| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takeshi Nakamura, Yoshinobu Kawamura, Hiroyoshi Miyakaw. Optical bioimaging: from living tissue to a single molecule: optical detection of synaptically induced glutamate transporter activity in hippocampal slices. Journal of pharmacological sciences. vol 93. issue 3. 2004-07-06. PMID:14646238. |
by applying this technology to hippocampal brain slices, we have found that astrocytes play indispensable roles in sequestering glutamate, maintenance of synaptic transmission, and neuronal survival. |
2004-07-06 |
2023-08-12 |
Not clear |
| I González-Burgos, M A López-Vázquez, C Beas-Zárat. Density, but not shape, of hippocampal dendritic spines varies after a seizure-inducing acute dose of monosodium glutamate in rats. Neuroscience letters. vol 363. issue 1. 2004-07-06. PMID:15157988. |
density, but not shape, of hippocampal dendritic spines varies after a seizure-inducing acute dose of monosodium glutamate in rats. |
2004-07-06 |
2023-08-12 |
rat |
| Hyoung-gon Lee, Xiongwei Zhu, Michael J O'Neill, Kate Webber, Gemma Casadesus, Michael Marlatt, Arun K Raina, George Perry, Mark A Smit. The role of metabotropic glutamate receptors in Alzheimer's disease. Acta neurobiologiae experimentalis. vol 64. issue 1. 2004-07-06. PMID:15190683. |
while glutamatergic transmission is severely altered by early degeneration of cortico-cortical connections and hippocampal projections in alzheimer's disease (ad), the role of glutamate receptors in the pathogenesis of ad is not yet defined clearly. |
2004-07-06 |
2023-08-12 |
Not clear |
| Troy L Carter, Robert A Rissman, Amanda J Mishizen-Eberz, Barry B Wolfe, Ronald L Hamilton, Sam Gandy, David M Armstron. Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage. Experimental neurology. vol 187. issue 2. 2004-06-30. PMID:15144856. |
we hypothesize that the glutamate-mediated vulnerability is highly influenced by the repertoire of glutamate receptors expressed on hippocampal neurons. |
2004-06-30 |
2023-08-12 |
Not clear |
| Barton R Harris, D Alex Gibson, Mark A Prendergast, John A Blanchard, Robert C Holley, Stewart R Hart, Rebecca L Scotland, Thomas C Foster, Norman W Pedigo, John M Littleto. The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptors. Alcoholism, clinical and experimental research. vol 27. issue 11. 2004-06-29. PMID:14634487. |
the neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and n-methyl-d-aspartate receptors. |
2004-06-29 |
2023-08-12 |
Not clear |
| Giacinto Bagetta, Ernesto Palma, Silvia Piccirilli, Claudio Del Duca, A Luigi Morrone, Guiseppe Nappi, M Tiziana Corasaniti, J Oliver Doll. Involvement of a glutamergic mechanism in gamma-dendrotoxin-induced hippocampal neuronal cell loss in the rat. Basic & clinical pharmacology & toxicology. vol 94. issue 3. 2004-06-25. PMID:15052999. |
the epileptogenic and neurodegenerative effects of gamma-dendrotoxin, from dendroaspis angusticeps, a specific blocker of a non-inactivating, voltage-sensitive k+ channel, were studied after focal injection into one dorsal hippocampus in rats pretreated with cgp040116, a n-methyl-d-aspartate (nmda) receptor antagonist, and in rats bearing a monolateral surgical lesion of the schaffer collaterals whose terminals originate from ca3 pyramids and release glutamate in the ca1 hippocampal area. |
2004-06-25 |
2023-08-12 |
rat |
| Marina Ioudina, Etsuro Uemura, Heather West Greenle. Glucose insufficiency alters neuronal viability and increases susceptibility to glutamate toxicity. Brain research. vol 1004. issue 1-2. 2004-06-24. PMID:15033434. |
we investigated the effect of a restricted supply of glucose on neuronal vulnerability to glutamate by assaying cellular atp levels (cellular energy production), 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (mtt) reduction (mitochondrial function), lactate dehydrogenase (ldh) release (cellular viability) and activation of caspase-3 (apoptosis) in rat hippocampal neurons cultured in media (1.7, 5 and 25 mm glucose) with or without 100 microm glutamate. |
2004-06-24 |
2023-08-12 |
rat |
| Monika Schäfer, Sharon Goodenough, Bernd Moosmann, Christian Beh. Inhibition of glycogen synthase kinase 3 beta is involved in the resistance to oxidative stress in neuronal HT22 cells. Brain research. vol 1005. issue 1-2. 2004-06-22. PMID:15044068. |
we have established clones of the murine hippocampal neuronal cell line ht22, which are resistant to the oxidative stress-causing agents glutamate and hydrogen peroxide, respectively. |
2004-06-22 |
2023-08-12 |
Not clear |
| Christine E Gee, Jean-Claude Lacaill. Group I metabotropic glutamate receptor actions in oriens/alveus interneurons of rat hippocampal CA1 region. Brain research. vol 1000. issue 1-2. 2004-06-22. PMID:15053957. |
group i metabotropic glutamate receptors (mglurs) are important for hippocampal interneuron function. |
2004-06-22 |
2023-08-12 |
rat |
| Michael Gruss, Katharina Brau. Age- and region-specific imbalances of basal amino acids and monoamine metabolism in limbic regions of female Fmr1 knock-out mice. Neurochemistry international. vol 45. issue 1. 2004-06-22. PMID:15082225. |
