Lars Krüger, Astrid Sydow, Frank Ja Dennissen, Zuzana Siskova, Eckhard Mandelkow, Eva-Maria Mandelko. The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity. EMBO reports. vol 17. issue 4. 2017-09-07. PMID:26931569. |
in organotypic hippocampal slices, extracellular glutamate increases early above control levels, followed by a rise in neurotoxicity. |
2017-09-07 |
2023-08-13 |
mouse |
| Cheng Wei Lu, Tzu Yu Lin, Ting Yang Hsie, Shu Kuei Huang, Su Jane Wan. Capsaicin presynaptically inhibits glutamate release through the activation of TRPV1 and calcineurin in the hippocampus of rats. Food & function. vol 8. issue 5. 2017-09-05. PMID:28418433. |
capsaicin presynaptically inhibits glutamate release through the activation of trpv1 and calcineurin in the hippocampus of rats. |
2017-09-05 |
2023-08-13 |
rat |
| Cheng Wei Lu, Tzu Yu Lin, Ting Yang Hsie, Shu Kuei Huang, Su Jane Wan. Capsaicin presynaptically inhibits glutamate release through the activation of TRPV1 and calcineurin in the hippocampus of rats. Food & function. vol 8. issue 5. 2017-09-05. PMID:28418433. |
capsaicin is the major ingredient in hot peppers of the plant capsicum genus with neuroprotective effects in several preclinical models; its effect on glutamate release has been investigated in the rat hippocampus using isolated nerve terminals (synaptosomes) and brain slices. |
2017-09-05 |
2023-08-13 |
rat |
| Valeria Famiglini, Giuseppe La Regina, Antonio Coluccia, Domiziana Masci, Andrea Brancale, Roger Badia, Eva Riveira-Muñoz, José A Esté, Emmanuele Crespan, Alessandro Brambilla, Giovanni Maga, Myriam Catalano, Cristina Limatola, Francesca Romana Formica, Roberto Cirilli, Ettore Novellino, Romano Silvestr. Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents. Journal of medicinal chemistry. vol 60. issue 15. 2017-09-05. PMID:28628334. |
compound 23 protected hippocampal neuronal cells from the excitotoxic insult, while efavirenz (efv) did not contrast the neurotoxic effect of glutamate. |
2017-09-05 |
2023-08-13 |
Not clear |