furthermore, compared to the wildtype animals, the juvenile knock-out mice displayed an increased level of neuronal inhibition in the hippocampus and brainstem reflected by decreased ratios of (aspartate + glutamate)/(taurine + gaba), as well as an increased dopamine (da) turnover in cortical regions, striatum, and hippocampus. |
2004-06-22 |
2023-08-12 |
mouse |
| Qinwen Wang, Dominic M Walsh, Michael J Rowan, Dennis J Selkoe, Roger Anwy. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 13. 2004-06-18. PMID:15056716. |
block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-jun n-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. |
2004-06-18 |
2023-08-12 |
human |
| Daisaku Yokomaku, Tadahiro Numakawa, Yumiko Numakawa, Shingo Suzuki, Tomoya Matsumoto, Naoki Adachi, Chika Nishio, Takahisa Taguchi, Hiroshi Hatanak. Estrogen enhances depolarization-induced glutamate release through activation of phosphatidylinositol 3-kinase and mitogen-activated protein kinase in cultured hippocampal neurons. Molecular endocrinology (Baltimore, Md.). vol 17. issue 5. 2004-06-17. PMID:12554763. |
estrogen enhances depolarization-induced glutamate release through activation of phosphatidylinositol 3-kinase and mitogen-activated protein kinase in cultured hippocampal neurons. |
2004-06-17 |
2023-08-12 |
Not clear |
| Qing-song Liu, Qiwu Xu, Gregory Arcuino, Jian Kang, Maiken Nedergaar. Astrocyte-mediated activation of neuronal kainate receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 9. 2004-06-17. PMID:14766987. |
we tested the hypothesis that astrocyte-derived glutamate activates kainate receptors on hippocampal interneurons. |
2004-06-17 |
2023-08-12 |
rat |
| Caroline R Elliott-Hunt, Barnaby Marsh, Andrea Bacon, Robert Pope, Penny Vanderplank, David Wynic. Galanin acts as a neuroprotective factor to the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 14. 2004-06-10. PMID:15041741. |
similarly, exposure to glutamate or staurosporine induced significantly more neuronal cell death in galanin knockout organotypic and dispersed primary hippocampal cultures than in wt controls. |
2004-06-10 |
2023-08-12 |
Not clear |
| Gerardo G Piroli, Claudia A Grillo, Maureen J Charron, Bruce S McEwen, Lawrence P Reaga. Biphasic effects of stress upon GLUT8 glucose transporter expression and trafficking in the diabetic rat hippocampus. Brain research. vol 1006. issue 1. 2004-06-07. PMID:15047021. |
glucose transporter (glut) expression, activity and translocation represent components of the glucoregulatory activities of the hippocampus that may be disrupted by diabetes and stress. |
2004-06-07 |
2023-08-12 |
human |
| Yan Gu, Shao-Yu Ge, Di-Yun Rua. Effect of 4-aminopyridine on synaptic transmission in rat hippocampal slices. Brain research. vol 1006. issue 2. 2004-06-07. PMID:15051526. |
the responses evoked by spontaneously released glutamate and gaba were recorded from area ca1 pyramidal neurons in rat hippocampal slices in whole-cell mode. |
2004-06-07 |
2023-08-12 |
rat |
| Mario Barbieri, Gianni Bregola, Andrea Buzzi, Silvia Marino, Silvia Zucchini, James P Stables, Marco Bergamaschi, Claudio Pietra, Gino Villetti, Michele Simonat. Mechanisms of action of CHF3381 in the forebrain. British journal of pharmacology. vol 139. issue 7. 2004-06-04. PMID:12890713. |
(4) consistent with the mild effects on voltage-gated na(+) channels, chf3381 (100 micro m) failed to affect electrical stimulation-evoked glutamate overflow in hippocampal slices. |
2004-06-04 |
2023-08-12 |
Not clear |
| Yasukazu Tanaka, Huiwan Han, Tairo Hagishita, Fumiko Fukui, Guoquan Liu, Susumu And. alpha-Sialylcholesterol enhances the depolarization-induced release of acetylcholine and glutamate in rat hippocampus: in vivo microdialysis study. Neuroscience letters. vol 357. issue 1. 2004-06-03. PMID:15036601. |
alpha-sialylcholesterol enhances the depolarization-induced release of acetylcholine and glutamate in rat hippocampus: in vivo microdialysis study. |
2004-06-03 |
2023-08-12 |
rat |
| Tiffany J Mellott, Christina L Williams, Warren H Meck, Jan Krzysztof Blusztaj. Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 3. 2004-06-01. PMID:14715695. |
moreover, phosphorylation and therefore activation of hippocampal mitogen-activated protein kinase (mapk) and camp-response element binding protein (creb) in response to stimulation by glutamate, n-methyl-d-aspartate, or depolarizing concentrations of k+ were increased by prenatal choline supplementation and reduced by prenatal choline deficiency. |
2004-06-01 |
2023-08-12 |
rat |
| W Vollmar, J Gloger, E Berger, G Kortenbruck, R Köhling, E-J Speckmann, U Musshof. RNA editing (R/G site) and flip-flop splicing of the AMPA receptor subunit GluR2 in nervous tissue of epilepsy patients. Neurobiology of disease. vol 15. issue 2. 2004-06-01. PMID:15006707. |
the increased editing at the r/g site in the hippocampal tissue of epilepsy patients may enhance responses to glutamate, resulting in a synapse operating at an increased gain. |
2004-06-01 |
2023-08-12 |
human |